This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
5-Methylcytosine hydrochloride
catalog :
M6751
citations: 65
Reference
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Hitchcock D, Fedorov A, Fedorov E, Almo S, Raushel F. Discovery of a bacterial 5-methylcytosine deaminase. Biochemistry. 2014;53:7426-35 pubmed publisher
Calvo X, Nomdedeu M, Navarro A, Tejero R, Costa D, Muñoz C, et al. High levels of global DNA methylation are an independent adverse prognostic factor in a series of 90 patients with de novo myelodysplastic syndrome. Leuk Res. 2014;38:874-81 pubmed publisher
Becker D, Lutsik P, Ebert P, Bock C, Lengauer T, Walter J. BiQ Analyzer HiMod: an interactive software tool for high-throughput locus-specific analysis of 5-methylcytosine and its oxidized derivatives. Nucleic Acids Res. 2014;42:W501-7 pubmed publisher
Niederberger C. Re: paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels. J Urol. 2014;191:1356 pubmed publisher
Messerschmidt D, Knowles B, Solter D. DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos. Genes Dev. 2014;28:812-28 pubmed publisher
Brooks S, Fischer R, Huh J, Eichman B. 5-methylcytosine recognition by Arabidopsis thaliana DNA glycosylases DEMETER and DML3. Biochemistry. 2014;53:2525-32 pubmed publisher
Jang H, Shin H, Eichman B, Huh J. Excision of 5-hydroxymethylcytosine by DEMETER family DNA glycosylases. Biochem Biophys Res Commun. 2014;446:1067-72 pubmed publisher
de Souza N. Protein nanopores to detect DNA methylation. Nat Methods. 2014;11:8 pubmed
van Ravenzwaay B, Kleinjans J, Vrijhof H. Editorial - epigenetics and chemical safety. Mutat Res Genet Toxicol Environ Mutagen. 2014;764-765:1-2 pubmed publisher
Liu Y, Liu P, Yang C, Cowley A, Liang M. Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence. Hypertension. 2014;63:827-38 pubmed publisher
Hashimoto H, Pais J, Zhang X, Saleh L, Fu Z, Dai N, et al. Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA. Nature. 2014;506:391-5 pubmed publisher
Tsai C, Tainer J. Probing DNA by 2-OG-dependent dioxygenase. Cell. 2013;155:1448-50 pubmed publisher
Hu L, Li Z, Cheng J, Rao Q, Gong W, Liu M, et al. Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation. Cell. 2013;155:1545-55 pubmed publisher
Liu Y, Olanrewaju Y, Zhang X, Cheng X. DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å. Biochemistry. 2013;52:9310-7 pubmed publisher
Schreiber J, Wescoe Z, Abu Shumays R, Vivian J, Baatar B, Karplus K, et al. Error rates for nanopore discrimination among cytosine, methylcytosine, and hydroxymethylcytosine along individual DNA strands. Proc Natl Acad Sci U S A. 2013;110:18910-5 pubmed publisher
Laszlo A, Derrington I, Brinkerhoff H, Langford K, Nova I, Samson J, et al. Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA. Proc Natl Acad Sci U S A. 2013;110:18904-9 pubmed publisher
Kohli R, Zhang Y. TET enzymes, TDG and the dynamics of DNA demethylation. Nature. 2013;502:472-9 pubmed publisher
Theruvathu J, Yin Y, Pettitt B, Sowers L. Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence. Biochemistry. 2013;52:8590-8 pubmed publisher
Huh Y, Cohen J, Sherley J. Higher 5-hydroxymethylcytosine identifies immortal DNA strand chromosomes in asymmetrically self-renewing distributed stem cells. Proc Natl Acad Sci U S A. 2013;110:16862-7 pubmed publisher
Jaber Hijazi F, Lo P, Mihaylova Y, Foster J, Benner J, Tejada Romero B, et al. Planarian MBD2/3 is required for adult stem cell pluripotency independently of DNA methylation. Dev Biol. 2013;384:141-53 pubmed publisher
Cadet J, Wagner J. TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine. Mutat Res Genet Toxicol Environ Mutagen. 2014;764-765:18-35 pubmed publisher
Dickson K, Gustafson C, Young J, Zuchner S, Wang G. Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate. Biochem Biophys Res Commun. 2013;439:522-7 pubmed publisher
Renciuk D, Blacque O, Vorlíčková M, Spingler B. Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine. Nucleic Acids Res. 2013;41:9891-900 pubmed publisher
Kasymov R, Grin I, Endutkin A, Smirnov S, Ishchenko A, Saparbaev M, et al. Excision of 8-oxoguanine from methylated CpG dinucleotides by human 8-oxoguanine DNA glycosylase. FEBS Lett. 2013;587:3129-34 pubmed publisher
Sharma S, Yang J, Watzinger P, Kötter P, Entian K. Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively. Nucleic Acids Res. 2013;41:9062-76 pubmed publisher
Parrilla Doblas J, Ponferrada Marín M, Roldan Arjona T, Ariza R. Early steps of active DNA demethylation initiated by ROS1 glycosylase require three putative helix-invading residues. Nucleic Acids Res. 2013;41:8654-64 pubmed publisher
Nawy T. Dynamics of DNA demethylation. Nat Methods. 2013;10:466 pubmed
Bhattacharyya S, Yu Y, Suzuki M, Campbell N, Mazdo J, Vasanthakumar A, et al. Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer. Nucleic Acids Res. 2013;41:e157 pubmed publisher
De Jonge C. Paternal age and sperm methylation status. Fertil Steril. 2013;100:940-1 pubmed publisher
Lister R, Mukamel E, Nery J, Urich M, Puddifoot C, Johnson N, et al. Global epigenomic reconfiguration during mammalian brain development. Science. 2013;341:1237905 pubmed publisher
Jenkins T, Aston K, Cairns B, Carrell D. Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels. Fertil Steril. 2013;100:945-51 pubmed publisher
Fneich S, Dheilly N, Adema C, Rognon A, Reichelt M, Bulla J, et al. 5-methyl-cytosine and 5-hydroxy-methyl-cytosine in the genome of Biomphalaria glabrata, a snail intermediate host of Schistosoma mansoni. Parasit Vectors. 2013;6:167 pubmed publisher
Ponnaluri V, Maciejewski J, Mukherji M. A mechanistic overview of TET-mediated 5-methylcytosine oxidation. Biochem Biophys Res Commun. 2013;436:115-20 pubmed publisher
Wang T, Wu H, Li Y, Szulwach K, Lin L, Li X, et al. Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nat Cell Biol. 2013;15:700-11 pubmed publisher
Jiang L, Zhang J, Wang J, Wang L, Zhang L, Li G, et al. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell. 2013;153:773-84 pubmed publisher
Liu S, Wang J, Su Y, Guerrero C, Zeng Y, Mitra D, et al. Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res. 2013;41:6421-9 pubmed publisher
Song C, Szulwach K, Dai Q, Fu Y, Mao S, Lin L, et al. Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell. 2013;153:678-91 pubmed publisher
Shen L, Wu H, Diep D, Yamaguchi S, D Alessio A, Fung H, et al. Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell. 2013;153:692-706 pubmed publisher
Thomson J, Hunter J, Lempiäinen H, Muller A, Terranova R, Moggs J, et al. Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver. Nucleic Acids Res. 2013;41:5639-54 pubmed publisher
Abdouni H, King J, Suliman M, Quinlan M, Fifield H, Larijani M. Zebrafish AID is capable of deaminating methylated deoxycytidines. Nucleic Acids Res. 2013;41:5457-68 pubmed publisher
Ko M, An J, Bandukwala H, Chavez L, Aijö T, Pastor W, et al. Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature. 2013;497:122-6 pubmed publisher
Hatanaka Y, Shimizu N, Nishikawa S, Tokoro M, Shin S, Nishihara T, et al. GSE is a maternal factor involved in active DNA demethylation in zygotes. PLoS ONE. 2013;8:e60205 pubmed publisher
Koh K, Rao A. DNA methylation and methylcytosine oxidation in cell fate decisions. Curr Opin Cell Biol. 2013;25:152-61 pubmed publisher
Shen L, Zhang Y. 5-Hydroxymethylcytosine: generation, fate, and genomic distribution. Curr Opin Cell Biol. 2013;25:289-96 pubmed publisher
Liu X, Gao Q, Li P, Zhao Q, Zhang J, Li J, et al. UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9. Nat Commun. 2013;4:1563 pubmed publisher
Zhang L, Szulwach K, Hon G, Song C, Park B, Yu M, et al. Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing. Nat Commun. 2013;4:1517 pubmed publisher
Spruijt C, Gnerlich F, Smits A, Pfaffeneder T, Jansen P, Bauer C, et al. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell. 2013;152:1146-59 pubmed publisher
Mariappa D, Pathak S, van Aalten D. A sweet TET-à-tête-synergy of TET proteins and O-GlcNAc transferase in transcription. EMBO J. 2013;32:612-3 pubmed publisher
Yamaguchi S, Hong K, Liu R, Inoue A, Shen L, Zhang K, et al. Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming. Cell Res. 2013;23:329-39 pubmed publisher
Gertych A, Oh J, Wawrowsky K, Weisenberger D, Tajbakhsh J. 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models. BMC Pharmacol Toxicol. 2013;14:11 pubmed publisher
Chen C, Wang K, Shen C. DNA 5-methylcytosine demethylation activities of the mammalian DNA methyltransferases. J Biol Chem. 2013;288:9084-91 pubmed publisher
Deplus R, Delatte B, Schwinn M, Defrance M, Méndez J, Murphy N, et al. TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS. EMBO J. 2013;32:645-55 pubmed publisher
Dawlaty M, Breiling A, Le T, Raddatz G, Barrasa M, Cheng A, et al. Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell. 2013;24:310-23 pubmed publisher
Chen M, Shen F, Huang W, Qi J, Wang Y, Feng Y, et al. Quantification of 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA from hepatocellular carcinoma tissues by capillary hydrophilic-interaction liquid chromatography/quadrupole TOF mass spectrometry. Clin Chem. 2013;59:824-32 pubmed publisher
Clark T, Lu X, Luong K, Dai Q, Boitano M, Turner S, et al. Enhanced 5-methylcytosine detection in single-molecule, real-time sequencing via Tet1 oxidation. BMC Biol. 2013;11:4 pubmed publisher
Martínez Macías M, Córdoba Cañero D, Ariza R, Roldan Arjona T. The DNA repair protein XRCC1 functions in the plant DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation. J Biol Chem. 2013;288:5496-505 pubmed publisher
Otani J, Arita K, Kato T, Kinoshita M, Kimura H, Suetake I, et al. Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4. J Biol Chem. 2013;288:6351-62 pubmed publisher
Wang T, Hong T, Tang T, Zhai Q, Xing X, Mao W, et al. Application of N-halogeno-N-sodiobenzenesulfonamide reagents to the selective detection of 5-methylcytosine in DNA sequences. J Am Chem Soc. 2013;135:1240-3 pubmed publisher
Aoi Y, Nakahama K, Morita I, Safronova O. The involvement of DNA and histone methylation in the repression of IL-1?-induced MCP-1 production by hypoxia. Biochem Biophys Res Commun. 2011;414:252-8 pubmed publisher
Kato D, Goto K, Fujii S, Takatsu A, Hirono S, Niwa O. Electrochemical DNA methylation detection for enzymatically digested CpG oligonucleotides. Anal Chem. 2011;83:7595-9 pubmed publisher
La H, Ding B, Mishra G, Zhou B, Yang H, Chen S, et al. A 5-methylcytosine DNA glycosylase/lyase demethylates the retrotransposon Tos17 and promotes its transposition in rice. Proc Natl Acad Sci U S A. 2011;108:15498-503 pubmed publisher
Gu T, Guo F, Yang H, Wu H, Xu G, Liu W, et al. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature. 2011;477:606-10 pubmed publisher
Nabel C, Kohli R. Molecular biology. Demystifying DNA demethylation. Science. 2011;333:1229-30 pubmed publisher
product information
Catalog Number :
M6751
Product Name :
5-Methylcytosine hydrochloride
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥99%
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA