product summary
company name :
MilliporeSigma
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, FLUKA, Sigma-Aldrich, Novabiochem, Guava, Roche Applied Science
product type :
antibody
product name :
Anti-MAP Kinase, Activated (Diphosphorylated ERK-1&2) antibody, Mouse monoclonal
catalog :
M9692
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MAPK-YT
reactivity :
human, mouse, rat, bovine, pigs , zebrafish , roundworm
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section, reverse phase protein lysate microarray
more info or order :
citations: 91
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3b
Gomes A, Ilter D, Low V, Rosenzweig A, Shen Z, Schild T, et al. Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell. 2019;36:402-417.e13 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 1a
  • western blot; mouse; loading ...; fig 1c
Kidger A, Rushworth L, Stellzig J, Davidson J, Bryant C, Bayley C, et al. Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling. Proc Natl Acad Sci U S A. 2017;114:E317-E326 pubmed publisher
  • western blot; pigs ; loading ...; fig 1b
Ismail H, Didangelos A, Vincent T, Saklatvala J. Rapid Activation of Transforming Growth Factor ?-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage. Arthritis Rheumatol. 2017;69:565-575 pubmed publisher
  • western blot; human; fig 7e
Schütz I, López Hernández T, Gao Q, Puchkov D, Jabs S, Nordmeyer D, et al. Lysosomal Dysfunction Caused by Cellular Accumulation of Silica Nanoparticles. J Biol Chem. 2016;291:14170-84 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 1
  • western blot; mouse; 1:2000; fig 2
Sipieter F, Cappe B, Gonzalez Pisfil M, Spriet C, Bodart J, Cailliau Maggio K, et al. Novel Reporter for Faithful Monitoring of ERK2 Dynamics in Living Cells and Model Organisms. PLoS ONE. 2015;10:e0140924 pubmed publisher
  • immunohistochemistry - frozen section; zebrafish ; 1:50; fig s5
Westcot S, Hatzold J, Urban M, Richetti S, Skuster K, Harm R, et al. Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis. PLoS ONE. 2015;10:e0130688 pubmed publisher
  • western blot; human; fig s5
Nan X, Tamgüney T, Collisson E, Lin L, Pitt C, Galeas J, et al. Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway. Proc Natl Acad Sci U S A. 2015;112:7996-8001 pubmed publisher
  • western blot; human
Pastor Clerigues A, Martí Bonmatí E, Milara J, Almudever P, Cortijo J. Anti-inflammatory and anti-fibrotic profile of fish oil emulsions used in parenteral nutrition-associated liver disease. PLoS ONE. 2014;9:e115404 pubmed publisher
  • western blot; mouse; 1:500
Doughton G, Wei J, Tapon N, Welham M, Chalmers A. Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling. PLoS ONE. 2014;9:e95434 pubmed publisher
  • immunocytochemistry; rat; 1:250; fig 3
Maier P, Zemoura K, Acu a M, Y venes G, Zeilhofer H, Benke D. Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface ?-aminobutyric acidB receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein (CH. J Biol Chem. 2014;289:12896-907 pubmed publisher
  • western blot; human
Chapnick D, Liu X. Leader cell positioning drives wound-directed collective migration in TGF?-stimulated epithelial sheets. Mol Biol Cell. 2014;25:1586-93 pubmed publisher
  • reverse phase protein lysate microarray; human; 1:500
Milara J, Peiró T, Serrano A, Guijarro R, Zaragozá C, Tenor H, et al. Roflumilast N-oxide inhibits bronchial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD. Pulm Pharmacol Ther. 2014;28:138-48 pubmed publisher
Dunipace L, Akos Z, Stathopoulos A. Coacting enhancers can have complementary functions within gene regulatory networks and promote canalization. PLoS Genet. 2019;15:e1008525 pubmed publisher
Liu B, Satou Y. Foxg specifies sensory neurons in the anterior neural plate border of the ascidian embryo. Nat Commun. 2019;10:4911 pubmed publisher
Doll M, Soltanmohammadi N, Schumacher B. ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstream of the Core Apoptotic Machinery in Caenorhabditis elegans. Genetics. 2019;213:173-194 pubmed publisher
Inamdar V, Reddy H, Dangelmaier C, Kostyak J, Kunapuli S. The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets. J Biol Chem. 2019;294:12547-12554 pubmed publisher
Samson S, Elliott A, Mueller B, Kim Y, Carney K, Bergman J, et al. p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration. J Biol Chem. 2019;: pubmed publisher
Achache H, Laurent L, Hecker Mimoun Y, Ishtayeh H, Rappaport Y, Kroizer E, et al. Progression of Meiosis Is Coordinated by the Level and Location of MAPK Activation Via OGR-2 in Caenorhabditis elegans. Genetics. 2019;212:213-229 pubmed publisher
Kalfon R, Friedman T, Eliachar S, Shofti R, Haas T, Koren L, et al. JDP2 and ATF3 deficiencies dampen maladaptive cardiac remodeling and preserve cardiac function. PLoS ONE. 2019;14:e0213081 pubmed publisher
Li Y, Peng R, Gao W, Liu P, Chen L, Zhang X, et al. The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality. Aging (Albany NY). 2019;11:1110-1128 pubmed publisher
Iavarone C, Zervantonakis I, Selfors L, Palakurthi S, Liu J, Drapkin R, et al. Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness. Mol Cancer Ther. 2019;18:642-655 pubmed publisher
Zhou Y, Popadowski S, Deutschman E, Halfon M. Distinct roles and requirements for Ras pathway signaling in visceral versus somatic muscle founder specification. Development. 2019;146: pubmed publisher
Hey F, Andreadi C, Noble C, Patel B, Jin H, Kamata T, et al. Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK. Heliyon. 2018;4:e01065 pubmed publisher
Milara J, Díaz Platas L, Contreras S, Ribera P, Roger I, Ballester B, et al. MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease. Respir Res. 2018;19:226 pubmed publisher
Tokuoka M, Kobayashi K, Satou Y. Distinct regulation of Snail in two muscle lineages of the ascidian embryo achieves temporal coordination of muscle development. Development. 2018;145: pubmed publisher
Garner K, Voliotis M, Alobaid H, Perrett R, Pham T, Tsaneva Atanasova K, et al. Information Transfer via Gonadotropin-Releasing Hormone Receptors to ERK and NFAT: Sensing GnRH and Sensing Dynamics. J Endocr Soc. 2017;1:260-277 pubmed publisher
Zhang X, Liu P, Yang Z, Zhao J, Gao L, Yuan B, et al. Pnma5 is essential to the progression of meiosis in mouse oocytes through a chain of phosphorylation. Oncotarget. 2017;8:96809-96825 pubmed publisher
Zega K, Jovanovic V, Vitic Z, Niedzielska M, Knaapi L, Jukic M, et al. Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool. Front Mol Neurosci. 2017;10:372 pubmed publisher
Jin T, Lavoie H, Sahmi M, David M, Hilt C, Hammell A, et al. RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition. Nat Commun. 2017;8:1211 pubmed publisher
Wilson C, Nimick M, Nehoff H, Ashton J. ALK and IGF-1R as independent targets in crizotinib resistant lung cancer. Sci Rep. 2017;7:13955 pubmed publisher
Wang Z, Zhang F, He J, Wu P, Tay L, Cai M, et al. Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells. Dev Cell. 2017;43:186-197.e7 pubmed publisher
Bluemn E, Coleman I, Lucas J, Coleman R, Hernández López S, Tharakan R, et al. Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling. Cancer Cell. 2017;32:474-489.e6 pubmed publisher
Bao H, Guo C, Qiu P, Zhang X, Dong Q, Wang Y. Long non-coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway. Oncol Lett. 2017;14:2831-2837 pubmed publisher
Kalfon R, Haas T, Shofti R, Moskovitz J, Schwartz O, Suss Toby E, et al. c-Jun dimerization protein 2 (JDP2) deficiency promotes cardiac hypertrophy and dysfunction in response to pressure overload. Int J Cardiol. 2017;249:357-363 pubmed publisher
Yoon D, Alfhili M, Friend K, Lee M. MPK-1/ERK regulatory network controls the number of sperm by regulating timing of sperm-oocyte switch in C. elegans germline. Biochem Biophys Res Commun. 2017;491:1077-1082 pubmed publisher
Tang H, Han M. Fatty Acids Regulate Germline Sex Determination through ACS-4-Dependent Myristoylation. Cell. 2017;169:457-469.e13 pubmed publisher
Altmüller F, Pothula S, Annamneedi A, Nakhaei Rad S, Montenegro Venegas C, Pina Fernández E, et al. Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy. PLoS Genet. 2017;13:e1006684 pubmed publisher
Xiao X, Yang L, Pang X, Zhang R, Zhu Y, Wang P, et al. A Mesh-Duox pathway regulates homeostasis in the insect gut. Nat Microbiol. 2017;2:17020 pubmed publisher
Kwon S, An S, Kim M, Kim K, Choi Y, Ahn K, et al. Phytosphingosine-1-phosphate and epidermal growth factor synergistically restore extracellular matrix in human dermal fibroblasts in vitro and in vivo. Int J Mol Med. 2017;39:741-748 pubmed publisher
Davaapil H, Brockes J, Yun M. Conserved and novel functions of programmed cellular senescence during vertebrate development. Development. 2017;144:106-114 pubmed publisher
Miao G, Hayashi S. Escargot controls the sequential specification of two tracheal tip cell types by suppressing FGF signaling in Drosophila. Development. 2016;143:4261-4271 pubmed
Lee J, Park S, Kim K, Ko J, Lee S, Kim K, et al. Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells. Dev Reprod. 2016;20:171-7 pubmed publisher
Milara J, Morell A, Ballester B, Armengot M, Morcillo E, Cortijo J. MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2017;139:855-862.e13 pubmed publisher
Abramovitch Dahan C, Asraf H, Bogdanovic M, Sekler I, Bush A, Hershfinkel M. Amyloid ? attenuates metabotropic zinc sensing receptor, mZnR/GPR39, dependent Ca2+ , ERK1/2 and Clusterin signaling in neurons. J Neurochem. 2016;139:221-233 pubmed publisher
Li Q, Davila J, Kannan A, Flaws J, Bagchi M, Bagchi I. Chronic Exposure to Bisphenol A Affects Uterine Function During Early Pregnancy in Mice. Endocrinology. 2016;157:1764-74 pubmed publisher
Stragier E, Martin V, Davenas E, Poilbout C, Mongeau R, Corradetti R, et al. Brain plasticity and cognitive functions after ethanol consumption in C57BL/6J mice. Transl Psychiatry. 2015;5:e696 pubmed publisher
Schroter C, Rué P, Mackenzie J, Martinez Arias A. FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells. Development. 2015;142:4205-16 pubmed publisher
Bar Lev T, Harris D, Tomić M, Stojilkovic S, Blumenfeld Z, Brown P, et al. Role of PI4K and PI3K-AKT in ERK1/2 activation by GnRH in the pituitary gonadotropes. Mol Cell Endocrinol. 2015;415:12-23 pubmed publisher
Maillard A, Ruef A, Pizzagalli F, Migliavacca E, Hippolyte L, Adaszewski S, et al. The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity. Mol Psychiatry. 2015;20:140-7 pubmed publisher
Lerner N, Beit Yannai E. Cross-talk between ciliary epithelium and trabecular meshwork cells in-vitro: a new insight into glaucoma. PLoS ONE. 2014;9:e112259 pubmed publisher
Tsuzuki S, Matsumoto H, Furihata S, Ryuda M, Tanaka H, Sung E, et al. Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP. Nat Commun. 2014;5:4628 pubmed publisher
Gonzalez Garcia J, Bradley J, Nomikos M, Paul L, Machaty Z, Lai F, et al. The dynamics of MAPK inactivation at fertilization in mouse eggs. J Cell Sci. 2014;127:2749-60 pubmed publisher
Leibovich Rivkin T, Liubomirski Y, Meshel T, Abashidze A, Brisker D, Solomon H, et al. The inflammatory cytokine TNF? cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells. BMC Cancer. 2014;14:158 pubmed publisher
Eberhard R, Stergiou L, Hofmann E, Hofmann J, Haenni S, Teo Y, et al. Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003943 pubmed publisher
Ohta N, Satou Y. Multiple signaling pathways coordinate to induce a threshold response in a chordate embryo. PLoS Genet. 2013;9:e1003818 pubmed publisher
Haupaix N, Stolfi A, Sirour C, Picco V, Levine M, Christiaen L, et al. p120RasGAP mediates ephrin/Eph-dependent attenuation of FGF/ERK signals during cell fate specification in ascidian embryos. Development. 2013;140:4347-52 pubmed publisher
Bickel R, Cleveland H, Barkas J, Jeschke C, Raz A, Stern D, et al. The pea aphid uses a version of the terminal system during oviparous, but not viviparous, development. Evodevo. 2013;4:10 pubmed publisher
Bluemn E, Spencer E, Mecham B, Gordon R, Coleman I, Lewinshtein D, et al. PPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortality. Mol Cancer Res. 2013;11:568-78 pubmed publisher
Norton J, Cooley J, Islam A, Cota C, Davidson B. Matrix adhesion polarizes heart progenitor induction in the invertebrate chordate Ciona intestinalis. Development. 2013;140:1301-11 pubmed publisher
Shi L, Ko M, Abbott L, Ko G. Identification of Peptide lv, a novel putative neuropeptide that regulates the expression of L-type voltage-gated calcium channels in photoreceptors. PLoS ONE. 2012;7:e43091 pubmed publisher
Wagner E, Levine M. FGF signaling establishes the anterior border of the Ciona neural tube. Development. 2012;139:2351-9 pubmed publisher
Kohno M, Tanimura S, Ozaki K. Targeting the extracellular signal-regulated kinase pathway in cancer therapy. Biol Pharm Bull. 2011;34:1781-4 pubmed
Stolfi A, Wagner E, Taliaferro J, Chou S, Levine M. Neural tube patterning by Ephrin, FGF and Notch signaling relays. Development. 2011;138:5429-39 pubmed publisher
Cheng S, Yin P, Hsu Y, Chang Y, Huang S, Lee J, et al. Leptin enhances migration of human papillary thyroid cancer cells through the PI3K/AKT and MEK/ERK signaling pathways. Oncol Rep. 2011;26:1265-71 pubmed publisher
Jung J, Moon S, Kim D, Choi C, Song J, Park K. Sprouty1 regulates neural and endothelial differentiation of mouse embryonic stem cells. Stem Cells Dev. 2012;21:554-61 pubmed publisher
Prabakaran S, Everley R, Landrieu I, Wieruszeski J, Lippens G, Steen H, et al. Comparative analysis of Erk phosphorylation suggests a mixed strategy for measuring phospho-form distributions. Mol Syst Biol. 2011;7:482 pubmed publisher
Steelman L, Chappell W, Abrams S, Kempf R, Long J, Laidler P, et al. Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY). 2011;3:192-222 pubmed
Stark F, Pfannstiel J, Klaiber I, Raabe T. Protein kinase CK2 links polyamine metabolism to MAPK signalling in Drosophila. Cell Signal. 2011;23:876-82 pubmed publisher
Hasin T, Elhanani O, Abassi Z, Hai T, Aronheim A. Angiotensin II signaling up-regulates the immediate early transcription factor ATF3 in the left but not the right atrium. Basic Res Cardiol. 2011;106:175-87 pubmed publisher
Guidi M, Muiños Gimeno M, Kagerbauer B, Marti E, Estivill X, Espinosa Parrilla Y. Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells. BMC Mol Biol. 2010;11:95 pubmed publisher
Sugden P, Markou T, Fuller S, Tham E, Molkentin J, Paterson H, et al. Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active. Cell Signal. 2011;23:468-77 pubmed publisher
Burkhard K, Shapiro P. Use of inhibitors in the study of MAP kinases. Methods Mol Biol. 2010;661:107-22 pubmed publisher
Heger P, Kroiher M, Ndifon N, Schierenberg E. Conservation of MAP kinase activity and MSP genes in parthenogenetic nematodes. BMC Dev Biol. 2010;10:51 pubmed publisher
Maier E, Von Hofsten J, Nord H, Fernandes M, Paek H, Hebert J, et al. Opposing Fgf and Bmp activities regulate the specification of olfactory sensory and respiratory epithelial cell fates. Development. 2010;137:1601-11 pubmed publisher
Hoffman G, Moerke N, Hsia M, Shamu C, Blenis J. A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique. Assay Drug Dev Technol. 2010;8:186-99 pubmed publisher
Schilling M, Maiwald T, Hengl S, Winter D, Kreutz C, Kolch W, et al. Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. Mol Syst Biol. 2009;5:334 pubmed publisher
Reischauer S, Levesque M, NUSSLEIN VOLHARD C, Sonawane M. Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis. PLoS Genet. 2009;5:e1000720 pubmed publisher
Chen P, Simons M, Friesel R. FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression. J Biol Chem. 2009;284:15980-92 pubmed publisher
Shi W, Levine M. Ephrin signaling establishes asymmetric cell fates in an endomesoderm lineage of the Ciona embryo. Development. 2008;135:931-40 pubmed publisher
Le X, Langenau D, Keefe M, Kutok J, Neuberg D, Zon L. Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish. Proc Natl Acad Sci U S A. 2007;104:9410-5 pubmed
Davidson B, Shi W, Beh J, Christiaen L, Levine M. FGF signaling delineates the cardiac progenitor field in the simple chordate, Ciona intestinalis. Genes Dev. 2006;20:2728-38 pubmed
Wu J, O DONNELL M, Gitler A, Klein P. Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Development. 2006;133:3651-60 pubmed
Guichard A, Park J, Cruz Moreno B, Karin M, Bier E. Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A. 2006;103:3244-9 pubmed
Wellbrock C, Marais R. Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation. J Cell Biol. 2005;170:703-8 pubmed
Gudermann T. Multiple pathways of ERK activation by G protein-coupled receptors. Novartis Found Symp. 2001;239:68-79; discussion 80-4, 150-9 pubmed
Davis R. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem. 1993;268:14553-6 pubmed
Lee J, Laydon J, McDonnell P, Gallagher T, Kumar S, Green D, et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 1994;372:739-46 pubmed
Rouse J, Cohen P, Trigon S, Morange M, Alonso Llamazares A, Zamanillo D, et al. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 1994;78:1027-37 pubmed
Han J, Lee J, Bibbs L, Ulevitch R. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 1994;265:808-11 pubmed
Davis R. MAPKs: new JNK expands the group. Trends Biochem Sci. 1994;19:470-3 pubmed
Seger R, Krebs E. The MAPK signaling cascade. FASEB J. 1995;9:726-35 pubmed
product information
Product No. :
M9692
Product Name :
Anti-MAP Kinase, Activated (Diphosphorylated ERK-1&2) antibody, Mouse monoclonal
Host :
mouse
Conjugate :
unconjugated
Antibody Type :
monoclonal
Clone Number (if monoclonal) :
MAPK-YT
Applications/Description :
Suitable for immunocytochemistry; western blot: 0.5-1 μg/mL using a whole cell extract of RAT-1 cells treated with vanadate and H 2 O 2 .; microarray; indirect ELISA; immunoprecipitation (IP); immunohistochemistry
Species Reactivity :
mouse, Xenopus, Drosophila, Caenorhabditis elegans, rat, yeast, hamster, bovine, human
Isotype :
IgG1
Concentration :
1.5-2 mg/mL
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA