This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
acetyl-alpha tubulin
catalog :
MABT868
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
6-11B-1
reactivity :
human, mouse
application :
immunocytochemistry, immunohistochemistry - paraffin section
citations: 86
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 1s1h
Lodge E, Santambrogio A, Russell J, Xekouki P, Jacques T, Johnson R, et al. Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade. elife. 2019;8: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2d
Katoh Y, Michisaka S, Nozaki S, Funabashi T, Hirano T, Takei R, et al. Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system. Mol Biol Cell. 2017;28:898-906 pubmed publisher
Thouvenin O, Keiser L, Cantaut Belarif Y, Carbó Tano M, Verweij F, Jurisch Yaksi N, et al. Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. elife. 2020;9: pubmed publisher
Blasius T, Takao D, Verhey K. NPHP proteins are binding partners of nucleoporins at the base of the primary cilium. PLoS ONE. 2019;14:e0222924 pubmed publisher
Fréal A, Rai D, Tas R, Pan X, Katrukha E, van de Willige D, et al. Feedback-Driven Assembly of the Axon Initial Segment. Neuron. 2019;104:305-321.e8 pubmed publisher
Beckers P, Helm C, Bartolomaeus T. The anatomy and development of the nervous system in Magelonidae (Annelida) - insights into the evolution of the annelid brain. BMC Evol Biol. 2019;19:173 pubmed publisher
Ramos A, Gustafsson O, Labert N, Salecker I, Nilsson D, Averof M. Analysis of the genetically tractable crustacean Parhyale hawaiensis reveals the organisation of a sensory system for low-resolution vision. BMC Biol. 2019;17:67 pubmed publisher
Frikstad K, Molinari E, Thoresen M, Ramsbottom S, Hughes F, Letteboer S, et al. A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Cell Rep. 2019;28:1907-1922.e6 pubmed publisher
Burkhalter M, Sridhar A, Sampaio P, Jacinto R, Burczyk M, Donow C, et al. Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. J Clin Invest. 2019;129:2841-2855 pubmed publisher
Kalinski A, Kar A, Craver J, Tosolini A, Sleigh J, Lee S, et al. Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition. J Cell Biol. 2019;218:1871-1890 pubmed publisher
Li J, Sekine Aizawa Y, Ebrahimi S, Tanaka S, Okabe S. Tumor suppressor protein CYLD regulates morphogenesis of dendrites and spines. Eur J Neurosci. 2019;: pubmed publisher
A M, Fung T, Kettenbach A, Chakrabarti R, Higgs H. A complex containing lysine-acetylated actin inhibits the formin INF2. Nat Cell Biol. 2019;21:592-602 pubmed publisher
Abdelhamed Z, Abdelmottaleb D, El Asrag M, Natarajan S, Wheway G, Inglehearn C, et al. The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5. Sci Rep. 2019;9:5446 pubmed publisher
Ortiz Álvarez G, Daclin M, Shihavuddin A, Lansade P, Fortoul A, Faucourt M, et al. Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members. Neuron. 2019;102:159-172.e7 pubmed publisher
Rangel L, Bernabé Rubio M, Fernández Barrera J, Casares Arias J, Millan J, Alonso M, et al. Caveolin-1α regulates primary cilium length by controlling RhoA GTPase activity. Sci Rep. 2019;9:1116 pubmed publisher
Casar Tena T, Maerz L, Szafranski K, Groth M, Blätte T, Donow C, et al. Resting cells rely on the DNA helicase component MCM2 to build cilia. Nucleic Acids Res. 2019;47:134-151 pubmed publisher
Sempou E, Lakhani O, Amalraj S, Khokha M. Candidate Heterotaxy Gene FGFR4 Is Essential for Patterning of the Left-Right Organizer in Xenopus. Front Physiol. 2018;9:1705 pubmed publisher
Lavado A, Park J, Pare J, Finkelstein D, Pan H, Xu B, et al. The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number. Dev Cell. 2018;47:576-591.e8 pubmed publisher
Chowdhury P, Powell R, Stephan C, Uray I, Talley T, Karki M, et al. Bexarotene - a novel modulator of AURKA and the primary cilium in VHL-deficient cells. J Cell Sci. 2018;131: pubmed publisher
Lewis T, Kundinger S, Link B, Insinna C, Besharse J. Kif17 phosphorylation regulates photoreceptor outer segment turnover. BMC Cell Biol. 2018;19:25 pubmed publisher
Wang R, Deng X, Yuan C, Xin H, Liu G, Zhu Y, et al. IFT80 Improves Invasion Ability in Gastric Cancer Cell Line via ift80/p75NGFR/MMP9 Signaling. Int J Mol Sci. 2018;19: pubmed publisher
Revinski D, Zaragosi L, Boutin C, Ruiz García S, Deprez M, Thomé V, et al. CDC20B is required for deuterosome-mediated centriole production in multiciliated cells. Nat Commun. 2018;9:4668 pubmed publisher
Ross K, Molinaro A, Romero C, Dockter B, Cable K, Gonzalez K, et al. SoxB1 Activity Regulates Sensory Neuron Regeneration, Maintenance, and Function in Planarians. Dev Cell. 2018;47:331-347.e5 pubmed publisher
Geyer N, Ridzewski R, Bauer J, Kuzyakova M, Dittmann K, Dullin C, et al. Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors. Front Oncol. 2018;8:396 pubmed publisher
Plaud C, Joshi V, Kajevu N, Poüs C, Curmi P, Burgo A. Functional differences of short and long isoforms of spastin harboring missense mutation. Dis Model Mech. 2018;11: pubmed publisher
Shamoto N, Narita K, Kubo T, Oda T, Takeda S. CFAP70 Is a Novel Axoneme-Binding Protein That Localizes at the Base of the Outer Dynein Arm and Regulates Ciliary Motility. Cells. 2018;7: pubmed publisher
Parker A, Teo W, Pandzic E, Vicente J, McCarroll J, Wordeman L, et al. β-tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cells. Life Sci Alliance. 2018;1: pubmed publisher
Green W, Uytingco C, Ukhanov K, Kolb Z, Moretta J, McIntyre J, et al. Peripheral Gene Therapeutic Rescue of an Olfactory Ciliopathy Restores Sensory Input, Axonal Pathfinding, and Odor-Guided Behavior. J Neurosci. 2018;38:7462-7475 pubmed publisher
Schiavon C, Griffin M, Pirozzi M, Parashuraman R, Zhou W, Jinnah H, et al. Compositional complexity of rods and rings. Mol Biol Cell. 2018;29:2303-2316 pubmed publisher
Miyasaka T, Shinzaki Y, Yoshimura S, Yoshina S, Kage Nakadai E, Mitani S, et al. Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy. Front Neurosci. 2018;12:415 pubmed publisher
Freixo F, Martínez Delgado P, Manso Y, Sánchez Huertas C, Lacasa C, Soriano E, et al. NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization. Nat Commun. 2018;9:2330 pubmed publisher
Münch J, Billig G, Hübner C, Leinders Zufall T, Zufall F, Jentsch T. Ca2+-activated Cl- currents in the murine vomeronasal organ enhance neuronal spiking but are dispensable for male-male aggression. J Biol Chem. 2018;293:10392-10403 pubmed publisher
Copeland S, McRae A, Guarguaglini G, Trinkle Mulcahy L, Copeland J. Actin-dependent regulation of cilia length by the inverted formin FHDC1. Mol Biol Cell. 2018;29:1611-1627 pubmed publisher
Johnson J, Watson J, Nikolić M, Rawlins E. Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium. Biol Open. 2018;7: pubmed publisher
Eguether T, Cordelières F, Pazour G. Intraflagellar transport is deeply integrated in hedgehog signaling. Mol Biol Cell. 2018;29:1178-1189 pubmed publisher
Ye F, Nager A, Nachury M. BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone. J Cell Biol. 2018;217:1847-1868 pubmed publisher
Kasahara K, Aoki H, Kiyono T, Wang S, Kagiwada H, Yuge M, et al. EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase. Nat Commun. 2018;9:758 pubmed publisher
Sharif A, Yu D, Loertscher S, Austin R, Nguyen K, Mathur P, et al. C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis. J Neurosci. 2018;38:3160-3176 pubmed publisher
Muthaiyan Shanmugam M, Bhan P, Huang H, Hsieh J, Hua T, Wu G, et al. Cilium Length and Intraflagellar Transport Regulation by Kinases PKG-1 and GCK-2 in Caenorhabditis elegans Sensory Neurons. Mol Cell Biol. 2018;38: pubmed publisher
Fernández Barrera J, Bernabé Rubio M, Casares Arias J, Rangel L, Fernández Martín L, Correas I, et al. The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression. J Cell Biol. 2018;217:929-944 pubmed publisher
Rosa J, Metzstein M, Ghabrial A. An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity. PLoS Genet. 2018;14:e1007146 pubmed publisher
Quiroga Artigas G, Lapébie P, Leclère L, Takeda N, Deguchi R, Jekely G, et al. A gonad-expressed opsin mediates light-induced spawning in the jellyfish Clytia. elife. 2018;7: pubmed publisher
Biswas S, Kalil K. The Microtubule-Associated Protein Tau Mediates the Organization of Microtubules and Their Dynamic Exploration of Actin-Rich Lamellipodia and Filopodia of Cortical Growth Cones. J Neurosci. 2018;38:291-307 pubmed publisher
Jenkins B, Saunders H, Record H, Johnson Schlitz D, Wildonger J. Effects of mutating ?-tubulin lysine 40 on sensory dendrite development. J Cell Sci. 2017;130:4120-4131 pubmed publisher
Kannan M, Bayam E, Wagner C, Rinaldi B, Kretz P, Tilly P, et al. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017;114:E9308-E9317 pubmed publisher
Dubois F, Alpha K, Turner C. Paxillin regulates cell polarization and anterograde vesicle trafficking during cell migration. Mol Biol Cell. 2017;28:3815-3831 pubmed publisher
Pitaval A, Senger F, Letort G, Gidrol X, Guyon L, Sillibourne J, et al. Microtubule stabilization drives 3D centrosome migration to initiate primary ciliogenesis. J Cell Biol. 2017;216:3713-3728 pubmed publisher
Goodyear R, Lu X, Deans M, Richardson G. A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane. Development. 2017;144:3978-3989 pubmed publisher
Légaré S, Chabot C, Basik M. SPEN, a new player in primary cilia formation and cell migration in breast cancer. Breast Cancer Res. 2017;19:104 pubmed publisher
Afreen S, Riherd Methner D, Ferreira A. Tau45-230 association with the cytoskeleton and membrane-bound organelles: Functional implications in neurodegeneration. Neuroscience. 2017;362:104-117 pubmed publisher
Dong B, Wu S, Wang J, Liu Y, Peng Z, Meng D, et al. Chlamydomonas IFT25 is dispensable for flagellar assembly but required to export the BBSome from flagella. Biol Open. 2017;6:1680-1691 pubmed publisher
Schvartz T, Aloush N, Goliand I, Segal I, Nachmias D, Arbely E, et al. Direct fluorescent-dye labeling of ?-tubulin in mammalian cells for live cell and superresolution imaging. Mol Biol Cell. 2017;28:2747-2756 pubmed publisher
Guo H, Kazadaeva Y, Ortega F, Manjunath N, Desai T. Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung. Dev Biol. 2017;430:214-223 pubmed publisher
Perdiz D, Lorin S, Leroy Gori I, Poüs C. Stress-induced hyperacetylation of microtubule enhances mitochondrial fission and modulates the phosphorylation of Drp1 at 616Ser. Cell Signal. 2017;39:32-43 pubmed publisher
Takao D, Wang L, Boss A, Verhey K. Protein Interaction Analysis Provides a Map of the Spatial and Temporal Organization of the Ciliary Gating Zone. Curr Biol. 2017;27:2296-2306.e3 pubmed publisher
Jacquier A, Delorme C, Belotti E, Juntas Morales R, Solé G, Dubourg O, et al. Cryptic amyloidogenic elements in mutant NEFH causing Charcot-Marie-Tooth 2 trigger aggresome formation and neuronal death. Acta Neuropathol Commun. 2017;5:55 pubmed publisher
Gadadhar S, Dadi H, Bodakuntla S, Schnitzler A, Bièche I, Rusconi F, et al. Tubulin glycylation controls primary cilia length. J Cell Biol. 2017;216:2701-2713 pubmed publisher
Potter C, Zhu W, Razafsky D, Ruzycki P, Kolesnikov A, Doggett T, et al. Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets. Curr Biol. 2017;27:2014-2022.e6 pubmed publisher
Van De Weghe J, Rusterholz T, Latour B, Grout M, Aldinger K, Shaheen R, et al. Mutations in ARMC9, which Encodes a Basal Body Protein, Cause Joubert Syndrome in Humans and Ciliopathy Phenotypes in Zebrafish. Am J Hum Genet. 2017;101:23-36 pubmed publisher
Monis W, Faundez V, Pazour G. BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia. J Cell Biol. 2017;216:2131-2150 pubmed publisher
Dharmat R, Liu W, Ge Z, Sun Z, Yang L, Li Y, et al. IFT81 as a Candidate Gene for Nonsyndromic Retinal Degeneration. Invest Ophthalmol Vis Sci. 2017;58:2483-2490 pubmed publisher
Huhn S, Liu J, Ye C, Lu H, Jiang X, Feng X, et al. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene. 2017;36:4750-4766 pubmed publisher
Green S, Uy B, Bronner M. Ancient evolutionary origin of vertebrate enteric neurons from trunk-derived neural crest. Nature. 2017;544:88-91 pubmed publisher
Thorpe S, Gambassi S, Thompson C, Chandrakumar C, Santucci A, Knight M. Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria. J Cell Physiol. 2017;232:2407-2417 pubmed publisher
Badgandi H, Hwang S, Shimada I, Loriot E, Mukhopadhyay S. Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J Cell Biol. 2017;216:743-760 pubmed publisher
Lessieur E, Fogerty J, Gaivin R, Song P, Perkins B. The Ciliopathy Gene ahi1 Is Required for Zebrafish Cone Photoreceptor Outer Segment Morphogenesis and Survival. Invest Ophthalmol Vis Sci. 2017;58:448-460 pubmed publisher
Hasanov E, Chen G, Chowdhury P, Weldon J, Ding Z, Jonasch E, et al. Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL. Oncogene. 2017;36:3450-3463 pubmed publisher
Funabashi T, Katoh Y, Michisaka S, Terada M, Sugawa M, Nakayama K. Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal. Mol Biol Cell. 2017;28:624-633 pubmed publisher
Takács Z, Jankovics F, Vilmos P, Lenart P, Röper K, Erdelyi M. The spectraplakin Short stop is an essential microtubule regulator involved in epithelial closure in Drosophila. J Cell Sci. 2017;130:712-724 pubmed publisher
Gao F, Shi L, Hines T, Hebbar S, Neufeld K, Smith D. Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. Mol Biol Cell. 2017;28:587-599 pubmed publisher
Foerster P, Daclin M, Asm S, Faucourt M, Boletta A, Genovesio A, et al. mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis. Development. 2017;144:201-210 pubmed publisher
Gornstein E, Schwarz T. Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects. Exp Neurol. 2017;288:153-166 pubmed publisher
Krey J, Krystofiak E, Dumont R, Vijayakumar S, Choi D, Rivero F, et al. Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid. J Cell Biol. 2016;215:467-482 pubmed
Vieillard J, Paschaki M, Duteyrat J, Augière C, Cortier E, Lapart J, et al. Transition zone assembly and its contribution to axoneme formation in Drosophila male germ cells. J Cell Biol. 2016;214:875-89 pubmed publisher
Pal K, Hwang S, Somatilaka B, Badgandi H, Jackson P, DeFea K, et al. Smoothened determines ?-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium. J Cell Biol. 2016;212:861-75 pubmed publisher
Lokaj M, Kösling S, Koerner C, Lange S, van Beersum S, van Reeuwijk J, et al. The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function. Structure. 2015;23:2122-32 pubmed publisher
Horani A, Druley T, Zariwala M, Patel A, Levinson B, Van Arendonk L, et al. Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia. Am J Hum Genet. 2012;91:685-93 pubmed publisher
Keller L, Geimer S, Romijn E, Yates J, Zamora I, Marshall W. Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control. Mol Biol Cell. 2009;20:1150-66 pubmed publisher
Keller L, Marshall W. Isolation and proteomic analysis of Chlamydomonas centrioles. Methods Mol Biol. 2008;432:289-300 pubmed publisher
Pandithage R, Lilischkis R, Harting K, Wolf A, Jedamzik B, Lüscher Firzlaff J, et al. The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. J Cell Biol. 2008;180:915-29 pubmed publisher
Witte H, Neukirchen D, Bradke F. Microtubule stabilization specifies initial neuronal polarization. J Cell Biol. 2008;180:619-32 pubmed publisher
Sfakianos J, Togawa A, Maday S, Hull M, Pypaert M, Cantley L, et al. Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells. J Cell Biol. 2007;179:1133-40 pubmed
Graser S, Stierhof Y, Lavoie S, Gassner O, Lamla S, Le Clech M, et al. Cep164, a novel centriole appendage protein required for primary cilium formation. J Cell Biol. 2007;179:321-30 pubmed
Yoshimura S, Egerer J, Fuchs E, Haas A, Barr F. Functional dissection of Rab GTPases involved in primary cilium formation. J Cell Biol. 2007;178:363-9 pubmed
Dubreuil V, Marzesco A, Corbeil D, Huttner W, Wilsch Bräuninger M. Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1. J Cell Biol. 2007;176:483-95 pubmed
Matsuura K, Lefebvre P, Kamiya R, Hirono M. Bld10p, a novel protein essential for basal body assembly in Chlamydomonas: localization to the cartwheel, the first ninefold symmetrical structure appearing during assembly. J Cell Biol. 2004;165:663-71 pubmed
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA