This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
α-Methyl-DL-tyrosine methyl ester hydrochloride
catalog :
M3281
citations: 31
Reference
Holland J, Sorrell J, Yates E, Smith K, Arbabi S, Arnold M, et al. A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake. Cell Rep. 2019;27:2399-2410.e6 pubmed publisher
Salvatore M, McInnis T, Cantu M, Apple D, Pruett B. Tyrosine Hydroxylase Inhibition in Substantia Nigra Decreases Movement Frequency. Mol Neurobiol. 2019;56:2728-2740 pubmed publisher
Sidor M, Spencer S, Dzirasa K, Parekh P, Tye K, Warden M, et al. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Mol Psychiatry. 2015;20:1406-19 pubmed publisher
Salvatore M, Pruett B. Dichotomy of tyrosine hydroxylase and dopamine regulation between somatodendritic and terminal field areas of nigrostriatal and mesoaccumbens pathways. PLoS ONE. 2012;7:e29867 pubmed publisher
Rung J, Rung E, Johansson A, Svensson K, Carlsson A, Carlsson M. Effects of the dopamine stabilizers (S)-(-)-OSU6162 and ACR16 on prolactin secretion in drug-naive and monoamine-depleted rats. Naunyn Schmiedebergs Arch Pharmacol. 2011;384:39-45 pubmed publisher
Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher
Miguelez C, Fernandez Aedo I, Torrecilla M, Grandoso L, Ugedo L. alpha(2)-Adrenoceptors mediate the acute inhibitory effect of fluoxetine on locus coeruleus noradrenergic neurons. Neuropharmacology. 2009;56:1068-73 pubmed publisher
Lu A, Steiner M, Whittle N, Vogl A, Walser S, Ableitner M, et al. Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Mol Psychiatry. 2008;13:1028-42 pubmed publisher
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
Venugopal J, Ramakrishna S. Inhibition of ATPases enzyme activities on brain disturbing normal oestrous cycle. Neurochem Res. 2005;30:315-23 pubmed
Kennedy S, Nickerson M, Campisi J, Johnson J, Smith T, Sharkey C, et al. Splenic norepinephrine depletion following acute stress suppresses in vivo antibody response. J Neuroimmunol. 2005;165:150-60 pubmed
McDougall S, Hernandez R, Reichel C, Farley C. The partial D2-like dopamine receptor agonist terguride acts as a functional antagonist in states of high and low dopaminergic tone: evidence from preweanling rats. Psychopharmacology (Berl). 2005;178:431-9 pubmed
Hibbert B, Fung I, McAuley R, Samia M, Trudeau V. Catecholamine depletion modulates serum LH levels, GAD67 mRNA, and GABA synthesis in the goldfish. Gen Comp Endocrinol. 2005;140:176-83 pubmed
Gołembiowska K, Dziubina A. Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats. Neuropharmacology. 2004;47:414-26 pubmed
Kuzmin A, Sandin J, Terenius L, Ogren S. Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol. 2004;141:132-40 pubmed
Sivitz W, Fink B, Morgan D, Fox J, Donohoue P, Haynes W. Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats. Am J Physiol. 1999;277:E668-77 pubmed publisher
Kelly M, Rubinstein M, Phillips T, Lessov C, Burkhart Kasch S, Zhang G, et al. Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. J Neurosci. 1998;18:3470-9 pubmed
Migliorini R, Garofalo M, Kettelhut I. Increased sympathetic activity in rat white adipose tissue during prolonged fasting. Am J Physiol. 1997;272:R656-61 pubmed
Nyquist Battie C, Cochran P, Evans V, Hitchcock J, Unal C. Regulation of sympathetic presynaptic components in rat left ventricle during ligation of abdominal aorta. Am J Physiol. 1996;271:H1547-54 pubmed
Neckameyer W. Multiple roles for dopamine in Drosophila development. Dev Biol. 1996;176:209-19 pubmed
Waters N, Svensson K, Haadsma Svensson S, Smith M, Carlsson A. The dopamine D3-receptor: a postsynaptic receptor inhibitory on rat locomotor activity. J Neural Transm Gen Sect. 1993;94:11-9 pubmed
Murthy C, Zheng W, Trudeau V, Nahorniak C, Rivier J, Peter R. In vivo actions of a gonadotropin-releasing hormone (GnRH) antagonist on gonadotropin-II and growth hormone secretion in goldfish, Carassius auratus. Gen Comp Endocrinol. 1994;96:427-37 pubmed
Kuhn C, Surwit R, Feinglos M. Glipizide stimulates sympathetic outflow in diabetes-prone mice. Life Sci. 1995;56:661-6 pubmed
Sundstrom E, Fredriksson A, Archer T. Chronic neurochemical and behavioral changes in MPTP-lesioned C57BL/6 mice: a model for Parkinson's disease. Brain Res. 1990;528:181-8 pubmed
Maruyama Y, Awaji T, Inoue M, Takeo S. Protective effects of befunolol on hypoxic respiration-induced alterations in myocardial energy metabolism of rats. Arzneimittelforschung. 1991;41:1022-6 pubmed
Di Lullo S, Martin Iverson M. Presynaptic dopaminergic neurotransmission mediates amphetamine-induced unconditioned but not amphetamine-conditioned locomotion and defecation in the rat. Brain Res. 1991;568:45-54 pubmed
Macdonald E, Scheinin M, Scheinin H, Virtanen R. Comparison of the behavioral and neurochemical effects of the two optical enantiomers of medetomidine, a selective alpha-2-adrenoceptor agonist. J Pharmacol Exp Ther. 1991;259:848-54 pubmed
Pequignot J, Hellstrom S, Forsgren S, Cottet Emard J, Peyrin L. Transection of carotid sinus nerve inhibits the turnover of dopamine and norepinephrine in long-term hypoxic carotid bodies: a biochemical and morphometric study. J Auton Nerv Syst. 1991;32:165-76 pubmed
Bazzett T, Lumley L, Bitran D, Markowski V, Warner R, Hull E. Male rat copulation following 6-OHDA lesions of the medial preoptic area: resistance to repeated administration and rapid behavioral recovery. Brain Res. 1992;580:164-70 pubmed
Paalzow G. L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses. J Pharmacol Exp Ther. 1992;263:470-9 pubmed
Liaw J, He J, Hartman R, Barraclough C. Changes in tyrosine hydroxylase mRNA levels in medullary A1 and A2 neurons and locus coeruleus following castration and estrogen replacement in rats. Brain Res Mol Brain Res. 1992;13:231-8 pubmed
product information
Catalog Number :
M3281
Product Name :
α-Methyl-DL-tyrosine methyl ester hydrochloride
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA