product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Anti-MLKL (58-70) antibody produced in rabbit
catalog :
M6697
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunocytochemistry
more info or order :
citations: 13
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 7b
Shi F, Zhou M, Shang L, Du Q, Li Y, Xie L, et al. EBV(LMP1)-induced metabolic reprogramming inhibits necroptosis through the hypermethylation of the RIP3 promoter. Theranostics. 2019;9:2424-2438 pubmed publisher
  • immunocytochemistry; human
Yoon S, Bogdanov K, Kovalenko A, Wallach D. Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ. 2016;23:253-60 pubmed publisher
Zhang S, Che L, He C, Huang J, Guo N, Shi J, et al. Drp1 and RB interaction to mediate mitochondria-dependent necroptosis induced by cadmium in hepatocytes. Cell Death Dis. 2019;10:523 pubmed publisher
Gaba A, Xu F, Lu Y, Park H, Liu G, Zhou Y. The NS1 Protein of Influenza A Virus Participates in Necroptosis by Interacting with MLKL and Increasing Its Oligomerization and Membrane Translocation. J Virol. 2019;93: pubmed publisher
Dionísio P, Oliveira S, Amaral J, Rodrigues C. Loss of Microglial Parkin Inhibits Necroptosis and Contributes to Neuroinflammation. Mol Neurobiol. 2019;56:2990-3004 pubmed publisher
Oliveira S, Dionísio P, Brito H, Franco L, Rodrigues C, Guedes R, et al. Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation. Cell Death Discov. 2018;4:10 pubmed publisher
Ali M, Mocarski E. Proteasome inhibition blocks necroptosis by attenuating death complex aggregation. Cell Death Dis. 2018;9:346 pubmed publisher
Mizumura K, Justice M, Schweitzer K, Krishnan S, Bronova I, Berdyshev E, et al. Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure. FASEB J. 2017;: pubmed publisher
Gong Y, Guy C, Olauson H, Becker J, Yang M, Fitzgerald P, et al. ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences. Cell. 2017;169:286-300.e16 pubmed publisher
Quarato G, Guy C, Grace C, Llambi F, Nourse A, Rodriguez D, et al. Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. Mol Cell. 2016;61:589-601 pubmed publisher
Rodriguez D, Weinlich R, Brown S, Guy C, Fitzgerald P, Dillon C, et al. Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis. Cell Death Differ. 2016;23:76-88 pubmed publisher
Selmi T, Alecci C, dell Aquila M, Montorsi L, Martello A, Guizzetti F, et al. ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly. BMC Cancer. 2015;15:357 pubmed publisher
Kim S, Kim W, Yoon J, Ji J, Morgan M, Cho H, et al. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis. J Invest Dermatol. 2015;135:2021-2030 pubmed publisher
product information
Product No. :
M6697
Product Name :
Anti-MLKL (58-70) antibody produced in rabbit
Host :
rabbit
Conjugate :
unconjugated
Antibody Type :
polyclonal
Applications/Description :
Suitable for western blot: 1:250-1:500
Species Reactivity :
human
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA