product summary
company name :
MilliporeSigma
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, FLUKA, Sigma-Aldrich, Novabiochem, Guava, Roche Applied Science
product type :
antibody
product name :
Monoclonal Anti-MAP Kinase, Activated (Diphosphorylated ERK-1&2) antibody produced in mouse
catalog :
M8159
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MAPK-YT
reactivity :
human, mouse, rat, dogs, bovine, zebrafish , fruit fly , Xenopus laevis, roundworm
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 324
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1500; loading ...; fig 2c
Gualtieri A, Kyprianou N, Gregory L, Vignola M, Nicholson J, Tan R, et al. Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans. Nat Commun. 2021;12:2028 pubmed publisher
  • western blot; human; loading ...; fig 2e
Gao Q, Ouyang W, Kang B, Han X, Xiong Y, Ding R, et al. Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression. Theranostics. 2020;10:5137-5153 pubmed publisher
  • western blot; human; loading ...; fig 6i
Haag A, Walser M, Henggeler A, Hajnal A. The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells. elife. 2020;9: pubmed publisher
  • western blot; human; 1:10,000; loading ...; fig s1c
Kennedy S, Jarboui M, Srihari S, Raso C, Bryan K, Dernayka L, et al. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. Nat Commun. 2020;11:499 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4c
Fossati G, Pozzi D, Canzi A, Mirabella F, Valentino S, Morini R, et al. Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin. EMBO J. 2019;38: pubmed publisher
  • western blot; rat; loading ...; fig 5a
De Pasquale V, Pezone A, Sarogni P, Tramontano A, Schiattarella G, Avvedimento V, et al. EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB. Cell Death Dis. 2018;9:40 pubmed publisher
  • western blot; human; loading ...; fig 2c
Bostner J, Alayev A, Berman A, Fornander T, Nordenskjold B, Holz M, et al. Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer. Breast Cancer Res Treat. 2018;168:17-27 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s5d
Zhao F, Franco H, Rodriguez K, Brown P, Tsai M, Tsai S, et al. Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice. Science. 2017;357:717-720 pubmed publisher
  • western blot; human; 1:500; fig 4b
Olivares O, Mayers J, Gouirand V, Torrence M, Gicquel T, Borge L, et al. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions. Nat Commun. 2017;8:16031 pubmed publisher
  • western blot; human; 1:1000; fig 4d
Szoka L, Karna E, Hlebowicz Sarat K, Karaszewski J, Palka J. Exogenous proline stimulates type I collagen and HIF-1? expression and the process is attenuated by glutamine in human skin fibroblasts. Mol Cell Biochem. 2017;435:197-206 pubmed publisher
  • immunohistochemistry; zebrafish ; 1:500; loading ...; fig 5I''
Kozlovskaja GumbrienÄ— A, Yi R, Alexander R, Aman A, Jiskra R, Nagelberg D, et al. Proliferation-independent regulation of organ size by Fgf/Notch signaling. elife. 2017;6: pubmed publisher
  • western blot; human; loading ...; tbl 4
Lopes M, Leal R, Guarnieri R, Schwarzbold M, Hoeller A, Diaz A, et al. A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. Transl Psychiatry. 2016;6:e986 pubmed publisher
  • western blot; fruit fly ; 1:2000; loading ...; fig s8a
Bangi E, Murgia C, Teague A, Sansom O, Cagan R. Functional exploration of colorectal cancer genomes using Drosophila. Nat Commun. 2016;7:13615 pubmed publisher
  • western blot; human; loading ...; fig 3c
Alekhina O, Marchese A. ?-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4. J Biol Chem. 2016;291:26083-26097 pubmed
  • western blot; human; loading ...; fig 4b
Greenwood E, Maisel S, Ebertz D, Russ A, Pandey R, SCHROEDER J. Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration. Oncotarget. 2016;7:60776-60792 pubmed publisher
  • western blot; Xenopus laevis; 1:5000; loading ...; fig 2f
Tadjuidje E, Kofron M, Mir A, Wylie C, Heasman J, Cha S. Nodal signalling in Xenopus: the role of Xnr5 in left/right asymmetry and heart development. Open Biol. 2016;6: pubmed publisher
  • western blot; human; fig 7e
Schütz I, López Hernández T, Gao Q, Puchkov D, Jabs S, Nordmeyer D, et al. Lysosomal Dysfunction Caused by Cellular Accumulation of Silica Nanoparticles. J Biol Chem. 2016;291:14170-84 pubmed publisher
  • western blot; human; 1:10,000; loading ...; fig 2a
Mendel I, Yacov N, Shoham A, Ishai E, Breitbart E. Treatment with Oxidized Phospholipids Directly Inhibits Nonalcoholic Steatohepatitis and Liver Fibrosis Without Affecting Steatosis. Dig Dis Sci. 2016;61:2545-53 pubmed publisher
  • western blot; human; fig 3
Sakakini N, Turchi L, Bergon A, Holota H, Rekima S, Lopez F, et al. A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem Cells. J Biol Chem. 2016;291:10684-99 pubmed publisher
  • western blot; mouse; fig 7
Morena D, Maestro N, Bersani F, Forni P, Lingua M, Foglizzo V, et al. Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes. elife. 2016;5: pubmed publisher
  • western blot; human; 1:1000; fig 5
Stefanovic M, Tutusaus A, Martinez Nieto G, Bárcena C, de Gregorio E, Moutinho C, et al. Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma. Oncotarget. 2016;7:8253-67 pubmed publisher
  • western blot; dogs; fig 1d
Shukla P, Vogl C, Wallner B, Rigler D, Müller M, Macho Maschler S. High-throughput mRNA and miRNA profiling of epithelial-mesenchymal transition in MDCK cells. BMC Genomics. 2015;16:944 pubmed publisher
  • western blot; fruit fly ; 1:500
Sun D, Buttitta L. Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila. Development. 2015;142:3033-45 pubmed publisher
  • immunohistochemistry - paraffin section; fruit fly ; 1:200; fig 2
Patel P, Dutta D, Edgar B. Niche appropriation by Drosophila intestinal stem cell tumours. Nat Cell Biol. 2015;17:1182-92 pubmed publisher
  • western blot; human; fig 8
Brohée L, Demine S, Willems J, Arnould T, Colige A, Deroanne C. Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment. Oncotarget. 2015;6:11264-80 pubmed
  • western blot; human; fig 5
Wilson F, Johannessen C, Piccioni F, Tamayo P, Kim J, Van Allen E, et al. A functional landscape of resistance to ALK inhibition in lung cancer. Cancer Cell. 2015;27:397-408 pubmed publisher
  • western blot; mouse; fig 4
Guillaumond F, Bidaut G, Ouaissi M, Servais S, Gouirand V, Olivares O, et al. Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2015;112:2473-8 pubmed publisher
  • western blot; human; fig s4
Diesenberg K, Beerbaum M, Fink U, Schmieder P, Krauss M. SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR. J Cell Sci. 2015;128:397-407 pubmed publisher
  • immunohistochemistry; fruit fly ; 1:200
Matsuoka S, Gupta S, Suzuki E, Hiromi Y, Asaoka M. gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. PLoS ONE. 2014;9:e113423 pubmed publisher
  • western blot; mouse; fig 2
Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014;33:2581-96 pubmed publisher
  • western blot; rat; 1:5000
  • western blot; mouse; 1:5000
Zeldich E, Chen C, Colvin T, Bove Fenderson E, Liang J, Tucker Zhou T, et al. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014;289:24700-15 pubmed publisher
  • western blot; human; 1:1000
Martínez Pinilla E, Reyes Resina I, Oñatibia Astibia A, Zamarbide M, Ricobaraza A, Navarro G, et al. CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum. Exp Neurol. 2014;261:44-52 pubmed publisher
  • western blot; human
Chen P, Qin L, Zhuang Z, Tellides G, Lax I, Schlessinger J, et al. The docking protein FRS2? is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A. 2014;111:5514-9 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Guerra M, Wauson E, McGlynn K, Cobb M. Muscarinic control of MIN6 pancreatic ? cells is enhanced by impaired amino acid signaling. J Biol Chem. 2014;289:14370-9 pubmed publisher
  • immunocytochemistry; human; fig 5
Bölck B, Ibrahim M, Steinritz D, Morguet C, Dühr S, Suhr F, et al. Detection of key enzymes, free radical reaction products and activated signaling molecules as biomarkers of cell damage induced by benzo[a]pyrene in human keratinocytes. Toxicol In Vitro. 2014;28:875-84 pubmed publisher
  • western blot; human
Fernandez Estevez M, Casarejos M, Lopez Sendon J, Garcia Caldentey J, Ruiz C, Gomez A, et al. Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition. PLoS ONE. 2014;9:e90202 pubmed publisher
  • western blot; bovine; fig 5, 6
Turner M, Cronin J, Healey G, Sheldon I. Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1, and TLR6. Endocrinology. 2014;155:1453-65 pubmed publisher
  • western blot; human
Zaganjor E, Osborne J, Weil L, Díaz Martínez L, Gonzales J, Singel S, et al. Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene. 2014;33:5457-66 pubmed publisher
Kaur H, Sharma S, Mandal S, Mandal L. Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche. Development. 2019;146: pubmed publisher
He Q, Shumate L, Matthias J, Aydin C, Wein M, Spatz J, et al. A G protein-coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23. JCI Insight. 2019;4: pubmed publisher
Wallroth A, Koch P, Marat A, Krause E, Haucke V. Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1. Nat Cell Biol. 2019;21:1093-1101 pubmed publisher
Kondo T, Hayashi S. Two-step regulation of trachealess ensures tight coupling of cell fate with morphogenesis in the Drosophila trachea. elife. 2019;8: pubmed publisher
Zingkou E, Pampalakis G, Charla E, Nauroy P, Kiritsi D, Sotiropoulou G. A proinflammatory role of KLK6 protease in Netherton syndrome. J Dermatol Sci. 2019;95:28-35 pubmed publisher
Ning S, Wang Z, Cao J, Dong Y, Chen Y. Mel1c Mediated Monochromatic Light-Stimulated IGF-I Synthesis through the Intracellular Gαq/PKC/ERK Signaling Pathway. Int J Mol Sci. 2019;20: pubmed publisher
Stundl J, Pospisilova A, Jandzik D, Fabian P, Dobiášová B, Minarik M, et al. Bichir external gills arise via heterochronic shift that accelerates hyoid arch development. elife. 2019;8: pubmed publisher
Achache H, Laurent L, Hecker Mimoun Y, Ishtayeh H, Rappaport Y, Kroizer E, et al. Progression of Meiosis Is Coordinated by the Level and Location of MAPK Activation Via OGR-2 in Caenorhabditis elegans. Genetics. 2019;212:213-229 pubmed publisher
Ishay Ronen D, Diepenbruck M, Kalathur R, Sugiyama N, Tiede S, Ivanek R, et al. Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis. Cancer Cell. 2019;35:17-32.e6 pubmed publisher
Packer L, Stehbens S, Bonazzi V, Gunter J, Ju R, Ward M, et al. Bcl-2 inhibitors enhance FGFR inhibitor-induced mitochondrial-dependent cell death in FGFR2-mutant endometrial cancer. Mol Oncol. 2019;13:738-756 pubmed publisher
Golderman V, Shavit Stein E, Gera O, Chapman J, Eisenkraft A, Maggio N. Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. J Mol Neurosci. 2019;67:227-234 pubmed publisher
Colle D, Santos D, de Souza V, Lopes M, Leal R, de Souza Brocardo P, et al. Sodium selenite protects from 3-nitropropionic acid-induced oxidative stress in cultured primary cortical neurons. Mol Biol Rep. 2019;46:751-762 pubmed publisher
Wang A, Hirose T, Ohsaki Y, Takahashi C, Sato E, Oba Yabana I, et al. Hydrochlorothiazide ameliorates polyuria caused by tolvaptan treatment of polycystic kidney disease in PCK rats. Clin Exp Nephrol. 2019;23:455-464 pubmed publisher
Beaudry K, Langlois M, Montagne A, Cagnol S, Carrier J, Rivard N. Dual-specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis. J Cell Physiol. 2019;234:6731-6745 pubmed publisher
Arbel Rubinstein T, Shahmoon S, Zigmond E, Etan T, Merenbakh Lamin K, Pasmanik Chor M, et al. Klotho suppresses colorectal cancer through modulation of the unfolded protein response. Oncogene. 2019;38:794-807 pubmed publisher
Shavit Stein E, Sheinberg E, Golderman V, Sharabi S, Wohl A, Gofrit S, et al. A Novel Compound Targeting Protease Receptor 1 Activators for the Treatment of Glioblastoma. Front Neurol. 2018;9:1087 pubmed publisher
Wong K, Akiyama R, Bessho Y, Matsui T. ERK Activity Dynamics during Zebrafish Embryonic Development. Int J Mol Sci. 2018;20: pubmed publisher
Zheng S, Qu Z, Zanetti M, Lam B, Chin Sang I. C. elegans PTEN and AMPK block neuroblast divisions by inhibiting a BMP-insulin-PP2A-MAPK pathway. Development. 2018;145: pubmed publisher
Boulter E, Estrach S, Tissot F, Hennrich M, Tosello L, Cailleteau L, et al. Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway. Nat Commun. 2018;9:4862 pubmed publisher
Zoranovic T, Manent J, Willoughby L, Matos de Simoes R, La Marca J, Golenkina S, et al. A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer. PLoS Genet. 2018;14:e1007688 pubmed publisher
Courgeon M, He D, Liu H, Legent K, Treisman J. The Drosophila Epidermal Growth Factor Receptor does not act in the nucleus. J Cell Sci. 2018;131: pubmed publisher
Taylor E, Heyland A. Thyroid Hormones Accelerate Initiation of Skeletogenesis via MAPK (ERK1/2) in Larval Sea Urchins (Strongylocentrotus purpuratus). Front Endocrinol (Lausanne). 2018;9:439 pubmed publisher
Raiders S, Eastwood M, Bacher M, Priess J. Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis. PLoS Genet. 2018;14:e1007417 pubmed publisher
Saydmohammed M, Vollmer L, Onuoha E, Maskrey T, Gibson G, Watkins S, et al. A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development. Molecules. 2018;23: pubmed publisher
Simsek M, Ozbudak E. Spatial Fold Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish. Cell Rep. 2018;24:66-78.e8 pubmed publisher
De Pasquale V, Sarogni P, Pistorio V, Cerulo G, Paladino S, Pavone L. Targeting Heparan Sulfate Proteoglycans as a Novel Therapeutic Strategy for Mucopolysaccharidoses. Mol Ther Methods Clin Dev. 2018;10:8-16 pubmed publisher
English E, Mahn S, Marchese A. Endocytosis is required for CXC chemokine receptor type 4 (CXCR4)-mediated Akt activation and antiapoptotic signaling. J Biol Chem. 2018;293:11470-11480 pubmed publisher
Zahavi E, Steinberg N, Altman T, Chein M, Joshi Y, Gradus Pery T, et al. The receptor tyrosine kinase TrkB signals without dimerization at the plasma membrane. Sci Signal. 2018;11: pubmed publisher
Shiloh R, Gilad Y, Ber Y, Eisenstein M, Aweida D, Bialik S, et al. Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy. Nat Commun. 2018;9:1759 pubmed publisher
Majorini M, Manenti G, Mano M, De Cecco L, Conti A, Pinciroli P, et al. cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells. Cell Death Differ. 2018;25:2147-2164 pubmed publisher
Loch C, Haeger J, Pfarrer C. IFNτ mediates chemotaxis, motility, metabolism and CK18 downregulation in bovine trophoblast cells in vitro via STAT1 and MAPK42/44 signaling. Placenta. 2018;64:17-26 pubmed publisher
Andriani F, Majorini M, Mano M, Landoni E, Miceli R, Facchinetti F, et al. MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner. J Hematol Oncol. 2018;11:45 pubmed publisher
Ferrer C, Alders M, Postma A, Park S, Klein M, Cetinbaş M, et al. An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality. Genes Dev. 2018;32:373-388 pubmed publisher
Yamamoto Fukuda T, Akiyama N, Takahashi M, Kojima H. Keratinocyte Growth Factor (KGF) Modulates Epidermal Progenitor Cell Kinetics through Activation of p63 in Middle Ear Cholesteatoma. J Assoc Res Otolaryngol. 2018;19:223-241 pubmed publisher
Miskolczi Z, Smith M, Rowling E, Ferguson J, Barriuso J, Wellbrock C. Collagen abundance controls melanoma phenotypes through lineage-specific microenvironment sensing. Oncogene. 2018;37:3166-3182 pubmed publisher
Sari D, Akiyama R, Naoki H, Ishijima H, Bessho Y, Matsui T. Time-lapse observation of stepwise regression of Erk activity in zebrafish presomitic mesoderm. Sci Rep. 2018;8:4335 pubmed publisher
van IJzendoorn D, Sleijfer S, Gelderblom H, Eskens F, van Leenders G, Szuhai K, et al. Telatinib Is an Effective Targeted Therapy for Pseudomyogenic Hemangioendothelioma. Clin Cancer Res. 2018;24:2678-2687 pubmed publisher
Maisel S, Broka D, SCHROEDER J. Intravesicular epidermal growth factor receptor subject to retrograde trafficking drives epidermal growth factor-dependent migration. Oncotarget. 2018;9:6463-6477 pubmed publisher
Missinato M, Saydmohammed M, Zuppo D, Rao K, Opie G, Kuhn B, et al. Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration. Development. 2018;145: pubmed publisher
Danziger O, Pupko T, Bacharach E, Ehrlich M. Interleukin-6 and Interferon-α Signaling via JAK1-STAT Differentially Regulate Oncolytic versus Cytoprotective Antiviral States. Front Immunol. 2018;9:94 pubmed publisher
Ando T, Fujiwara H, Kojima T. The pivotal role of aristaless in development and evolution of diverse antennal morphologies in moths and butterflies. BMC Evol Biol. 2018;18:8 pubmed publisher
Van Boxtel A, Economou A, Heliot C, Hill C. Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages. Dev Cell. 2018;44:179-191.e5 pubmed publisher
Završnik J, Butinar M, Prebanda M, Krajnc A, Vidmar R, Fonovic M, et al. Cystatin C deficiency suppresses tumor growth in a breast cancer model through decreased proliferation of tumor cells. Oncotarget. 2017;8:73793-73809 pubmed publisher
Wolfstetter G, Pfeifer K, van Dijk J, Hugosson F, Lu X, Palmer R. The scaffolding protein Cnk binds to the receptor tyrosine kinase Alk to promote visceral founder cell specification in Drosophila. Sci Signal. 2017;10: pubmed publisher
Zhao J, Zhao J, Xu G, Wang Z, Gao J, Cui S, et al. Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha expression and attenuated fertility in male mice. Biol Reprod. 2017;97:497-513 pubmed publisher
Kirsch N, Chang L, Koch S, Glinka A, Dolde C, Colozza G, et al. Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover. Dev Cell. 2017;43:71-82.e6 pubmed publisher
Neiswender J, Kortum R, Bourque C, Kasheta M, Zon L, Morrison D, et al. KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling. Cancer Res. 2017;77:5820-5830 pubmed publisher
Cao J, Heijkants R, Jochemsen A, Dogrusöz M, de Lange M, van der Velden P, et al. Targeting of the MAPK and AKT pathways in conjunctival melanoma shows potential synergy. Oncotarget. 2017;8:58021-58036 pubmed publisher
Szoka L, Karna E, Hlebowicz Sarat K, Karaszewski J, Boryczka S, Palka J. Acetylenic derivative of betulin induces apoptosis in endometrial adenocarcinoma cell line. Biomed Pharmacother. 2017;95:429-436 pubmed publisher
Yoon D, Alfhili M, Friend K, Lee M. MPK-1/ERK regulatory network controls the number of sperm by regulating timing of sperm-oocyte switch in C. elegans germline. Biochem Biophys Res Commun. 2017;491:1077-1082 pubmed publisher
Glennon E, Torrevillas B, Morrissey S, Ejercito J, Luckhart S. Abscisic acid induces a transient shift in signaling that enhances NF-κB-mediated parasite killing in the midgut of Anopheles stephensi without reducing lifespan or fecundity. Parasit Vectors. 2017;10:333 pubmed publisher
Yoon S, Kovalenko A, Bogdanov K, Wallach D. MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Immunity. 2017;47:51-65.e7 pubmed publisher
Gamage T, Anderson J, Abood M. CB1 allosteric modulator Org27569 is an antagonist/inverse agonist of ERK1/2 signaling. Cannabis Cannabinoid Res. 2016;1:272-280 pubmed publisher
Suisse A, He D, Legent K, Treisman J. COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation. Development. 2017;144:2673-2682 pubmed publisher
Rives Quinto N, Franco M, de Torres Jurado A, Carmena A. Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia. Development. 2017;144:2570-2583 pubmed publisher
Liu W, Cvekl A. Six3 in a small population of progenitors at E8.5 is required for neuroretinal specification via regulating cell signaling and survival in mice. Dev Biol. 2017;428:164-175 pubmed publisher
Kugita M, Nishii K, Yamaguchi T, Suzuki A, Yuzawa Y, Horie S, et al. Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease. PLoS ONE. 2017;12:e0177934 pubmed publisher
Sala V, Gallo S, Gatti S, Vigna E, Ponzetto A, Crepaldi T. Anti-Differentiation Effect of Oncogenic Met Receptor in Terminally-Differentiated Myotubes. Biomedicines. 2015;3:124-137 pubmed publisher
Dorard C, Estrada C, Barbotin C, Larcher M, Garancher A, Leloup J, et al. RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma. Nat Commun. 2017;8:15262 pubmed publisher
Budai M, Tozser J, Benko S. Different dynamics of NLRP3 inflammasome-mediated IL?1? production in GM-CSF- and M-CSF-differentiated human macrophages. J Leukoc Biol. 2017;101:1335-1347 pubmed publisher
Guerra M, Kalwat M, McGlynn K, Cobb M. Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis. FEBS Open Bio. 2017;7:174-186 pubmed publisher
Schmukler E, Wolfson E, Elazar Z, Kloog Y, Pinkas Kramarski R. Continuous treatment with FTS confers resistance to apoptosis and affects autophagy. PLoS ONE. 2017;12:e0171351 pubmed publisher
Mendel I, Yacov N, Salem Y, Propheta Meiran O, Ishai E, Breitbart E. Identification of Motile Sperm Domain-Containing Protein 2 as Regulator of Human Monocyte Migration. J Immunol. 2017;198:2125-2132 pubmed publisher
Kidger A, Rushworth L, Stellzig J, Davidson J, Bryant C, Bayley C, et al. Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling. Proc Natl Acad Sci U S A. 2017;114:E317-E326 pubmed publisher
Steinhauer J. Co-culture Activation of MAP Kinase in Drosophila S2 Cells. Methods Mol Biol. 2017;1487:235-241 pubmed
Rieger D, Navarro E, Buendia I, Parada E, González Lafuente L, Leon R, et al. ConBr, A Lectin Purified from the Seeds of Canavalia brasiliensis, Protects Against Ischemia in Organotypic Culture of Rat Hippocampus: Potential Implication of Voltage-Gated Calcium Channels. Neurochem Res. 2017;42:347-359 pubmed publisher
Hoffmann H, Crouzin N, Moreno E, Raivio N, Fuentes S, McCormick P, et al. Long-Lasting Impairment of mGluR5-Activated Intracellular Pathways in the Striatum After Withdrawal of Cocaine Self-Administration. Int J Neuropsychopharmacol. 2017;20:72-82 pubmed publisher
Levinson S, Cagan R. Drosophila Cancer Models Identify Functional Differences between Ret Fusions. Cell Rep. 2016;16:3052-3061 pubmed publisher
Peterse E, Cleven A, de Jong Y, Briaire de Bruijn I, Fletcher J, Danen E, et al. No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone. BMC Cancer. 2016;16:475 pubmed publisher
Filippi S, Barnes C, Kirk P, Kudo T, Kunida K, McMahon S, et al. Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling. Cell Rep. 2016;15:2524-35 pubmed publisher
Jin M, Eblimit A, Pulikkathara M, Corr S, Chen R, Mardon G. Conditional knockout of retinal determination genes in differentiating cells in Drosophila. FEBS J. 2016;283:2754-66 pubmed publisher
PETRUCCELLI E, Li Q, Rao Y, Kitamoto T. The Unique Dopamine/Ecdysteroid Receptor Modulates Ethanol-Induced Sedation in Drosophila. J Neurosci. 2016;36:4647-57 pubmed publisher
Ferenczi E, Vierock J, Atsuta Tsunoda K, Tsunoda S, Ramakrishnan C, Gorini C, et al. Optogenetic approaches addressing extracellular modulation of neural excitability. Sci Rep. 2016;6:23947 pubmed publisher
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Bhargava A, Anant M, Mack H. Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. elife. 2016;5: pubmed publisher
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product information
Product No. :
M8159
Product Name :
Monoclonal Anti-MAP Kinase, Activated (Diphosphorylated ERK-1&2) antibody produced in mouse
Host :
mouse
Conjugate :
unconjugated
Antibody Type :
monoclonal
Clone Number (if monoclonal) :
MAPK-YT
Applications/Description :
Suitable for immunocytochemistry; western blot: 1:10,000 using rat brain extract; indirect ELISA; immunoprecipitation (IP); immunohistochemistry (formalin-fixed, paraffin-embedded sections)
Species Reactivity :
yeast, Xenopus, human, rat, bovine, Caenorhabditis elegans, Drosophila, hamster, mouse
Isotype :
IgG1
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA