This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Monastrol
catalog :
M8515
citations: 20
Reference
Klosin A, Oltsch F, Harmon T, Honigmann A, Jülicher F, Hyman A, et al. Phase separation provides a mechanism to reduce noise in cells. Science. 2020;367:464-468 pubmed publisher
Zielinska A, Bellou E, Sharma N, Frombach A, Seres K, Gruhn J, et al. Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs. Curr Biol. 2019;29:3749-3765.e7 pubmed publisher
Roeles J, Tsiavaliaris G. Actin-microtubule interplay coordinates spindle assembly in human oocytes. Nat Commun. 2019;10:4651 pubmed publisher
Takagi J, Sakamoto R, Shiratsuchi G, Maeda Y, Shimamoto Y. Mechanically Distinct Microtubule Arrays Determine the Length and Force Response of the Meiotic Spindle. Dev Cell. 2019;: pubmed publisher
Clift D, McEwan W, Labzin L, Konieczny V, Mogessie B, James L, et al. A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell. 2017;171:1692-1706.e18 pubmed publisher
Quartuccio S, Dipali S, Schindler K. Haspin inhibition reveals functional differences of interchromatid axis-localized AURKB and AURKC. Mol Biol Cell. 2017;28:2233-2240 pubmed publisher
Maeda M, Hasegawa H, Sugiyama M, Hyodo T, Ito S, Chen D, et al. Arginine methylation of ubiquitin-associated protein 2-like is required for the accurate distribution of chromosomes. FASEB J. 2016;30:312-23 pubmed publisher
Barr A, Bakal C. A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly. Sci Rep. 2015;5:10564 pubmed publisher
Tanaka H, Goto H, Inoko A, Makihara H, Enomoto A, Horimoto K, et al. Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice. J Biol Chem. 2015;290:12984-98 pubmed publisher
Takagi J, Itabashi T, Suzuki K, Ishiwata S. Chromosome position at the spindle equator is regulated by chromokinesin and a bipolar microtubule array. Sci Rep. 2013;3:2808 pubmed publisher
Shrestha R, Draviam V. Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. Curr Biol. 2013;23:1514-26 pubmed publisher
Haney S, Zhao J, Tiwari S, Eng K, Guey L, Tien E. RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation. PLoS ONE. 2013;8:e64946 pubmed publisher
Kitagawa M, Fung S, Onishi N, Saya H, Lee S. Targeting Aurora B to the equatorial cortex by MKlp2 is required for cytokinesis. PLoS ONE. 2013;8:e64826 pubmed publisher
Verstraeten V, Peckham L, Olive M, Capell B, Collins F, Nabel E, et al. Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect. Proc Natl Acad Sci U S A. 2011;108:4997-5002 pubmed publisher
Bolhy S, Bouhlel I, Dultz E, Nayak T, Zuccolo M, Gatti X, et al. A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase. J Cell Biol. 2011;192:855-71 pubmed publisher
Liu L, Parameswaran S, Liu J, Kim S, Wojcik E. Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanisms. J Biol Chem. 2011;286:6201-10 pubmed publisher
Kaur J, Sundar S, Singh N. Molecular docking, structure-activity relationship and biological evaluation of the anticancer drug monastrol as a pteridine reductase inhibitor in a clinical isolate of Leishmania donovani. J Antimicrob Chemother. 2010;65:1742-8 pubmed publisher
van Leuken R, Clijsters L, van Zon W, Lim D, Yao X, Wolthuis R, et al. Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1. PLoS ONE. 2009;4:e5282 pubmed publisher
Castillo A, Morse H, Godfrey V, Naeem R, Justice M. Overexpression of Eg5 causes genomic instability and tumor formation in mice. Cancer Res. 2007;67:10138-47 pubmed
Mayer T, Kapoor T, Haggarty S, King R, Schreiber S, Mitchison T. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999;286:971-4 pubmed
product information
Catalog Number :
M8515
Product Name :
Monastrol
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC), solid
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA