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Segovia M, Russo S, Jeldres M, Mahmoud Y, Perez V, Duhalde M, et al. Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation. Cancer Cell. 2019;35:767-781.e6 pubmed publisher

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Warwick C, Shutov L, Shepherd A, Mohapatra D, Usachev Y. Mechanisms underlying mechanical sensitization induced by complement C5a: the roles of macrophages, TRPV1, and calcitonin gene-related peptide receptors. Pain. 2019;160:702-711 pubmed publisher

Bae S, Yu J, Jeong H, Oh T. Anti-pruritic effect of topical capsaicin against histamine-induced pruritus on canine skin. Pol J Vet Sci. 2018;21:789-796 pubmed publisher

Mo K, Wu S, Gu X, Xiong M, Cai W, Atianjoh F, et al. MBD1 Contributes to the Genesis of Acute Pain and Neuropathic Pain by Epigenetic Silencing of Oprm1 and Kcna2 Genes in Primary Sensory Neurons. J Neurosci. 2018;38:9883-9899 pubmed publisher

Zhang Y, Liu S, Zhang Y, Goulding M, Wang Y, Ma Q. Timing Mechanisms Underlying Gate Control by Feedforward Inhibition. Neuron. 2018;99:941-955.e4 pubmed publisher

Jeong J, Lee D, Liu S, Chua S, Schwartz G, Jo Y. Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. PLoS Biol. 2018;16:e2004399 pubmed publisher

Wang S, Ko S, Kim Y, Jo S, Lee S, Jung S, et al. Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice. Exp Mol Med. 2018;50:e455 pubmed publisher

Dawes J, Weir G, Middleton S, Patel R, Chisholm K, Pettingill P, et al. Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability. Neuron. 2018;97:806-822.e10 pubmed publisher

Barragán Iglesias P, Lou T, Bhat V, Megat S, Burton M, Price T, et al. Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice. Nat Commun. 2018;9:10 pubmed publisher

Krull A, Larsen S, Clifton D, Neal Perry G, Steiner R. A Comprehensive Method To Quantify Adaptations by Male and Female Mice With Hot Flashes Induced by the Neurokinin B Receptor Agonist Senktide. Endocrinology. 2017;158:3259-3268 pubmed publisher

Khoutorsky A, Sorge R, Prager Khoutorsky M, Pawlowski S, Longo G, Jafarnejad S, et al. eIF2? phosphorylation controls thermal nociception. Proc Natl Acad Sci U S A. 2016;113:11949-11954 pubmed

Sarwa K, Mazumder B, Suresh P, Kaur C. Topical Analgesic Nanolipid Vesicles Formulation of Capsaicinoids Extract of Bhut Jolokia (Capsicum chinense Jacq): Pharmacodynamic Evaluation in Rat Models and Acceptability studies in Human Volunteers. Curr Drug Deliv. 2016;13:1325-1338 pubmed

Fong S, Lin H, Wu M, Chen C, Huang Y. CPEB3 Deficiency Elevates TRPV1 Expression in Dorsal Root Ganglia Neurons to Potentiate Thermosensation. PLoS ONE. 2016;11:e0148491 pubmed publisher

Shim Y, Kim J, Jeong S. Simultaneous Determination of Piperine, Capsaicin, and Dihydrocapsaicin in Korean Instant-Noodle (Ramyun) Soup Base Using High-Performance Liquid Chromatography with Ultraviolet Detection. J AOAC Int. 2016;99:187-92 pubmed publisher

Ogawa N, Kurokawa T, Fujiwara K, Polat O, Badr H, Takahashi N, et al. Functional and Structural Divergence in Human TRPV1 Channel Subunits by Oxidative Cysteine Modification. J Biol Chem. 2016;291:4197-210 pubmed publisher

Beerman R, Matty M, Au G, Looger L, Choudhury K, Keller P, et al. Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux. Cell Rep. 2015;13:2107-17 pubmed publisher

Chen S, Chiu C, McArthur K, Fetcho J, Prober D. TRP channel mediated neuronal activation and ablation in freely behaving zebrafish. Nat Methods. 2016;13:147-50 pubmed publisher

Marini E, Magi G, Mingoia M, Pugnaloni A, Facinelli B. Antimicrobial and Anti-Virulence Activity of Capsaicin Against Erythromycin-Resistant, Cell-Invasive Group A Streptococci. Front Microbiol. 2015;6:1281 pubmed publisher

Park C. Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus. Mediators Inflamm. 2015;2015:275126 pubmed publisher

Wang X, Tian B, Huang Y, Peng X, Chen L, Li J, et al. Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice. Sci Rep. 2015;5:16768 pubmed publisher

Silva D, de Almeida M, Chaves C, Braz A, Gomes M, Pinho da Silva L, et al. TRPM8 Channel Activation Induced by Monoterpenoid Rotundifolone Underlies Mesenteric Artery Relaxation. PLoS ONE. 2015;10:e0143171 pubmed publisher

Boisvert E, Engle S, Hallowell S, Liu P, Wang Z, Li X. The Specification and Maturation of Nociceptive Neurons from Human Embryonic Stem Cells. Sci Rep. 2015;5:16821 pubmed publisher

Iwata T, Ito I, Niimi A, Ikegami K, Marumo S, Tanabe N, et al. Mechanical Stimulation by Postnasal Drip Evokes Cough. PLoS ONE. 2015;10:e0141823 pubmed publisher

Martinez Espinosa P, Wu J, Yang C, González Pérez V, Zhou H, Liang H, et al. Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. elife. 2015;4: pubmed publisher

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Lim J, Kim G, Mo C, Kim M. Design and Fabrication of a Real-Time Measurement System for the Capsaicinoid Content of Korean Red Pepper (Capsicum annuum L.) Powder by Visible and Near-Infrared Spectroscopy. Sensors (Basel). 2015;15:27420-35 pubmed publisher

Ciardo M, Andrés Bordería A, Cuesta N, Valente P, Camprubí Robles M, Yang J, et al. Whirlin increases TRPV1 channel expression and cellular stability. Biochim Biophys Acta. 2016;1863:115-27 pubmed publisher

Vijayvergiya V, Acharya S, Wilson S, Schmidt J. Measurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers. PLoS ONE. 2015;10:e0141366 pubmed publisher

Hu M, Liu Y, Wu J, Liu X. Influx-Operated Ca(2+) Entry via PKD2-L1 and PKD1-L3 Channels Facilitates Sensory Responses to Polymodal Transient Stimuli. Cell Rep. 2015;13:798-811 pubmed publisher

Raoof M, Esmaeili Mahani S, Nourzadeh M, Raoof R, Abbasnejad M, Amirkhosravi L, et al. Noxious Stimulation of the Rat Tooth Pulp May Impair Learning and Memory Through the Induction of Hippocampal Apoptosis. J Oral Facial Pain Headache. 2015;29:390-7 pubmed publisher

Tamaddonfard E, Tamaddonfard S, Pourbaba S. Effects of intra-fourth ventricle injection of crocin on capsaicin-induced orofacial pain in rats. Avicenna J Phytomed. 2015;5:450-7 pubmed

Li J, Cong X, Zhang Y, Xiang R, Mei M, Yang N, et al. ZO-1 and -2 Are Required for TRPV1-Modulated Paracellular Permeability. J Dent Res. 2015;94:1748-56 pubmed publisher

Gao X, Qin Q, Yu X, Liu K, Li L, Qiao H, et al. Acupuncture at heterotopic acupoints facilitates distal colonic motility via activating M3 receptors and somatic afferent C-fibers in normal, constipated, or diarrhoeic rats. Neurogastroenterol Motil. 2015;27:1817-30 pubmed publisher

Kimura M, Suto T, Eisenach J, Hayashida K. Down-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in rats. Neurosci Lett. 2015;608:18-22 pubmed publisher

Kim S, Oh E, Lee J, Nam D, Lee S, Lee J, et al. Brassinin Combined with Capsaicin Enhances Apoptotic and Anti-metastatic Effects in PC-3 Human Prostate Cancer Cells. Phytother Res. 2015;29:1828-36 pubmed publisher

Li Y, Adamek P, Zhang H, Tatsui C, Rhines L, Mrozkova P, et al. The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4. J Neurosci. 2015;35:13487-500 pubmed publisher

Deba F, Bessac B. Anoctamin-1 Cl(-) channels in nociception: activation by an N-aroylaminothiazole and capsaicin and inhibition by T16A[inh]-A01. Mol Pain. 2015;11:55 pubmed publisher

Lagatta D, Ferreira Junior N, Resstel L. Medial prefrontal cortex TRPV1 channels modulate the baroreflex cardiac activity in rats. Br J Pharmacol. 2015;172:5377-89 pubmed publisher

Nguelefack T, Dutra R, Paszcuk A, de Andrade E, Calixto J. TRPV1 channel inhibition contributes to the antinociceptive effects of Croton macrostachyus extract in mice. BMC Complement Altern Med. 2015;15:293 pubmed publisher

Shinoda M, Takeda M, Honda K, Maruno M, Katagiri A, Satoh Kuriwada S, et al. Involvement of peripheral artemin signaling in tongue pain: possible mechanism in burning mouth syndrome. Pain. 2015;156:2528-37 pubmed publisher

Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Sawada S, et al. A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals. Nat Commun. 2015;6:7940 pubmed publisher

Bomba F, Wandji B, Piegang B, Awouafack M, Sriram D, Yogeeswari P, et al. Antinociceptive properties of the aqueous and methanol extracts of the stem bark of Petersianthus macrocarpus (P. Beauv.) Liben (Lecythidaceae) in mice. J Ethnopharmacol. 2015;174:66-73 pubmed publisher

Lee Y, Chen H, Su L, Chueh P. Sirtuin 1 (SIRT1) Deacetylase Activity and NAD⁺/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death. J Agric Food Chem. 2015;63:7361-70 pubmed publisher

Gregorio Teruel L, Valente P, Liu B, Fernández Ballester G, Qin F, Ferrer Montiel A. The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating. Biophys J. 2015;109:529-41 pubmed publisher

Byrnes N, Nestrud M, Hayes J. Perceptual mapping of chemesthetic stimuli in naïve assessors. Chemosens Percept. 2015;8:19-32 pubmed

Giummarra M, Georgiou Karistianis N, Verdejo Garcia A, Gibson S. Feeling the burn: When it looks like it hurts, and belongs to me, it really does hurt more. Conscious Cogn. 2015;36:314-26 pubmed publisher

Gentry C, Andersson D, Bevan S. TRPA1 mediates the hypothermic action of acetaminophen. Sci Rep. 2015;5:12771 pubmed publisher

Ramirez H, Queeney T, Dunbar M, Eichner M, Del Castillo D, BATTLES A, et al. Assessment of an Orofacial Operant Pain Assay as a Preclinical Tool for Evaluating Analgesic Efficacy in Rodents. J Am Assoc Lab Anim Sci. 2015;54:426-32 pubmed

Javed S, Alam U, Malik R. Burning through the pain: treatments for diabetic neuropathy. Diabetes Obes Metab. 2015;17:1115-25 pubmed publisher

Szteyn K, Rowan M, Gomez R, Du J, Carlton S, Jeske N. A-kinase anchoring protein 79/150 coordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons. Pain. 2015;156:2364-72 pubmed publisher

Jiao H, Su W, Li P, Liao Y, Zhou Q, Zhu N, et al. Therapeutic effects of naringin in a guinea pig model of ovalbumin-induced cough-variant asthma. Pulm Pharmacol Ther. 2015;33:59-65 pubmed publisher

Bencsik T, Sándor Z, Bartho L. High-Concentration Piperine: Capsaicin-Sensitive and -Insensitive Effects on Isolated Organs. Pharmacology. 2015;96:86-9 pubmed publisher

Sasaki T, Kinoshita Y, Matsui S, Kakuta S, Yokota Hashimoto H, Kinoshita K, et al. N-methyl-d-aspartate receptor coagonist d-serine suppresses intake of high-preference food. Am J Physiol Regul Integr Comp Physiol. 2015;309:R561-75 pubmed publisher

Panneton W, Gan Q, Ariel M. Injections of Algesic Solutions into Muscle Activate the Lateral Reticular Formation: A Nociceptive Relay of the Spinoreticulothalamic Tract. PLoS ONE. 2015;10:e0130939 pubmed publisher

Zhu S, Vik S. Constraining the Lateral Helix of Respiratory Complex I by Cross-linking Does Not Impair Enzyme Activity or Proton Translocation. J Biol Chem. 2015;290:20761-73 pubmed publisher

Kiani J, Sajedi F, Nasrollahi S, Esna Ashari F. A randomized clinical trial of efficacy and safety of the topical clonidine and capsaicin in the treatment of painful diabetic neuropathy. J Res Med Sci. 2015;20:359-63 pubmed

Périco L, Heredia Vieira S, Beserra F, de Cássia Dos Santos R, Weiss M, Resende F, et al. Does the gastroprotective action of a medicinal plant ensure healing effects? An integrative study of the biological effects of Serjania marginata Casar. (Sapindaceae) in rats. J Ethnopharmacol. 2015;172:312-24 pubmed publisher

Pérez Burgos A, Wang L, McVey Neufeld K, Mao Y, Ahmadzai M, Janssen L, et al. The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938. J Physiol. 2015;593:3943-57 pubmed publisher

Morales Ledesma L, Trujillo A, Apolonio J. In the pubertal rat, the regulation of ovarian function involves the synergic participation of the sensory and sympathetic innervations that arrive at the gonad. Reprod Biol Endocrinol. 2015;13:61 pubmed publisher

Zheng L, Chen J, Ma Z, Liu W, Yang F, Yang Z, et al. Capsaicin causes inactivation and degradation of the androgen receptor by inducing the restoration of miR-449a in prostate cancer. Oncol Rep. 2015;34:1027-34 pubmed publisher

Tajerian M, Sahbaie P, Sun Y, Leu D, Yang H, Li W, et al. Sex differences in a Murine Model of Complex Regional Pain Syndrome. Neurobiol Learn Mem. 2015;123:100-9 pubmed publisher

Billeter A, Galbraith N, Walker S, Lawson C, Gardner S, Sarojini H, et al. TRPA1 mediates the effects of hypothermia on the monocyte inflammatory response. Surgery. 2015;158:646-54 pubmed publisher

Eskander M, Ruparel S, Green D, Chen P, Por E, Jeske N, et al. Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms. J Neurosci. 2015;35:8593-603 pubmed publisher

Mukkavilli R, Gundala S, Yang C, Jadhav G, Vangala S, Reid M, et al. Noscapine recirculates enterohepatically and induces self-clearance. Eur J Pharm Sci. 2015;77:90-9 pubmed publisher

Sarko D, Rice F, Reep R. Elaboration and Innervation of the Vibrissal System in the Rock Hyrax (Procavia capensis). Brain Behav Evol. 2015;85:170-88 pubmed publisher

Keir S, Spina D, Page C. Bradykinin and capsaicin induced airways obstruction in the guinea pig are platelet dependent. Pulm Pharmacol Ther. 2015;33:25-31 pubmed publisher

Ibrahim M, Jang M, Park M, Gobianand K, You S, Yeon S, et al. Capsaicin inhibits the adipogenic differentiation of bone marrow mesenchymal stem cells by regulating cell proliferation, apoptosis, oxidative and nitrosative stress. Food Funct. 2015;6:2165-78 pubmed publisher

Giorno T, Ballard Y, Cordeiro M, Silva B, Pinto A, Fernandes P. Central and peripheral antinociceptive activity of 3-(2-oxopropyl)-3-hydroxy-2-oxindoles. Pharmacol Biochem Behav. 2015;135:13-9 pubmed publisher

Moon H, Kim M, Son H, Kweon H, Kim J, Kim Y, et al. Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa. PLoS ONE. 2015;10:e0127060 pubmed publisher

Watanabe M, Ueda T, Shibata Y, Kumamoto N, Shimada S, Ugawa S. Expression and Regulation of Cav3.2 T-Type Calcium Channels during Inflammatory Hyperalgesia in Mouse Dorsal Root Ganglion Neurons. PLoS ONE. 2015;10:e0127572 pubmed publisher

Ganley R, Iwagaki N, Del Río P, Baseer N, Dickie A, Boyle K, et al. Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets. J Neurosci. 2015;35:7626-42 pubmed publisher

Mickle A, Shepherd A, Loo L, Mohapatra D. Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking. Pain. 2015;156:1620-36 pubmed publisher

Kaiser M, Pereira S, Pohl L, Ketelhut S, Kemper B, Gorzelanny C, et al. Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells. Sci Rep. 2015;5:10048 pubmed publisher

Wang P, Sun Y, Lu W, Huang P, Hu Y. Selective killing of K-ras-transformed pancreatic cancer cells by targeting NAD(P)H oxidase. Chin J Cancer. 2015;34:166-76 pubmed publisher

Jeong J, Lee J, Lee S. TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer. Int J Mol Sci. 2015;16:10411-25 pubmed publisher

Ramachandran R, Lam C, Yaksh T. Botulinum toxin in migraine: Role of transport in trigemino-somatic and trigemino-vascular afferents. Neurobiol Dis. 2015;79:111-22 pubmed publisher

Patrício E, Costa R, Figueiredo C, Gers Barlag K, Bicca M, Manjavachi M, et al. Mechanisms Underlying the Scratching Behavior Induced by the Activation of Proteinase-Activated Receptor-4 in Mice. J Invest Dermatol. 2015;135:2484-2491 pubmed publisher

Kimball C, Luo J, Yin S, Hu H, Dhaka A. The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane. Mol Pharmacol. 2015;88:131-8 pubmed publisher

Shi H, Liu C, Ding L, Zheng Y, Fei X, Lu L, et al. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. World J Gastroenterol. 2015;21:4852-63 pubmed publisher

Hatakeyama Y, Takahashi K, Tominaga M, Kimura H, Ohta T. Polysulfide evokes acute pain through the activation of nociceptive TRPA1 in mouse sensory neurons. Mol Pain. 2015;11:24 pubmed publisher

Samour M, Nagi S, Mahns D. Cav3.2-expressing low-threshold C fibres in human hairy skin contribute to cold allodynia--a non-TRPV1- and non-TRPM8-dependent phenomenon. Pain. 2015;156:1566-75 pubmed publisher

Glowka T, Steinebach A, Stein K, Schwandt T, Lysson M, Holzmann B, et al. The novel CGRP receptor antagonist BIBN4096BS alleviates a postoperative intestinal inflammation and prevents postoperative ileus. Neurogastroenterol Motil. 2015;27:1038-49 pubmed publisher

Calzetta L, Luongo L, Cazzola M, Page C, Rogliani P, Facciolo F, et al. Contribution of sensory nerves to LPS-induced hyperresponsiveness of human isolated bronchi. Life Sci. 2015;131:44-50 pubmed publisher

Helyes Z, Kun J, Dobrosi N, Sándor K, Németh J, Perkecz A, et al. Pituitary Adenylate Cyclase-Activating Polypeptide Is Upregulated in Murine Skin Inflammation and Mediates Transient Receptor Potential Vanilloid-1-Induced Neurogenic Edema. J Invest Dermatol. 2015;135:2209-2218 pubmed publisher

Ma X, Zhang F, Dong F, Bao L, Zhang X. Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin. Mol Pain. 2015;11:22 pubmed publisher

Choi Y, Kim J, Jin W, Kim Y, Lee J, Jahng J. Anxiolytic efficacy of repeated oral capsaicin in rats with partial aberration of oral sensory relay to brain. Arch Oral Biol. 2015;60:989-97 pubmed publisher

Matsuda T, Kubo A, Taguchi T, Mizumura K. ATP decreases mechanical sensitivity of muscle thin-fiber afferents in rats. Neurosci Res. 2015;97:36-44 pubmed publisher

Mogilski S, Kubacka M, Redzicka A, Kazek G, Dudek M, Malinka W, et al. Antinociceptive, anti-inflammatory and smooth muscle relaxant activities of the pyrrolo[3,4-d]pyridazinone derivatives: Possible mechanisms of action. Pharmacol Biochem Behav. 2015;133:99-110 pubmed publisher

Liu Z, Zhu P, Tao Y, Shen C, Wang S, Zhao L, et al. Cancer-promoting effect of capsaicin on DMBA/TPA-induced skin tumorigenesis by modulating inflammation, Erk and p38 in mice. Food Chem Toxicol. 2015;81:1-8 pubmed publisher

So K, Haraguchi K, Asakura K, Isami K, Sakimoto S, Shirakawa H, et al. Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models. J Pharmacol Sci. 2015;127:237-43 pubmed publisher

Qiu Q, Wang J, Deng X, Qian H, Lin H, Huang W. Synthesis of carbamide derivatives bearing tetrahydroisoquinoline moieties and biological evaluation as analgesia drugs in mice. Arch Pharm (Weinheim). 2015;348:347-52 pubmed publisher

De Clercq K, Held K, Van Bree R, Meuleman C, Peeraer K, Tomassetti C, et al. Functional expression of transient receptor potential channels in human endometrial stromal cells during the luteal phase of the menstrual cycle. Hum Reprod. 2015;30:1421-36 pubmed publisher

Zhu Y, Lu Y, Qu C, Miller M, Tian J, Thakur D, et al. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol. 2015;172:3495-509 pubmed publisher

Lewinska A, Jarosz P, Czech J, Rzeszutek I, Bielak Zmijewska A, Grabowska W, et al. Capsaicin-induced genotoxic stress does not promote apoptosis in A549 human lung and DU145 prostate cancer cells. Mutat Res Genet Toxicol Environ Mutagen. 2015;779:23-34 pubmed publisher

Huang W, Yu F, Sanchez R, Liu Y, Min J, Hu J, et al. TRPV1 promotes repetitive febrile seizures by pro-inflammatory cytokines in immature brain. Brain Behav Immun. 2015;48:68-77 pubmed publisher

Xiao X, Zhao X, Xu L, Yue L, Liu F, Cai J, et al. Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats. Pain. 2015;156:597-608 pubmed publisher

Ono K, Ye Y, Viet C, Dang D, Schmidt B. TRPV1 expression level in isolectin Bâ‚„-positive neurons contributes to mouse strain difference in cutaneous thermal nociceptive sensitivity. J Neurophysiol. 2015;113:3345-55 pubmed publisher

Fang D, Kong L, Cai J, Li S, Liu X, Han J, et al. Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model. Pain. 2015;156:1124-44 pubmed publisher

Magierowski M, Jasnos K, Kwiecien S, Drozdowicz D, Surmiak M, Strzalka M, et al. Endogenous prostaglandins and afferent sensory nerves in gastroprotective effect of hydrogen sulfide against stress-induced gastric lesions. PLoS ONE. 2015;10:e0118972 pubmed publisher

Segerdahl A, Mezue M, Okell T, Farrar J, Tracey I. The dorsal posterior insula subserves a fundamental role in human pain. Nat Neurosci. 2015;18:499-500 pubmed publisher

Yee J, Kenkel W, Caccaviello J, Gamber K, Simmons P, Nedelman M, et al. Identifying the integrated neural networks involved in capsaicin-induced pain using fMRI in awake TRPV1 knockout and wild-type rats. Front Syst Neurosci. 2015;9:15 pubmed publisher

Sałat K, Filipek B. Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. J Zhejiang Univ Sci B. 2015;16:167-78 pubmed publisher

Kunkler P, Zhang L, Pellman J, Oxford G, Hurley J. Sensitization of the trigeminovascular system following environmental irritant exposure. Cephalalgia. 2015;35:1192-201 pubmed publisher

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Ronchi G, Ryu V, Fornaro M, Czaja K. Hippocampal plasticity after a vagus nerve injury in the rat. Neural Regen Res. 2012;7:1055-63 pubmed publisher

Souza G, Simas A, Bastos Pereira A, Frois G, Ribas J, Verdan M, et al. Antinociceptive activity of the ethanolic extract, fractions, and aggregatin D isolated from Sinningia aggregata tubers. PLoS ONE. 2015;10:e0117501 pubmed publisher

Akiba Y, Kaunitz J, Million M. Peripheral corticotropin-releasing factor receptor type 2 activation increases colonic blood flow through nitric oxide pathway in rats. Dig Dis Sci. 2015;60:858-67 pubmed publisher

Zheng L, Zhang Y, Han J, Sun Z, Zhou S, Zhao W, et al. Nerve growth factor rescues diabetic mice heart after ischemia/reperfusion injury via up-regulation of the TRPV1 receptor. J Diabetes Complications. 2015;29:323-8 pubmed publisher

Chen K, Chen P, Hsieh Y, Lin C, Lee Y, Chu S. Capsaicin protects endothelial cells and macrophage against oxidized low-density lipoprotein-induced injury by direct antioxidant action. Chem Biol Interact. 2015;228:35-45 pubmed publisher

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Arzuman L, Beale P, Chan C, Yu J, Huq F. Synergism from combinations of tris(benzimidazole) monochloroplatinum(II) chloride with capsaicin, quercetin, curcumin and cisplatin in human ovarian cancer cell lines. Anticancer Res. 2014;34:5453-64 pubmed

Impheng H, Pongcharoen S, Richert L, Pekthong D, Srisawang P. The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells. PLoS ONE. 2014;9:e107842 pubmed publisher

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Hegarty D, Hermes S, Largent Milnes T, Aicher S. Capsaicin-responsive corneal afferents do not contain TRPV1 at their central terminals in trigeminal nucleus caudalis in rats. J Chem Neuroanat. 2014;61-62:1-12 pubmed publisher

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Jia X, Zhang H, Cao X, Yin Y, Zhang B. Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells. FEBS Lett. 2014;588:3047-54 pubmed publisher

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Rathsman B, Jensen Urstad K, Nystrom T. Intensified insulin treatment is associated with improvement in skin microcirculation and ischaemic foot ulcer in patients with type 1 diabetes mellitus: a long-term follow-up study. Diabetologia. 2014;57:1703-10 pubmed publisher

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Luviano A, Aguiñiga Sánchez I, Demare P, Tiburcio R, Ledesma Martínez E, Santiago Osorio E, et al. Antineoplastic activity of rinvanil and phenylacetylrinvanil in leukaemia cell lines. Oncol Lett. 2014;7:1651-1656 pubmed

McGovern A, Robusto J, Rakoczy J, Simmons D, Phipps S, Mazzone S. The effect of hyperpolarization-activated cyclic nucleotide-gated ion channel inhibitors on the vagal control of guinea pig airway smooth muscle tone. Br J Pharmacol. 2014;171:3633-50 pubmed publisher

Darling R, Zhao H, Kinch D, Li A, Simasko S, Ritter S. Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors. Am J Physiol Regul Integr Comp Physiol. 2014;307:R35-43 pubmed publisher

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Li J, Ma D, Lin Y, Fu J, Zhang A. An exploration of the estrogen receptor transcription activity of capsaicin analogues via an integrated approach based on in silico prediction and in vitro assays. Toxicol Lett. 2014;227:179-88 pubmed publisher

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Contri R, Katzer T, Ourique A, da Silva A, Beck R, Pohlmann A, et al. Combined effect of polymeric nanocapsules and chitosan hydrogel on the increase of capsaicinoids adhesion to the skin surface. J Biomed Nanotechnol. 2014;10:820-30 pubmed

Sałat K, Cios A, Wyska E, Sałat R, Mogilski S, Filipek B, et al. Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice. Pharmacol Biochem Behav. 2014;122:173-81 pubmed publisher

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Trevisan G, Rossato M, Tonello R, Hoffmeister C, Klafke J, Rosa F, et al. Gallic acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice. Naunyn Schmiedebergs Arch Pharmacol. 2014;387:679-89 pubmed publisher

Schöbel N, Radtke D, Kyereme J, Wollmann N, Cichy A, Obst K, et al. Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds. Chem Senses. 2014;39:471-87 pubmed publisher

Zhou C, Liang P, Liu J, Zhang W, Liao D, Chen Y, et al. Emulsified isoflurane enhances thermal transient receptor potential vanilloid-1 channel activation-mediated sensory/nociceptive blockade by QX-314. Anesthesiology. 2014;121:280-9 pubmed publisher

Shima T, Shiina T, Naitou K, Nakamori H, Shimizu Y. Functional roles of capsaicin-sensitive intrinsic neural circuit in the regulation of esophageal peristalsis in rats: in vivo studies using a novel method. Am J Physiol Gastrointest Liver Physiol. 2014;306:G811-8 pubmed publisher

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Senning E, Collins M, Stratiievska A, Ufret Vincenty C, Gordon S. Regulation of TRPV1 ion channel by phosphoinositide (4,5)-bisphosphate: the role of membrane asymmetry. J Biol Chem. 2014;289:10999-1006 pubmed publisher

Feketa V, Zhang Y, Cao Z, Balasubramanian A, Flores C, Player M, et al. Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. Crit Care Med. 2014;42:e355-63 pubmed publisher

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Gonzales C, Kirma N, De La Chapa J, Chen R, Henry M, Luo S, et al. Vanilloids induce oral cancer apoptosis independent of TRPV1. Oral Oncol. 2014;50:437-47 pubmed publisher

Ibrahimi K, Vermeersch S, Danser A, Villalon C, van den Meiracker A, de Hoon J, et al. Development of an experimental model to study trigeminal nerve-mediated vasodilation on the human forehead. Cephalalgia. 2014;34:514-22 pubmed publisher

Sridharan V, Tripathi P, Sharma S, Moros E, Zheng J, Hauer Jensen M, et al. Roles of sensory nerves in the regulation of radiation-induced structural and functional changes in the heart. Int J Radiat Oncol Biol Phys. 2014;88:167-74 pubmed publisher

Alhelal M, Palaska I, Panagiotidou S, Letourneau R, Theoharides T. Trigeminal nerve stimulation triggers oral mast cell activation and vascular permeability. Ann Allergy Asthma Immunol. 2014;112:40-5 pubmed publisher

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Cao Z, Balasubramanian A, Marrelli S. Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. Am J Physiol Regul Integr Comp Physiol. 2014;306:R149-56 pubmed publisher

Peters C, RIRIE D, Houle T, Aschenbrenner C, Eisenach J. Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats. Anesthesiology. 2014;120:976-86 pubmed publisher

Tsantoulas C, Farmer C, Machado P, Baba K, McMahon S, Raouf R. Probing functional properties of nociceptive axons using a microfluidic culture system. PLoS ONE. 2013;8:e80722 pubmed publisher

Couto M, de Diego A, Perpiñi M, Delgado L, Moreira A. Cough reflex testing with inhaled capsaicin and TRPV1 activation in asthma and comorbid conditions. J Investig Allergol Clin Immunol. 2013;23:289-301 pubmed

Kim J, Kwon J, Kim H, Josselyn S, Han J. Memory recall and modifications by activating neurons with elevated CREB. Nat Neurosci. 2014;17:65-72 pubmed publisher

Zhang X, Koronowski K, Li L, Freeman B, Woodcock S, de Groat W. Nitro-oleic acid desensitizes TRPA1 and TRPV1 agonist responses in adult rat DRG neurons. Exp Neurol. 2014;251:12-21 pubmed publisher

Mizuno M, Lozano G, Siddique K, Baum M, Smith S. Enalapril attenuates the exaggerated sympathetic response to physical stress in prenatally programmed hypertensive rats. Hypertension. 2014;63:324-9 pubmed publisher

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