This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Niflumic acid
catalog :
N0630
citations: 70
Reference
Soulard C, Salsac C, Mouzat K, Hilaire C, Roussel J, Mezghrani A, et al. Spinal Motoneuron TMEM16F Acts at C-boutons to Modulate Motor Resistance and Contributes to ALS Pathogenesis. Cell Rep. 2020;30:2581-2593.e7 pubmed publisher
Oh S, Lee J, Kim H, Lee J, Han S, Bae J, et al. Ultrasonic Neuromodulation via Astrocytic TRPA1. Curr Biol. 2019;29:3386-3401.e8 pubmed publisher
Beekharry C, Gu Y, Magoski N. Protein Kinase C Enhances Electrical Synaptic Transmission by Acting on Junctional and Postsynaptic Ca2+ Currents. J Neurosci. 2018;38:2796-2808 pubmed publisher
Marsh A, Casey Green K, Probert F, Withall D, Mitchell D, Dilly S, et al. Simvastatin Sodium Salt and Fluvastatin Interact with Human Gap Junction Gamma-3 Protein. PLoS ONE. 2016;11:e0148266 pubmed publisher
Matsumoto T, Matsubara Y, Mizuhara Y, Sekiguchi K, Koseki J, Tsuchiya K, et al. Plasma Pharmacokinetics of Polyphenols in a Traditional Japanese Medicine, Jumihaidokuto, Which Suppresses Propionibacterium acnes-Induced Dermatitis in Rats. Molecules. 2015;20:18031-46 pubmed publisher
Fujii T, Takahashi Y, Takeshima H, Saitoh C, Shimizu T, Takeguchi N, et al. Inhibition of gastric H+,K+-ATPase by 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl)oxybutyric acid (DCPIB), an inhibitor of volume-regulated anion channel. Eur J Pharmacol. 2015;765:34-41 pubmed publisher
Guijarro Díez M, Nozal L, Marina M, Crego A. Metabolomic fingerprinting of saffron by LC/MS: novel authenticity markers. Anal Bioanal Chem. 2015;407:7197-213 pubmed publisher
Kitagawa H, Munekage M, Ichikawa K, Fukudome I, Munekage E, Takezaki Y, et al. Pharmacokinetics of Active Components of Yokukansan, a Traditional Japanese Herbal Medicine after a Single Oral Administration to Healthy Japanese Volunteers: A Cross-Over, Randomized Study. PLoS ONE. 2015;10:e0131165 pubmed publisher
Pineda Farias J, Barragán Iglesias P, Loeza Alcocer E, Torres López J, Rocha González H, Pérez Severiano F, et al. Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats. Mol Pain. 2015;11:41 pubmed publisher
Liang S, Ge G, Xia Y, Zhang J, Qi X, Tu C, et al. In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis. J Pharm Sci. 2015;104:3557-64 pubmed publisher
Musrap N, Tuccitto A, Karagiannis G, Saraon P, Batruch I, Diamandis E. Comparative Proteomics of Ovarian Cancer Aggregate Formation Reveals an Increased Expression of Calcium-activated Chloride Channel Regulator 1 (CLCA1). J Biol Chem. 2015;290:17218-27 pubmed publisher
Sun H, Ma Z, Lu D, Wu B. Regio- and isoform-specific glucuronidation of psoralidin: evaluation of 3-o-glucuronidation as a functional marker for UGT1A9. J Pharm Sci. 2015;104:2369-77 pubmed publisher
Ramírez J, Mirkov S, House L, Ratain M. Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10. Drug Metab Dispos. 2015;43:928-35 pubmed publisher
Pujol Giménez J, Pérez A, Reyes A, Loo D, Lostao M. Functional characterization of the human facilitative glucose transporter 12 (GLUT12) by electrophysiological methods. Am J Physiol Cell Physiol. 2015;308:C1008-22 pubmed publisher
Lin J, Jiang Y, Li L, Liu Y, Tang H, Jiang D. TMEM16A mediates the hypersecretion of mucus induced by Interleukin-13. Exp Cell Res. 2015;334:260-9 pubmed publisher
Azzouz A, Ballesteros E. Multiresidue method for the determination of pharmacologically active substances in egg and honey using a continuous solid-phase extraction system and gas chromatography-mass spectrometry. Food Chem. 2015;178:63-9 pubmed publisher
Xia Y, Ge G, Wang P, Liang S, He Y, Ning J, et al. Structural modifications at the C-4 position strongly affect the glucuronidation of 6,7-dihydroxycoumarins. Drug Metab Dispos. 2015;43:553-60 pubmed publisher
Müller Calleja N, Köhler A, Siebald B, Canisius A, Orning C, Radsak M, et al. Cofactor-independent antiphospholipid antibodies activate the NLRP3-inflammasome via endosomal NADPH-oxidase: implications for the antiphospholipid syndrome. Thromb Haemost. 2015;113:1071-83 pubmed publisher
Lee S, Park J, Kim D, Bae S, Chin Y, Oh E, et al. In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug-drug interactions. Toxicol Lett. 2015;232:458-65 pubmed publisher
Matsuba S, Niwa S, Muraki K, Kanatsuka S, Nakazono Y, Hatano N, et al. Downregulation of Ca2+-activated Cl- channel TMEM16A by the inhibition of histone deacetylase in TMEM16A-expressing cancer cells. J Pharmacol Exp Ther. 2014;351:510-8 pubmed publisher
Ito Y, Fukami T, Yokoi T, Nakajima M. An orphan esterase ABHD10 modulates probenecid acyl glucuronidation in human liver. Drug Metab Dispos. 2014;42:2109-16 pubmed publisher
Romei C, Sabolla C, Raiteri L. High-affinity GABA uptake by neuronal GAT1 transporters provokes release of [(3)H]GABA by homoexchange and through GAT1-independent Ca(2+)-mediated mechanisms. Neuropharmacology. 2015;88:164-70 pubmed publisher
Adams K, Abraham V, Spielman D, Kolls J, Rubenstein R, Conner G, et al. IL-17A induces Pendrin expression and chloride-bicarbonate exchange in human bronchial epithelial cells. PLoS ONE. 2014;9:e103263 pubmed publisher
Mitsui R, Hashitani H. Functional properties of submucosal venules in the rat stomach. Pflugers Arch. 2015;467:1327-42 pubmed publisher
Singh R, Gibbons S, Saravanaperumal S, Du P, Hennig G, Eisenman S, et al. Ano1, a Ca2+-activated Cl- channel, coordinates contractility in mouse intestine by Ca2+ transient coordination between interstitial cells of Cajal. J Physiol. 2014;592:4051-68 pubmed publisher
Jeong E, Kim Y, Kim H, Shin H, Shin J, Kim K, et al. Glucuronidation of fimasartan, a new angiotensin receptor antagonist, is mainly mediated by UGT1A3. Xenobiotica. 2015;45:10-8 pubmed publisher
Choi E, Park J, Yoon K, Bae S. Evaluation of the in vitro/in vivo potential of five berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) commonly used as herbal supplements to inhibit uridine diphospho-glucuronosyltransferase. Food Chem Toxicol. 2014;72:13-9 pubmed publisher
Barnes K, Rowland A, Polasek T, Miners J. Inhibition of human drug-metabolising cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in vitro by uremic toxins. Eur J Clin Pharmacol. 2014;70:1097-106 pubmed publisher
Inoue K, Mizuo H, Kawaguchi S, Fukuda K, Kusano K, Yoshimura T. Oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase. Drug Metab Dispos. 2014;42:1326-33 pubmed publisher
Bae S, Kwon M, Park J, Kim D, Kim D, Kang J, et al. Metabolic drug-drug interaction potential of macrolactin A and 7-O-succinyl macrolactin A assessed by evaluating cytochrome P450 inhibition and induction and UDP-glucuronosyltransferase inhibition in vitro. Antimicrob Agents Chemother. 2014;58:5036-46 pubmed publisher
Imbrici P, Liantonio A, Gradogna A, Pusch M, Camerino D. Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes. Biochim Biophys Acta. 2014;1838:2484-91 pubmed publisher
Schöbel N, Radtke D, Kyereme J, Wollmann N, Cichy A, Obst K, et al. Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds. Chem Senses. 2014;39:471-87 pubmed publisher
Salzer I, Gafar H, Gindl V, Mahlknecht P, Drobny H, Boehm S. Excitation of rat sympathetic neurons via M1 muscarinic receptors independently of Kv7 channels. Pflugers Arch. 2014;466:2289-303 pubmed publisher
Zheng Y, Bae S, Choi E, Park J, Kim S, Jang M, et al. Evaluation of the in vitro/in vivo drug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition. Food Chem Toxicol. 2014;68:117-27 pubmed publisher
Jinno N, Tagashira M, Tsurui K, Yamada S. Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes. Xenobiotica. 2014;44:677-86 pubmed publisher
Simon S, Grabellus F, Ferrera L, Galietta L, Schwindenhammer B, Mühlenberg T, et al. DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors. Cancer Res. 2013;73:3661-70 pubmed publisher
Mero F, Nettis E, Aloia A, Di Leo E, Ferrannini A, Vacca A. Short-term tolerability of morniflumate in patients with cutaneous hypersensitivity reactions to non-steroidal anti-inflammatory drugs. Int J Immunopathol Pharmacol. 2013;26:247-50 pubmed
Abouzid K, Khalil N, Ahmed E, Zaitone S. Synthesis and biological evaluation of new heteroaryl carboxylic acid derivatives as anti-inflammatory-analgesic agents. Chem Pharm Bull (Tokyo). 2013;61:222-8 pubmed
François A, Grauso M, Demondion E, Bozzolan F, Debernard S, Lucas P. Bestrophin-encoded Ca²⁺-activated Cl⁻ channels underlie a current with properties similar to the native current in the moth Spodoptera littoralis olfactory receptor neurons. PLoS ONE. 2012;7:e52691 pubmed publisher
Ambrus R, Radacsi N, Szunyogh T, van der Heijden A, ter Horst J, Szabó Révész P. Analysis of submicron-sized niflumic acid crystals prepared by electrospray crystallization. J Pharm Biomed Anal. 2013;76:1-7 pubmed publisher
Al Saabi A, Allorge D, Sauvage F, Tournel G, Gaulier J, Marquet P, et al. Involvement of UDP-glucuronosyltransferases UGT1A9 and UGT2B7 in ethanol glucuronidation, and interactions with common drugs of abuse. Drug Metab Dispos. 2013;41:568-74 pubmed publisher
Ganapathi S, Wei S, Zaremba A, Lamb F, Shears S. Functional regulation of ClC-3 in the migration of vascular smooth muscle cells. Hypertension. 2013;61:174-9 pubmed publisher
Romero T, Pacheco D, Duarte I. Probable involvement of Ca(2+)-activated Cl(-) channels (CaCCs) in the activation of CB1 cannabinoid receptors. Life Sci. 2013;92:815-20 pubmed publisher
Forrest A, Joyce T, Huebner M, Ayon R, Wiwchar M, Joyce J, et al. Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension. Am J Physiol Cell Physiol. 2012;303:C1229-43 pubmed publisher
Viitanen T, Sukumaran P, Löf C, Törnquist K. Functional coupling of TRPC2 cation channels and the calcium-activated anion channels in rat thyroid cells: implications for iodide homeostasis. J Cell Physiol. 2013;228:814-23 pubmed publisher
Garg P, Sanguinetti M. Structure-activity relationship of fenamates as Slo2.1 channel activators. Mol Pharmacol. 2012;82:795-802 pubmed publisher
Pacheco D, Pacheco C, Duarte I. ?-Opioid receptor agonist SNC80 induces central antinociception mediated by Ca2+ -activated Cl- channels. J Pharm Pharmacol. 2012;64:1084-9 pubmed publisher
Dibattista M, Amjad A, Maurya D, Sagheddu C, Montani G, Tirindelli R, et al. Calcium-activated chloride channels in the apical region of mouse vomeronasal sensory neurons. J Gen Physiol. 2012;140:3-15 pubmed publisher
Aguilera L, Galindo B, S nchez D, Santill n M. What is the core oscillator in the speract-activated pathway of the Strongylocentrotus purpuratus sperm flagellum?. Biophys J. 2012;102:2481-8 pubmed publisher
Baniak N, Luan X, Grunow A, Machen T, Ianowski J. The cytokines interleukin-1? and tumor necrosis factor-? stimulate CFTR-mediated fluid secretion by swine airway submucosal glands. Am J Physiol Lung Cell Mol Physiol. 2012;303:L327-33 pubmed publisher
He X, Goyal R. CaMKII inhibition hyperpolarizes membrane and blocks nitrergic IJP by closing a Cl(-) conductance in intestinal smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2012;303:G240-6 pubmed publisher
Shen B, Li X, Wang F, Yao X, Yang D. A synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells. PLoS ONE. 2012;7:e34694 pubmed publisher
Miyagi S, Milne A, Coughtrie M, Collier A. Neonatal development of hepatic UGT1A9: implications of pediatric pharmacokinetics. Drug Metab Dispos. 2012;40:1321-7 pubmed publisher
Kondo M, Nakata J, Arai N, Izumo T, Tagaya E, Takeyama K, et al. Niflumic acid inhibits goblet cell degranulation in a guinea pig asthma model. Allergol Int. 2012;61:133-42 pubmed publisher
Alvarez L, Dai L, Friedrich B, Kashikar N, Gregor I, Pascal R, et al. The rate of change in Ca(2+) concentration controls sperm chemotaxis. J Cell Biol. 2012;196:653-63 pubmed publisher
Han S, Kim J, Jung B, Han S, Nam J, Kwon Y, et al. Effects of ginsenoside on pacemaker potentials of cultured interstitial cells of Cajal clusters from the small intestine of mice. Mol Cells. 2012;33:243-9 pubmed publisher
Rievaj J, Davidson C, Nadeem A, Hollenberg M, Duszyk M, Vliagoftis H. Allergic sensitization enhances anion current responsiveness of murine trachea to PAR-2 activation. Pflugers Arch. 2012;463:497-509 pubmed publisher
Pacheco D, Pacheco C, Duarte I. Peripheral antinociception induced by ?-opioid receptors activation, but not ?- or ?-, is mediated by Ca²?-activated Cl? channels. Eur J Pharmacol. 2012;674:255-9 pubmed publisher
Sancho M, Garcia Pascual A, Triguero D. Presence of the Ca2+-activated chloride channel anoctamin 1 in the urethra and its role in excitatory neurotransmission. Am J Physiol Renal Physiol. 2012;302:F390-400 pubmed publisher
Banderali U, Jayanthan A, Hoeksema K, Narendran A, Giles W. Ion channels in pediatric CNS Atypical Teratoid/Rhabdoid Tumor (AT/RT) cells: potential targets for novel therapeutic agents. J Neurooncol. 2012;107:111-9 pubmed publisher
Okada Y, Imendra K, Miyazaki T, Hotokezaka H, Fujiyama R, Toda K. High extracellular Ca2+ stimulates Ca2+-activated Cl- currents in frog parathyroid cells through the mediation of arachidonic acid cascade. PLoS ONE. 2011;6:e19158 pubmed publisher
Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher
Lee P, Conradi R, Shanmugasundaram V. Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Bioorg Med Chem Lett. 2010;20:69-73 pubmed publisher
Rajagopal S, Fang H, Patanavanich S, Sando J, Kamatchi G. Protein kinase C isozyme-specific potentiation of expressed Ca v 2.3 currents by acetyl-beta-methylcholine and phorbol-12-myristate, 13-acetate. Brain Res. 2008;1210:1-10 pubmed publisher
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
Kiang T, Ensom M, Chang T. UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacol Ther. 2005;106:97-132 pubmed
Barnett J, Chow J, Ives D, Chiou M, Mackenzie R, Osen E, et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta. 1994;1209:130-9 pubmed
Alessandri J, Abossolo T, Reynaud I, Montbrun A, Sommer J, Tilmont P. [Non-steroidal anti-inflammatory agents and pregnancy. A study of renal and digestive toxicity of niflumic acid in the perinatal period]. J Gynecol Obstet Biol Reprod (Paris). 1994;23:813-8 pubmed
Johnson J, Wimsatt J, Buckel S, Dyer R, Maddipati K. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys. 1995;324:26-34 pubmed
Danysz A. [Niflumic acid]. Reumatologia. 1975;13:227-32 pubmed
product information
Catalog Number :
N0630
Product Name :
Niflumic acid
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA