Reference |
---|
Chambers E, White A, Vang A, Wang Z, Ayala A, Weng T, et al. Blockade of equilibrative nucleoside transporter 1/2 protects against Pseudomonas aeruginosa-induced acute lung injury and NLRP3 inflammasome activation. FASEB J. 2020;34:1516-1531 pubmed publisher
|
Oyama Y, Ono K, Kawamura M. Mild hypothermia protects synaptic transmission from experimental ischemia through reduction in the function of nucleoside transporters in the mouse hippocampus. Neuropharmacology. 2020;163:107853 pubmed publisher
|
Giroud Gerbetant J, Joffraud M, Giner M, Cercillieux A, Bártová S, Makarov M, et al. A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor. Mol Metab. 2019;30:192-202 pubmed publisher
|
Vlachodimou A, Ijzerman A, Heitman L. Label-free detection of transporter activity via GPCR signalling in living cells: A case for SLC29A1, the equilibrative nucleoside transporter 1. Sci Rep. 2019;9:13802 pubmed publisher
|
Hendriks D, Hurrell T, Riede J, van der Horst M, Tuovinen S, Ingelman Sundberg M. Mechanisms of chronic fialuridine hepatotoxicity as revealed in primary human hepatocyte spheroids. Toxicol Sci. 2019;: pubmed publisher
|
Zeng Q, Bai M, Li C, Lu S, Ma Z, Zhao Y, et al. Multiple drug transporters contribute to the placental transfer of emtricitabine. Antimicrob Agents Chemother. 2019;: pubmed publisher
|
Karbanova S, Cerveny L, Jirásková L, Karahoda R, Ceckova M, Ptackova Z, et al. Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters. Biochem Pharmacol. 2019;163:60-70 pubmed publisher
|
Gorzkiewicz M, Deriu M, Studzian M, Janaszewska A, Grasso G, Pułaski Ł, et al. Fludarabine-Specific Molecular Interactions with Maltose-Modified Poly(propyleneimine) Dendrimer Enable Effective Cell Entry of the Active Drug Form: Comparison with Clofarabine. Biomacromolecules. 2019;20:1429-1442 pubmed publisher
|
Guo Z, Wang F, Di Y, Yao L, Yu X, Fu D, et al. Antitumor effect of gemcitabine-loaded albumin nanoparticle on gemcitabine-resistant pancreatic cancer induced by low hENT1 expression. Int J Nanomedicine. 2018;13:4869-4880 pubmed publisher
|
Erdei T, Szabo A, Lampé N, Szabo K, Kiss R, Zsuga J, et al. FSCPX, a Chemical Widely Used as an Irreversible A₁ Adenosine Receptor Antagonist, Modifies the Effect of NBTI, a Nucleoside Transport Inhibitor, by Reducing the Interstitial Adenosine Level in the Guinea Pig Atrium. Molecules. 2018;23: pubmed publisher
|
Damaraju V, Kuzma M, Cass C, Putman C, Sawyer M. Multitargeted kinase inhibitors imatinib, sorafenib and sunitinib perturb energy metabolism and cause cytotoxicity to cultured C2C12 skeletal muscle derived myotubes. Biochem Pharmacol. 2018;155:162-171 pubmed publisher
|
Logie L, Lees Z, Allwood J, McDougall G, Beall C, Rena G. Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1). Diabetes Obes Metab. 2018;20:2748-2758 pubmed publisher
|
Yu H, Wu C, Nilsson K, Kajitani N, Schwartz S. Adenosine causes read-through into the late region of the HPV16 genome in a guanosine-dependent manner. Virology. 2018;521:1-19 pubmed publisher
|
Pleli T, Mondorf A, Ferreirós N, Thomas D, Dvorak K, Biondi R, et al. Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors. Cell Physiol Biochem. 2018;45:2516-2528 pubmed publisher
|
Losenkova K, Zuccarini M, Helenius M, Jacquemet G, Gerasimovskaya E, Tallgren C, et al. Endothelial cells cope with hypoxia-induced depletion of ATP via activation of cellular purine turnover and phosphotransfer networks. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1804-1815 pubmed publisher
|
Guarracino J, Cinalli A, Veggetti M, Losavio A. Endogenous purines modulate K+ -evoked ACh secretion at the mouse neuromuscular junction. J Neurosci Res. 2018;96:1066-1079 pubmed publisher
|
Karbanova S, Cerveny L, Ceckova M, Ptackova Z, Jirásková L, Greenwood S, et al. Role of nucleoside transporters in transplacental pharmacokinetics of nucleoside reverse transcriptase inhibitors zidovudine and emtricitabine. Placenta. 2017;60:86-92 pubmed publisher
|
Urtasun N, Boces Pascual C, Boix L, Bruix J, Pastor Anglada M, Pérez Torras S. Role of drug-dependent transporter modulation on the chemosensitivity of cholangiocarcinoma. Oncotarget. 2017;8:90185-90196 pubmed publisher
|
Diez R, Richardson M, Wall M. Reducing Extracellular Ca2+ Induces Adenosine Release via Equilibrative Nucleoside Transporters to Provide Negative Feedback Control of Activity in the Hippocampus. Front Neural Circuits. 2017;11:75 pubmed publisher
|
Kim S, Jung J, Lee H, Soh H, Lee S, Oh S, et al. [18F]fluorothymidine PET Informs the Synergistic Efficacy of Capecitabine and Trifluridine/Tipiracil in Colon Cancer. Cancer Res. 2017;77:7120-7130 pubmed publisher
|
Silva I, Costa A, Moreira S, Ferreirinha F, Magalhães Cardoso M, Calejo I, et al. Inhibition of cholinergic neurotransmission by β3-adrenoceptors depends on adenosine release and A1-receptor activation in human and rat urinary bladders. Am J Physiol Renal Physiol. 2017;313:F388-F403 pubmed publisher
|
Russell J, Pillarsetty N, Kramer R, Romesser P, Desai P, Haimovitz Friedman A, et al. In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models. Mol Imaging Biol. 2017;19:885-892 pubmed publisher
|
Rehan S, Paavilainen V, Jaakola V. Functional reconstitution of human equilibrative nucleoside transporter-1 into styrene maleic acid co-polymer lipid particles. Biochim Biophys Acta Biomembr. 2017;1859:1059-1065 pubmed publisher
|
Macanas Pirard P, Broekhuizen R, Gonzalez A, Oyanadel C, Ernst D, Garcia P, et al. Resistance of leukemia cells to cytarabine chemotherapy is mediated by bone marrow stroma, involves cell-surface equilibrative nucleoside transporter-1 removal and correlates with patient outcome. Oncotarget. 2017;8:23073-23086 pubmed publisher
|
Kao Y, Lin M, Chen C, Wu Y, Chen H, Lai H, et al. Targeting ENT1 and adenosine tone for the treatment of Huntington's disease. Hum Mol Genet. 2017;26:467-478 pubmed publisher
|
Aungraheeta R, Conibear A, Butler M, Kelly E, Nylander S, Mumford A, et al. Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 2016;128:2717-2728 pubmed
|
Stumpel D, Schneider P, Pieters R, Stam R. The potential of clofarabine in MLL-rearranged infant acute lymphoblastic leukaemia. Eur J Cancer. 2015;51:2008-21 pubmed publisher
|
Otsuguro K, Tomonari Y, Otsuka S, Yamaguchi S, Kon Y, Ito S. An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat. Neuropharmacology. 2015;97:160-70 pubmed publisher
|
Pardo F, Silva L, Sáez T, Salsoso R, Gutiérrez J, Sanhueza C, et al. Human supraphysiological gestational weight gain and fetoplacental vascular dysfunction. Int J Obes (Lond). 2015;39:1264-73 pubmed publisher
|
Hughes S, Cravetchi X, Vilas G, Hammond J. Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281. Cell Signal. 2015;27:1008-18 pubmed publisher
|
Choi I, Cho J, Lee M, Jang I. Enzymatic conversion of ATP to adenosine contributes to ATP-induced inhibition of glutamate release in rat medullary dorsal horn neurons. Neuropharmacology. 2015;93:94-102 pubmed publisher
|
Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, et al. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. Cell Death Dis. 2015;6:e1629 pubmed publisher
|
Hung S, Marrache S, Cummins S, Bhutia Y, Mody H, Hooks S, et al. Defective hCNT1 transport contributes to gemcitabine chemoresistance in ovarian cancer subtypes: overcoming transport defects using a nanoparticle approach. Cancer Lett. 2015;359:233-40 pubmed publisher
|
Blanco D, Pérez Herrán E, Cacho M, Ballell L, Castro J, González Del RÃo R, et al. Mycobacterium tuberculosis gyrase inhibitors as a new class of antitubercular drugs. Antimicrob Agents Chemother. 2015;59:1868-75 pubmed publisher
|
Siebel A, Menezes F, Capiotti K, Kist L, da Costa Schaefer I, Frantz J, et al. Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish. Zebrafish. 2015;12:127-36 pubmed publisher
|
Sousa J, Fresco P, Diniz C. Endothelial dysfunction impairs vascular neurotransmission in tail arteries. Neurochem Int. 2015;80:7-13 pubmed publisher
|
Hinton D, Lee M, Jang J, Choi D. Type 1 equilibrative nucleoside transporter regulates astrocyte-specific glial fibrillary acidic protein expression in the striatum. Brain Behav. 2014;4:903-14 pubmed publisher
|
Choi M, Kim M, Maeng H, Song I. Contribution of CNT1 and ENT1 to ribavirin uptake in human hepatocytes. Arch Pharm Res. 2015;38:904-13 pubmed publisher
|
Soares A, Costa V, Diniz C, Fresco P. Inosine strongly enhances proliferation of human C32 melanoma cells through PLC-PKC-MEK1/2-ERK1/2 and PI3K pathways. Basic Clin Pharmacol Toxicol. 2015;116:25-36 pubmed publisher
|
Arimany Nardi C, Errasti Murugarren E, Minuesa G, Martinez Picado J, Gorboulev V, Koepsell H, et al. Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors. Br J Pharmacol. 2014;171:3868-80 pubmed publisher
|
Bobba A, Amadoro G, Azzariti A, Pizzuto R, Atlante A. Extracellular ADP prevents neuronal apoptosis via activation of cell antioxidant enzymes and protection of mitochondrial ANT-1. Biochim Biophys Acta. 2014;1837:1338-49 pubmed publisher
|
Ramadan A, Naydenova Z, Stevanovic K, Rose J, Coe I. The adenosine transporter, ENT1, in cardiomyocytes is sensitive to inhibition by ethanol in a kinase-dependent manner: implications for ethanol-dependent cardioprotection and nucleoside analog drug cytotoxicity. Purinergic Signal. 2014;10:305-12 pubmed publisher
|
Abd Elfattah A, Tuchy G, Jessen M, Salter D, Goldstein J, Brunsting L, et al. Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial stunning in acutely ischemic hearts despite metabolic derangement: hot shot drug delivery . J Thorac Cardiovasc Surg. 2013;146:961-970.e3 pubmed publisher
|
Akanuma S, Soutome T, Hisada E, Tachikawa M, Kubo Y, Hosoya K. Na+-independent nucleoside transporters regulate adenosine and hypoxanthine levels in Müller cells and the inner blood-retinal barrier. Invest Ophthalmol Vis Sci. 2013;54:1469-77 pubmed publisher
|
Guzman Gutierrez E, Westermeier F, Salomon C, Gonzalez M, Pardo F, Leiva A, et al. Insulin-increased L-arginine transport requires A(2A) adenosine receptors activation in human umbilical vein endothelium. PLoS ONE. 2012;7:e41705 pubmed publisher
|
Park J, Hammond J. Cysteine residues in the transmembrane (TM) 9 to TM11 region of the human equilibrative nucleoside transporter subtype 1 play an important role in inhibitor binding and translocation function. Mol Pharmacol. 2012;82:784-94 pubmed publisher
|
Nishimura T, Chishu T, Tomi M, Nakamura R, Sato K, Kose N, et al. Mechanism of nucleoside uptake in rat placenta and induction of placental CNT2 in experimental diabetes. Drug Metab Pharmacokinet. 2012;27:439-46 pubmed
|
Abd Elfattah A, Aly H, Hanan S, Wechsler A. Myocardial protection in beating heart cardiac surgery: I: pre- or postconditioning with inhibition of es-ENT1 nucleoside transporter and adenosine deaminase attenuates post-MI reperfusion-mediated ventricular fibrillation and regional contractile dy. J Thorac Cardiovasc Surg. 2012;144:250-5 pubmed publisher
|
Abd Elfattah A, Ding M, Jessen M, Wechsler A. On-pump inhibition of es-ENT1 nucleoside transporter and adenosine deaminase during aortic crossclamping entraps intracellular adenosine and protects against reperfusion injury: role of adenosine A1 receptor. J Thorac Cardiovasc Surg. 2012;144:243-9 pubmed publisher
|
Iikura M, Furihata T, Mizuguchi M, Nagai M, Ikeda M, Kato N, et al. ENT1, a ribavirin transporter, plays a pivotal role in antiviral efficacy of ribavirin in a hepatitis C virus replication cell system. Antimicrob Agents Chemother. 2012;56:1407-13 pubmed publisher
|
Kalkan S, Hocaoglu N, Oransay K, Buyukdeligoz M, Tuncok Y. Adenosine-mediated cardiovascular toxicity in amitriptyline-poisoned rats. Drug Chem Toxicol. 2012;35:423-31 pubmed publisher
|
Iadevaia V, Zhang Z, Jan E, Proud C. mTOR signaling regulates the processing of pre-rRNA in human cells. Nucleic Acids Res. 2012;40:2527-39 pubmed publisher
|
Niu H, Xia C, Qu G, Wu S, Jiang Y, Jin X, et al. Microwave-promoted "one-pot" synthesis of 4-nitrobenzylthioinosine analogues using thiourea as a sulfur precursor. Chem Asian J. 2012;7:45-9 pubmed publisher
|
Ben Sghaier M, Boubaker J, Skandrani I, Bouhlel I, Limem I, Ghedira K, et al. Antimutagenic, antigenotoxic and antioxidant activities of phenolic-enriched extracts from Teucrium ramosissimum: combination with their phytochemical composition. Environ Toxicol Pharmacol. 2011;31:220-32 pubmed publisher
|
Kost S, Sun C, Xiong W, Graham K, Cass C, Young J, et al. Behavioral effects of elevated expression of human equilibrative nucleoside transporter 1 in mice. Behav Brain Res. 2011;224:44-9 pubmed publisher
|
Zizzo M, Mastropaolo M, Lentini L, Mule F, Serio R. Adenosine negatively regulates duodenal motility in mice: role of A(1) and A(2A) receptors. Br J Pharmacol. 2011;164:1580-9 pubmed publisher
|
Parmar S, Seeringer A, Denich D, Gärtner F, Pitterle K, Syrovets T, et al. Variability in transport and biotransformation of cytarabine is associated with its toxicity in peripheral blood mononuclear cells. Pharmacogenomics. 2011;12:503-14 pubmed publisher
|
Zhang D, Xiong W, Albensi B, Parkinson F. Expression of human equilibrative nucleoside transporter 1 in mouse neurons regulates adenosine levels in physiological and hypoxic-ischemic conditions. J Neurochem. 2011;118:4-11 pubmed publisher
|
Ohashi A, Sugawara Y, Mamada K, Harada Y, Sumi T, Anzai N, et al. Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters: a plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis. Mol Genet Metab. 2011;102:18-28 pubmed publisher
|
Takano M, Kimura E, Suzuki S, Nagai J, Yumoto R. Human erythrocyte nucleoside transporter ENT1 functions at ice-cold temperatures. Drug Metab Pharmacokinet. 2010;25:351-60 pubmed
|
Burnett L, Blais E, Unadkat J, Hille B, Tilley S, Babcock D. Testicular expression of Adora3i2 in Adora3 knockout mice reveals a role of mouse A3Ri2 and human A3Ri3 adenosine receptors in sperm. J Biol Chem. 2010;285:33662-70 pubmed publisher
|
Guzmán Gutiérrez E, Sandoval C, Nova E, Castillo J, Vera J, Lamperti L, et al. Differential expression of functional nucleoside transporters in non-differentiated and differentiated human endothelial progenitor cells. Placenta. 2010;31:928-36 pubmed publisher
|
Paproski R, Wuest M, Jans H, Graham K, Gati W, McQuarrie S, et al. Biodistribution and uptake of 3'-deoxy-3'-fluorothymidine in ENT1-knockout mice and in an ENT1-knockdown tumor model. J Nucl Med. 2010;51:1447-55 pubmed publisher
|
Robins M, Peng Y, Damaraju V, Mowles D, Barron G, Tackaberry T, et al. Improved syntheses of 5'-S-(2-aminoethyl)-6-N-(4-nitrobenzyl)-5'-thioadenosine (SAENTA), analogues, and fluorescent probe conjugates: analysis of cell-surface human equilibrative nucleoside transporter 1 (hENT1) levels for prediction of the antitumor. J Med Chem. 2010;53:6040-53 pubmed publisher
|
Chen C, Jafvert C. Photoreactivity of carboxylated single-walled carbon nanotubes in sunlight: reactive oxygen species production in water. Environ Sci Technol. 2010;44:6674-9 pubmed publisher
|
Shah N, Sunderland A, Grdzelishvili V. Cell type mediated resistance of vesicular stomatitis virus and Sendai virus to ribavirin. PLoS ONE. 2010;5:e11265 pubmed publisher
|
Tian L, Ji G, Wang C, Bai X, Lu Y, Xiong L. Excitatory synaptic transmission in the spinal substantia gelatinosa is under an inhibitory tone of endogenous adenosine. Neurosci Lett. 2010;477:28-32 pubmed publisher
|
Reyes G, Naydenova Z, Abdulla P, Chalsev M, Villani A, Rose J, et al. Characterization of mammalian equilibrative nucleoside transporters (ENTs) by mass spectrometry. Protein Expr Purif. 2010;73:1-9 pubmed publisher
|
Yamamoto T, Sugawara M, Kikukawa T, Miyauchi S, Yamaguchi M, Tero A, et al. Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes. Biophys Chem. 2010;147:59-65 pubmed publisher
|
. Guide to Receptors and Channels (GRAC), 4th Edition. Br J Pharmacol. 2009;158 Suppl 1:S1-254 pubmed publisher
|
Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher
|
Liu Y, Cao Y, Ye J, Wang W, Song K, Wang X, et al. Immunomodulatory effects of proanthocyanidin A-1 derived in vitro from Rhododendron spiciferum. Fitoterapia. 2010;81:108-14 pubmed publisher
|
Lagisetty P, Vilekar P, Awasthi V. Synthesis of radiolabeled cytarabine conjugates. Bioorg Med Chem Lett. 2009;19:4764-7 pubmed publisher
|
Gupte A, Buolamwini J. Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors. Bioorg Med Chem Lett. 2009;19:917-21 pubmed publisher
|
Gupte A, Buolamwini J. CoMFA and CoMSIA 3D-QSAR studies on S(6)-(4-nitrobenzyl)mercaptopurine riboside (NBMPR) analogs as inhibitors of human equilibrative nucleoside transporter 1 (hENT1). Bioorg Med Chem Lett. 2009;19:314-8 pubmed publisher
|
Zhu Z, Buolamwini J. Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity. Bioorg Med Chem. 2008;16:3848-65 pubmed publisher
|
Gupte A, Buolamwini J. Novel C2-purine position analogs of nitrobenzylmercaptopurine riboside as human equilibrative nucleoside transporter 1 inhibitors. Bioorg Med Chem. 2007;15:7726-37 pubmed
|
Lin W, Buolamwini J. Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J Med Chem. 2007;50:3906-20 pubmed
|
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
|
Minetti P, Tinti M, Carminati P, Castorina M, Di Cesare M, Di Serio S, et al. 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. J Med Chem. 2005;48:6887-96 pubmed
|
Tandon A, Collier B. Increased acetylcholine content induced by adenosine in a sympathetic ganglion and its subsequent mobilization by electrical stimulation. J Neurochem. 1993;60:2124-33 pubmed
|
Poucher S, Brooks R, Pleeth R, Conant A, Collis M. Myocardial infarction and purine transport inhibition in anaesthetised ferrets. Eur J Pharmacol. 1994;252:19-27 pubmed
|