Chao A, Chen C, Wu M, Hou B, Yang D. Roles of Id1/HIF-1 and CDK5/HIF-1 in cell cycle reentry induced by amyloid-beta peptide in post-mitotic cortical neuron. Biochim Biophys Acta Mol Cell Res. 2020;1867:118628 pubmed publisher

Pal P, HALES K, Petrik J, Hales D. Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancer. J Ovarian Res. 2019;12:49 pubmed publisher

Lee H, Liu S, Lin C, Lee S, Hsu C, Sytwu H, et al. A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke. Theranostics. 2017;7:855-875 pubmed publisher

Elis E, Ehrlich M, Bacharach E. Dynamics and restriction of murine leukemia virus cores in mitotic and interphase cells. Retrovirology. 2015;12:95 pubmed publisher

Qin W, Li C, Zheng W, Guo Q, Zhang Y, Kang M, et al. Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells. Oncotarget. 2015;6:39839-54 pubmed publisher

Costa R, Ragusa S, Russo M, Certo G, Franchina F, Zanotto A, et al. Phytochemical screening of Artemisia arborescens L. by means of advanced chromatographic techniques for identification of health-promoting compounds. J Pharm Biomed Anal. 2016;117:499-509 pubmed publisher

Yang F, Song L, Wang H, Wang J, Xu Z, Xing N. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS ONE. 2015;10:e0128277 pubmed publisher

Lee Y, Kubli D, Hanna R, Cortez M, Lee H, Miyamoto S, et al. Cellular redox status determines sensitivity to BNIP3-mediated cell death in cardiac myocytes. Am J Physiol Cell Physiol. 2015;308:C983-92 pubmed publisher

Li X, Franke A. Improved profiling of estrogen metabolites by orbitrap LC/MS. Steroids. 2015;99:84-90 pubmed publisher

Lin C, Chiu L, Lee H, Chiang C, Liu S, Hsu Y, et al. PACAP38/PAC1 signaling induces bone marrow-derived cells homing to ischemic brain. Stem Cells. 2015;33:1153-72 pubmed publisher

Fuhrman B, Xu X, Falk R, Dallal C, Veenstra T, Keefer L, et al. Assay reproducibility and interindividual variation for 15 serum estrogens and estrogen metabolites measured by liquid chromatography-tandem mass spectrometry. Cancer Epidemiol Biomarkers Prev. 2014;23:2649-57 pubmed publisher

Martin Y, Manlove L, Dong J, Carey W, Thompson M, Pabelick C, et al. Hyperoxia-induced changes in estradiol metabolism in postnatal airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2015;308:L141-6 pubmed publisher

Ma L, Li G, Zhu H, Dong X, Zhao D, Jiang X, et al. 2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2. Cancer Lett. 2014;355:96-105 pubmed publisher

Hua Y, Shun T, Strock C, Johnston P. High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions. Assay Drug Dev Technol. 2014;12:395-418 pubmed publisher

Yang Z, Zhao T, Zou Y, Zhang J, Feng H. Hypoxia Induces autophagic cell death through hypoxia-inducible factor 1? in microglia. PLoS ONE. 2014;9:e96509 pubmed publisher

Shan T, Cui X, Li W, Lin W, Li Y, Chen X, et al. Novel regulatory program for norepinephrine-induced epithelial-mesenchymal transition in gastric adenocarcinoma cell lines. Cancer Sci. 2014;105:847-56 pubmed publisher

Yang Y, Lane K, Sehgal P. Subcellular mechanisms in pulmonary arterial hypertension: combinatorial modalities that inhibit anterograde trafficking and cause bone morphogenetic protein receptor type 2 mislocalization. Pulm Circ. 2013;3:533-50 pubmed publisher

Cheng Y, Park J, Manzanero S, Choi Y, Baik S, Okun E, et al. Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke. Neurobiol Dis. 2014;62:286-95 pubmed publisher

Miyauchi Y, Sato Y, Kobayashi T, Yoshida S, Mori T, Kanagawa H, et al. HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proc Natl Acad Sci U S A. 2013;110:16568-73 pubmed publisher

Kohen P, Henríquez S, Rojas C, Gerk P, Palomino W, Strauss J, et al. 2-Methoxyestradiol in the human corpus luteum throughout the luteal phase and its influence on lutein cell steroidogenesis and angiogenic activity. Fertil Steril. 2013;100:1397-404 pubmed publisher

Corrigan A, Shrestha R, Zulkipli I, Hiroi N, Liu Y, Tamura N, et al. Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance. Cell Cycle. 2013;12:2643-55 pubmed publisher

Wang G, Song L, Wang H, Xing N. Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells. Oncol Rep. 2013;30:357-63 pubmed publisher

Yang C, Shogren K, Goyal R, Bravo D, Yaszemski M, Maran A. RNA-dependent protein kinase is essential for 2-methoxyestradiol-induced autophagy in osteosarcoma cells. PLoS ONE. 2013;8:e59406 pubmed publisher

Pérez Sepúlveda A, España Perrot P, Norwitz E, Illanes S. Metabolic pathways involved in 2-methoxyestradiol synthesis and their role in preeclampsia. Reprod Sci. 2013;20:1020-9 pubmed publisher

Ehteda A, Galettis P, Pillai K, Morris D. Combination of albendazole and 2-methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice. BMC Cancer. 2013;13:86 pubmed publisher

Wojcik M, Bobowiec R, Lisiecka U, Kostro K. Proliferation, differentiation and apoptosis of choline deficient ethionine supplemented diet-rat oval cells under the influence of 2-methoxyestradiol. J Physiol Pharmacol. 2012;63:669-76 pubmed

Maran A, Dadsetan M, Buenz C, Shogren K, Lu L, Yaszemski M. Hydrogel-PLGA delivery system prolongs 2-methoxyestradiol-mediated anti-tumor effects in osteosarcoma cells. J Biomed Mater Res A. 2013;101:2491-9 pubmed publisher

Ali H, Kilic G, Vincent K, Motamedi M, Rytting E. Nanomedicine for uterine leiomyoma therapy. Ther Deliv. 2013;4:161-75 pubmed publisher

Elis E, Ehrlich M, Prizan Ravid A, Laham Karam N, Bacharach E. p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes. PLoS Pathog. 2012;8:e1003103 pubmed publisher

Sarkar S, Brautigan D, Parsons S, Larner J. Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells. Oncogene. 2014;33:26-33 pubmed publisher

Yuan W, Yu Y, Li J, Singh P, Li D, Gui Y, et al. Estrogen metabolite 2-methoxyestradiol prevents hypertension in deoxycorticosterone acetate-salt rats. Cardiovasc Drugs Ther. 2013;27:17-22 pubmed publisher

Duncan G, Brenner D, Tusche M, Brüstle A, Knobbe C, Elia A, et al. 2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation. Proc Natl Acad Sci U S A. 2012;109:21034-9 pubmed publisher

Zhou H, Chen X, Zhang W, Zhu L, Cheng L. HIF-1? inhibition reduces nasal inflammation in a murine allergic rhinitis model. PLoS ONE. 2012;7:e48618 pubmed publisher

Shenaq M, Kassem H, Peng C, Schafer S, Ding J, Fredrickson V, et al. Neuronal damage and functional deficits are ameliorated by inhibition of aquaporin and HIF1? after traumatic brain injury (TBI). J Neurol Sci. 2012;323:134-40 pubmed publisher

Drzewiecki B, Anumanthan G, Penn H, Tanaka S, Thomas J, Adams M, et al. Modulation of the hypoxic response following partial bladder outlet obstruction. J Urol. 2012;188:1549-54 pubmed publisher

Pérez Sepúlveda A, Torres M, Valenzuela F, Larraín R, Figueroa Diesel H, Galaz J, et al. Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia. Prenat Diagn. 2012;32:1053-8 pubmed publisher

Legesse Miller A, Raitman I, Haley E, Liao A, Sun L, Wang D, et al. Quiescent fibroblasts are protected from proteasome inhibition-mediated toxicity. Mol Biol Cell. 2012;23:3566-81 pubmed publisher

Machado Linde F, Pelegrin P, Sánchez Ferrer M, Leon J, Cascales P, Parrilla J. 2-methoxyestradiol in the pathophysiology of endometriosis: focus on angiogenesis and therapeutic potential. Reprod Sci. 2012;19:1018-29 pubmed publisher

Peyrat J, Brion J, Alami M. Synthetic 2-methoxyestradiol derivatives: structure-activity relationships. Curr Med Chem. 2012;19:4142-56 pubmed

Stubelius A, Wilhelmson A, Gogos J, Tivesten A, Islander U, Carlsten H. Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout mice. Immunobiology. 2012;217:751-60 pubmed publisher

Guo X, Xing Y, Zhang X, Li J, Mei Q, Zhang H, et al. In vivo controlled release and prolonged antitumor effects of 2-methoxyestradiol solid lipid nanoparticles incorporated into a thermosensitive hydrogel. Drug Deliv. 2012;19:188-93 pubmed publisher

Choi H, Zhu B. Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol. Biochim Biophys Acta. 2012;1823:1306-15 pubmed publisher

Wang Z, Meng C, Shen X, Shu Z, Ma C, Zhu G, et al. Potential contribution of hypoxia-inducible factor-1?, aquaporin-4, and matrix metalloproteinase-9 to blood-brain barrier disruption and brain edema after experimental subarachnoid hemorrhage. J Mol Neurosci. 2012;48:273-80 pubmed publisher

Chen Z, Chen L, Akentieva N, Lichti C, Darbandi R, Hastings R, et al. A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis. Electrophoresis. 2012;33:666-74 pubmed publisher

Gu J, Li J, Zhou Z, Liu J, Huang B, Zheng D, et al. Differentiation induction enhances bortezomib efficacy and overcomes drug resistance in multiple myeloma. Biochem Biophys Res Commun. 2012;420:644-50 pubmed publisher

Ali A, Konakondla S, Zwagerman N, Peng C, Schafer S, Ding J, et al. Glycerol accumulation in edema formation following diffuse traumatic brain injury. Neurol Res. 2012;34:462-8 pubmed publisher

Guo X, Mei Q, Xing Y, Ye L, Zhang H, Shi X, et al. Preparation and cytotoxicity of poly (DL-lactide-co-glycolide) microspheres encapsulating 2-methoxyestradiol. Drug Deliv. 2012;19:143-8 pubmed publisher

Koganti S, Snyder R, Thekkumkara T. Pharmacologic effects of 2-methoxyestradiol on angiotensin type 1 receptor down-regulation in rat liver epithelial and aortic smooth muscle cells. Gend Med. 2012;9:76-93 pubmed publisher

Guo X, Cui F, Xing Y, Mei Q, Zhang Z. Investigation of a new injectable thermosensitive hydrogel loading solid lipid nanoparticles. Pharmazie. 2011;66:948-52 pubmed

Prakasham A, Shanker K, Negi A. A simple and convenient synthesis of 2-methoxyestradiol from estrone. Steroids. 2012;77:467-70 pubmed publisher

Wu S, Xu Z, Huang H, Lin J, Zhan R. [Mechanism associated to enhancing the sensitivity of myeloma cells U266 to bortezomib by 2-methoxyestradiol]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011;19:1424-8 pubmed

Anderson S, Oyama T, Lindsley J, Schutzer W, Beard D, Gattone V, et al. 2-Hydroxyestradiol slows progression of experimental polycystic kidney disease. Am J Physiol Renal Physiol. 2012;302:F636-45 pubmed publisher

Gažák R, Valentova K, Fuksová K, Marhol P, Kuzma M, Medina M, et al. Synthesis and antiangiogenic activity of new silybin galloyl esters. J Med Chem. 2011;54:7397-407 pubmed publisher

Belibi F, Zafar I, Ravichandran K, Segvic A, Jani A, Ljubanovic D, et al. Hypoxia-inducible factor-1? (HIF-1?) and autophagy in polycystic kidney disease (PKD). Am J Physiol Renal Physiol. 2011;300:F1235-43 pubmed publisher

Chetrit D, Barzilay L, Horn G, Bielik T, Smorodinsky N, Ehrlich M. Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis. J Biol Chem. 2011;286:5392-403 pubmed publisher

Gangjee A, Zhao Y, Lin L, Raghavan S, Roberts E, Risinger A, et al. Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance. J Med Chem. 2010;53:8116-28 pubmed publisher

Verenich S, Gerk P. Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges. Mol Pharm. 2010;7:2030-9 pubmed publisher

Leslie B, Holaday C, Nguyen T, Hergenrother P. Phenylcinnamides as novel antimitotic agents. J Med Chem. 2010;53:3964-72 pubmed publisher

Stefely J, Palchaudhuri R, Miller P, Peterson R, Moraski G, Hergenrother P, et al. N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines. J Med Chem. 2010;53:3389-95 pubmed publisher

Jourdan F, Leese M, Dohle W, Hamel E, Ferrandis E, Newman S, et al. Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate. J Med Chem. 2010;53:2942-51 pubmed publisher

Mueck A, Seeger H. 2-Methoxyestradiol--biology and mechanism of action. Steroids. 2010;75:625-31 pubmed publisher

Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher

Suwandi L, Agoston G, Shah J, Hanson A, Zhan X, LaVallee T, et al. Synthesis and antitumor activities of 3-modified 2-methoxyestradiol analogs. Bioorg Med Chem Lett. 2009;19:6459-62 pubmed publisher

Agoston G, Shah J, Suwandi L, Hanson A, Zhan X, LaVallee T, et al. Synthesis, antiproliferative, and pharmacokinetic properties of 3- and 17-double-modified analogs of 2-methoxyestradiol. Bioorg Med Chem Lett. 2009;19:6241-4 pubmed publisher

Shah J, Agoston G, Suwandi L, Hunsucker K, Pribluda V, Zhan X, et al. Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure-activity relationships compared to 2-methoxyestradiol. Bioorg Med Chem. 2009;17:7344-52 pubmed publisher

Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher

Dubey R, Jackson E. Potential vascular actions of 2-methoxyestradiol. Trends Endocrinol Metab. 2009;20:374-9 pubmed publisher

Kirches E, Warich Kirches M. 2-methoxyestradiol as a potential cytostatic drug in gliomas?. Anticancer Agents Med Chem. 2009;9:55-65 pubmed

Dragun D, Haase Fielitz A. Low catechol-O-methyltransferase and 2-methoxyestradiol in preeclampsia: more than a unifying hypothesis. Nephrol Dial Transplant. 2009;24:31-3 pubmed publisher

Ahlin G, Karlsson J, Pedersen J, Gustavsson L, Larsson R, Matsson P, et al. Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. J Med Chem. 2008;51:5932-42 pubmed publisher

Cherkasov A, Ban F, Santos Filho O, Thorsteinson N, Fallahi M, Hammond G. An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin. J Med Chem. 2008;51:2047-56 pubmed publisher

Leese M, Jourdan F, Gaukroger K, Mahon M, Newman S, Foster P, et al. Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. J Med Chem. 2008;51:1295-308 pubmed publisher

Edsall A, Agoston G, Treston A, Plum S, McClanahan R, Lu T, et al. Synthesis and in vivo antitumor evaluation of 2-methoxyestradiol 3-phosphate, 17-phosphate, and 3,17-diphosphate. J Med Chem. 2007;50:6700-5 pubmed

Agoston G, Shah J, LaVallee T, Zhan X, Pribluda V, Treston A. Synthesis and structure-activity relationships of 16-modified analogs of 2-methoxyestradiol. Bioorg Med Chem. 2007;15:7524-37 pubmed

Zhou D, Matchett G, Jadhav V, Dach N, Zhang J. The effect of 2-methoxyestradiol, a HIF-1 alpha inhibitor, in global cerebral ischemia in rats. Neurol Res. 2008;30:268-71 pubmed

Bubert C, Leese M, Mahon M, Ferrandis E, Regis Lydi S, Kasprzyk P, et al. 3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activity. J Med Chem. 2007;50:4431-43 pubmed

Sutherland T, Anderson R, Hughes R, Altmann E, Schuliga M, Ziogas J, et al. 2-Methoxyestradiol--a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents. Drug Discov Today. 2007;12:577-84 pubmed

Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed

Dantas A, Sandberg K. Does 2-methoxyestradiol represent the new and improved hormone replacement therapy for atherosclerosis?. Circ Res. 2006;99:234-7 pubmed

Kachadourian R, Day B. Flavonoid-induced glutathione depletion: potential implications for cancer treatment. Free Radic Biol Med. 2006;41:65-76 pubmed

Ho A, Kim Y, Lee H, Cyrus K, Baek S, Kim K. SAR studies of 2-methoxyestradiol and development of its analogs as probes of anti-tumor mechanisms. Bioorg Med Chem Lett. 2006;16:3383-7 pubmed

Schumacher G, Neuhaus P. [2-Methoxyestradiol -- a new compound for cancer treatment]. Dtsch Med Wochenschr. 2006;131:825-30 pubmed

Leese M, Hejaz H, Mahon M, Newman S, Purohit A, Reed M, et al. A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents. J Med Chem. 2005;48:5243-56 pubmed

Bonham M, Posakony J, Coleman I, Montgomery B, Simon J, Nelson P. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res. 2005;11:3905-14 pubmed

Lakhani N, Lepper E, Sparreboom A, Dahut W, Venitz J, Figg W. Determination of 2-methoxyestradiol in human plasma, using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2005;19:1176-82 pubmed

Lakhani N, Sparreboom A, Dahut W, Venitz J, Figg W. Determination of the antiangiogenesis agent 2-methoxyestradiol in human plasma by liquid chromatography with ultraviolet detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;806:289-93 pubmed

Mooberry S. Mechanism of action of 2-methoxyestradiol: new developments. Drug Resist Updat. 2003;6:355-61 pubmed

Lambert C, Apel K, Biesalski H, Frank J. 2-methoxyestradiol induces caspase-independent, mitochondria-centered apoptosis in DS-sarcoma cells. Int J Cancer. 2004;108:493-501 pubmed

Mooberry S. New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. Curr Opin Oncol. 2003;15:425-30 pubmed

Lakhani N, Sarkar M, Venitz J, Figg W. 2-Methoxyestradiol, a promising anticancer agent. Pharmacotherapy. 2003;23:165-72 pubmed

Pita A, Wakabayashi Y, Fernandez Bustos M, Virgili N, Riudor E, Soler J, et al. Plasma urea-cycle-related amino acids, ammonium levels, and urinary orotic acid excretion in short-bowel patients managed with an oral diet. Clin Nutr. 2003;22:93-8 pubmed

Bu S, Blaukat A, Fu X, Heldin N, Landström M. Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells. FEBS Lett. 2002;531:141-51 pubmed

Kumar A, Garcia G, Slaga T. 2-methoxyestradiol blocks cell-cycle progression at G(2)/M phase and inhibits growth of human prostate cancer cells. Mol Carcinog. 2001;31:111-24 pubmed

Schumacher G, Neuhaus P. The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors. J Cancer Res Clin Oncol. 2001;127:405-10 pubmed

Pribluda V, Gubish E, Lavallee T, Treston A, Swartz G, Green S. 2-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate. Cancer Metastasis Rev. 2000;19:173-9 pubmed

Zhu B, Conney A. Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis?. Cancer Res. 1998;58:2269-77 pubmed

Dubey R, Gillespie D, Jackson E, Keller P. 17Beta-estradiol, its metabolites, and progesterone inhibit cardiac fibroblast growth. Hypertension. 1998;31:522-8 pubmed

Yue T, Wang X, Louden C, Gupta S, Pillarisetti K, Gu J, et al. 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression. Mol Pharmacol. 1997;51:951-62 pubmed

Klauber N, Parangi S, Flynn E, Hamel E, D Amato R. Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer Res. 1997;57:81-6 pubmed

Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M. Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995;176:61-8 pubmed