Published Application/Species/Sample/Dilution | Reference |
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- western blot; human; 1:1500; loading ...; fig 2c
| Gualtieri A, Kyprianou N, Gregory L, Vignola M, Nicholson J, Tan R, et al. Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans. Nat Commun. 2021;12:2028 pubmed publisher
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- western blot; human; loading ...; fig 2e
| Gao Q, Ouyang W, Kang B, Han X, Xiong Y, Ding R, et al. Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression. Theranostics. 2020;10:5137-5153 pubmed publisher
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- western blot; human; loading ...; fig 6i
| Haag A, Walser M, Henggeler A, Hajnal A. The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells. elife. 2020;9: pubmed publisher
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- western blot; human; 1:10,000; loading ...; fig s1c
| Kennedy S, Jarboui M, Srihari S, Raso C, Bryan K, Dernayka L, et al. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. Nat Commun. 2020;11:499 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 4c
| Fossati G, Pozzi D, Canzi A, Mirabella F, Valentino S, Morini R, et al. Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin. EMBO J. 2019;38: pubmed publisher
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- western blot; rat; loading ...; fig 5a
| De Pasquale V, Pezone A, Sarogni P, Tramontano A, Schiattarella G, Avvedimento V, et al. EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB. Cell Death Dis. 2018;9:40 pubmed publisher
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- western blot; human; loading ...; fig 2c
| Bostner J, Alayev A, Berman A, Fornander T, Nordenskjold B, Holz M, et al. Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer. Breast Cancer Res Treat. 2018;168:17-27 pubmed publisher
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- immunohistochemistry; mouse; loading ...; fig s5d
| Zhao F, Franco H, Rodriguez K, Brown P, Tsai M, Tsai S, et al. Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice. Science. 2017;357:717-720 pubmed publisher
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- western blot; human; 1:500; fig 4b
| Olivares O, Mayers J, Gouirand V, Torrence M, Gicquel T, Borge L, et al. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions. Nat Commun. 2017;8:16031 pubmed publisher
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- western blot; human; 1:1000; fig 4d
| Szoka L, Karna E, Hlebowicz Sarat K, Karaszewski J, Palka J. Exogenous proline stimulates type I collagen and HIF-1? expression and the process is attenuated by glutamine in human skin fibroblasts. Mol Cell Biochem. 2017;435:197-206 pubmed publisher
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- immunohistochemistry; zebrafish ; 1:500; loading ...; fig 5I''
| Kozlovskaja GumbrienÄ— A, Yi R, Alexander R, Aman A, Jiskra R, Nagelberg D, et al. Proliferation-independent regulation of organ size by Fgf/Notch signaling. elife. 2017;6: pubmed publisher
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- western blot; human; loading ...; tbl 4
| Lopes M, Leal R, Guarnieri R, Schwarzbold M, Hoeller A, Diaz A, et al. A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. Transl Psychiatry. 2016;6:e986 pubmed publisher
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- western blot; fruit fly ; 1:2000; loading ...; fig s8a
| Bangi E, Murgia C, Teague A, Sansom O, Cagan R. Functional exploration of colorectal cancer genomes using Drosophila. Nat Commun. 2016;7:13615 pubmed publisher
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- western blot; human; loading ...; fig 3c
| Alekhina O, Marchese A. ?-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4. J Biol Chem. 2016;291:26083-26097 pubmed
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- western blot; human; loading ...; fig 4b
| Greenwood E, Maisel S, Ebertz D, Russ A, Pandey R, SCHROEDER J. Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration. Oncotarget. 2016;7:60776-60792 pubmed publisher
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- western blot; Xenopus laevis; 1:5000; loading ...; fig 2f
| Tadjuidje E, Kofron M, Mir A, Wylie C, Heasman J, Cha S. Nodal signalling in Xenopus: the role of Xnr5 in left/right asymmetry and heart development. Open Biol. 2016;6: pubmed publisher
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- western blot; human; fig 7e
| Schütz I, López Hernández T, Gao Q, Puchkov D, Jabs S, Nordmeyer D, et al. Lysosomal Dysfunction Caused by Cellular Accumulation of Silica Nanoparticles. J Biol Chem. 2016;291:14170-84 pubmed publisher
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- western blot; human; 1:10,000; loading ...; fig 2a
| Mendel I, Yacov N, Shoham A, Ishai E, Breitbart E. Treatment with Oxidized Phospholipids Directly Inhibits Nonalcoholic Steatohepatitis and Liver Fibrosis Without Affecting Steatosis. Dig Dis Sci. 2016;61:2545-53 pubmed publisher
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- western blot; human; fig 3
| Sakakini N, Turchi L, Bergon A, Holota H, Rekima S, Lopez F, et al. A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem Cells. J Biol Chem. 2016;291:10684-99 pubmed publisher
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- western blot; mouse; fig 7
| Morena D, Maestro N, Bersani F, Forni P, Lingua M, Foglizzo V, et al. Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes. elife. 2016;5: pubmed publisher
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- western blot; human; 1:1000; fig 5
| Stefanovic M, Tutusaus A, Martinez Nieto G, Bárcena C, de Gregorio E, Moutinho C, et al. Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma. Oncotarget. 2016;7:8253-67 pubmed publisher
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- western blot; dogs; fig 1d
| Shukla P, Vogl C, Wallner B, Rigler D, Müller M, Macho Maschler S. High-throughput mRNA and miRNA profiling of epithelial-mesenchymal transition in MDCK cells. BMC Genomics. 2015;16:944 pubmed publisher
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- western blot; fruit fly ; 1:500
| Sun D, Buttitta L. Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila. Development. 2015;142:3033-45 pubmed publisher
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- immunohistochemistry - paraffin section; fruit fly ; 1:200; fig 2
| Patel P, Dutta D, Edgar B. Niche appropriation by Drosophila intestinal stem cell tumours. Nat Cell Biol. 2015;17:1182-92 pubmed publisher
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- western blot; human; fig 8
| Brohée L, Demine S, Willems J, Arnould T, Colige A, Deroanne C. Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment. Oncotarget. 2015;6:11264-80 pubmed
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- western blot; human; fig 5
| Wilson F, Johannessen C, Piccioni F, Tamayo P, Kim J, Van Allen E, et al. A functional landscape of resistance to ALK inhibition in lung cancer. Cancer Cell. 2015;27:397-408 pubmed publisher
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- western blot; mouse; fig 4
| Guillaumond F, Bidaut G, Ouaissi M, Servais S, Gouirand V, Olivares O, et al. Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2015;112:2473-8 pubmed publisher
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- western blot; human; fig s4
| Diesenberg K, Beerbaum M, Fink U, Schmieder P, Krauss M. SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR. J Cell Sci. 2015;128:397-407 pubmed publisher
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- immunohistochemistry; fruit fly ; 1:200
| Matsuoka S, Gupta S, Suzuki E, Hiromi Y, Asaoka M. gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. PLoS ONE. 2014;9:e113423 pubmed publisher
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- western blot; mouse; fig 2
| Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014;33:2581-96 pubmed publisher
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- western blot; rat; 1:5000
- western blot; mouse; 1:5000
| Zeldich E, Chen C, Colvin T, Bove Fenderson E, Liang J, Tucker Zhou T, et al. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014;289:24700-15 pubmed publisher
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- western blot; human; 1:1000
| Martínez Pinilla E, Reyes Resina I, Oñatibia Astibia A, Zamarbide M, Ricobaraza A, Navarro G, et al. CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum. Exp Neurol. 2014;261:44-52 pubmed publisher
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| Chen P, Qin L, Zhuang Z, Tellides G, Lax I, Schlessinger J, et al. The docking protein FRS2? is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A. 2014;111:5514-9 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 4a
| Guerra M, Wauson E, McGlynn K, Cobb M. Muscarinic control of MIN6 pancreatic ? cells is enhanced by impaired amino acid signaling. J Biol Chem. 2014;289:14370-9 pubmed publisher
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- immunocytochemistry; human; fig 5
| Bölck B, Ibrahim M, Steinritz D, Morguet C, Dühr S, Suhr F, et al. Detection of key enzymes, free radical reaction products and activated signaling molecules as biomarkers of cell damage induced by benzo[a]pyrene in human keratinocytes. Toxicol In Vitro. 2014;28:875-84 pubmed publisher
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| Fernandez Estevez M, Casarejos M, Lopez Sendon J, Garcia Caldentey J, Ruiz C, Gomez A, et al. Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition. PLoS ONE. 2014;9:e90202 pubmed publisher
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- western blot; bovine; fig 5, 6
| Turner M, Cronin J, Healey G, Sheldon I. Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1, and TLR6. Endocrinology. 2014;155:1453-65 pubmed publisher
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| Zaganjor E, Osborne J, Weil L, Díaz Martínez L, Gonzales J, Singel S, et al. Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene. 2014;33:5457-66 pubmed publisher
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| Kaur H, Sharma S, Mandal S, Mandal L. Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche. Development. 2019;146: pubmed publisher
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| He Q, Shumate L, Matthias J, Aydin C, Wein M, Spatz J, et al. A G protein-coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23. JCI Insight. 2019;4: pubmed publisher
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| Wallroth A, Koch P, Marat A, Krause E, Haucke V. Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1. Nat Cell Biol. 2019;21:1093-1101 pubmed publisher
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| Kondo T, Hayashi S. Two-step regulation of trachealess ensures tight coupling of cell fate with morphogenesis in the Drosophila trachea. elife. 2019;8: pubmed publisher
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| Zingkou E, Pampalakis G, Charla E, Nauroy P, Kiritsi D, Sotiropoulou G. A proinflammatory role of KLK6 protease in Netherton syndrome. J Dermatol Sci. 2019;95:28-35 pubmed publisher
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| Ning S, Wang Z, Cao J, Dong Y, Chen Y. Mel1c Mediated Monochromatic Light-Stimulated IGF-I Synthesis through the Intracellular Gαq/PKC/ERK Signaling Pathway. Int J Mol Sci. 2019;20: pubmed publisher
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| Stundl J, Pospisilova A, Jandzik D, Fabian P, Dobiášová B, Minarik M, et al. Bichir external gills arise via heterochronic shift that accelerates hyoid arch development. elife. 2019;8: pubmed publisher
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| Achache H, Laurent L, Hecker Mimoun Y, Ishtayeh H, Rappaport Y, Kroizer E, et al. Progression of Meiosis Is Coordinated by the Level and Location of MAPK Activation Via OGR-2 in Caenorhabditis elegans. Genetics. 2019;212:213-229 pubmed publisher
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| Ishay Ronen D, Diepenbruck M, Kalathur R, Sugiyama N, Tiede S, Ivanek R, et al. Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis. Cancer Cell. 2019;35:17-32.e6 pubmed publisher
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| Packer L, Stehbens S, Bonazzi V, Gunter J, Ju R, Ward M, et al. Bcl-2 inhibitors enhance FGFR inhibitor-induced mitochondrial-dependent cell death in FGFR2-mutant endometrial cancer. Mol Oncol. 2019;13:738-756 pubmed publisher
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| Golderman V, Shavit Stein E, Gera O, Chapman J, Eisenkraft A, Maggio N. Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. J Mol Neurosci. 2019;67:227-234 pubmed publisher
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| Colle D, Santos D, de Souza V, Lopes M, Leal R, de Souza Brocardo P, et al. Sodium selenite protects from 3-nitropropionic acid-induced oxidative stress in cultured primary cortical neurons. Mol Biol Rep. 2019;46:751-762 pubmed publisher
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| Wang A, Hirose T, Ohsaki Y, Takahashi C, Sato E, Oba Yabana I, et al. Hydrochlorothiazide ameliorates polyuria caused by tolvaptan treatment of polycystic kidney disease in PCK rats. Clin Exp Nephrol. 2019;23:455-464 pubmed publisher
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| Beaudry K, Langlois M, Montagne A, Cagnol S, Carrier J, Rivard N. Dual-specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis. J Cell Physiol. 2019;234:6731-6745 pubmed publisher
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| Arbel Rubinstein T, Shahmoon S, Zigmond E, Etan T, Merenbakh Lamin K, Pasmanik Chor M, et al. Klotho suppresses colorectal cancer through modulation of the unfolded protein response. Oncogene. 2019;38:794-807 pubmed publisher
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| Shavit Stein E, Sheinberg E, Golderman V, Sharabi S, Wohl A, Gofrit S, et al. A Novel Compound Targeting Protease Receptor 1 Activators for the Treatment of Glioblastoma. Front Neurol. 2018;9:1087 pubmed publisher
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| Wong K, Akiyama R, Bessho Y, Matsui T. ERK Activity Dynamics during Zebrafish Embryonic Development. Int J Mol Sci. 2018;20: pubmed publisher
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| Zheng S, Qu Z, Zanetti M, Lam B, Chin Sang I. C. elegans PTEN and AMPK block neuroblast divisions by inhibiting a BMP-insulin-PP2A-MAPK pathway. Development. 2018;145: pubmed publisher
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| Boulter E, Estrach S, Tissot F, Hennrich M, Tosello L, Cailleteau L, et al. Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway. Nat Commun. 2018;9:4862 pubmed publisher
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| Zoranovic T, Manent J, Willoughby L, Matos de Simoes R, La Marca J, Golenkina S, et al. A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer. PLoS Genet. 2018;14:e1007688 pubmed publisher
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| Courgeon M, He D, Liu H, Legent K, Treisman J. The Drosophila Epidermal Growth Factor Receptor does not act in the nucleus. J Cell Sci. 2018;131: pubmed publisher
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| Taylor E, Heyland A. Thyroid Hormones Accelerate Initiation of Skeletogenesis via MAPK (ERK1/2) in Larval Sea Urchins (Strongylocentrotus purpuratus). Front Endocrinol (Lausanne). 2018;9:439 pubmed publisher
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| Simsek M, Ozbudak E. Spatial Fold Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish. Cell Rep. 2018;24:66-78.e8 pubmed publisher
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| De Pasquale V, Sarogni P, Pistorio V, Cerulo G, Paladino S, Pavone L. Targeting Heparan Sulfate Proteoglycans as a Novel Therapeutic Strategy for Mucopolysaccharidoses. Mol Ther Methods Clin Dev. 2018;10:8-16 pubmed publisher
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| Yamamoto Fukuda T, Akiyama N, Takahashi M, Kojima H. Keratinocyte Growth Factor (KGF) Modulates Epidermal Progenitor Cell Kinetics through Activation of p63 in Middle Ear Cholesteatoma. J Assoc Res Otolaryngol. 2018;19:223-241 pubmed publisher
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| Ando T, Fujiwara H, Kojima T. The pivotal role of aristaless in development and evolution of diverse antennal morphologies in moths and butterflies. BMC Evol Biol. 2018;18:8 pubmed publisher
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