This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
MDL 28170
catalog :
M6690
citations: 55
Reference
Shiga Y, Shiga A, Mesci P, Kwon H, Brifault C, Kim J, et al. Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury. Sci Rep. 2019;9:19291 pubmed publisher
Yong Y, Gamage K, Cheng I, Barford K, Spano A, Winckler B, et al. p75NTR and DR6 Regulate Distinct Phases of Axon Degeneration Demarcated by Spheroid Rupture. J Neurosci. 2019;39:9503-9520 pubmed publisher
Pan L, Zhang P, Hu F, Yan R, He M, Li W, et al. Hypotonic Stress Induces Fast, Reversible Degradation of the Vimentin Cytoskeleton via Intracellular Calcium Release. Adv Sci (Weinh). 2019;6:1900865 pubmed publisher
Kwon H, Neupane C, Shin J, Gwon D, Yin Y, Shin N, et al. Calpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats. Exp Neurobiol. 2019;28:529-536 pubmed publisher
Hou Q, Liu R, Zhang W, Zhou G. Nitric oxide synthase in beef semimembranosus muscle during postmortem aging. Food Chem. 2019;288:187-192 pubmed publisher
Hu J, Chen L, Huang X, Wu K, Ding S, Wang W, et al. Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury. Stem Cell Res Ther. 2019;10:96 pubmed publisher
Lien B, Tuszynski M, Lu P. Astrocytes migrate from human neural stem cell grafts and functionally integrate into the injured rat spinal cord. Exp Neurol. 2019;314:46-57 pubmed publisher
Wang W, Han P, Xie R, Yang M, Zhang C, Mi Q, et al. TAT-mGluR1 Attenuation of Neuronal Apoptosis through Prevention of MGluR1α Truncation after Experimental Subarachnoid Hemorrhage. ACS Chem Neurosci. 2019;10:746-756 pubmed publisher
Wang Q, He Q, Chen Y, Shao W, Yuan C, Wang Y. JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss. J Neuroinflammation. 2018;15:184 pubmed publisher
de Sousa Araújo P, de Oliveira S, d Avila Levy C, Dos Santos A, Branquinha M. Susceptibility of promastigotes and intracellular amastigotes from distinct Leishmania species to the calpain inhibitor MDL28170. Parasitol Res. 2018;117:2085-2094 pubmed publisher
Templeman N, Luo S, Kaletsky R, Shi C, Ashraf J, Keyes W, et al. Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity. Curr Biol. 2018;28:753-760.e4 pubmed publisher
Scott I, Majithiya J, Sandén C, Thornton P, Sanders P, Moore T, et al. Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage. Sci Rep. 2018;8:3363 pubmed publisher
Weber J, Kloock S, Nagel M, Ortiz Rios M, Hofmann J, Riess O, et al. Calpastatin ablation aggravates the molecular phenotype in cell and animal models of Huntington disease. Neuropharmacology. 2018;133:94-106 pubmed publisher
Pease Raissi S, Pazyra Murphy M, Li Y, Wachter F, Fukuda Y, Fenstermacher S, et al. Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration. Neuron. 2017;96:373-386.e6 pubmed publisher
Liang J, Li J, Han Y, Luo Y, Xue Y, Zhang Y, et al. Calpain-GRIP Signaling in Nucleus Accumbens Core Mediates the Reconsolidation of Drug Reward Memory. J Neurosci. 2017;37:8938-8951 pubmed publisher
Clark A, Kanekura K, Lavagnino Z, Spears L, Abreu D, Mahadevan J, et al. Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death. Sci Rep. 2017;7:5611 pubmed publisher
Yuan X, Wu C, Gao F, Li H, Xiang H, Zhu H, et al. Activation and expression of ?-calpain in dorsal root contributes to RTX-induced mechanical allodynia. Mol Pain. 2017;13:1744806917719169 pubmed publisher
Zhu G, Briz V, Seinfeld J, Liu Y, Bi X, Baudry M. Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction. Sci Rep. 2017;7:42788 pubmed publisher
Li J, Chen H, Wu S, Cheng Y, Li Q, Wang J, et al. MPP+ inhibits mGluR1/5-mediated long-term depression in mouse hippocampus by calpain activation. Eur J Pharmacol. 2017;795:22-27 pubmed publisher
Alluri H, Grimsley M, Anasooya Shaji C, Varghese K, Zhang S, Peddaboina C, et al. Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition. J Biol Chem. 2016;291:26958-26969 pubmed publisher
Välimäki E, Cypryk W, Virkanen J, Nurmi K, Turunen P, Eklund K, et al. Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages. J Immunol. 2016;197:3315-3325 pubmed
Kircher P, Hermanns C, Nossek M, Drexler M, Grosse R, Fischer M, et al. Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration. Sci Signal. 2015;8:ra112 pubmed publisher
Murase S. Impaired Focal Adhesion Kinase-Grb2 Interaction during Elevated Activity in Hippocampal Neurons. Int J Mol Sci. 2015;16:15659-69 pubmed publisher
Sun J, Kil C, Stankewich M, Yao Z, Li J, Vortmeyer A. A 10-minute prototype assay for tissue degradation monitoring in clinical specimens. Exp Mol Pathol. 2015;99:86-94 pubmed publisher
Zhu G, Liu Y, Wang Y, Bi X, Baudry M. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways. J Neurosci. 2015;35:621-33 pubmed publisher
Williams P, Marincu B, Sorbara C, Mahler C, Schumacher A, Griesbeck O, et al. A recoverable state of axon injury persists for hours after spinal cord contusion in vivo. Nat Commun. 2014;5:5683 pubmed publisher
Steward O, Sharp K, Yee K, Hatch M, Bonner J. Characterization of ectopic colonies that form in widespread areas of the nervous system with neural stem cell transplants into the site of a severe spinal cord injury. J Neurosci. 2014;34:14013-21 pubmed publisher
Zang Y, Chen S, Liao G, Zhu H, Wei X, Cui Y, et al. Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons. Brain Behav Immun. 2015;44:37-47 pubmed publisher
Sharp K, Yee K, Steward O. A re-assessment of long distance growth and connectivity of neural stem cells after severe spinal cord injury. Exp Neurol. 2014;257:186-204 pubmed publisher
Andres A, Regev L, Phi L, Seese R, Chen Y, Gall C, et al. NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. J Neurosci. 2013;33:16945-60 pubmed publisher
Mattheij N, Gilio K, van Kruchten R, Jobe S, Wieschhaus A, Chishti A, et al. Dual mechanism of integrin ?IIb?3 closure in procoagulant platelets. J Biol Chem. 2013;288:13325-36 pubmed publisher
Briz V, Hsu Y, Li Y, Lee E, Bi X, Baudry M. Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis. J Neurosci. 2013;33:4317-28 pubmed publisher
Del Bello B, Toscano M, Moretti D, Maellaro E. Cisplatin-induced apoptosis inhibits autophagy, which acts as a pro-survival mechanism in human melanoma cells. PLoS ONE. 2013;8:e57236 pubmed publisher
Li X, Luo R, Jiang R, Meng X, Wu X, Zhang S, et al. The role of the Hsp90/Akt pathway in myocardial calpain-induced caspase-3 activation and apoptosis during sepsis. BMC Cardiovasc Disord. 2013;13:8 pubmed publisher
Silverman Gavrila L, Praver M, Mykles D, Charlton M. Calcium, calpain, and calcineurin in low-frequency depression of transmitter release. J Neurosci. 2013;33:1975-90 pubmed publisher
Zhou M, Xu S, Mi J, Ueda K, Chan P. Nuclear translocation of alpha-synuclein increases susceptibility of MES23.5 cells to oxidative stress. Brain Res. 2013;1500:19-27 pubmed publisher
Zhang J, Tong W, Wu F, Bi S, Xu M, Jin Z, et al. Different roles for contracture and calpain in calcium paradox-induced heart injury. PLoS ONE. 2012;7:e52270 pubmed publisher
Duregotti E, Tedesco E, Montecucco C, Rigoni M. Calpains participate in nerve terminal degeneration induced by spider and snake presynaptic neurotoxins. Toxicon. 2013;64:20-8 pubmed publisher
Sheng Z, Oka S, Tsuchimoto D, Abolhassani N, Nomaru H, Sakumi K, et al. 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair. J Clin Invest. 2012;122:4344-61 pubmed publisher
Zadran S, Akopian G, Zadran H, Walsh J, Baudry M. RVG-mediated calpain2 gene silencing in the brain impairs learning and memory. Neuromolecular Med. 2013;15:74-81 pubmed publisher
Puskarjov M, Ahmad F, Kaila K, Blaesse P. Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain. J Neurosci. 2012;32:11356-64 pubmed publisher
Berry J, Sharrett Field L, Butler T, Prendergast M. Temporal dependence of cysteine protease activation following excitotoxic hippocampal injury. Neuroscience. 2012;222:147-58 pubmed publisher
Lade A, Ranganathan S, Luo J, Monga S. Calpain induces N-terminal truncation of ?-catenin in normal murine liver development: diagnostic implications in hepatoblastomas. J Biol Chem. 2012;287:22789-98 pubmed publisher
AHMAD H, Lu L, Ye S, Schwartz G, GREYSON C. Calpain inhibition preserves talin and attenuates right heart failure in acute pulmonary hypertension. Am J Respir Cell Mol Biol. 2012;47:379-86 pubmed publisher
Ali M, Stepanko A, Fan X, Holt A, Schulz R. Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity. Biochem Biophys Res Commun. 2012;423:1-5 pubmed publisher
Lopez Castejon G, Corbett D, Goldrick M, Roberts I, Brough D. Inhibition of calpain blocks the phagosomal escape of Listeria monocytogenes. PLoS ONE. 2012;7:e35936 pubmed publisher
Cai W, Pritchard T, Florea S, Lam C, Han P, Zhou X, et al. Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion. Cardiovasc Res. 2012;94:333-41 pubmed publisher
Bi S, Jin Z, Zhang J, Chen T, Zhang S, Yang Y, et al. Calpain inhibitor MDL 28170 protects against the Ca2+ paradox in rat hearts. Clin Exp Pharmacol Physiol. 2012;39:385-92 pubmed publisher
Lee E, Eom J, Kim H, Kang D, Jun K, Jung D, et al. Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of ?-calpain. Eur J Pharm Sci. 2012;46:17-25 pubmed publisher
Walko G, Vukasinovic N, Gross K, Fischer I, Sibitz S, Fuchs P, et al. Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna. PLoS Genet. 2011;7:e1002396 pubmed publisher
Ma M, Li L, Wang X, Bull D, Shofer F, Meaney D, et al. Short-duration treatment with the calpain inhibitor MDL-28170 does not protect axonal transport in an in vivo model of traumatic axonal injury. J Neurotrauma. 2012;29:445-51 pubmed publisher
Chen Q, Paillard M, Gomez L, Ross T, Hu Y, Xu A, et al. Activation of mitochondrial ?-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion. Biochem Biophys Res Commun. 2011;415:533-8 pubmed publisher
Ma W, Han W, Greer P, Tuder R, Toque H, Wang K, et al. Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. J Clin Invest. 2011;121:4548-66 pubmed publisher
Jantas D, Lorenc Koci E, Kubera M, Lason W. Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons. Neurotoxicology. 2011;32:845-56 pubmed publisher
Ennes Vidal V, Menna Barreto R, Santos A, Branquinha M, D Ávila Levy C. MDL28170, a calpain inhibitor, affects Trypanosoma cruzi metacyclogenesis, ultrastructure and attachment to Rhodnius prolixus midgut. PLoS ONE. 2011;6:e18371 pubmed publisher
product information
Catalog Number :
M6690
Product Name :
MDL 28170
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥95% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA