This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Mefenamic acid
catalog :
M4267
citations: 70
Reference
Yamaoka T, Kitamura Y. Characterization of a highly sensitive and selective novel trapping reagent, stable isotope labeled glutathione ethyl ester, for the detection of reactive metabolites. J Pharmacol Toxicol Methods. 2015;76:83-95 pubmed publisher
Gautschi N, van Hoogevest P, Kuentz M. Amorphous drug dispersions with mono- and diacyl lecithin: On molecular categorization of their feasibility and UV dissolution imaging. Int J Pharm. 2015;491:218-30 pubmed publisher
Mirzaei M, Mehravi B, Ardestani M, Ziaee S, Pourghasem P. In Vitro Evaluation of Gd(3+)-Anionic Linear Globular Dendrimer-Monoclonal Antibody: Potential Magnetic Resonance Imaging Contrast Agents for Prostate Cancer Cell Imaging. Mol Imaging Biol. 2015;17:770-6 pubmed publisher
Alshehri S, Park J, Alsulays B, Tiwari R, Almutairy B, Alshetaili A, et al. Mefenamic acid taste-masked oral disintegrating tablets with enhanced solubility via molecular interaction produced by hot melt extrusion technology. J Drug Deliv Sci Technol. 2015;27:18-27 pubmed
Wu J, Li M. Inhibitory effects of pain relief drugs on neurological enzymes: implications on their potential neurotoxicity to aquatic animals. Environ Toxicol Pharmacol. 2015;39:898-905 pubmed publisher
Tian X, Huo X, Dong P, Wu B, Wang X, Wang C, et al. Sulfation of melatonin: enzymatic characterization, differences of organs, species and genders, and bioactivity variation. Biochem Pharmacol. 2015;94:282-96 pubmed publisher
Nebot C, Falcon R, Boyd K, Gibb S. Introduction of human pharmaceuticals from wastewater treatment plants into the aquatic environment: a rural perspective. Environ Sci Pollut Res Int. 2015;22:10559-68 pubmed publisher
Azzouz A, Ballesteros E. Multiresidue method for the determination of pharmacologically active substances in egg and honey using a continuous solid-phase extraction system and gas chromatography-mass spectrometry. Food Chem. 2015;178:63-9 pubmed publisher
Chen G, den Braver M, Van Gestel C, Van Straalen N, Roelofs D. Ecotoxicogenomic assessment of diclofenac toxicity in soil. Environ Pollut. 2015;199:253-60 pubmed publisher
Miller T, McEneff G, Brown R, Owen S, Bury N, Barron L. Pharmaceuticals in the freshwater invertebrate, Gammarus pulex, determined using pulverised liquid extraction, solid phase extraction and liquid chromatography-tandem mass spectrometry. Sci Total Environ. 2015;511:153-60 pubmed publisher
Pugh C, Pouncey D, Hartman J, Nshimiyimana R, Desrochers L, Goodwin T, et al. Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites. Arch Biochem Biophys. 2014;564:244-53 pubmed publisher
Tanwar S, Di Carro M, Magi E. Innovative sampling and extraction methods for the determination of nonsteroidal anti-inflammatory drugs in water. J Pharm Biomed Anal. 2015;106:100-6 pubmed publisher
Ba S, Jones J, Cabana H. Hybrid bioreactor (HBR) of hollow fiber microfilter membrane and cross-linked laccase aggregates eliminate aromatic pharmaceuticals in wastewaters. J Hazard Mater. 2014;280:662-70 pubmed publisher
Manzo V, Honda L, Navarro O, Ascar L, Richter P. Microextraction of non-steroidal anti-inflammatory drugs from waste water samples by rotating-disk sorptive extraction. Talanta. 2014;128:486-92 pubmed publisher
Shah U, Olusanmi D, Narang A, Hussain M, Tobyn M, Hinder S, et al. Decoupling the contribution of surface energy and surface area on the cohesion of pharmaceutical powders. Pharm Res. 2015;32:248-59 pubmed publisher
Shah K, Shrivastava S, Mishra P. Formulation and evaluation of suspensions: mefenamic acid prodrugs. Pak J Pharm Sci. 2014;27:917-23 pubmed
Venkataraman H, Verkade Vreeker M, Capoferri L, Geerke D, Vermeulen N, Commandeur J. Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs. Bioorg Med Chem. 2014;22:5613-20 pubmed publisher
Tanoue R, Nomiyama K, Nakamura H, Hayashi T, Kim J, Isobe T, et al. Simultaneous determination of polar pharmaceuticals and personal care products in biological organs and tissues. J Chromatogr A. 2014;1355:193-205 pubmed publisher
Shah U, Olusanmi D, Narang A, Hussain M, Gamble J, Tobyn M, et al. Effect of crystal habits on the surface energy and cohesion of crystalline powders. Int J Pharm. 2014;472:140-7 pubmed publisher
Reichert C, Reichert P, Monnet Tschudi F, Kupferschmidt H, Ceschi A, Rauber Lüthy C. Seizures after single-agent overdose with pharmaceutical drugs: analysis of cases reported to a poison center. Clin Toxicol (Phila). 2014;52:629-34 pubmed publisher
Uehara K, Tagami T, Miyazaki I, Murata N, Takahashi Y, Ohkubo H, et al. Effect of X-ray exposure on the pharmaceutical quality of drug tablets using X-ray inspection equipment. Drug Dev Ind Pharm. 2015;41:953-8 pubmed publisher
Al Qaim F, Abdullah M, Othman M, Latip J, Zakaria Z. Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals. J Chromatogr A. 2014;1345:139-53 pubmed publisher
Williams H, Van Speybroeck M, Augustijns P, Porter C. Lipid-based formulations solidified via adsorption onto the mesoporous carrier Neusilin® US2: effect of drug type and formulation composition on in vitro pharmaceutical performance. J Pharm Sci. 2014;103:1734-46 pubmed publisher
Jinno N, Tagashira M, Tsurui K, Yamada S. Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes. Xenobiotica. 2014;44:677-86 pubmed publisher
Bansal Y, Silakari O. Synthesis and pharmacological evaluation of polyfunctional benzimidazole-NSAID chimeric molecules combining anti-inflammatory, immunomodulatory and antioxidant activities. Arch Pharm Res. 2014;37:1426-36 pubmed publisher
Shah K, Shrivastava S, Mishra P. Synthesis, kinetics and pharmacological evaluation of mefenamic acid mutual prodrug. Acta Pol Pharm. 2013;70:905-11 pubmed
Cimolai N. The potential and promise of mefenamic acid. Expert Rev Clin Pharmacol. 2013;6:289-305 pubmed publisher
Sørdal T, Inki P, Draeby J, O Flynn M, Schmelter T. Management of initial bleeding or spotting after levonorgestrel-releasing intrauterine system placement: a randomized controlled trial. Obstet Gynecol. 2013;121:934-41 pubmed publisher
Soper D. The intrauterine device: a good thing revisited. Obstet Gynecol. 2013;121:919-20 pubmed publisher
Gander T, Bingoel A, Mascolo L, Gratz K, Lübbers H. [Infection after dental intervention. Iatrogenic or general medical cause? Case report]. Schweiz Monatsschr Zahnmed. 2013;123:19-31 pubmed
Horng H, Benet L. Characterization of the acyl-adenylate linked metabolite of mefenamic Acid. Chem Res Toxicol. 2013;26:465-76 pubmed publisher
Zhang X, Gong Z. Fluorescent transgenic zebrafish Tg(nkx2.2a:mEGFP) provides a highly sensitive monitoring tool for neurotoxins. PLoS ONE. 2013;8:e55474 pubmed publisher
Gupta J, Kai J, Middleton L, Pattison H, Gray R, Daniels J. Levonorgestrel intrauterine system versus medical therapy for menorrhagia. N Engl J Med. 2013;368:128-37 pubmed publisher
Kasichayanula S, Liu X, Griffen S, LaCreta F, Boulton D. Effects of rifampin and mefenamic acid on the pharmacokinetics and pharmacodynamics of dapagliflozin. Diabetes Obes Metab. 2013;15:280-3 pubmed publisher
Lee E, Byrn S, Pinal R. The solution properties of mefenamic acid and a closely related analogue are indistinguishable in polar solvents but significantly different in nonpolar environments. J Pharm Sci. 2012;101:4529-39 pubmed publisher
Jabeen S, Dines T, Leharne S, Chowdhry B. Raman and IR spectroscopic studies of fenamates--conformational differences in polymorphs of flufenamic acid, mefenamic acid and tolfenamic acid. Spectrochim Acta A Mol Biomol Spectrosc. 2012;96:972-85 pubmed publisher
Flanagan J, Yosaatmadja Y, Teague R, Chai M, Turnbull A, Squire C. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. PLoS ONE. 2012;7:e43965 pubmed publisher
Pulgarin J, Molina A, Ferreras F. Simultaneous determination of mefenamic and tolfenamic acids in real samples by terbium-sensitized luminescence. J Fluoresc. 2012;22:1483-92 pubmed publisher
Downard C, Matheson P, Shepherd J, Maki A, Garrison R. Direct peritoneal resuscitation augments ileal blood flow in necrotizing enterocolitis via a novel mechanism. J Pediatr Surg. 2012;47:1128-34 pubmed publisher
Grillo M, Tadano Lohr M, Wait J. Metabolic activation of mefenamic acid leading to mefenamyl-S-acyl-glutathione adduct formation in vitro and in vivo in rat. Drug Metab Dispos. 2012;40:1515-26 pubmed publisher
Han D, Zheng Y, Chen X, He J, Zhao D, Yang S, et al. Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of salvianolic acid A. Drug Metab Pharmacokinet. 2012;27:579-85 pubmed
Chittenden B, Dallas S, Jack S. Trends in the surgical options for the treatment of menorrhagia in Scotland: examination of health episode statistics, 2000-2008. Scott Med J. 2012;57:92-4 pubmed publisher
Armagan G, Kanit L, Yalcin A. Effects of non-steroidal antiinflammatory drugs on D-serine-induced oxidative stress in vitro. Drug Chem Toxicol. 2012;35:393-8 pubmed publisher
Armagan G, Turunc E, Kanit L, Yalcin A. Neuroprotection by mefenamic acid against D-serine: involvement of oxidative stress, inflammation and apoptosis. Free Radic Res. 2012;46:726-39 pubmed publisher
Takekuma Y, Yagisawa K, Sugawara M. Mutual inhibition between carvedilol enantiomers during racemate glucuronidation mediated by human liver and intestinal microsomes. Biol Pharm Bull. 2012;35:151-63 pubmed
Mahadik M, Dhaneshwar S, Bhavsar R. A high performance liquid chromatography-tandem mass spectrometric method for the determination of mefenamic acid in human plasma: application to pharmacokinetic study. Biomed Chromatogr. 2012;26:1137-42 pubmed publisher
Hegazy G, Ali H. Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids. Bioorg Med Chem. 2012;20:1259-70 pubmed publisher
Kojima T, Higashi K, Suzuki T, Tomono K, Moribe K, Yamamoto K. Stabilization of a supersaturated solution of mefenamic acid from a solid dispersion with EUDRAGIT(®) EPO. Pharm Res. 2012;29:2777-91 pubmed publisher
Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W. Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS Comput Biol. 2011;7:e1002310 pubmed publisher
Hasanzadeh M, Shadjou N, Saghatforoush L, Dolatabadi J. Preparation of a new electrochemical sensor based on iron (III) complexes modified carbon paste electrode for simultaneous determination of mefenamic acid and indomethacin. Colloids Surf B Biointerfaces. 2012;92:91-7 pubmed publisher
Etman M, Farid R, Nada A, Ebian A. In vitro/in vivo correlation of fast release mephenamic acid microspheres in humans. Med Princ Pract. 2012;21:223-7 pubmed publisher
Dimiza F, Fountoulaki S, Papadopoulos A, Kontogiorgis C, Tangoulis V, Raptopoulou C, et al. Non-steroidal antiinflammatory drug-copper(II) complexes: structure and biological perspectives. Dalton Trans. 2011;40:8555-68 pubmed publisher
Pomykalski A, Hopkała H. Comparison of classic and derivative UV spectrophotometric methods for quantification of meloxicam and mefenamic acid in pharmaceutical preparations. Acta Pol Pharm. 2011;68:317-23 pubmed
Moll R, Derry S, Moore R, McQuay H. Single dose oral mefenamic acid for acute postoperative pain in adults. Cochrane Database Syst Rev. 2011;:CD007553 pubmed publisher
Choi S, Kelly J. A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin. Bioorg Med Chem. 2011;19:1505-14 pubmed publisher
Uramaru N, Shigematsu H, Toda A, Eyanagi R, Kitamura S, Ohta S. Design, synthesis, and pharmacological activity of nonallergenic pyrazolone-type antipyretic analgesics. J Med Chem. 2010;53:8727-33 pubmed publisher
Ekins S, Williams A, Xu J. A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug Metab Dispos. 2010;38:2302-8 pubmed publisher
Gozalbes R, Pineda Lucena A. QSAR-based solubility model for drug-like compounds. Bioorg Med Chem. 2010;18:7078-84 pubmed publisher
Greene N, Fisk L, Naven R, Note R, Patel M, Pelletier D. Developing structure-activity relationships for the prediction of hepatotoxicity. Chem Res Toxicol. 2010;23:1215-22 pubmed publisher
Uehara T, Ono A, Maruyama T, Kato I, Yamada H, Ohno Y, et al. The Japanese toxicogenomics project: application of toxicogenomics. Mol Nutr Food Res. 2010;54:218-27 pubmed publisher
Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher
Abdel Azeem A, Abdel Hafez A, El Karamany G, Farag H. Chlorzoxazone esters of some non-steroidal anti-inflammatory (NSAI) carboxylic acids as mutual prodrugs: design, synthesis, pharmacological investigations and docking studies. Bioorg Med Chem. 2009;17:3665-70 pubmed publisher
Brickelmaier M, Lugovskoy A, Kartikeyan R, Reviriego Mendoza M, Allaire N, Simon K, et al. Identification and characterization of mefloquine efficacy against JC virus in vitro. Antimicrob Agents Chemother. 2009;53:1840-9 pubmed publisher
Pérez Garrido A, Morales Helguera A, Abellán Guillén A, Cordeiro M, Garrido Escudero A. Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Bioorg Med Chem. 2009;17:896-904 pubmed publisher
Molvi K, Vasu K, Yerande S, Sudarsanam V, Haque N. Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents. Eur J Med Chem. 2007;42:1049-58 pubmed
Künzel A, Haschke M, Surber C, Lambrecht J. [Mefenamic acid and other non-steroidal anti-inflammatory agents in dental practice. A review of the literature]. Schweiz Monatsschr Zahnmed. 2007;117:12-8 pubmed
Stock N, Munoz B, Wrigley J, Shearman M, Beher D, Peachey J, et al. The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006;16:2219-23 pubmed
Kiang T, Ensom M, Chang T. UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacol Ther. 2005;106:97-132 pubmed
Petrova I, Aleksandrova G. [Effect of mefenamic acid and sodium salicylate on lymphocyte transformation due to phytohemagglutinin]. Farmakol Toksikol. 1980;43:184-6 pubmed
Singh G, Choudhury P. Mefenamic acid. Indian Pediatr. 1989;26:577-9 pubmed
product information
Catalog Number :
M4267
Product Name :
Mefenamic acid
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA