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product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Oxotremorine M
catalog :
O100
citations: 44
Reference
Soulard C, Salsac C, Mouzat K, Hilaire C, Roussel J, Mezghrani A, et al. Spinal Motoneuron TMEM16F Acts at C-boutons to Modulate Motor Resistance and Contributes to ALS Pathogenesis. Cell Rep. 2020;30:2581-2593.e7 pubmed publisher
Kirmiz M, Gillies T, Dickson E, Trimmer J. Neuronal ER-plasma membrane junctions organized by Kv2-VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis. J Biol Chem. 2019;294:17735-17757 pubmed publisher
Frinchi M, Nuzzo D, Scaduto P, DI Carlo M, Massenti M, Belluardo N, et al. Anti-inflammatory and antioxidant effects of muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus. Sci Rep. 2019;9:14233 pubmed publisher
Spensley M, Del Borrello S, Pajkic D, Fraser A. Acute Effects of Drugs on Caenorhabditis elegans Movement Reveal Complex Responses and Plasticity. G3 (Bethesda). 2018;8:2941-2952 pubmed publisher
Jing M, Zhang P, Wang G, Feng J, Mesik L, Zeng J, et al. A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nat Biotechnol. 2018;36:726-737 pubmed publisher
Frinchi M, Scaduto P, Cappello F, Belluardo N, Mudo G. Heat shock protein (Hsp) regulation by muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus. J Cell Physiol. 2018;233:6107-6116 pubmed publisher
Seemann W, Wenzel D, Schrage R, Etscheid J, Bödefeld T, Bartol A, et al. Engineered Context-Sensitive Agonism: Tissue-Selective Drug Signaling through a G Protein-Coupled Receptor. J Pharmacol Exp Ther. 2017;360:289-299 pubmed publisher
Berizzi A, Gentry P, Rueda P, den Hoedt S, Sexton P, Langmead C, et al. Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators. Mol Pharmacol. 2016;90:427-36 pubmed publisher
Nadal L, Garcia N, Hurtado E, Simó A, Tomas M, Lanuza M, et al. Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction. Mol Brain. 2016;9:67 pubmed publisher
Zhou P, Zhu Q, Liu M, Li J, Wang Y, Zhang C, et al. Muscarinic acetylcholine receptor in cerebellar cortex participates in acetylcholine-mediated blood depressor response in rats. Neurosci Lett. 2015;593:129-33 pubmed publisher
Abiraman K, Pol S, O Bara M, Chen G, Khaku Z, Wang J, et al. Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair. J Neurosci. 2015;35:3676-88 pubmed publisher
Silveira M, Malcolm E, Shoaib M, Winstanley C. Scopolamine and amphetamine produce similar decision-making deficits on a rat gambling task via independent pathways. Behav Brain Res. 2015;281:86-95 pubmed publisher
Odagaki Y, Kinoshita M, Toyoshima R. Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes. J Pharmacol Sci. 2014;125:157-68 pubmed
Croy C, Schober D, Xiao H, Quets A, Christopoulos A, Felder C. Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors. Mol Pharmacol. 2014;86:106-15 pubmed publisher
Correa P, LeBoeuf B, Garcia L. C. elegans dopaminergic D2-like receptors delimit recurrent cholinergic-mediated motor programs during a goal-oriented behavior. PLoS Genet. 2012;8:e1003015 pubmed publisher
Gholami M, Saboory E, Zare S, Roshan Milani S, Hajizadeh Moghaddam A. The effect of dorsal hippocampal administration of nicotinic and muscarinic cholinergic ligands on pentylenetetrazol-induced generalized seizures in rats. Epilepsy Behav. 2012;25:244-9 pubmed publisher
Chang S, Ross E. Activation biosensor for G protein-coupled receptors: a FRET-based m1 muscarinic activation sensor that regulates G(q). PLoS ONE. 2012;7:e45651 pubmed publisher
Daigle T, Caron M. Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation. J Neurosci. 2012;32:11461-6 pubmed publisher
Won Y, Ono F, Ikeda S. Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS ONE. 2012;7:e42602 pubmed publisher
Dedoni S, Olianas M, Ingianni A, Onali P. Type I interferons impair BDNF-induced cell signaling and neurotrophic activity in differentiated human SH-SY5Y neuroblastoma cells and mouse primary cortical neurons. J Neurochem. 2012;122:58-71 pubmed publisher
Vivas O, Arenas I, Garcia D. Voltage-independent inhibition of Ca(V)2.2 channels is delimited to a specific region of the membrane potential in rat SCG neurons. Acta Biochim Biophys Sin (Shanghai). 2012;44:544-9 pubmed publisher
Bista P, Meuth S, Kanyshkova T, Cerina M, Pawlowski M, Ehling P, et al. Identification of the muscarinic pathway underlying cessation of sleep-related burst activity in rat thalamocortical relay neurons. Pflugers Arch. 2012;463:89-102 pubmed publisher
Soukup O, Kumar U, Proska J, Bratova L, Adem A, Jun D, et al. The effect of oxime reactivators on muscarinic receptors: functional and binding examinations. Environ Toxicol Pharmacol. 2011;31:364-70 pubmed publisher
Chen S, Chen H, Yuan W, Wess J, Pan H. Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice. J Biol Chem. 2010;285:40427-37 pubmed publisher
Yu Y, de Groat W. Effects of stimulation of muscarinic receptors on bladder afferent nerves in the in vitro bladder-pelvic afferent nerve preparation of the rat. Brain Res. 2010;1361:43-53 pubmed publisher
Ziegler N, Bätz J, Zabel U, Lohse M, Hoffmann C. FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors. Bioorg Med Chem. 2011;19:1048-54 pubmed publisher
Han S, Wilson S, Bolter C. Tertiapin-Q removes a mechanosensitive component of muscarinic control of the sinoatrial pacemaker in the rat. Clin Exp Pharmacol Physiol. 2010;37:900-4 pubmed publisher
Harada T, Fushimi K, Kato A, Ito Y, Nishijima S, Sugaya K, et al. Demonstration of muscarinic and nicotinic receptor binding activities of distigmine to treat detrusor underactivity. Biol Pharm Bull. 2010;33:653-8 pubmed
Pak K, Ostrom R, Matsui M, Ehlert F. Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder. Naunyn Schmiedebergs Arch Pharmacol. 2010;381:441-54 pubmed publisher
Thomas D, Dada A, Jones G, Deisz R, Gigout S, Langmead C, et al. N-desmethylclozapine (NDMC) is an antagonist at the human native muscarinic M(1) receptor. Neuropharmacology. 2010;58:1206-14 pubmed publisher
Foster D, Heacock A, Fisher S. Muscarinic receptor stimulation of D-aspartate uptake into human SH-SY5Y neuroblastoma cells is attenuated by hypoosmolarity. J Pharmacol Exp Ther. 2010;333:297-309 pubmed publisher
Kebig A, Kostenis E, Mohr K, Mohr Andrä M. An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators. J Recept Signal Transduct Res. 2009;29:140-5 pubmed publisher
Griffin M, Matsui M, Ostrom R, Ehlert F. The guinea pig ileum lacks the direct, high-potency, M(2)-muscarinic, contractile mechanism characteristic of the mouse ileum. Naunyn Schmiedebergs Arch Pharmacol. 2009;380:327-35 pubmed publisher
Liu J, Rasul I, Sun Y, Wu G, Li L, Premont R, et al. GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. J Biol Chem. 2009;284:19564-71 pubmed publisher
Salah Uddin H, Scarr E, Pavey G, Harris K, Hagan J, Dean B, et al. Altered M(1) muscarinic acetylcholine receptor (CHRM1)-Galpha(q/11) coupling in a schizophrenia endophenotype. Neuropsychopharmacology. 2009;34:2156-66 pubmed publisher
Masuda H, Chancellor M, Kihara K, Sakai Y, Koga F, Azuma H, et al. Effects of cholinesterase inhibition in supraspinal and spinal neural pathways on the micturition reflex in rats. BJU Int. 2009;104:1163-9 pubmed publisher
Tapia L, García Eguiagaray J, Garcia A, Gandia L. Preconditioning stimuli that augment chromaffin cell secretion. Am J Physiol Cell Physiol. 2009;296:C792-800 pubmed publisher
Zhang H, Chen S, Cai Y, Richardson T, Driver L, Lopez Berestein G, et al. Signaling mechanisms mediating muscarinic enhancement of GABAergic synaptic transmission in the spinal cord. Neuroscience. 2009;158:1577-88 pubmed publisher
Perez C, Limon A, Vega R, Soto E. The muscarinic inhibition of the potassium M-current modulates the action-potential discharge in the vestibular primary-afferent neurons of the rat. Neuroscience. 2009;158:1662-74 pubmed publisher
Foster D, Vitvitsky V, Banerjee R, Heacock A, Fisher S. Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells. J Neurochem. 2009;108:437-49 pubmed publisher
Mirajkar N, Pope C. In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases. Biochem Pharmacol. 2008;76:1047-58 pubmed publisher
Park E, Lee Y, Kim Y, Lee C. Cholinergic modulation of neural activity in the telencephalon of the zebrafish. Neurosci Lett. 2008;439:79-83 pubmed publisher
Tayebati S, Piergentili A, Natale D, Amenta F. Evaluation of an agonist index: affinity ratio for compounds active on muscarinic cholinergic M2 receptors. J Auton Pharmacol. 1999;19:77-84 pubmed
Gillard M, Waelbroeck M, Christophe J. Muscarinic receptor heterogeneity in rat central nervous system. II. Brain receptors labeled by [3H]oxotremorine-M correspond to heterogeneous M2 receptors with very high affinity for agonists. Mol Pharmacol. 1987;32:100-8 pubmed
product information
Catalog Number :
O100
Product Name :
Oxotremorine M
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
solid
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA