This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
NKH 477
catalog :
N3290
citations: 37
Reference
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Stathopoulou K, Schobesberger S, Bork N, Sprenger J, Perera R, Sotoud H, et al. Divergent off-target effects of RSK N-terminal and C-terminal kinase inhibitors in cardiac myocytes. Cell Signal. 2019;63:109362 pubmed publisher
Koblish M, Carr R, Siuda E, Rominger D, Gowen MacDonald W, Cowan C, et al. TRV0109101, a G Protein-Biased Agonist of the µ-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration. J Pharmacol Exp Ther. 2017;362:254-262 pubmed publisher
Dibattista M, Reisert J. The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons. J Neurosci. 2016;36:2995-3006 pubmed publisher
Iida S, Chen W, Nakadai T, Ohkuma Y, Roeder R. PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1. Genes Dev. 2015;29:308-21 pubmed publisher
Ghorbani A, Jeddi Tehrani M, Saidpour A, Safa M, Bayat A, Zand H. PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in human pre-B NALM-6 cells. Arch Biochem Biophys. 2015;566:58-66 pubmed publisher
Efird W, Kellam P, Yeazell S, Weinhold P, Dahners L. An evaluation of prophylactic treatments to prevent post traumatic joint stiffness. J Orthop Res. 2014;32:1520-4 pubmed publisher
Ikari A, Watanabe R, Sato T, Taga S, Shimobaba S, Yamaguchi M, et al. Nuclear distribution of claudin-2 increases cell proliferation in human lung adenocarcinoma cells. Biochim Biophys Acta. 2014;1843:2079-88 pubmed publisher
Takarada Iemata M, Kezuka D, Takeichi T, Ikawa M, Hattori T, Kitao Y, et al. Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury. J Neurochem. 2014;130:374-87 pubmed publisher
Chiang Y, Ip W, Shao W, Song Z, Chernoff J, Jin T. Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice. Endocrinology. 2014;155:2122-32 pubmed publisher
Ricciarelli R, Puzzo D, Bruno O, Canepa E, Gardella E, Rivera D, et al. A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta. Ann Neurol. 2014;75:602-7 pubmed publisher
Aflaki M, Qi X, Xiao L, Ordog B, Tadevosyan A, Luo X, et al. Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained ?-adrenergic activation in guinea pig hearts. Circ Res. 2014;114:993-1003 pubmed publisher
Marlar S, Arnspang E, Koffman J, Løcke E, Christensen B, Nejsum L. Elevated cAMP increases aquaporin-3 plasma membrane diffusion. Am J Physiol Cell Physiol. 2014;306:C598-606 pubmed publisher
Jin Y, Sato K, Tobo A, Mogi C, Tobo M, Murata N, et al. Inhibition of interleukin-1? production by extracellular acidification through the TDAG8/cAMP pathway in mouse microglia. J Neurochem. 2014;129:683-95 pubmed publisher
Shirasu M, Yoshikawa K, Takai Y, Nakashima A, Takeuchi H, Sakano H, et al. Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors. Neuron. 2014;81:165-78 pubmed publisher
Lingam G, Wong T. Systemic medical management of diabetic retinopathy. Middle East Afr J Ophthalmol. 2013;20:301-8 pubmed publisher
Shi X, Cheng Q, Xu L, Yan J, Jiang M, He J, et al. Cholesterol sulfate and cholesterol sulfotransferase inhibit gluconeogenesis by targeting hepatocyte nuclear factor 4α. Mol Cell Biol. 2014;34:485-97 pubmed publisher
Kim S, Park J, Moon J, Choi H. Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress. Exp Neurol. 2014;252:63-74 pubmed publisher
Cai W, Du A, Feng K, Zhao X, Qian L, Ostrom R, et al. Adenylyl cyclase 6 activation negatively regulates TLR4 signaling through lipid raft-mediated endocytosis. J Immunol. 2013;191:6093-100 pubmed publisher
Xu C, Tabebordbar M, Iovino S, Ciarlo C, Liu J, Castiglioni A, et al. A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species. Cell. 2013;155:909-921 pubmed publisher
Sunkara L, Zeng X, Curtis A, Zhang G. Cyclic AMP synergizes with butyrate in promoting ?-defensin 9 expression in chickens. Mol Immunol. 2014;57:171-80 pubmed publisher
Su H, Chen M, Sands J, Chen G. Activation of the cAMP/PKA pathway induces UT-A1 urea transporter monoubiquitination and targets it for lysosomal degradation. Am J Physiol Renal Physiol. 2013;305:F1775-82 pubmed publisher
Wertheimer E, Krapf D, de la Vega Beltrán J, Sanchez Cardenas C, Navarrete F, Haddad D, et al. Compartmentalization of distinct cAMP signaling pathways in mammalian sperm. J Biol Chem. 2013;288:35307-20 pubmed publisher
Nakamura Y, Sato T, Shiimura Y, Miura Y, Kojima M. FABP3 and brown adipocyte-characteristic mitochondrial fatty acid oxidation enzymes are induced in beige cells in a different pathway from UCP1. Biochem Biophys Res Commun. 2013;441:42-6 pubmed publisher
Iancu C, Zamoon J, Woo S, Aleshin A, Choe J. Crystal structure of a glucose/H+ symporter and its mechanism of action. Proc Natl Acad Sci U S A. 2013;110:17862-7 pubmed publisher
Loo C, Chen C, Wang P, Chen P, Lin S, Khoo K, et al. Quantitative apical membrane proteomics reveals vasopressin-induced actin dynamics in collecting duct cells. Proc Natl Acad Sci U S A. 2013;110:17119-24 pubmed publisher
Lu D, Aroonsakool N, Yokoyama U, Patel H, Insel P. Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Mol Pharmacol. 2013;84:787-93 pubmed publisher
Simon B, Parlee S, Learman B, Mori H, Scheller E, Cawthorn W, et al. Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors. J Biol Chem. 2013;288:32475-89 pubmed publisher
Amaro Ortiz A, Vanover J, Scott T, D Orazio J. Pharmacologic induction of epidermal melanin and protection against sunburn in a humanized mouse model. J Vis Exp. 2013;: pubmed publisher
Stangherlin A, Koschinski A, Terrin A, Zoccarato A, Jiang H, Fields L, et al. Analysis of compartmentalized cAMP: a method to compare signals from differently targeted FRET reporters. Methods Mol Biol. 2014;1071:59-71 pubmed publisher
Zou S, Wang X, Deng L, Wang Y, Huang B, Zhang N, et al. CREB, another culprit for TIGAR promoter activity and expression. Biochem Biophys Res Commun. 2013;439:481-6 pubmed publisher
Ferrero J, Alvarez A, Ramírez Franco J, Godino M, Bartolomé Martín D, Aguado C, et al. ?-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1? interaction to potentiate glutamate release at cerebrocortical nerve terminals. J Biol Chem. 2013;288:31370-85 pubmed publisher
Masuda S, Wu J, Hishida T, Pandian G, Sugiyama H, Izpisua Belmonte J. Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach. J Mol Cell Biol. 2013;5:354-5 pubmed publisher
Cottingham C, Lu R, Jiao K, Wang Q. Cross-talk from ?-adrenergic receptors modulates ?2A-adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin. J Biol Chem. 2013;288:29193-205 pubmed publisher
Tao Y, Pan M, Liu S, Fang F, Lu R, Lu C, et al. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia. PLoS ONE. 2013;8:e71441 pubmed publisher
Hang L, Yang J, Shao D, Chen Z, Wang H. Involvement of spinal PKA/CREB signaling pathway in the development of bone cancer pain. Pharmacol Rep. 2013;65:710-6 pubmed
Chang S, Yang L, Huang T, Chen C, Sheu S, Liu P, et al. Biotransformation of dihydroisosteviol and the effects of transformed products on steroidogenic gene expressions. Phytochemistry. 2013;95:268-76 pubmed publisher
product information
Catalog Number :
N3290
Product Name :
NKH 477
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA