This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Pimonidazole
catalog :
N1165
citations: 99
Reference
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Grkovski M, Fanchon L, Pillarsetty N, Russell J, Humm J. 18F-fluoromisonidazole predicts evofosfamide uptake in pancreatic tumor model. EJNMMI Res. 2018;8:53 pubmed publisher
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Chidlow G, Wood J, Casson R. Investigations into Hypoxia and Oxidative Stress at the Optic Nerve Head in a Rat Model of Glaucoma. Front Neurosci. 2017;11:478 pubmed publisher
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Sharma A, Broggini Tenzer A, Vuong V, Messikommer A, Nytko K, Guckenberger M, et al. The novel microtubule targeting agent BAL101553 in combination with radiotherapy in treatment-refractory tumor models. Radiother Oncol. 2017;124:433-438 pubmed publisher
Gagner J, Sarfraz Y, Ortenzi V, Alotaibi F, Chiriboga L, Tayyib A, et al. Multifaceted C-X-C Chemokine Receptor 4 (CXCR4) Inhibition Interferes with Anti-Vascular Endothelial Growth Factor Therapy-Induced Glioma Dissemination. Am J Pathol. 2017;187:2080-2094 pubmed publisher
Lucien F, Pelletier P, Lavoie R, Lacroix J, Roy S, Parent J, et al. Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance. Nat Commun. 2017;8:15884 pubmed publisher
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Jiang P, Tsai H, Drake P, Wang F, Chiang C. Gadolinium-doped iron oxide nanoparticles induced magnetic field hyperthermia combined with radiotherapy increases tumour response by vascular disruption and improved oxygenation. Int J Hyperthermia. 2017;33:770-778 pubmed publisher
Dufu K, Yalcin O, Ao Ieong E, Hutchaleelala A, Xu Q, Li Z, et al. GBT1118, a potent allosteric modifier of hemoglobin O2 affinity, increases tolerance to severe hypoxia in mice. Am J Physiol Heart Circ Physiol. 2017;313:H381-H391 pubmed publisher
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Agrawal V, Kim D, Kwon Y. Hhip regulates tumor-stroma-mediated upregulation of tumor angiogenesis. Exp Mol Med. 2017;49:e289 pubmed publisher
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Shi K, Bayer C, Gaertner F, Astner S, Wilkens J, Nüsslin F, et al. Matching the reaction-diffusion simulation to dynamic [18F]FMISO PET measurements in tumors: extension to a flow-limited oxygen-dependent model. Physiol Meas. 2017;38:188-204 pubmed publisher
Takano S, Ishikawa E, Matsuda M, Sakamoto N, Akutsu H, Yamamoto T, et al. The anti-angiogenic role of soluble-form VEGF receptor in malignant gliomas. Int J Oncol. 2017;50:515-524 pubmed publisher
Scharping N, Menk A, Whetstone R, Zeng X, Delgoffe G. Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia. Cancer Immunol Res. 2017;5:9-16 pubmed publisher
Thompson L, Pence L, Pinkas G, Song H, Telugu B. Placental Hypoxia During Early Pregnancy Causes Maternal Hypertension and Placental Insufficiency in the Hypoxic Guinea Pig Model. Biol Reprod. 2016;95:128 pubmed
Kleibeuker E, Fokas E, Allen P, Kersemans V, Griffioen A, Beech J, et al. Low dose angiostatic treatment counteracts radiotherapy-induced tumor perfusion and enhances the anti-tumor effect. Oncotarget. 2016;7:76613-76627 pubmed publisher
Kajiwara T, Tanaka T, Kukita K, Kutomi G, Saito K, Okuya K, et al. Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-?-mediated oxidative folding in murine tumor cells. Eur J Immunol. 2016;46:2842-2851 pubmed publisher
Ham S, Joshi R, Luker G, Tavana H. Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors. Adv Healthc Mater. 2016;5:2788-2798 pubmed publisher
Duran R, Mirpour S, Pekurovsky V, Ganapathy Kanniappan S, Brayton C, Cornish T, et al. Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer. Clin Cancer Res. 2017;23:536-548 pubmed publisher
Schadde E, Tsatsaris C, Swiderska Syn M, Breitenstein S, Urner M, Schimmer R, et al. Hypoxia of the growing liver accelerates regeneration. Surgery. 2017;161:666-679 pubmed publisher
Burrows N, Cane G, Robson M, Gaude E, Howat W, Szlosarek P, et al. Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20). Sci Rep. 2016;6:22950 pubmed publisher
Panth K, van den Beucken T, Biemans R, Lieuwes N, Weber M, Losen M, et al. In vivo optical imaging of MMP2 immuno protein antibody: tumor uptake is associated with MMP2 activity. Sci Rep. 2016;6:22198 pubmed publisher
O Connor J, Boult J, Jamin Y, Babur M, Finegan K, Williams K, et al. Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models. Cancer Res. 2016;76:787-95 pubmed publisher
Corroyer Dulmont A, Pérès E, Gérault A, Savina A, Bouquet F, Divoux D, et al. Multimodal imaging based on MRI and PET reveals [(18)F]FLT PET as a specific and early indicator of treatment efficacy in a preclinical model of recurrent glioblastoma. Eur J Nucl Med Mol Imaging. 2016;43:682-94 pubmed publisher
Adamo H, Strömvall K, Nilsson M, Halin Bergström S, Bergh A. Adaptive (TINT) Changes in the Tumor Bearing Organ Are Related to Prostate Tumor Size and Aggressiveness. PLoS ONE. 2015;10:e0141601 pubmed publisher
André H, Tunik S, Aronsson M, Kvanta A. Hypoxia-Inducible Factor-1α Is Associated With Sprouting Angiogenesis in the Murine Laser-Induced Choroidal Neovascularization Model. Invest Ophthalmol Vis Sci. 2015;56:6591-604 pubmed publisher
Leroi N, Sounni N, Van Overmeire E, Blacher S, Marée R, Van Ginderachter J, et al. The timing of surgery after neoadjuvant radiotherapy influences tumor dissemination in a preclinical model. Oncotarget. 2015;6:36825-37 pubmed publisher
Zhou F, Zanganeh S, Mohammad I, Dietz C, Abuteen A, Smith M, et al. Targeting tumor hypoxia: a third generation 2-nitroimidazole-indocyanine dye-conjugate with improved fluorescent yield. Org Biomol Chem. 2015;13:11220-7 pubmed publisher
Kolb T, Peabody J, Baddoura P, Fallica J, Mock J, Singer B, et al. Right Ventricular Angiogenesis is an Early Adaptive Response to Chronic Hypoxia-Induced Pulmonary Hypertension. Microcirculation. 2015;22:724-36 pubmed publisher
Ledaki I, McIntyre A, Wigfield S, Buffa F, McGowan S, Baban D, et al. Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition. Oncotarget. 2015;6:19413-27 pubmed
Bruine de Bruin L, Bollineni V, Wachters J, Schuuring E, van Hemel B, van der Wal J, et al. Assessment of hypoxic subvolumes in laryngeal cancer with (18)F-fluoroazomycinarabinoside ((18)F-FAZA)-PET/CT scanning and immunohistochemistry. Radiother Oncol. 2015;117:106-12 pubmed publisher
Bill R, Fagiani E, Zumsteg A, Antoniadis H, Johansson D, Haefliger S, et al. Nintedanib Is a Highly Effective Therapeutic for Neuroendocrine Carcinoma of the Pancreas (PNET) in the Rip1Tag2 Transgenic Mouse Model. Clin Cancer Res. 2015;21:4856-67 pubmed publisher
Kaida A, Miura M. Unusual prolongation of radiation-induced G2 arrest in tumor xenografts derived from HeLa cells. Cancer Sci. 2015;106:1370-6 pubmed publisher
Garhyan J, Bhuyan S, Pulu I, Kalita D, Das B, Bhatnagar R. Preclinical and Clinical Evidence of Mycobacterium tuberculosis Persistence in the Hypoxic Niche of Bone Marrow Mesenchymal Stem Cells after Therapy. Am J Pathol. 2015;185:1924-34 pubmed publisher
Zheng L, Li Y, Geng F, Zheng S, Yan R, Han Y, et al. Using semi-quantitative dynamic contrast-enhanced magnetic resonance imaging parameters to evaluate tumor hypoxia: a preclinical feasibility study in a maxillofacial VX2 rabbit model. Am J Transl Res. 2015;7:535-47 pubmed
Gao H, Xue J, Zhou L, Lan J, He J, Na F, et al. Bevacizumab radiosensitizes non-small cell lung cancer xenografts by inhibiting DNA double-strand break repair in endothelial cells. Cancer Lett. 2015;365:79-88 pubmed publisher
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Senkowski W, Zhang X, Olofsson M, Isacson R, Höglund U, Gustafsson M, et al. Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer. Mol Cancer Ther. 2015;14:1504-16 pubmed publisher
Ogino A, Takemura G, Hashimoto A, Kanamori H, Okada H, Nakagawa M, et al. OPC-28326, a selective peripheral vasodilator with angiogenic activity, mitigates postinfarction cardiac remodeling. Am J Physiol Heart Circ Physiol. 2015;309:H213-21 pubmed publisher
Cohen N, Zeng S, Seifert A, Kim T, Sorenson E, Greer J, et al. Pharmacological Inhibition of KIT Activates MET Signaling in Gastrointestinal Stromal Tumors. Cancer Res. 2015;75:2061-70 pubmed publisher
Ohnishi H, Mizuno S, Mizuno Horikawa Y, Kato T. Stromal cell-derived factor-1 (SDF1)-dependent recruitment of bone marrow-derived renal endothelium-like cells in a mouse model of acute kidney injury. J Vet Med Sci. 2015;77:313-9 pubmed publisher
Licht T, Dor Wollman T, Ben Zvi A, Rothe G, Keshet E. Vessel maturation schedule determines vulnerability to neuronal injuries of prematurity. J Clin Invest. 2015;125:1319-28 pubmed publisher
Zheng X, Wang X, Mao H, Wu W, Liu B, Jiang X. Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo. Nat Commun. 2015;6:5834 pubmed publisher
Kulic I, Robertson G, Chang L, Baker J, Lockwood W, Mok W, et al. Loss of the Notch effector RBPJ promotes tumorigenesis. J Exp Med. 2015;212:37-52 pubmed publisher
Zhuang P, Wang J, Tang Z, Zhou X, Yang Y, Quan Z, et al. Peritumoral Neuropilin-1 and VEGF receptor-2 expression increases time to recurrence in hepatocellular carcinoma patients undergoing curative hepatectomy. Oncotarget. 2014;5:11121-32 pubmed
Zhang J, Cao J, Ma S, Dong R, Meng W, Ying M, et al. Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling. Oncotarget. 2014;5:9664-77 pubmed
Ullsten S, Lau J, Carlsson P. Vascular heterogeneity between native rat pancreatic islets is responsible for differences in survival and revascularisation post transplantation. Diabetologia. 2015;58:132-9 pubmed publisher
Fatema C, Zhao S, Zhao Y, Yu W, Nishijima K, Yasuda K, et al. Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative states after radiotherapy of human head and neck cancer xenografts using radiolabeled FMISO and FLT. BMC Cancer. 2014;14:692 pubmed publisher
Meijer T, Bussink J, Zatovicova M, Span P, Lok J, Supuran C, et al. Tumor microenvironmental changes induced by the sulfamate carbonic anhydrase IX inhibitor S4 in a laryngeal tumor model. PLoS ONE. 2014;9:e108068 pubmed publisher
Lee K, Agrawal V, Kim K, Kim J, Park H, Lee S, et al. Combined effect of vascular-leakage-blocker Sac-1004 and antiangiogenic drug sunitinib on tumor angiogenesis. Biochem Biophys Res Commun. 2014;450:1320-6 pubmed publisher
Villasante A, Marturano Kruik A, Vunjak Novakovic G. Bioengineered human tumor within a bone niche. Biomaterials. 2014;35:5785-94 pubmed publisher
Stegeman H, Rademakers S, Span P, Takes R, van der Kogel A, Kaanders J, et al. Hypoxia, metabolism, and growth factor signaling in head and neck squamous cell carcinoma: correlation between primary and xenograft tumors. Head Neck. 2014;36:1288-95 pubmed publisher
Abdelkader A, Ho J, Ow C, Eppel G, Rajapakse N, Schlaich M, et al. Renal oxygenation in acute renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2014;306:F1026-38 pubmed publisher
product information
Catalog Number :
N1165
Product Name :
Pimonidazole
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA