This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
NS-398
catalog :
N194
citations: 100
Reference
Segelcke D, Reichl S, Neuffer S, Zapp S, Rüther T, Evers D, et al. The role of the spinal cyclooxygenase (COX) for incisional pain in rats at different developmental stages. Eur J Pain. 2020;24:312-324 pubmed publisher
Lee J, Jeong M, Park S, Ryu S, Lee J, Song Z, et al. Chemical Constituents of the Leaves of Butterbur (Petasites japonicus) and Their Anti-Inflammatory Effects. Biomolecules. 2019;9: pubmed publisher
Wiley C, Brumwell A, Davis S, Jackson J, Valdovinos A, Calhoun C, et al. Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis. JCI Insight. 2019;4: pubmed publisher
Tseng H, Lin C, Hsiao L, Yang C. Lysophosphatidylcholine-induced mitochondrial fission contributes to collagen production in human cardiac fibroblasts. J Lipid Res. 2019;60:1573-1589 pubmed publisher
Jung J, Lee Y, Choi Y, Park E, Kim H, Kang J. Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE2, PGD2 and Their Receptors. Cells. 2019;8: pubmed publisher
Hu C, Kosaka Y, Marcus P, Rashedi I, Keating A. Differential immunomodulatory effects of human bone marrow-derived mesenchymal stromal cells on natural killer cells. Stem Cells Dev. 2019;: pubmed publisher
Lucotti S, Cerutti C, Soyer M, Gil Bernabé A, Gomes A, Allen P, et al. Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2. J Clin Invest. 2019;130:1845-1862 pubmed publisher
Tang F, Zhang R, Wang J. Cyclooxygenase-2-Mediated Up-Regulation of Mitochondrial Transcription Factor A Mitigates the Radio-Sensitivity of Cancer Cells. Int J Mol Sci. 2019;20: pubmed publisher
Lin C, Liao L, Yang T, Chang Y, Tung C, Hsu S, et al. Microglia-Derived Adiposomes are Potential Targets for the Treatment of Ischemic Stroke. Cell Mol Neurobiol. 2019;39:591-604 pubmed publisher
Ford C, Wang Y, Morgan K, Boktor M, Jordan P, Castor T, et al. Interferon-gamma depresses human intestinal smooth muscle cell contractility: Relevance to inflammatory gut motility disturbances. Life Sci. 2019;222:69-77 pubmed publisher
Feng F, Wang Z, Li R, Wu Q, Gu C, Xu Y, et al. Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2. Biomed Pharmacother. 2019;112:108669 pubmed publisher
Peng Y, Zang T, Zhou L, Ni K, Zhou X. COX-2 contributed to the remifentanil-induced hyperalgesia related to ephrinB/EphB signaling. Neurol Res. 2019;41:519-527 pubmed publisher
Liao Y, Du W, Hu Y, Li F, Ma Y, Wang H, et al. CREB/Wnt10b mediates the effect of COX-2 on promoting BMP9-induced osteogenic differentiation via reducing adipogenic differentiation in mesenchymal stem cells. J Cell Biochem. 2019;120:9572-9587 pubmed publisher
Sahin E, Sahin M. Epigenetical Targeting of the FOXP3 Gene by S-Adenosylmethionine Diminishes the Suppressive Capacity of Regulatory T Cells Ex Vivo and Alters the Expression Profiles. J Immunother. 2019;42:11-22 pubmed publisher
Riehl T, Alvarado D, Ee X, Zuckerman A, Foster L, Kapoor V, et al. Lactobacillus rhamnosus GG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells. Gut. 2019;68:1003-1013 pubmed publisher
Yi Y, Cheng J, Klausen C, Leung P. TGF-β1 inhibits human trophoblast cell invasion by upregulating cyclooxygenase-2. Placenta. 2018;68:44-51 pubmed publisher
Han H, Shin J, Lee S, Park J, Lee K. Cirsimarin, a flavone glucoside from the aerial part of Cirsium japonicum var. ussuriense (Regel) Kitam. ex Ohwi, suppresses the JAK/STAT and IRF-3 signaling pathway in LPS-stimulated RAW 264.7 macrophages. Chem Biol Interact. 2018;293:38-47 pubmed publisher
Arnett E, Weaver A, Woodyard K, Montoya M, Li M, Hoang K, et al. PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis. PLoS Pathog. 2018;14:e1007100 pubmed publisher
Zhang Y, Ma K, Liu J, Wang H, Tian W, Tu Y, et al. γ-tocotrienol inhibits the invasion and migration of human gastric cancer cells through downregulation of cyclooxygenase-2 expression. Oncol Rep. 2018;40:999-1007 pubmed publisher
Boisvert N, Holterman C, Thibodeau J, Nasrallah R, Kamto E, Comin C, et al. Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice. Clin Sci (Lond). 2018;132:1453-1470 pubmed publisher
Zhen Y, Wu Q, Ding Y, Zhang W, Zhai Y, Lin X, et al. Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway. Oncol Lett. 2018;15:6562-6570 pubmed publisher
William M, Leroux L, Chaparro V, Lorent J, Graber T, M Boutchou M, et al. eIF4E-Binding Proteins 1 and 2 Limit Macrophage Anti-Inflammatory Responses through Translational Repression of IL-10 and Cyclooxygenase-2. J Immunol. 2018;200:4102-4116 pubmed publisher
Zheng B, Gao W, Huang X, Lin L, Fang X, Chen Z, et al. HBx promotes the proliferative ability of HL‑7702 cells via the COX‑2/Wnt/β‑catenin pathway. Mol Med Rep. 2018;17:8432-8438 pubmed publisher
Tamosiuniene R, Manouvakhova O, Mésange P, Saito T, Qian J, Sanyal M, et al. Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension. Circ Res. 2018;122:1689-1702 pubmed publisher
Kawao N, Moritake A, Tatsumi K, Kaji H. Roles of Irisin in the Linkage from Muscle to Bone During Mechanical Unloading in Mice. Calcif Tissue Int. 2018;103:24-34 pubmed publisher
Maseda D, Johnson E, Nyhoff L, Baron B, Kojima F, Wilhelm A, et al. mPGES1-Dependent Prostaglandin E2 (PGE2) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE2 Production. J Immunol. 2018;200:725-736 pubmed publisher
Cheng F, Chen Y, Zhan Z, Liu Y, Hu P, Ren H, et al. Curc-mPEG454, a PEGylated Curcumin Derivative, Improves Anti-inflammatory and Antioxidant Activities: a Comparative Study. Inflammation. 2018;41:579-594 pubmed publisher
Kolgazi M, Ozdemir Kumral Z, Cantali Ozturk C, Demirci E, Yuksel M, Sirvanci S, et al. Anti-inflammatory effects of nesfatin-1 on acetic acid-induced gastric ulcer in rats: involvement of cyclo-oxygenase pathway. J Physiol Pharmacol. 2017;68:765-777 pubmed
Wei S, Yu Y, Felder R. Blood-borne Interleukin-1? Acts upon the Subfornical Organ to Upregulate the Sympathoexcitatory Milieu of the Hypothalamic Paraventricular Nucleus. Am J Physiol Regul Integr Comp Physiol. 2017;:ajpregu.00211.2017 pubmed publisher
Liao X, Huang C, Zhang D, Wang J, Li J, Jin H, et al. Mitochondrial catalase induces cells transformation through nucleolin-dependent Cox-2 mRNA stabilization. Free Radic Biol Med. 2017;113:478-486 pubmed publisher
Lima J, Araújo Santos T, Lázaro Souza M, Carneiro A, Ibraim I, Jesus Santos F, et al. Leishmania infantum lipophosphoglycan induced-Prostaglandin E2 production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2. Sci Rep. 2017;7:14321 pubmed publisher
Kim W, Lee H, Jang J, Kim S, Lee Y, Hahn Y, et al. 15-Deoxy-Δ12,14-Prostaglandin J2 Exerts Proresolving Effects Through Nuclear Factor E2-Related Factor 2-Induced Expression of CD36 and Heme Oxygenase-1. Antioxid Redox Signal. 2017;27:1412-1431 pubmed publisher
Gao W, Sun Y, Shi J, Li C, Fang S, Wang D, et al. Effects of mesenchymal stem cells from human induced pluripotent stem cells on differentiation, maturation, and function of dendritic cells. Stem Cell Res Ther. 2017;8:48 pubmed publisher
Kohi S, Sato N, Koga A, Matayoshi N, Hirata K. KIAA1199 is induced by inflammation and enhances malignant phenotype in pancreatic cancer. Oncotarget. 2017;8:17156-17163 pubmed publisher
Lee H, Shin J, Lee K, Park S, Jang Y, Nam J, et al. Ethanol Extract of Potentilla supina Linne Suppresses LPS-induced Inflammatory Responses through NF-κB and AP-1 Inactivation in Macrophages and in Endotoxic mice. Phytother Res. 2017;31:475-487 pubmed publisher
Bonfill Teixidor E, Otxoa de Amezaga A, Font Nieves M, Sans Fons M, Planas A. Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide. J Neuroinflammation. 2017;14:3 pubmed publisher
He L, Tong X, Zeng J, Tu Y, Wu S, Li M, et al. Paeonol Suppresses Neuroinflammatory Responses in LPS-Activated Microglia Cells. Inflammation. 2016;39:1904-1917 pubmed
Madonna R, Giovannelli G, Confalone P, Renna F, Geng Y, De Caterina R. High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy. Cardiovasc Diabetol. 2016;15:18 pubmed publisher
Liu H, Xu X, Zhao Y, Tang M, Zhou Y, Gao F. NS-398 promotes pancreatic cancer cell invasion by CD147 and MMP-2 via the activation of P38. Mol Med Rep. 2016;13:2208-14 pubmed publisher
Zhang R, Liu Z, Zhang H, Zhang Y, Lin D. The COX-2-Selective Antagonist (NS-398) Inhibits Choroidal Neovascularization and Subretinal Fibrosis. PLoS ONE. 2016;11:e0146808 pubmed publisher
Kim J, Shim M. COX-2 inhibitor NS-398 suppresses doxorubicin-induced p53 accumulation through inhibition of ROS-mediated Jnk activation. Mol Carcinog. 2016;55:2156-2167 pubmed publisher
Zhang Y, Hao X, Zhang L, Tian Y. Enhanced cyclooxygenase-2 activity leads to intestinal dysmotility following hemorrhagic shock. Acta Cir Bras. 2015;30:838-43 pubmed publisher
Mouawad C, Mrad M, El Achkar G, Abdul Sater A, Nemer G, Creminon C, et al. Statins Modulate Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 in Human Hepatic Myofibroblasts. J Cell Biochem. 2016;117:1176-86 pubmed publisher
Chen Q, Chen R, Liu J, Yuan H, Liu P, Hu A, et al. Hypodermin A, a potential agent for prevention of allogeneic acute rejection. Transpl Immunol. 2015;33:198-203 pubmed publisher
Seebacher W, Faist J, Presser A, Weis R, Saf R, Kaserer T, et al. Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2. Eur J Med Chem. 2015;101:552-9 pubmed publisher
Tetz L, Aronoff D, Loch Caruso R. Mono-ethylhexyl phthalate stimulates prostaglandin secretion in human placental macrophages and THP-1 cells. Reprod Biol Endocrinol. 2015;13:56 pubmed publisher
Entrena A, Varas A, Vázquez M, Melen G, Fernández Sevilla L, García Castro J, et al. Mesenchymal stem cells derived from low risk acute lymphoblastic leukemia patients promote NK cell antitumor activity. Cancer Lett. 2015;363:156-65 pubmed publisher
Chignalia A, Oliveira M, Debbas V, Dull R, Laurindo F, Touyz R, et al. Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms. Clin Sci (Lond). 2015;129:39-48 pubmed publisher
Na Y, Yoon Y, Son D, Jung D, Gu G, Seok S. Consistent inhibition of cyclooxygenase drives macrophages towards the inflammatory phenotype. PLoS ONE. 2015;10:e0118203 pubmed publisher
Xie C, Sun X, Chen J, Ng C, Lau K, Cai Z, et al. Down-regulated CFTR During Aging Contributes to Benign Prostatic Hyperplasia. J Cell Physiol. 2015;230:1906-15 pubmed publisher
Lin Y, Fu Y, Wu C, Xu G, Huang L, Shi X. Colon distention induces persistent visceral hypersensitivity by mechanotranscription of pain mediators in colonic smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2015;308:G434-41 pubmed publisher
Park H, Kamau P, Korte C, Loch Caruso R. Tetrabromobisphenol A activates inflammatory pathways in human first trimester extravillous trophoblasts in vitro. Reprod Toxicol. 2014;50:154-62 pubmed publisher
Huang C, Wang H, Pan J, Zhou D, Chen W, Li W, et al. Benzalkonium chloride induces subconjunctival fibrosis through the COX-2-modulated activation of a TGF-β1/Smad3 signaling pathway. Invest Ophthalmol Vis Sci. 2014;55:8111-22 pubmed publisher
Chandrasekaran S, Marshall J, Messing J, Hsu J, King M. TRAIL-mediated apoptosis in breast cancer cells cultured as 3D spheroids. PLoS ONE. 2014;9:e111487 pubmed publisher
Martínez A, Hernández M, Novella S, Martínez M, Pagán R, Hermenegildo C, et al. Diminished neurogenic femoral artery vasoconstrictor response in a Zucker obese rat model: differential regulation of NOS and COX derivatives. PLoS ONE. 2014;9:e106372 pubmed publisher
Maeda Y, Sekiguchi F, Yamanaka R, Sugimoto R, Yamasoba D, Tomita S, et al. Mechanisms for proteinase-activated receptor 1-triggered prostaglandin E2 generation in mouse osteoblastic MC3T3-E1 cells. Biol Chem. 2015;396:153-62 pubmed publisher
Hsu C, Lee I, Lin C, Hsiao L, Yang C. Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. J Cell Physiol. 2015;230:702-15 pubmed publisher
Ruan D, So S. Prostaglandin E2 produced by inducible COX-2 and mPGES-1 promoting cancer cell proliferation in vitro and in vivo. Life Sci. 2014;116:43-50 pubmed publisher
Park S, Ma W, Yoon S, Kang M, Han J. Phospholipase D1 increases Bcl-2 expression during neuronal differentiation of rat neural stem cells. Mol Neurobiol. 2015;51:1089-102 pubmed publisher
Majumder M, Xin X, Liu L, Girish G, Lala P. Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions. Cancer Sci. 2014;105:1142-51 pubmed publisher
Qiu X, Cheng J, Chang H, Leung P. COX2 and PGE2 mediate EGF-induced E-cadherin-independent human ovarian cancer cell invasion. Endocr Relat Cancer. 2014;21:533-43 pubmed publisher
Zheng B, Fang X, Zou L, Huang Y, Chen Z, Li D, et al. The co-localization of HBx and COXIII upregulates COX-2 promoting HepG2 cell growth. Int J Oncol. 2014;45:1143-50 pubmed publisher
Lee J, Kim B, Jin W, Kim J, Kim H, Ha H, et al. Trolox inhibits osteolytic bone metastasis of breast cancer through both PGE2-dependent and independent mechanisms. Biochem Pharmacol. 2014;91:51-60 pubmed publisher
Paudel U, Lee Y, Kwon T, Park N, Yun B, Hwang P, et al. Eckols reduce dental pulp inflammation through the ERK1/2 pathway independent of COX-2 inhibition. Oral Dis. 2014;20:827-32 pubmed publisher
Dang S, Xu H, Xu C, Cai W, Li Q, Cheng Y, et al. Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis. Autophagy. 2014;10:1301-15 pubmed publisher
Fujii R, Imanishi Y, Shibata K, Sakai N, Sakamoto K, Shigetomi S, et al. Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma. J Exp Clin Cancer Res. 2014;33:40 pubmed publisher
Bocca C, Bozzo F, Miglietta A. COX2 inhibitor NS398 reduces HT-29 cell invasiveness by modulating signaling pathways mediated by EGFR and HIF1-?. Anticancer Res. 2014;34:1793-800 pubmed
Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton K, Tyminski E, et al. Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6. PLoS ONE. 2014;9:e92608 pubmed publisher
Suzuki R, Nemoto E, Shimauchi H. Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells. Exp Cell Res. 2014;323:232-41 pubmed publisher
Won S, Kim S, Maeng S, Jin B. Interleukin-13/Interleukin-4-induced oxidative stress contributes to death of prothrombinkringle-2 (pKr-2)-activated microglia. J Neuroimmunol. 2013;265:36-42 pubmed publisher
Yoon Y, Lee Y, Choi J, Cho M, Kang J. Coordinated induction of cyclooxygenase-2/prostaglandin E2 and hepatocyte growth factor by apoptotic cells prevents lung fibrosis. J Leukoc Biol. 2013;94:1037-49 pubmed publisher
Leclerc P, Wähämaa H, Idborg H, Jakobsson P, Harris H, Korotkova M. IL-1β/HMGB1 complexes promote The PGE2 biosynthesis pathway in synovial fibroblasts. Scand J Immunol. 2013;77:350-60 pubmed publisher
Fu Y, Lu Y, Liu E, Zhu X, Mahajan G, Lu D, et al. Testosterone enhances tubuloglomerular feedback by increasing superoxide production in the macula densa. Am J Physiol Regul Integr Comp Physiol. 2013;304:R726-33 pubmed publisher
Jung S, Saxena A, Kaur K, Fletcher E, Ponemone V, Nottingham J, et al. The role of adipose tissue-associated macrophages and T lymphocytes in the pathogenesis of inflammatory bowel disease. Cytokine. 2013;61:459-68 pubmed publisher
Ramer R, Heinemann K, Merkord J, Rohde H, Salamon A, Linnebacher M, et al. COX-2 and PPAR-? confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013;12:69-82 pubmed publisher
Ramos Alves F, de Queiroz D, Santos Rocha J, Duarte G, Xavier F. Increased cyclooxygenase-2-derived prostanoids contributes to the hyperreactivity to noradrenaline in mesenteric resistance arteries from offspring of diabetic rats. PLoS ONE. 2012;7:e50593 pubmed publisher
Abraki S, Khalaj L, Shaerzadeh F, Khodagholi F. Simultaneous inhibition of COX-2 and activation of PPAR-γ resulted in the same level and pattern of neuroprotection as they were targeted separately. J Mol Neurosci. 2013;49:116-29 pubmed publisher
Chotjumlong P, Bolscher J, Nazmi K, Reutrakul V, Supanchart C, Buranaphatthana W, et al. Involvement of the P2X7 purinergic receptor and c-Jun N-terminal and extracellular signal-regulated kinases in cyclooxygenase-2 and prostaglandin E2 induction by LL-37. J Innate Immun. 2013;5:72-83 pubmed publisher
Unsal Tan O, Ozadali K, Piskin K, Balkan A. Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity. Eur J Med Chem. 2012;57:59-64 pubmed publisher
Bassal N, Hughes B, Costabile M. Arachidonic acid and its COX1/2 metabolites inhibit interferon-γ mediated induction of indoleamine-2,3 dioxygenase in THP-1 cells and human monocytes. Prostaglandins Leukot Essent Fatty Acids. 2012;87:119-26 pubmed publisher
Hattar K, Savai R, Subtil F, Wilhelm J, Schmall A, Lang D, et al. Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation. Cancer Immunol Immunother. 2013;62:309-20 pubmed publisher
Duan D, Dang X, Wang K, Wang Y, Zhang H, You W. The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. Oncol Rep. 2012;28:1693-700 pubmed publisher
Gu K, Chen Y. Mechanism of P-glycoprotein expression in the SGC7901 human gastric adenocarcinoma cell line induced by cyclooxygenase-2. Asian Pac J Cancer Prev. 2012;13:2379-83 pubmed
Zhang J, Barasch N, Li R, Sapirstein A. Inhibition of cytosolic phospholipase A(2) alpha protects against focal ischemic brain damage in mice. Brain Res. 2012;1471:129-37 pubmed publisher
Tanabe Y, Saito Tanji M, Morikawa Y, Kamataki A, Sawai T, Nakayama K. Role of secretory phospholipase A(2) in rhythmic contraction of pulmonary arteries of rats with monocrotaline-induced pulmonary arterial hypertension. J Pharmacol Sci. 2012;119:271-81 pubmed
Lee M, Kim S, Lee S, Jung Y, Choi S, Kim W, et al. Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner. Exp Mol Med. 2012;44:536-44 pubmed
Morita Y, Hata K, Nakanishi M, Nishisho T, Yura Y, Yoneda T. Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma. Int J Oncol. 2012;41:885-92 pubmed publisher
Silver K, Desormaux A, Freeman L, Lillich J. Expression of pleiotrophin, an important regulator of cell migration, is inhibited in intestinal epithelial cells by treatment with non-steroidal anti-inflammatory drugs. Growth Factors. 2012;30:258-66 pubmed publisher
Palayoor S, J Aryankalayil M, Makinde A, Cerna D, Falduto M, Magnuson S, et al. Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012;59:487-99 pubmed publisher
Chatterjee A, Chatterjee S, Das S, Saha A, Chattopadhyay S, Bandyopadhyay S. Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation. Acta Biochim Biophys Sin (Shanghai). 2012;44:565-76 pubmed publisher
Targosz A, Brzozowski T, Pierzchalski P, Szczyrk U, Ptak Belowska A, Konturek S, et al. Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells. Inflamm Res. 2012;61:955-66 pubmed publisher
Wang D, Ji Y, Chen K, Du W, Yang Z, Han Z, et al. IL-6 production stimulated by CD14(+) monocytes-paracrined IL-1β does not contribute to the immunosuppressive activity of human umbilical cord mesenchymal stem cells. Cell Physiol Biochem. 2012;29:551-60 pubmed publisher
Zeng Y, Xie K, Dong H, Zhang H, Wang F, Li Y, et al. Hyperbaric oxygen preconditioning protects cortical neurons against oxygen-glucose deprivation injury: role of peroxisome proliferator-activated receptor-gamma. Brain Res. 2012;1452:140-50 pubmed publisher
Sugiyama T, Meakin L, Galea G, Lanyon L, Price J. The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice. Osteoporos Int. 2013;24:383-8 pubmed publisher
Cruz Duarte P, St Jacques B, Ma W. Prostaglandin E2 contributes to the synthesis of brain-derived neurotrophic factor in primary sensory neuron in ganglion explant cultures and in a neuropathic pain model. Exp Neurol. 2012;234:466-81 pubmed publisher
Wang C, Lee W, Ghanta V, Wang W, Cheng S, Hsueh C. Molecules involve in the self-protection of neurons against glucose-oxygen-serum deprivation (GOSD)-induced cell damage. Brain Res Bull. 2009;79:169-76 pubmed publisher
Kennedy J, Korn N, Thurston R. Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility. Reprod Biol Endocrinol. 2003;1:74 pubmed
Coffey R, Hawkey C, Damstrup L, Graves Deal R, Daniel V, Dempsey P, et al. Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells. Proc Natl Acad Sci U S A. 1997;94:657-62 pubmed
Yamamoto T, Nozaki Taguchi N. Analysis of the effects of cyclooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor, and NS-398, a COX-2 selective inhibitor. Brain Res. 1996;739:104-10 pubmed
Futaki N, Takahashi S, Yokoyama M, Arai I, Higuchi S, Otomo S. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 1994;47:55-9 pubmed
product information
Catalog Number :
N194
Product Name :
NS-398
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC), solid
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA