This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Nutlin-3
catalog :
N6287
citations: 175
Reference
Xie X, He G, Siddik Z. Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill. Mol Pharmacol. 2020;97:237-249 pubmed publisher
Kang J, Lago C, Lee J, Park J, Donnelly M, Starost M, et al. A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53. Cell Rep. 2020;30:783-792.e5 pubmed publisher
Miyajima C, Kawarada Y, Inoue Y, Suzuki C, Mitamura K, Morishita D, et al. Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence. Cells. 2020;9: pubmed publisher
Jaskova Z, Pavlova S, Malcikova J, Brychtova Y, Trbusek M. PRIMA-1MET cytotoxic effect correlates with p53 protein reduction in TP53-mutated chronic lymphocytic leukemia cells. Leuk Res. 2020;89:106288 pubmed publisher
Guo L, Xu Y, Zhou A, Zhang L, Sun L, Gao Y, et al. A stimuli-responsive combination therapy for recovering p53-inactivation associated drug resistance. Mater Sci Eng C Mater Biol Appl. 2020;108:110403 pubmed publisher
Wu J, Liang Y, Tan Y, Tang Y, Song H, Wang Z, et al. CDK9 inhibitors reactivate p53 by downregulating iASPP. Cell Signal. 2020;67:109508 pubmed publisher
Merugu S, Chen L, Gavens E, Gabra H, Brougham M, Makin G, et al. Detection of Circulating and Disseminated Neuroblastoma Cells Using the ImageStream Flow Cytometer for Use as Predictive and Pharmacodynamic Biomarkers. Clin Cancer Res. 2020;26:122-134 pubmed publisher
Kanagasabai T, Venkatesan T, Natarajan U, Alobid S, Alhazzani K, Algahtani M, et al. Regulation of cell cycle by MDM2 in prostate cancer cells through Aurora Kinase-B and p21WAF1/CIP1 mediated pathways. Cell Signal. 2020;66:109435 pubmed publisher
Cao L, Xue M, Chen J, Shi H, Zhang X, Shi D, et al. Porcine parvovirus replication is suppressed by activation of the PERK signaling pathway and endoplasmic reticulum stress-mediated apoptosis. Virology. 2020;539:1-10 pubmed publisher
Nguyen P, Dagley L, Preaudet A, Lam N, Giam M, Fung K, et al. Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer. Cell Death Differ. 2020;27:742-757 pubmed publisher
Friedrich D, Friedel L, Finzel A, Herrmann A, Preibisch S, Loewer A. Stochastic transcription in the p53-mediated response to DNA damage is modulated by burst frequency. Mol Syst Biol. 2019;15:e9068 pubmed publisher
Bersuker K, Hendricks J, Li Z, Magtanong L, Ford B, Tang P, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575:688-692 pubmed publisher
Park J, Bae Y. Dephosphorylation of p53 Ser 392 Enhances Trimethylation of Histone H3 Lys 9 via SUV39h1 Stabilization in CK2 Downregulation-Mediated Senescence. Mol Cells. 2019;42:773-782 pubmed publisher
Wu L, He Y, Hu Y, Lu H, Cao Z, Yi X, et al. Real-time surface plasmon resonance monitoring of site-specific phosphorylation of p53 protein and its interaction with MDM2 protein. Analyst. 2019;144:6033-6040 pubmed publisher
Abe K, Yano T, Tanno M, Miki T, Kuno A, Sato T, et al. mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation. Biochim Biophys Acta Mol Basis Dis. 2019;1865:165552 pubmed publisher
Tran T, Guha R, Portugal S, Skinner J, Ongoiba A, Bhardwaj J, et al. A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation. Immunity. 2019;51:750-765.e10 pubmed publisher
Xu H, Li X, Wu X, Yang Y, Dai S, Lei T, et al. Iduna protects HT22 cells by inhibiting parthanatos: The role of the p53-MDM2 pathway. Exp Cell Res. 2019;384:111547 pubmed publisher
Uroda T, Anastasakou E, Rossi A, Teulon J, Pellequer J, Annibale P, et al. Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway. Mol Cell. 2019;75:982-995.e9 pubmed publisher
Liu B, Song J, Han H, Hu Z, Chen N, Cui J, et al. Blockade of MDM2 with inactive Cas9 prevents epithelial to mesenchymal transition in retinal pigment epithelial cells. Lab Invest. 2019;99:1874-1886 pubmed publisher
Wang X, Chen Y, Liu H, Guo S, Hu Y, Zhan Y, et al. A novel anti-cancer mechanism of Nutlin-3 through downregulation of Eag1 channel and PI3K/AKT pathway. Biochem Biophys Res Commun. 2019;517:445-451 pubmed publisher
Verboom K, Everaert C, Bolduc N, Livak K, Yigit N, Rombaut D, et al. SMARTer single cell total RNA sequencing. Nucleic Acids Res. 2019;47:e93 pubmed publisher
Huang J, Du J, Lin W, Long Z, Zhang N, Huang X, et al. Regulation of lactate production through p53/β-enolase axis contributes to statin-associated muscle symptoms. EBioMedicine. 2019;: pubmed publisher
Scott G, Yau C, Becker B, Khateeb S, Mahoney S, Borch Jensen M, et al. Targeting mitochondrial proline dehydrogenase with a suicide inhibitor to exploit synthetic lethal interactions with p53 upregulation and glutaminase inhibition. Mol Cancer Ther. 2019;: pubmed publisher
Caller L, Davies C, Antrobus R, Lehner P, Weekes M, Crump C. Temporal proteomic analysis of BK polyomavirus infection reveals virus-induced G2 arrest and highly effective evasion of innate immune sensing. J Virol. 2019;: pubmed publisher
Wu L, Hu Y, He Y, Xia Y, Lu H, Cao Z, et al. Dual-channel surface plasmon resonance monitoring of intracellular levels of the p53-MDM2 complex and caspase-3 induced by MDM2 antagonist Nutlin-3. Analyst. 2019;144:3959-3966 pubmed publisher
Kain H, Glennon E, Vijayan K, Arang N, Douglass A, Fortin C, et al. Liver stage malaria infection is controlled by host regulators of lipid peroxidation. Cell Death Differ. 2019;: pubmed publisher
Lee B, Min J, Nashed A, Lee S, Yoo J, Chi S, et al. A novel mechanism of irinotecan targeting MDM2 and Bcl-xL. Biochem Biophys Res Commun. 2019;: pubmed publisher
Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems S, Devriese L, et al. Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy. Cancer Discov. 2019;: pubmed publisher
Kopper O, de Witte C, Lõhmussaar K, Valle Inclan J, Hami N, Kester L, et al. An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity. Nat Med. 2019;25:838-849 pubmed publisher
Sica V, Bravo San Pedro J, Izzo V, Pol J, Pierredon S, Enot D, et al. Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate. Cell Rep. 2019;27:820-834.e9 pubmed publisher
Su H, Kang Q, Wang H, Yin H, Duan L, Liu Y, et al. Changes in expression of p53 and inflammatory factors in patients with ulcerative colitis. Exp Ther Med. 2019;17:2451-2456 pubmed publisher
Aho E, Wang J, Gogliotti R, Howard G, Phan J, Acharya P, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019;26:2916-2928.e13 pubmed publisher
Wang M, Wang X, Li Y, Xiao Q, Cui X, Xiao G, et al. Nutlin-3-Induced Sensitization of Non-Small Cell Lung Cancer Stem Cells to Axitinib-Induced Apoptosis Through Repression of Akt1/Wnt Signaling. Oncol Res. 2019;27:987-995 pubmed publisher
Yu X, Zhang S, Zhao D, Zhang X, Xia C, Wang T, et al. SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494. Int J Mol Med. 2019;43:1758-1768 pubmed publisher
Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, et al. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. J Clin Invest. 2019;129:1129-1151 pubmed publisher
Yoon M, Kang S, Lee S, Woo T, Oh A, Park S, et al. p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation. Cell Death Dis. 2019;10:107 pubmed publisher
Daniele S, Giacomelli C, Pietrobono D, Barresi E, Piccarducci R, La Pietra V, et al. Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts. Biochim Biophys Acta Mol Cell Res. 2019;1866:737-749 pubmed publisher
Llanos S, Megias D, Blanco Aparicio C, Hernández Encinas E, Rovira M, Pietrocola F, et al. Lysosomal trapping of palbociclib and its functional implications. Oncogene. 2019;38:3886-3902 pubmed publisher
Breton Y, Desrosiers V, Ouellet M, Deshiere A, Torresilla C, Cohen E, et al. Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53. J Virol. 2019;93: pubmed publisher
Sarisozen C, Tan Y, Liu J, Bilir C, Shen L, Filipczak N, et al. MDM2 antagonist-loaded targeted micelles in combination with doxorubicin: effective synergism against human glioblastoma via p53 re-activation. J Drug Target. 2019;27:624-633 pubmed publisher
Santoro A, Vlachou T, Luzi L, Melloni G, Mazzarella L, D Elia E, et al. p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value. Cell Rep. 2019;26:624-638.e8 pubmed publisher
Chen S, Zhang C, Liu L, Lu S, Pan Y, Wang C, et al. A GYS2/p53 Negative Feedback Loop Restricts Tumor Growth in HBV-Related Hepatocellular Carcinoma. Cancer Res. 2019;79:534-545 pubmed publisher
Liu B, Yi J, Yang X, Liu L, Lou X, Zhang Z, et al. MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner. Oncogene. 2019;38:2501-2515 pubmed publisher
Shihabudeen Haider Ali M, Cheng X, Moran M, Haemmig S, Naldrett M, Alvarez S, et al. LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Nucleic Acids Res. 2019;47:1505-1522 pubmed publisher
Wei Z, Guo H, Qin J, Lu S, Liu Q, Zhang X, et al. Pan-senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence. Free Radic Biol Med. 2019;130:267-277 pubmed publisher
Guo Y, Li Y, Wang F, Xiang B, Huang X, Ma H, et al. The combination of Nutlin-3 and Tanshinone IIA promotes synergistic cytotoxicity in acute leukemic cells expressing wild-type p53 by co-regulating MDM2-P53 and the AKT/mTOR pathway. Int J Biochem Cell Biol. 2019;106:8-20 pubmed publisher
Di Leo L, Vegliante R, Ciccarone F, Salvatori I, Scimeca M, Bonanno E, et al. Forcing ATGL expression in hepatocarcinoma cells imposes glycolytic rewiring through PPAR-α/p300-mediated acetylation of p53. Oncogene. 2019;38:1860-1875 pubmed publisher
Arnandis T, Monteiro P, Adams S, Bridgeman V, Rajeeve V, Gadaleta E, et al. Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Dev Cell. 2018;47:409-424.e9 pubmed publisher
Azatyan A, Gallo Oller G, Diao Y, Selivanova G, Johnsen J, Zaphiropoulos P. RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism. Cancer Lett. 2018;442:341-350 pubmed publisher
Ding C, Ong J, Goh H, Coffill C, Tan L. Benderamide A, a Cyclic Depsipeptide from a Singapore Collection of Marine Cyanobacterium cf. Lyngbya sp. Mar Drugs. 2018;16: pubmed publisher
Simões Sousa S, Littler S, Thompson S, Minshall P, Whalley H, Bakker B, et al. The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α. Cell Rep. 2018;25:749-760.e6 pubmed publisher
Fekry B, Jeffries K, Esmaeilniakooshkghazi A, Szulc Z, Knagge K, Kirchner D, et al. C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Nat Commun. 2018;9:4149 pubmed publisher
Chen H, Xue L, Huang H, Wang H, Zhang X, Zhu W, et al. Synergistic effect of Nutlin-3 combined with MG-132 on schwannoma cells through restoration of merlin and p53 tumour suppressors. EBioMedicine. 2018;36:252-265 pubmed publisher
Alsanafi M, Kelly S, Jubair K, McNaughton M, Tate R, Merrill A, et al. Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival. Mol Cell Biol. 2018;38: pubmed publisher
Sriraman A, Dickmanns A, Najafova Z, Johnsen S, Dobbelstein M. CDK4 inhibition diminishes p53 activation by MDM2 antagonists. Cell Death Dis. 2018;9:918 pubmed publisher
Tajan M, Hock A, Blagih J, Robertson N, Labuschagne C, Kruiswijk F, et al. A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3. Cell Metab. 2018;28:721-736.e6 pubmed publisher
Chung S, Kim G, Kweon S, Lee H, Choi J, Mahmud F, et al. Metronomic oral doxorubicin in combination of Chk1 inhibitor MK-8776 for p53-deficient breast cancer treatment. Biomaterials. 2018;182:35-43 pubmed publisher
Dijkstra K, Cattaneo C, Weeber F, Chalabi M, van de Haar J, Fanchi L, et al. Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids. Cell. 2018;174:1586-1598.e12 pubmed publisher
Nanki K, Toshimitsu K, Takano A, Fujii M, Shimokawa M, Ohta Y, et al. Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis. Cell. 2018;174:856-869.e17 pubmed publisher
Trepte P, Kruse S, Kostova S, Hoffmann S, Buntru A, Tempelmeier A, et al. LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells. Mol Syst Biol. 2018;14:e8071 pubmed publisher
Li Y, Stockton M, Eisinger B, Zhao Y, Miller J, Bhuiyan I, et al. Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome. Nat Commun. 2018;9:2494 pubmed publisher
Dhar D, Antonucci L, Nakagawa H, Kim J, Glitzner E, Caruso S, et al. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018;33:1061-1077.e6 pubmed publisher
Wong G, Zhou J, Liu J, Wu Z, Xu X, Li T, et al. Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nat Med. 2018;24:968-977 pubmed publisher
Gonçalves I, Brecht J, Thelen M, Rehorst W, Peters M, Lee H, et al. Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy. Sci Rep. 2018;8:7907 pubmed publisher
Miyazaki M, Otomo R, Matsushima Hibiya Y, Suzuki H, Nakajima A, Abe N, et al. The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas. Cell Death Discov. 2018;4:56 pubmed publisher
Venkatesan T, Alaseem A, Chinnaiyan A, Dhandayuthapani S, Kanagasabai T, Alhazzani K, et al. MDM2 Overexpression Modulates the Angiogenesis-Related Gene Expression Profile of Prostate Cancer Cells. Cells. 2018;7: pubmed publisher
Liu L, Tian F, Xiong Y, Zhao Y, Song J. Gadd45a gene silencing by RNAi promotes cell proliferation and inhibits apoptosis and senescence in skin squamous cell carcinoma through the p53 signaling pathway. J Cell Physiol. 2018;233:7424-7434 pubmed publisher
Oda T, Sekimoto T, Kurashima K, Fujimoto M, Nakai A, Yamashita T. Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. J Cell Sci. 2018;131: pubmed publisher
Warnier M, Flaman J, Chouabe C, Wiel C, Gras B, Griveau A, et al. The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway. Aging Cell. 2018;17:e12736 pubmed publisher
Ingallina E, Sorrentino G, Bertolio R, Lisek K, Zannini A, Azzolin L, et al. Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis. Nat Cell Biol. 2018;20:28-35 pubmed publisher
Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, et al. A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. Cell. 2018;172:373-386.e10 pubmed publisher
Norlin S, Parekh V, Edlund H. The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018;145: pubmed publisher
Briest F, Grass I, Sedding D, Möbs M, Christen F, Benecke J, et al. Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-Differentiated Intestinal Neuroendocrine Tumors. Neuroendocrinology. 2018;107:1-23 pubmed publisher
Canli O, Nicolas A, Gupta J, Finkelmeier F, Goncharova O, Pesic M, et al. Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis. Cancer Cell. 2017;32:869-883.e5 pubmed publisher
Choi M, Shi J, Zhu Y, Yang R, Cho K. Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response. Nat Commun. 2017;8:1940 pubmed publisher
Slomnicki L, CHUNG D, Parker A, Hermann T, Boyd N, Hetman M. Ribosomal stress and Tp53-mediated neuronal apoptosis in response to capsid protein of the Zika virus. Sci Rep. 2017;7:16652 pubmed publisher
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle N, et al. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017;32:824-839.e8 pubmed publisher
Li C, Tao Y, Yang Y, Feng C, Xiang Y, Li G. Dynamic sandwich-type electrochemical assay for protein quantification and protein-protein interaction. Analyst. 2017;142:4399-4404 pubmed publisher
Salech F, Ponce D, SanMartin C, Rogers N, Chacón C, Henriquez M, et al. PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients. Front Aging Neurosci. 2017;9:310 pubmed publisher
Wu M, Ye H, Tang Z, Shao C, Lu G, Chen B, et al. p53 dynamics orchestrates with binding affinity to target genes for cell fate decision. Cell Death Dis. 2017;8:e3130 pubmed publisher
Khan M, Xiang S, Song Z, Wu M. The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation. EMBO J. 2017;36:3483-3500 pubmed publisher
Lu H, Liufu N, Dong Y, Xu G, Zhang Y, Shu L, et al. Sevoflurane Acts on Ubiquitination-Proteasome Pathway to Reduce Postsynaptic Density 95 Protein Levels in Young Mice. Anesthesiology. 2017;127:961-975 pubmed publisher
Díaz Muñoz M, Kiselev V, Le Novère N, Curk T, Ule J, Turner M. Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells. Nat Commun. 2017;8:530 pubmed publisher
Andrysik Z, Galbraith M, Guarnieri A, Zaccara S, Sullivan K, Pandey A, et al. Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity. Genome Res. 2017;27:1645-1657 pubmed publisher
Yang H, Chung M, Kudo T, Meyer T. Competing memories of mitogen and p53 signalling control cell-cycle entry. Nature. 2017;549:404-408 pubmed publisher
Lessel D, Wu D, Trujillo C, Ramezani T, Lessel I, Alwasiyah M, et al. Dysfunction of the MDM2/p53 axis is linked to premature aging. J Clin Invest. 2017;127:3598-3608 pubmed publisher
Chen Y, Wang D, Wu Y, Su D, Zhou T, Gai R, et al. MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells. Br J Cancer. 2017;117:1192-1201 pubmed publisher
Giono L, Resnick Silverman L, Carvajal L, St Clair S, Manfredi J. Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase. Oncogene. 2017;36:6762-6773 pubmed publisher
Lee D, Kim I, Seo M, Kwon M, Choi K. Nutlin-3 enhances the bortezomib sensitivity of p53-defective cancer cells by inducing paraptosis. Exp Mol Med. 2017;49:e365 pubmed publisher
Wang J, Zhou Y, Li D, Sun X, Deng Y, Zhao Q. TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells. FEBS Lett. 2017;591:2905-2918 pubmed publisher
Zhang Y, Zhu C, Sun B, Lv J, Liu Z, Liu S, et al. Integrated High Throughput Analysis Identifies GSK3 as a Crucial Determinant of p53-Mediated Apoptosis in Lung Cancer Cells. Cell Physiol Biochem. 2017;42:1177-1191 pubmed publisher
Wang X, Zhang S, Bao J, Liu F. Oridonin synergizes with Nutlin-3 in osteosarcoma cells by modulating the levels of multiple Bcl-2 family proteins. Tumour Biol. 2017;39:1010428317701638 pubmed publisher
Jain J, Jain S, Walker L, Tekwani B. Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads. BMC Pharmacol Toxicol. 2017;18:40 pubmed publisher
McNally J, Millen S, Chaturvedi V, Lakes N, Terrell C, Elfers E, et al. Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases. Proc Natl Acad Sci U S A. 2017;114:E4782-E4791 pubmed publisher
Riegel E, Heimbucher T, Hofer T, Czerny T. A sensitive, semi-quantitative mammalian two-hybrid assay. Biotechniques. 2017;62:206-214 pubmed publisher
He Z, Hu X, Liu W, Dorrance A, Garzon R, Houghton P, et al. P53 suppresses ribonucleotide reductase via inhibiting mTORC1. Oncotarget. 2017;8:41422-41431 pubmed publisher
Bhattacharya S, Yin J, Winborn C, Zhang Q, Yue J, Chaum E. Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci. 2017;58:2366-2387 pubmed publisher
Pok S, Vohra H, Wehbe C, Barn V, Arfianti E, Dan Y, et al. Deriving and testing of dysplastic murine hepatocytes: A new platform in liver cancer research. Exp Cell Res. 2017;356:48-56 pubmed publisher
De Sousa E Melo F, Kurtova A, Harnoss J, Kljavin N, Hoeck J, Hung J, et al. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer. Nature. 2017;543:676-680 pubmed publisher
Corbel C, Sartini S, Levati E, Colas P, Maillet L, Couturier C, et al. Screening for Protein-Protein Interaction Inhibitors Using a Bioluminescence Resonance Energy Transfer (BRET)-Based Assay in Yeast. SLAS Discov. 2017;22:751-759 pubmed publisher
Barr A, Cooper S, Heldt F, Butera F, Stoy H, Mansfeld J, et al. DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression. Nat Commun. 2017;8:14728 pubmed publisher
Coaxum S, Tiedeken J, Garrett Mayer E, Myers J, Rosenzweig S, Neskey D. The tumor suppressor capability of p53 is dependent on non-muscle myosin IIA function in head and neck cancer. Oncotarget. 2017;8:22991-23007 pubmed publisher
Fava L, Schüler F, Sladky V, Haschka M, Soratroi C, Eiterer L, et al. The PIDDosome activates p53 in response to supernumerary centrosomes. Genes Dev. 2017;31:34-45 pubmed publisher
Hoppe Seyler K, Bossler F, Lohrey C, Bulkescher J, Rösl F, Jansen L, et al. Induction of dormancy in hypoxic human papillomavirus-positive cancer cells. Proc Natl Acad Sci U S A. 2017;114:E990-E998 pubmed publisher
Castellini L, Moon E, Razorenova O, Krieg A, von Eyben R, Giaccia A. KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Res. 2017;45:3674-3692 pubmed publisher
You L, Liu H, Huang J, Xie W, Wei J, Ye X, et al. The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins. Oncotarget. 2017;8:7777-7790 pubmed publisher
Yang K, Wang M, Zhao Y, Sun X, Yang Y, Li X, et al. A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nat Commun. 2016;7:13599 pubmed publisher
Quintas Cardama A, Hu C, Qutub A, Qiu Y, Zhang X, Post S, et al. p53 pathway dysfunction is highly prevalent in acute myeloid leukemia independent of TP53 mutational status. Leukemia. 2017;31:1296-1305 pubmed publisher
Green M, Thayer S. NMDARs Adapt to Neurotoxic HIV Protein Tat Downstream of a GluN2A-Ubiquitin Ligase Signaling Pathway. J Neurosci. 2016;36:12640-12649 pubmed
Lu J, Guan S, Zhao Y, Yu Y, Wang Y, Shi Y, et al. Novel MDM2 inhibitor SAR405838 (MI-773) induces p53-mediated apoptosis in neuroblastoma. Oncotarget. 2016;7:82757-82769 pubmed publisher
Hwang S, Park H, Park Y, Lee H. An α-quaternary chiral latam derivative, YH-304 as a novel broad-spectrum anticancer agent. Int J Oncol. 2016;49:2480-2486 pubmed publisher
Logan I, McClurg U, Jones D, O Neill D, Shaheen F, Lunec J, et al. Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells. Oncotarget. 2016;7:74724-74733 pubmed publisher
Liu T, Xiong J, Yi S, Zhang H, Zhou S, Gu L, et al. FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2. Oncogene. 2017;36:1678-1686 pubmed publisher
Rizzo F, Ronchi D, Salani S, Nizzardo M, Fortunato F, Bordoni A, et al. Selective mitochondrial depletion, apoptosis resistance, and increased mitophagy in human Charcot-Marie-Tooth 2A motor neurons. Hum Mol Genet. 2016;25:4266-4281 pubmed publisher
Hallenborg P, Siersbæk M, Barrio Hernandez I, Nielsen R, Kristiansen K, Mandrup S, et al. MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3. Cell Death Dis. 2016;7:e2289 pubmed publisher
Cortes C, Veiga S, Almacellas E, Hernández Losa J, Ferreres J, Kozma S, et al. Effect of low doses of actinomycin D on neuroblastoma cell lines. Mol Cancer. 2016;15:1 pubmed publisher
Suvorova I, Grigorash B, Chuykin I, Pospelova T, Pospelov V. G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling. Cell Cycle. 2016;15:52-63 pubmed publisher
Pujals A, Favre L, Pioche Durieu C, Robert A, Meurice G, Le Gentil M, et al. Constitutive autophagy contributes to resistance to TP53-mediated apoptosis in Epstein-Barr virus-positive latency III B-cell lymphoproliferations. Autophagy. 2015;11:2275-87 pubmed publisher
Voon Y, Ahmad M, Wong P, Husaini R, Ng W, Leong C, et al. Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity. Oncol Rep. 2015;34:1692-700 pubmed publisher
Mondesert O, Frongia C, Clayton O, Boizeau M, Lobjois V, Ducommun B. Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model. PLoS ONE. 2015;10:e0134411 pubmed publisher
Shatz M, Shats I, Menendez D, Resnick M. p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways. Oncotarget. 2015;6:16963-80 pubmed
Woodard C, Liao G, Goodwin C, Hu J, Xie Z, Dos Reis T, et al. A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP. J Virol. 2015;89:9232-41 pubmed publisher
Bock F, Tanzer M, Haschka M, Krumschnabel G, Sohm B, Goetsch K, et al. The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death. Sci Rep. 2015;5:11268 pubmed publisher
Rueda Rincon N, Bloch K, Derua R, Vyas R, Harms A, Hankemeier T, et al. p53 attenuates AKT signaling by modulating membrane phospholipid composition. Oncotarget. 2015;6:21240-54 pubmed
Yun J, Espinoza I, Pannuti A, Romero D, Martinez L, Caskey M, et al. p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1. J Cell Physiol. 2015;230:3115-27 pubmed publisher
Sachweh M, Stafford W, Drummond C, McCarthy A, Higgins M, Campbell J, et al. Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells. Oncotarget. 2015;6:16488-506 pubmed
Belletti D, Tosi G, Riva G, Lagreca I, Galliania M, Luppi M, et al. Nutlin-3 loaded nanocarriers: Preparation, characterization and in vitro antineoplastic effect against primary effusion lymphoma. Int J Pharm. 2015;490:85-93 pubmed publisher
Gillory L, Stewart J, Megison M, Waters A, Beierle E. Focal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival. J Surg Res. 2015;196:339-49 pubmed publisher
Miyajima C, Inoue Y, Hayashi H. Pseudokinase tribbles 1 (TRB1) negatively regulates tumor-suppressor activity of p53 through p53 deacetylation. Biol Pharm Bull. 2015;38:618-24 pubmed publisher
Sonnemann J, Grauel D, Blümel L, Hentschel J, Marx C, Blumrich A, et al. RETRA exerts anticancer activity in Ewing's sarcoma cells independent of their TP53 status. Eur J Cancer. 2015;51:841-51 pubmed publisher
Grawenda A, Møller E, Lam S, Repapi E, Teunisse A, Alnæs G, et al. Interaction between p53 mutation and a somatic HDMX biomarker better defines metastatic potential in breast cancer. Cancer Res. 2015;75:698-708 pubmed publisher
Douglass A, Kain H, Abdullahi M, Arang N, Austin L, Mikolajczak S, et al. Host-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites. Mol Ther. 2015;23:857-865 pubmed publisher
Ajayi A, Yu X, Wahlo Svedin C, Tsirigotaki G, Karlström V, Ström A. Altered p53 and NOX1 activity cause bioenergetic defects in a SCA7 polyglutamine disease model. Biochim Biophys Acta. 2015;1847:418-428 pubmed publisher
Bhardwaj V, Noto J, Wei J, Andl C, El Rifai W, Peek R, et al. Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway. Oncotarget. 2015;6:1531-43 pubmed
Chander H, Brien C, Truesdell P, Watt K, Meens J, Schick C, et al. Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis. Breast Cancer Res. 2014;16:3413 pubmed publisher
Agnoletto C, Brunelli L, Melloni E, Pastorelli R, Casciano F, Rimondi E, et al. The anti-leukemic activity of sodium dichloroacetate in p53mutated/null cells is mediated by a p53-independent ILF3/p21 pathway. Oncotarget. 2015;6:2385-96 pubmed
Shi X, Yang J, Mao N, Wu J, Ren L, Yang Y, et al. Nutlin-3-induced redistribution of chromatin-bound IFI16 in human hepatocellular carcinoma cells in vitro is associated with p53 activation. Acta Pharmacol Sin. 2015;36:252-8 pubmed publisher
Guerzoni C, Fiori V, Terracciano M, Manara M, Moricoli D, Pasello M, et al. CD99 triggering in Ewing sarcoma delivers a lethal signal through p53 pathway reactivation and cooperates with doxorubicin. Clin Cancer Res. 2015;21:146-56 pubmed publisher
Sullivan K, Palaniappan V, Espinosa J. ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels. Cell Cycle. 2015;14:56-63 pubmed publisher
Wei Z, Guo H, Liu Z, Zhang X, Liu Q, Qian Y, et al. CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop. Free Radic Biol Med. 2015;79:1-13 pubmed publisher
El Khattouti A, Sheehan N, Monico J, Drummond H, Haikel Y, Brodell R, et al. CD133⁺ melanoma subpopulation acquired resistance to caffeic acid phenethyl ester-induced apoptosis is attributed to the elevated expression of ABCB5: significance for melanoma treatment. Cancer Lett. 2015;357:83-104 pubmed publisher
Dogra S, Bandi S, Viswanathan P, Gupta S. Arsenic trioxide amplifies cisplatin toxicity in human tubular cells transformed by HPV-16 E6/E7 for further therapeutic directions in renal cell carcinoma. Cancer Lett. 2015;356:953-61 pubmed publisher
Yamauchi Yamada A, Yamamoto T, Nakayama Y, Ikeda K, Miyake T, Yamaguchi M, et al. Immune escape phenomenon in molluscum contagiosum and the induction of apoptosis. J Dermatol. 2014;41:1058-64 pubmed publisher
Davaadelger B, Shen H, Maki C. Novel roles for p53 in the genesis and targeting of tetraploid cancer cells. PLoS ONE. 2014;9:e110844 pubmed publisher
Morgado Palacin L, Llanos S, Urbano Cuadrado M, Blanco Aparicio C, Megias D, Pastor J, et al. Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway. Carcinogenesis. 2014;35:2822-30 pubmed publisher
Peltonen K, Colis L, Liu H, Jäämaa S, Zhang Z, Af Hällström T, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014;13:2537-46 pubmed publisher
Bibikova E, Youn M, Danilova N, Ono Uruga Y, Konto Ghiorghi Y, Ochoa R, et al. TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors. Blood. 2014;124:3791-8 pubmed publisher
Michaelis M, Selt F, Rothweiler F, Löschmann N, Nüsse B, Dirks W, et al. Aurora kinases as targets in drug-resistant neuroblastoma cells. PLoS ONE. 2014;9:e108758 pubmed publisher
Gehrke I, Bouchard E, Beiggi S, Poeppl A, Johnston J, Gibson S, et al. On-target effect of FK866, a nicotinamide phosphoribosyl transferase inhibitor, by apoptosis-mediated death in chronic lymphocytic leukemia cells. Clin Cancer Res. 2014;20:4861-72 pubmed publisher
Odkhuu E, Mendjargal A, Koide N, Naiki Y, Komatsu T, Yokochi T. Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B. Immunobiology. 2015;220:136-41 pubmed publisher
Yang Y, Tang Y, Shieh J, Lin R, Hsu H, Wang Y. DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer. J Thorac Oncol. 2014;9:1305-15 pubmed publisher
Ireno I, Wiehe R, Stahl A, Hampp S, Aydin S, Troester M, et al. Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53. Carcinogenesis. 2014;35:2273-82 pubmed publisher
Polański R, Noon A, Blaydes J, Phillips A, Rubbi C, Parsons K, et al. Senescence induction in renal carcinoma cells by Nutlin-3: a potential therapeutic strategy based on MDM2 antagonism. Cancer Lett. 2014;353:211-9 pubmed publisher
Weilbacher A, Gutekunst M, Oren M, Aulitzky W, van der Kuip H. RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38. Cell Death Dis. 2014;5:e1318 pubmed publisher
van der Ent W, Jochemsen A, Teunisse A, Krens S, Szuhai K, Spaink H, et al. Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53. J Pathol. 2014;233:415-24 pubmed publisher
Agnoletto C, Melloni E, Casciano F, Rigolin G, Rimondi E, Celeghini C, et al. Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3. Oncotarget. 2014;5:4347-60 pubmed
Chen L, Zhao Y, Halliday G, Berry P, Rousseau R, Middleton S, et al. Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma. Br J Cancer. 2014;111:716-25 pubmed publisher
Paulus Hock V, Cheung E, Roxburgh P, Vousden K, Hock A. iRFP is a real time marker for transformation based assays in high content screening. PLoS ONE. 2014;9:e98399 pubmed publisher
Lee S, Choi H, Choe Y, Shin S, Lee S, Kim H. Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1/2 pathway. Int J Oncol. 2014;45:675-82 pubmed publisher
Bouafia A, Corre S, Gilot D, Mouchet N, Prince S, Galibert M. p53 requires the stress sensor USF1 to direct appropriate cell fate decision. PLoS Genet. 2014;10:e1004309 pubmed publisher
Afshari A, Uhde Stone C, Lu B. Live visualization and quantification of pathway signaling with dual fluorescent and bioluminescent reporters. Biochem Biophys Res Commun. 2014;448:281-6 pubmed publisher
Bouchalova P, Nenutil R, Muller P, Hrstka R, Appleyard M, Murray K, et al. Mutant p53 accumulation in human breast cancer is not an intrinsic property or dependent on structural or functional disruption but is regulated by exogenous stress and receptor status. J Pathol. 2014;233:238-46 pubmed publisher
Read M, Seed R, Fong J, Modasia B, Ryan G, Watkins R, et al. The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells. Endocrinology. 2014;155:1222-34 pubmed publisher
Schneeberger V, Luetteke N, Ren Y, Berns H, Chen L, Foroutan P, et al. SHP2E76K mutant promotes lung tumorigenesis in transgenic mice. Carcinogenesis. 2014;35:1717-25 pubmed publisher
Chudasama P, Konrad A, Jochmann R, Lausen B, Holz P, Naschberger E, et al. Structural proteins of Kaposi's sarcoma-associated herpesvirus antagonize p53-mediated apoptosis. Oncogene. 2015;34:639-49 pubmed publisher
Choe Y, Lee S, Ko K, Shin S, Kim H. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53. Int J Oncol. 2014;44:761-8 pubmed publisher
Tamura M, Sasaki Y, Koyama R, Takeda K, Idogawa M, Tokino T. Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness. Oncogene. 2014;33:4837-46 pubmed publisher
van Leeuwen I, Rao B, Sachweh M, Lain S. An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells. Cell Cycle. 2012;11:1851-61 pubmed publisher
Shen H, Maki C. p53 and p21(Waf1) are recruited to distinct PML-containing nuclear foci in irradiated and Nutlin-3a-treated U2OS cells. J Cell Biochem. 2010;111:1280-90 pubmed publisher
Merkel C, da Silva Soares R, de Carvalho A, Zanatta D, Bajgelman M, Fratini P, et al. Activation of endogenous p53 by combined p19Arf gene transfer and nutlin-3 drug treatment modalities in the murine cell lines B16 and C6. BMC Cancer. 2010;10:316 pubmed publisher
Shen H, Maki C. Persistent p21 expression after Nutlin-3a removal is associated with senescence-like arrest in 4N cells. J Biol Chem. 2010;285:23105-14 pubmed publisher
Laurie N, Mohan A, McEvoy J, Reed D, Zhang J, Schweers B, et al. Changes in retinoblastoma cell adhesion associated with optic nerve invasion. Mol Cell Biol. 2009;29:6268-82 pubmed publisher
Gammoh N, Gardiol D, Massimi P, Banks L. The Mdm2 ubiquitin ligase enhances transcriptional activity of human papillomavirus E2. J Virol. 2009;83:1538-43 pubmed publisher
Vassilev L, Vu B, Graves B, Carvajal D, Podlaski F, Filipovic Z, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004;303:844-8 pubmed
Wakatsuki T, Wysolmerski R, Elson E. Mechanics of cell spreading: role of myosin II. J Cell Sci. 2003;116:1617-25 pubmed
product information
Catalog Number :
N6287
Product Name :
Nutlin-3
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA