This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
N ω -Nitro-L-arginine
catalog :
N5501
citations: 69
Reference
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Grekov I, Pombinho A, Kobets T, Bartunek P, Lipoldová M. Calcium Ionophore, Calcimycin, Kills Leishmania Promastigotes by Activating Parasite Nitric Oxide Synthase. Biomed Res Int. 2017;2017:1309485 pubmed publisher
Taguchi K, Hida M, Matsumoto T, Kobayashi T. Resveratrol Ameliorates Clonidine-Induced Endothelium-Dependent Relaxation Involving Akt and Endothelial Nitric Oxide Synthase Regulation in Type 2 Diabetic Mice. Biol Pharm Bull. 2015;38:1864-72 pubmed publisher
Deng S, Yu K, Zhang B, Yao Y, Wang Z, Zhang J, et al. Toll-Like Receptor 4 Promotes NO Synthesis by Upregulating GCHI Expression under Oxidative Stress Conditions in Sheep Monocytes/Macrophages. Oxid Med Cell Longev. 2015;2015:359315 pubmed publisher
Matsumoto T, Watanabe S, Yamada K, Ando M, Iguchi M, Taguchi K, et al. Relaxation Induced by Atrial Natriuretic Peptide Is Impaired in Carotid but Not Renal Arteries from Spontaneously Hypertensive Rats Due to Reduced BKCa Channel Activity. Biol Pharm Bull. 2015;38:1801-8 pubmed publisher
Sofronova S, Gaynullina D, Martyanov A, Tarasova O. Endogenous oestrogens do not regulate endothelial nitric oxide production in early postnatal rats. Eur J Pharmacol. 2015;765:598-605 pubmed publisher
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Ridder D, Wenzel J, Müller K, Töllner K, Tong X, Assmann J, et al. Brain endothelial TAK1 and NEMO safeguard the neurovascular unit. J Exp Med. 2015;212:1529-49 pubmed publisher
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Lesterhuis W, Rinaldi C, Jones A, Rozali E, Dick I, Khong A, et al. Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations. Sci Rep. 2015;5:12298 pubmed publisher
Singh J, Kumar S, Rattan S. Bimodal effect of oxidative stress in internal anal sphincter smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2015;309:G292-300 pubmed publisher
Glass M, Wang G, Coleman C, Chan J, Ogorodnik E, Van Kempen T, et al. NMDA Receptor Plasticity in the Hypothalamic Paraventricular Nucleus Contributes to the Elevated Blood Pressure Produced by Angiotensin II. J Neurosci. 2015;35:9558-67 pubmed publisher
Smirnova E, Michunskaya A, Terekhina O, Kobozeva L, Kruglov S, Belkina L, et al. Effect of Nitric Oxide Synthesis Blockade on the Morphology of Langerhans Islets in August and Wistar Rats with Acute Alloxan Diabetes. Bull Exp Biol Med. 2015;159:273-7 pubmed publisher
Prast H, Hornick A, Kraus M, Philippu A. Origin of endogenous nitric oxide released in the nucleus accumbens under real-time in vivo conditions. Life Sci. 2015;134:79-84 pubmed publisher
Efremova L, Schildknecht S, Adam M, Pape R, Gutbier S, Hanf B, et al. Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism. Br J Pharmacol. 2015;172:4119-32 pubmed publisher
Goulopoulou S, Hannan J, Matsumoto T, Ogbi S, Ergul A, Webb R. Reduced vascular responses to soluble guanylyl cyclase but increased sensitivity to sildenafil in female rats with type 2 diabetes. Am J Physiol Heart Circ Physiol. 2015;309:H297-304 pubmed publisher
Cipriani G, Gibbons S, Saravanaperumal S, Malysz J, Sha L, Szurszewski J, et al. Changes in nitrergic and tachykininergic pathways in rat proximal colon in response to chronic treatment with otilonium bromide. Neurogastroenterol Motil. 2015;27:997-1009 pubmed publisher
Gaynullina D, Shestopalov V, Panchin Y, Tarasova O. Pannexin 1 facilitates arterial relaxation via an endothelium-derived hyperpolarization mechanism. FEBS Lett. 2015;589:1164-70 pubmed publisher
Fujii N, McGinn R, Halili L, Singh M, Kondo N, Kenny G. Cutaneous vascular and sweating responses to intradermal administration of ATP: a role for nitric oxide synthase and cyclooxygenase?. J Physiol. 2015;593:2515-25 pubmed publisher
Youn Y, Choi E, Lee Y, Oshima T, Miwa H, Park H. The effects of 5-hydroxytryptamine1a receptor agonist, buspirone on the gastric fundus accommodation in an animal model using guinea pigs. Neurogastroenterol Motil. 2015;27:532-41 pubmed publisher
O Leary B, Fath M, Bellizzi A, Hrabe J, Button A, Allen B, et al. Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2015;21:1741-51 pubmed publisher
Yu C, Luo X, Duquette N, Thorin Trescases N, Thorin E. Knockdown of angiopoietin like-2 protects against angiotensin II-induced cerebral endothelial dysfunction in mice. Am J Physiol Heart Circ Physiol. 2015;308:H386-97 pubmed publisher
Gasperini L, Meneghetti E, Pastore B, Benetti F, Legname G. Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation. Antioxid Redox Signal. 2015;22:772-84 pubmed publisher
Obara Michlewska M, Ruszkiewicz J, Zielińska M, Verkhratsky A, Albrecht J. Astroglial NMDA receptors inhibit expression of Kir4.1 channels in glutamate-overexposed astrocytes in vitro and in the brain of rats with acute liver failure. Neurochem Int. 2015;88:20-5 pubmed publisher
Nasser A, Ali S, Wilsbech S, Bjerrum O, Møller L. Intraplantar injection of tetrahydrobiopterin induces nociception in mice. Neurosci Lett. 2015;584:247-52 pubmed publisher
Böhmer A, Gambaryan S, Tsikas D. Human blood platelets lack nitric oxide synthase activity. Platelets. 2015;26:583-8 pubmed publisher
Nishiyama K, Azuma Y, Shintaku K, Yoshida N, Nakajima H, Takeuchi T. Evidence that nitric oxide is a non-adrenergic non-cholinergic inhibitory neurotransmitter in the circular muscle of the mouse distal colon: a study on the mechanism of nitric oxide-induced relaxation. Pharmacology. 2014;94:99-108 pubmed publisher
Kito Y, Kurahashi M, Mitsui R, Ward S, Sanders K. Spontaneous transient hyperpolarizations in the rabbit small intestine. J Physiol. 2014;592:4733-45 pubmed publisher
Zádori Z, Tóth V, Fehér Ã, Philipp K, Németh J, Gyires K. Evidence for the gastric cytoprotective effect of centrally injected agmatine. Brain Res Bull. 2014;108:51-9 pubmed publisher
Villela N, dos Santos A, de Miranda M, Bouskela E. Fluid resuscitation therapy in endotoxemic hamsters improves survival and attenuates capillary perfusion deficits and inflammatory responses by a mechanism related to nitric oxide. J Transl Med. 2014;12:232 pubmed publisher
Wu X, Wang A, Chen L, Huang E, Xie W, Liu C, et al. S-Nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells. Toxicol Lett. 2014;230:19-27 pubmed publisher
Yang Z, Pan A, Zuo W, Guo J, Zhou W. Relaxant effect of flavonoid naringenin on contractile activity of rat colonic smooth muscle. J Ethnopharmacol. 2014;155:1177-83 pubmed publisher
Janols H, Bergenfelz C, Allaoui R, Larsson A, Rydén L, Björnsson S, et al. A high frequency of MDSCs in sepsis patients, with the granulocytic subtype dominating in gram-positive cases. J Leukoc Biol. 2014;96:685-93 pubmed publisher
Pauwels B, Boydens C, Decaluwé K, Van de Voorde J. NO-donating oximes relax corpora cavernosa through mechanisms other than those involved in arterial relaxation. J Sex Med. 2014;11:1664-74 pubmed publisher
Fujii N, Brunt V, Minson C. Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers. Am J Physiol Heart Circ Physiol. 2014;306:H1507-11 pubmed publisher
Jung C, Lee M, Kang Y, Lee Y, Yoon H, Kang S, et al. Vaspin inhibits cytokine-induced nuclear factor-kappa B activation and adhesion molecule expression via AMP-activated protein kinase activation in vascular endothelial cells. Cardiovasc Diabetol. 2014;13:41 pubmed publisher
Shimizu M, Kochi T, Shirakami Y, Genovese S, Epifano F, Fiorito S, et al. A newly synthesized compound, 4'-geranyloxyferulic acid-N(omega)-nitro-L-arginine methyl ester suppresses inflammation-associated colorectal carcinogenesis in male mice. Int J Cancer. 2014;135:774-84 pubmed publisher
Schreurs M, Cipolla M. Cerebrovascular dysfunction and blood-brain barrier permeability induced by oxidized LDL are prevented by apocynin and magnesium sulfate in female rats. J Cardiovasc Pharmacol. 2014;63:33-9 pubmed publisher
Lin A, Zheng W, Halloran J, Burbank R, Hussong S, Hart M, et al. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease. J Cereb Blood Flow Metab. 2013;33:1412-21 pubmed publisher
Voinot F, Fischer C, Schmidt C, Ehret Sabatier L, Angel F. Controlled ingestion of kaolinite (5%) modulates enteric nitrergic innervation in rats. Fundam Clin Pharmacol. 2014;28:405-13 pubmed publisher
Bakr A, Pak O, Taye A, Hamada F, Hemeida R, Janssen W, et al. Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia. Am J Respir Cell Mol Biol. 2013;49:491-500 pubmed publisher
Watanabe M, Miyai A, Danjo S, Nakamura Y, Itoh K. The threshold of pentylenetetrazole-induced convulsive seizures, but not that of nonconvulsive seizures, is controlled by the nitric oxide levels in murine brains. Exp Neurol. 2013;247:645-52 pubmed publisher
Chen Y, Chitapanarux T, Wu J, Soon R, Melton A, Yee H. Inducible NOS mediates CNP-induced relaxation of intestinal myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2013;304:G673-9 pubmed publisher
Keef K, Saxton S, McDowall R, Kaminski R, Duffy A, Cobine C. Functional role of vasoactive intestinal polypeptide in inhibitory motor innervation in the mouse internal anal sphincter. J Physiol. 2013;591:1489-506 pubmed publisher
Duluc L, Jacques C, Soleti R, Iacobazzi F, Simard G, Andriantsitohaina R. Modulation of mitochondrial capacity and angiogenesis by red wine polyphenols via estrogen receptor, NADPH oxidase and nitric oxide synthase pathways. Int J Biochem Cell Biol. 2013;45:783-91 pubmed publisher
Reimann K, Krishnamoorthy G, Wangemann P. NOS inhibition enhances myogenic tone by increasing rho-kinase mediated Ca2+ sensitivity in the male but not the female gerbil spiral modiolar artery. PLoS ONE. 2013;8:e53655 pubmed publisher
Tiurenkov I, Perfilova V, Arsenova N. [Effect of immobilization-painful stress on cardiac ino- and chronotropic functions of animals under the conditions of nitric oxide synthesis supression]. Ross Fiziol Zh Im I M Sechenova. 2012;98:1131-9 pubmed
Sinagra T, Tamburella A, Urso V, Siarkos I, Drago F, Bucolo C, et al. Reversible inhibition of vasoconstriction by thiazolidinediones related to PI3K/Akt inhibition in vascular smooth muscle cells. Biochem Pharmacol. 2013;85:551-9 pubmed publisher
Kringelholt S, Simonsen U, Bek T. Neurogenic contractions in intraocular porcine ciliary arteries are mediated by α₂-adrenoceptors and NPY₁ receptors and are inhibited by prostaglandin E₂ acting on prejunctional EP₄ receptors. Exp Eye Res. 2013;107:32-6 pubmed publisher
Telegdy G, Adamik A, Jászberényi M. Involvement of neurotransmitters in the action of apelin-13 on passive avoidance learning in mice. Peptides. 2013;39:171-4 pubmed publisher
Clapp K, Peng H, Jenkins G, Ford M, Morishima Y, Lau M, et al. Ubiquitination of neuronal nitric-oxide synthase in the calmodulin-binding site triggers proteasomal degradation of the protein. J Biol Chem. 2012;287:42601-10 pubmed publisher
Kim S, Malik G, Saad M, Yoon S, Gonzalez J, Crystal G. Nitric oxide has no obligatory role in isoflurane late preconditioning against myocardial stunning. Life Sci. 2012;91:1201-6 pubmed publisher
Petry A, BelAiba R, Weitnauer M, Gorlach A. Inhibition of endothelial nitric oxyde synthase increases capillary formation via Rac1-dependent induction of hypoxia-inducible factor-1α and plasminogen activator inhibitor-1. Thromb Haemost. 2012;108:849-62 pubmed publisher
Evers J, Buffini M, Craven S, O Connell P, Jones J. Is there a nitrergic modulation of the rat external anal sphincter?. Exp Physiol. 2013;98:397-404 pubmed publisher
Jin H, Yang Y, Song Y, Yang Y, Li Y. Nitric oxide modulated the expression of DREAM/calsenilin/KChIP3 in inflammatory pain of rats. Inflammation. 2012;35:1867-71 pubmed publisher
Stavreva G, Radomirov R. Region-related modular nerve-dependent motor activity in anorectum--cholinergic and nitrergic contribution to rat model. Acta Neurobiol Exp (Wars). 2012;72:185-93 pubmed
Andersson M, Aronsson P, Doufish D, Lampert A, Tobin G. Muscarinic receptor subtypes involved in urothelium-derived relaxatory effects in the inflamed rat urinary bladder. Auton Neurosci. 2012;170:5-11 pubmed publisher
Smolyaninova L, Dergalev A, Kulebyakin K, Carpenter D, Boldyrev A. Carnosine prevents necrotic and apoptotic death of rat thymocytes via ouabain-sensitive Na/K-ATPase. Cell Biochem Funct. 2013;31:30-5 pubmed publisher
Iacopucci A, Mello R, Barbosa Silva R, Melo Thomas L. L-NOARG-induced catalepsy can be influenced by glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus. Behav Brain Res. 2012;234:149-54 pubmed publisher
Gehad A, Lichtman M, Schmults C, Teague J, Calarese A, Jiang Y, et al. Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E-selectin expression in human squamous cell carcinomas. J Invest Dermatol. 2012;132:2642-51 pubmed publisher
Feng M, Prieto M, Navar L. Nebivolol-induced vasodilation of renal afferent arterioles involves ?3-adrenergic receptor and nitric oxide synthase activation. Am J Physiol Renal Physiol. 2012;303:F775-82 pubmed publisher
Simonet S, Isabelle M, Bousquenaud M, Clavreul N, Feletou M, Vayssettes Courchay C, et al. KCa 3.1 channels maintain endothelium-dependent vasodilatation in isolated perfused kidneys of spontaneously hypertensive rats after chronic inhibition of NOS. Br J Pharmacol. 2012;167:854-67 pubmed publisher
Gil V, Gallego D, Moha Ou Maati H, Peyronnet R, Martinez Cutillas M, Heurteaux C, et al. Relative contribution of SKCa and TREK1 channels in purinergic and nitrergic neuromuscular transmission in the rat colon. Am J Physiol Gastrointest Liver Physiol. 2012;303:G412-23 pubmed publisher
Kimura K, Ohkita M, Koyama M, Matsumura Y. Reduced NO production rapidly aggravates renal function through the NF-κB/ET-1/ETA receptor pathway in DOCA-salt-induced hypertensive rats. Life Sci. 2012;91:644-50 pubmed publisher
Matsumoto F, Watanabe Y, Obi T, Islam M, Yamazaki Himeno E, Shiraishi M, et al. Characterization of 5-hydroxytryptamine-induced contraction and acetylcholine-induced relaxation in isolated chicken basilar artery. Poult Sci. 2012;91:1158-64 pubmed publisher
Chen D, Xiong Y, Wang L, Lv B, Lin Y. Characteristics of emodin on modulating the contractility of jejunal smooth muscle. Can J Physiol Pharmacol. 2012;90:455-62 pubmed publisher
Yang W, Zhao Z, Wang L, Yu S, Liang Z. Control of hypertension in rats using volatile components of leaves of Taxus chinensis var. mairei. J Ethnopharmacol. 2012;141:309-13 pubmed publisher
Gorman M, Rooke G, Savage M, Jayasekara M, Jacobson K, Feigl E. Adenine nucleotide control of coronary blood flow during exercise. Am J Physiol Heart Circ Physiol. 2010;299:H1981-9 pubmed publisher
Korbelik M, Parkins C, Shibuya H, Cecic I, Stratford M, Chaplin D. Nitric oxide production by tumour tissue: impact on the response to photodynamic therapy. Br J Cancer. 2000;82:1835-43 pubmed
product information
Catalog Number :
N5501
Product Name :
N ω -Nitro-L-arginine
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (TLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA