This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Melphalan
catalog :
M2011
citations: 230
Reference
Qian W, Wang L, Li P, Hu Y, Wang Q, Yi K, et al. Efficiency and Tolerability of Induction and Consolidation Therapy with Arsenic Trioxide/Bortezomib/Ascorbic Acid/Dexamethasone (ABCD) Regimen Compared to Bortezomib/Dexamethasone (BD) Regimen in Newly Diagnosed Myeloma Patients. Cancer Manag Res. 2020;12:431-441 pubmed publisher
Valdez B, Li Y, Murray D, Liu Y, Nieto Y, Bashir Q, et al. Panobinostat and venetoclax enhance the cytotoxicity of gemcitabine, busulfan, and melphalan in multiple myeloma cells. Exp Hematol. 2020;81:32-41 pubmed publisher
Finazzi M, Boschini C, Craddock C, Rambaldi A, Ward J, Malladi R. Characteristics of graft-versus-host disease occurring after alemtuzumab-containing allogeneic stem cell transplants: incidence, organ involvement, risk factors and survival. Br J Haematol. 2020;188:550-559 pubmed publisher
Tabata M, Tsubaki M, Takeda T, Tateishi K, Maekawa S, Tsurushima K, et al. Inhibition of HSP90 overcomes melphalan resistance through downregulation of Src in multiple myeloma cells. Clin Exp Med. 2020;20:63-71 pubmed publisher
Guadagni S, Fiorentini G, De Simone M, Masedu F, Zoras O, Mackay A, et al. Precision oncotherapy based on liquid biopsies in multidisciplinary treatment of unresectable recurrent rectal cancer: a retrospective cohort study. J Cancer Res Clin Oncol. 2020;146:205-219 pubmed publisher
Teras J, Mägi A, Teras M, Pata P, Teras R, Randhawa N, et al. Soft Tissue Cancer Management: Isolated Limb Infusion for Sarcoma. Visc Med. 2019;35:373-379 pubmed publisher
Faict S, Oudaert I, D Auria L, Dehairs J, Maes K, Vlummens P, et al. The Transfer of Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma. Cancers (Basel). 2019;11: pubmed publisher
Srisongkram T, Weerapreeyakul N, Kärkkäinen J, Rautio J. Role of L-Type Amino Acid Transporter 1 (LAT1) for the Selective Cytotoxicity of Sesamol in Human Melanoma Cells. Molecules. 2019;24: pubmed publisher
Kanakkanthara A, Huntoon C, Hou X, Zhang M, Heinzen E, O Brien D, et al. ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer. Nat Commun. 2019;10:4632 pubmed publisher
Sharpley F, Petrie A, Mahmood S, Sachchithanantham S, Lachmann H, Gillmore J, et al. A 24-year experience of autologous stem cell transplantation for light chain amyloidosis patients in the United Kingdom. Br J Haematol. 2019;187:642-652 pubmed publisher
Pocasap P, Weerapreeyakul N, Thumanu K. Alyssin and Iberin in Cruciferous Vegetables Exert Anticancer Activity in HepG2 by Increasing Intracellular Reactive Oxygen Species and Tubulin Depolymerization. Biomol Ther (Seoul). 2019;27:540-552 pubmed publisher
Klager S, Lacouture M, Hannum M, Devlin S, Maloy M, Pulitzer M, et al. Drugs as a Frequent Cause of Acute Rash in Patients after CD34+-Selected Peripheral Blood Stem Cell Transplantation. Biol Blood Marrow Transplant. 2019;25:2172-2180 pubmed publisher
Harrington K, Freeman D, Kelly B, Harper J, Soria J. Optimizing oncolytic virotherapy in cancer treatment. Nat Rev Drug Discov. 2019;18:689-706 pubmed publisher
Bashir Q, Chamoun K, Milton D, Khan M, Ahmed S, Mehta R, et al. Outcomes of autologous hematopoietic cell transplantation in myeloma patients aged ≥75 years. Leuk Lymphoma. 2019;60:3536-3543 pubmed publisher
Tacconi E, Badie S, De Gregoriis G, Reisländer T, Lai X, Porru M, et al. Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance. EMBO Mol Med. 2019;11:e9982 pubmed publisher
Kucab J, Zou X, Morganella S, Joel M, Nanda A, Nagy E, et al. A Compendium of Mutational Signatures of Environmental Agents. Cell. 2019;177:821-836.e16 pubmed publisher
Abruzzese M, Bilotta M, Fionda C, Zingoni A, Soriani A, Petrucci M, et al. The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors. Cell Death Dis. 2019;10:324 pubmed publisher
Grueneisen J, Schaarschmidt B, Demircioglu A, Chodyla M, Martin O, Bertram S, et al. 18F-FDG PET/MRI for Therapy Response Assessment of Isolated Limb Perfusion in Patients with Soft-Tissue Sarcomas. J Nucl Med. 2019;60:1537-1542 pubmed publisher
Gourzones C, Bellanger C, Lamure S, Gadacha O, de Paco E, Vincent L, et al. Antioxidant Defenses Confer Resistance to High Dose Melphalan in Multiple Myeloma Cells. Cancers (Basel). 2019;11: pubmed publisher
Bashir Q, Thall P, Milton D, Fox P, Kawedia J, Kebriaei P, et al. Conditioning with busulfan plus melphalan versus melphalan alone before autologous haemopoietic cell transplantation for multiple myeloma: an open-label, randomised, phase 3 trial. Lancet Haematol. 2019;6:e266-e275 pubmed publisher
Tabatabaei S, Derbali R, Yang C, Superstein R, Hamel P, Chain J, et al. Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma. J Control Release. 2019;298:177-185 pubmed publisher
Assi T, Cavalcanti A, Le Cesne A, Faron M, Honart J, Hadiji A, et al. Neoadjuvant isolated limb perfusion in newly diagnosed untreated patients with locally advanced soft tissue sarcomas of the extremities: the Gustave Roussy experience. Clin Transl Oncol. 2019;: pubmed publisher
Belgrano V, Pettersson J, Nilsson J, Mattsson J, Katsarelias D, Olofsson Bagge R. Response and Toxicity of Repeated Isolated Limb Perfusion (re-ILP) for Patients With In-Transit Metastases of Malignant Melanoma. Ann Surg Oncol. 2019;26:1055-1062 pubmed publisher
Rule S, Cook G, Russell N, Hunter A, Robinson S, Morley N, et al. Allogeneic stem cell transplantation as part of front line therapy for Mantle cell lymphoma. Br J Haematol. 2019;184:999-1005 pubmed publisher
Schäfer J, Burhenne J, Weiss J, Theile D. Elucidating the beneficial effects of melphalan, adriamycin, and corticoids in combination with bortezomib against multiple myeloma in vitro. Naunyn Schmiedebergs Arch Pharmacol. 2019;392:461-466 pubmed publisher
Brierley C, Jones F, Hanlon K, Peniket A, Hatton C, Collins G, et al. Impact of graft-versus-lymphoma effect on outcomes after reduced intensity conditioned-alemtuzumab allogeneic haematopoietic stem cell transplantation for patients with mature lymphoid malignancies. Br J Haematol. 2019;184:547-557 pubmed publisher
Mashimo K, Tsubaki M, Takeda T, Asano R, Jinushi M, Imano M, et al. RANKL-induced c-Src activation contributes to conventional anti-cancer drug resistance and dasatinib overcomes this resistance in RANK-expressing multiple myeloma cells. Clin Exp Med. 2019;19:133-141 pubmed publisher
Li N, Lopez M, Linares M, Kumar S, Oliva S, Martinez Lopez J, et al. Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenström Macroglobulinemia. Clin Cancer Res. 2019;25:369-377 pubmed publisher
van de Donk N, van der Holt B, Minnema M, Vellenga E, Croockewit S, Kersten M, et al. Thalidomide before and after autologous stem cell transplantation in recently diagnosed multiple myeloma (HOVON-50): long-term results from the phase 3, randomised controlled trial. Lancet Haematol. 2018;5:e479-e492 pubmed publisher
Reese M, Knapp D, Anderson K, Mund J, Case J, Jones D, et al. In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs. PLoS ONE. 2018;13:e0203517 pubmed publisher
Gudmundsson B, Thormar H, Sigurdsson A, Dankers W, Steinarsdottir M, Hermanowicz S, et al. Northern lights assay: a versatile method for comprehensive detection of DNA damage. Nucleic Acids Res. 2018;46:e118 pubmed publisher
Stevenson M, Hoekstra H, Song W, Suurmeijer A, Been L. Histopathological tumor response following neoadjuvant hyperthermic isolated limb perfusion in extremity soft tissue sarcomas: Evaluation of the EORTC-STBSG response score. Eur J Surg Oncol. 2018;44:1406-1411 pubmed publisher
Bentley R, Thomovsky S, Miller M, Knapp D, Cohen Gadol A. Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial. World Neurosurg. 2018;116:e534-e542 pubmed publisher
Lam C, Ferguson I, Mariano M, Lin Y, Murnane M, Liu H, et al. Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. Haematologica. 2018;103:1218-1228 pubmed publisher
Anunobi R, Boone B, Cheh N, Tang D, Kang R, Loux T, et al. Extracellular DNA promotes colorectal tumor cell survival after cytotoxic chemotherapy. J Surg Res. 2018;226:181-191 pubmed publisher
Tretiakova D, Onishchenko N, Boldyrev I, Mikhalyov I, Tuzikov A, Bovin N, et al. Influence of stabilizing components on the integrity of antitumor liposomes loaded with lipophilic prodrug in the bilayer. Colloids Surf B Biointerfaces. 2018;166:45-53 pubmed publisher
Stevenson M, Seinen J, Pras E, Brouwers A, van Ginkel R, van Leeuwen B, et al. Hyperthermic isolated limb perfusion, preoperative radiotherapy, and surgery (PRS) a new limb saving treatment strategy for locally advanced sarcomas. J Surg Oncol. 2018;117:1447-1454 pubmed publisher
Abate M, Paioli A, Cammelli S, Cesari M, Longhi A, Palmerini E, et al. Sinusoidal obstruction syndrome/veno-occlusive disease after high-dose intravenous busulfan/melphalan conditioning therapy in high-risk Ewing Sarcoma. Bone Marrow Transplant. 2018;53:591-599 pubmed publisher
Landini I, Lapucci A, Pratesi A, Massai L, Napoli C, Perrone G, et al. Selection and characterization of a human ovarian cancer cell line resistant to auranofin. Oncotarget. 2017;8:96062-96078 pubmed publisher
Campbell J, Heaney J, Pandya S, Afzal Z, Kaiser M, Owen R, et al. Response comparison of multiple myeloma and monoclonal gammopathy of undetermined significance to the same anti-myeloma therapy: a retrospective cohort study. Lancet Haematol. 2017;4:e584-e594 pubmed publisher
Chai R, McDonald M, Terry R, Kovacic N, Down J, Pettitt J, et al. Melphalan modifies the bone microenvironment by enhancing osteoclast formation. Oncotarget. 2017;8:68047-68058 pubmed publisher
Jeon H, Kim D, Choi M, Kang S, Kim J, Kim S, et al. Targeted Cancer Therapy Using Fusion Protein of TNF? and Tumor-Associated Fibronectin-Specific Aptide. Mol Pharm. 2017;14:3772-3779 pubmed publisher
Rojas E, Corchete L, San Segundo L, Martinez Blanch J, Codoñer F, Paíno T, et al. Amiloride, An Old Diuretic Drug, Is a Potential Therapeutic Agent for Multiple Myeloma. Clin Cancer Res. 2017;23:6602-6615 pubmed publisher
Yang H, Zheng Y, Zhang Y, Cao Z, Jiang Y. Mesenchymal stem cells derived from multiple myeloma patients protect against chemotherapy through autophagy-dependent activation of NF-κB signaling. Leuk Res. 2017;60:82-88 pubmed publisher
Mei M, Cao T, Chen L, Song J, Siddiqi T, Cai J, et al. Long-Term Results of High-Dose Therapy and Autologous Stem Cell Transplantation for Mantle Cell Lymphoma: Effectiveness of Maintenance Rituximab. Biol Blood Marrow Transplant. 2017;23:1861-1869 pubmed publisher
Yang Q, Tripathy A, Yu W, Eberhart C, Asnaghi L. Hypoxia inhibits growth, proliferation, and increases response to chemotherapy in retinoblastoma cells. Exp Eye Res. 2017;162:48-61 pubmed publisher
Borriello L, Nakata R, Sheard M, Fernandez G, Sposto R, Malvar J, et al. Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells. Cancer Res. 2017;77:5142-5157 pubmed publisher
Salvador D, Soave D, Sacono N, de Castro E, Silva G, E Silva L, et al. Effect of photobiomodulation therapy on reducing the chemo-induced oral mucositis severity and on salivary levels of CXCL8/interleukin 8, nitrite, and myeloperoxidase in patients undergoing hematopoietic stem cell transplantation: a randomized clinic. Lasers Med Sci. 2017;32:1801-1810 pubmed publisher
Berry J, Bechtold M, Shah S, Zolfaghari E, Reid M, Jubran R, et al. Not All Seeds Are Created Equal: Seed Classification Is Predictive of Outcomes in Retinoblastoma. Ophthalmology. 2017;124:1817-1825 pubmed publisher
Szalat R, Samur M, Fulciniti M, Lopez M, Nanjappa P, Cleynen A, et al. Nucleotide excision repair is a potential therapeutic target in multiple myeloma. Leukemia. 2017;: pubmed publisher
Saijo R, Sekiya H, Tamai E, Kurihara K, Maki J, Sakagami H, et al. A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest. Chem Pharm Bull (Tokyo). 2017;65:365-372 pubmed publisher
Glazer E, Zager J. Chemosaturation With Percutaneous Hepatic Perfusion in Unresectable Hepatic Metastases. Cancer Control. 2017;24:96-101 pubmed
Lin L, Wu M, Pidugu V, Ho I, Su T, Lee T. P-glycoprotein attenuates DNA repair activity in multidrug-resistant cells by acting through the Cbp-Csk-Src cascade. Oncotarget. 2017;8:45072-45087 pubmed publisher
Burton J, Knych H, Stanley S, Rebhun R. Potency and stability of compounded formulations of chlorambucil, melphalan and cyclophosphamide. Vet Comp Oncol. 2017;15:1558-1563 pubmed publisher
Kiratli H, Koç İ, Varan A, Akyuz C. Intravitreal chemotherapy in the management of vitreous disease in retinoblastoma. Eur J Ophthalmol. 2017;27:423-427 pubmed publisher
Bespalov V, Vyshinskaya E, Vasil eva I, Semenov A, Maidin M, Barakova N, et al. Comparative Study of Antitumor Efficiency of Intraperitoneal and Intravenous Cytostatics in Experimental Rats with Disseminated Ovarian Cancer. Bull Exp Biol Med. 2017;162:383-386 pubmed publisher
Zatula A, Dikic A, Mulder C, Sharma A, Vågbø C, Sousa M, et al. Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia. Oncotarget. 2017;8:19427-19442 pubmed publisher
Ryu J, Koh Y, Park H, Kim D, Kim D, Byun J, et al. Highly Expressed Integrin-α8 Induces Epithelial to Mesenchymal Transition-Like Features in Multiple Myeloma with Early Relapse. Mol Cells. 2016;39:898-908 pubmed publisher
Strese S, Hassan S, Velander E, Haglund C, Höglund M, Larsson R, et al. In vitro and in vivo anti-leukemic activity of the peptidase-potentiated alkylator melflufen in acute myeloid leukemia. Oncotarget. 2017;8:6341-6352 pubmed publisher
Antonangeli F, Soriani A, Ricci B, Ponzetta A, Benigni G, Morrone S, et al. Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells. Oncoimmunology. 2016;5:e1218105 pubmed
Jakubikova J, Cholujova D, Hideshima T, Gronesova P, Soltysova A, Harada T, et al. A novel 3D mesenchymal stem cell model of the multiple myeloma bone marrow niche: biologic and clinical applications. Oncotarget. 2016;7:77326-77341 pubmed publisher
Suzuki K, Yano S, Nishiwaki K, Sano K, Shimada T, Yahagi Y, et al. Clinical significance of granule-containing myeloma cells in patients with newly diagnosed multiple myeloma. Cancer Med. 2016;5:3051-3058 pubmed publisher
Cao J, Lin G, Gong Y, Pan P, Ma Y, Huang P, et al. DNA-PKcs, a novel functional target of acriflavine, mediates acriflavine's p53-dependent synergistic anti-tumor efficiency with melphalan. Cancer Lett. 2016;383:115-124 pubmed publisher
Wang C, He Z, Shi Y, Zhang L, Chen Y, Chen Z, et al. Low-dose lenalidomide and dexamethasone combination treatment in elderly patients with relapsed and refractory multiple myeloma. Hematology. 2017;22:88-92 pubmed publisher
Chen P, Li J, Chen Y, Qian H, Chen Y, Su J, et al. The functional status of DNA repair pathways determines the sensitization effect to cisplatin in non-small cell lung cancer cells. Cell Oncol (Dordr). 2016;39:511-522 pubmed
Boukes G, van de Venter M. The apoptotic and autophagic properties of two natural occurring prodrugs, hyperoside and hypoxoside, against pancreatic cancer cell lines. Biomed Pharmacother. 2016;83:617-626 pubmed publisher
Cook G, Ashcroft A, Cairns D, Williams C, Brown J, Cavenagh J, et al. The effect of salvage autologous stem-cell transplantation on overall survival in patients with relapsed multiple myeloma (final results from BSBMT/UKMF Myeloma X Relapse [Intensive]): a randomised, open-label, phase 3 trial. Lancet Haematol. 2016;3:e340-51 pubmed publisher
Cecchin D, Negri A, Frigo A, Bui F, Zucchetta P, Bodanza V, et al. Calculating regional tissue volume for hyperthermic isolated limb perfusion: Four methods compared. Eur J Surg Oncol. 2016;42:1898-1905 pubmed publisher
Ferroudj S, Yildiz G, Bouras M, Iscan E, Ekin U, Ozturk M. Role of Fanconi anemia/BRCA pathway genes in hepatocellular carcinoma chemoresistance. Hepatol Res. 2016;46:1264-1274 pubmed publisher
Lub S, Maes A, Maes K, De Veirman K, De Bruyne E, Menu E, et al. Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells. Oncotarget. 2016;7:4062-76 pubmed publisher
Ramachandran I, Condamine T, Lin C, Herlihy S, Garfall A, Vogl D, et al. Bone marrow PMN-MDSCs and neutrophils are functionally similar in protection of multiple myeloma from chemotherapy. Cancer Lett. 2016;371:117-24 pubmed publisher
Lawson M, McDonald M, Kovacic N, Hua Khoo W, Terry R, Down J, et al. Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche. Nat Commun. 2015;6:8983 pubmed publisher
Ben Shabat I, Belgrano V, Ny L, Nilsson J, Lindnér P, Olofsson Bagge R. Long-Term Follow-Up Evaluation of 68 Patients with Uveal Melanoma Liver Metastases Treated with Isolated Hepatic Perfusion. Ann Surg Oncol. 2016;23:1327-34 pubmed publisher
Ramani V, Zhan F, He J, Barbieri P, Noseda A, Tricot G, et al. Targeting heparanase overcomes chemoresistance and diminishes relapse in myeloma. Oncotarget. 2016;7:1598-607 pubmed publisher
Hughes M, Zager J, Faries M, Alexander H, Royal R, Wood B, et al. Results of a Randomized Controlled Multicenter Phase III Trial of Percutaneous Hepatic Perfusion Compared with Best Available Care for Patients with Melanoma Liver Metastases. Ann Surg Oncol. 2016;23:1309-19 pubmed publisher
Legenzov E, Sims S, Dirda N, Rosen G, Kao J. Disulfide-Linked Dinitroxides for Monitoring Cellular Thiol Redox Status through Electron Paramagnetic Resonance Spectroscopy. Biochemistry. 2015;54:6973-82 pubmed publisher
Zhao J, Chu Z, Hu Y, Lin J, Wang Z, Jiang M, et al. Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma. Cancer Res. 2015;75:4384-4397 pubmed publisher
Nishihara K, Huang R, Zhao J, Shahane S, Witt K, Smith Roe S, et al. Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform. Mutagenesis. 2016;31:69-81 pubmed publisher
Hanley P, Melenhorst J, Nikiforow S, Scheinberg P, Blaney J, Demmler Harrison G, et al. CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo. Sci Transl Med. 2015;7:285ra63 pubmed publisher
Scarselli A, Di Cesare S, Capponi C, Cascioli S, Romiti M, Di Matteo G, et al. Longitudinal Evaluation of Immune Reconstitution and B-cell Function After Hematopoietic Cell Transplantation for Primary Immunodeficiency. J Clin Immunol. 2015;35:373-83 pubmed publisher
Suzuki S, Aihara Y, Fujiwara M, Sano S, Kaneko A. Intravitreal injection of melphalan for intraocular retinoblastoma. Jpn J Ophthalmol. 2015;59:164-72 pubmed publisher
Zub K, Sousa M, Sarno A, Sharma A, Demirovic A, Rao S, et al. Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells. PLoS ONE. 2015;10:e0119857 pubmed publisher
Dudek Perić A, Ferreira G, Muchowicz A, Wouters J, Prada N, Martin S, et al. Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulin. Cancer Res. 2015;75:1603-14 pubmed publisher
Ngwube A, Hayashi R, Murray L, Loechelt B, Dalal J, Jaroscak J, et al. Alemtuzumab based reduced intensity transplantation for pediatric severe aplastic anemia. Pediatr Blood Cancer. 2015;62:1270-6 pubmed publisher
Asada H, Tomiyasu H, Goto Koshino Y, Fujino Y, Ohno K, Tsujimoto H. Evaluation of the drug sensitivity and expression of 16 drug resistance-related genes in canine histiocytic sarcoma cell lines. J Vet Med Sci. 2015;77:677-84 pubmed publisher
Xu H, He J, Zhang Y, Fan L, Zhao Y, Xu T, et al. Synthesis and in vitro evaluation of a hyaluronic acid-quantum dots-melphalan conjugate. Carbohydr Polym. 2015;121:132-9 pubmed publisher
Lombardi A, Hoskins E, Foglesong G, Wikenheiser Brokamp K, Wiesmüller L, Hanenberg H, et al. Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers. Clin Cancer Res. 2015;21:1962-72 pubmed publisher
Tamargo J, Caballero R, Delpón E. Cancer chemotherapy and cardiac arrhythmias: a review. Drug Saf. 2015;38:129-52 pubmed publisher
Lu X, Ding Z, Cao Y, Liu C, Habtetsion T, Yu M, et al. Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells. J Immunol. 2015;194:2011-21 pubmed publisher
Beider K, Bitner H, Leiba M, Gutwein O, Koren Michowitz M, Ostrovsky O, et al. Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype. Oncotarget. 2014;5:11283-96 pubmed
Ongaro A, Pellati A, De Mattei M, de Terlizzi F, Rossi C, Campana L. Enhancement of melphalan activity by buthionine sulfoximine and electroporation in melanoma cells. Anticancer Drugs. 2015;26:284-92 pubmed publisher
Lawson B, Saktanasate J, Say E, Shields C. Intravitreal chemotherapy provides control for massive vitreous seeding from retinoblastoma. J Pediatr Ophthalmol Strabismus. 2014;51 Online:e92-4 pubmed publisher
Gertz M. Immunoglobulin light chain amyloidosis: 2014 update on diagnosis, prognosis, and treatment. Am J Hematol. 2014;89:1132-40 pubmed publisher
Cioch M, Jawniak D, Kotwica K, Wach M, Mańko J, Gorący A, et al. Biosimilar granulocyte colony-stimulating factor is effective in reducing the duration of neutropenia after autologous peripheral blood stem cell transplantation. Transplant Proc. 2014;46:2882-4 pubmed publisher
Voermans N, Benveniste O, Minnema M, Lokhorst H, Lammens M, Meersseman W, et al. Sporadic late-onset nemaline myopathy with MGUS: long-term follow-up after melphalan and SCT. Neurology. 2014;83:2133-9 pubmed publisher
Dahan A, Wolk O, Yang P, Mittal S, Wu Z, Landowski C, et al. Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers. Mol Pharm. 2014;11:4385-94 pubmed publisher
Song X, Kim S, Zhang L, Tang D, Bartlett D, Kwon Y, et al. Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer. Cell Death Dis. 2014;5:e1504 pubmed publisher
Xiong T, Wei H, Chen X, Xiao H. PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R. Int J Oncol. 2015;46:223-32 pubmed publisher
van Broekhoven D, Deroose J, Bonvalot S, Gronchi A, Grunhagen D, Eggermont A, et al. Isolated limb perfusion using tumour necrosis factor α and melphalan in patients with advanced aggressive fibromatosis. Br J Surg. 2014;101:1674-80 pubmed publisher
Avigan D, Rosenblatt J. Current treatment for multiple myeloma. N Engl J Med. 2014;371:961-2 pubmed publisher
Benboubker L, Dimopoulos M, Dispenzieri A, Catalano J, Belch A, Cavo M, et al. Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. N Engl J Med. 2014;371:906-17 pubmed publisher
Palumbo A, Cavallo F, Gay F, Di Raimondo F, Ben Yehuda D, Petrucci M, et al. Autologous transplantation and maintenance therapy in multiple myeloma. N Engl J Med. 2014;371:895-905 pubmed publisher
Yamada A, Moritake H, Kamimura S, Yamashita S, Takeshima H, Nunoi H. Proposed strategy for the use of high-dose chemotherapy with stem cell rescue and intrathecal topotecan without whole-brain irradiation for infantile classic medulloblastoma. Pediatr Blood Cancer. 2014;61:2316-8 pubmed publisher
Palladini G, Milani P, Foli A, Vidus Rosin M, Basset M, Lavatelli F, et al. Melphalan and dexamethasone with or without bortezomib in newly diagnosed AL amyloidosis: a matched case-control study on 174 patients. Leukemia. 2014;28:2311-6 pubmed publisher
Hamouda M, Belhacene N, Puissant A, Colosetti P, Robert G, Jacquel A, et al. The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells. Oncotarget. 2014;5:6252-66 pubmed
Tagde A, Singh H, Kang M, Reynolds C. The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma. Blood Cancer J. 2014;4:e229 pubmed publisher
Rancea M, Will A, Borchmann P, Monsef I, Engert A, Skoetz N. Sixteenth biannual report of the Cochrane Haematological Malignancies Group: focus on Non-Hodgkin's lymphoma. J Natl Cancer Inst. 2014;106: pubmed publisher
Pencavel T, Wilkinson M, Mansfield D, Khan A, Seth R, Karapanagiotou E, et al. Isolated limb perfusion with melphalan, tumour necrosis factor-alpha and oncolytic vaccinia virus improves tumour targeting and prolongs survival in a rat model of advanced extremity sarcoma. Int J Cancer. 2015;136:965-76 pubmed publisher
Rytelewski M, Tong J, Buensuceso A, Leong H, Maleki Vareki S, Figueredo R, et al. BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis. Mol Oncol. 2014;8:1429-40 pubmed publisher
Huerta Yepez S, Liu H, Baritaki S, Del Lourdes Cebrera Muñoz M, Rivera Pazos C, Maldonado Valenzuela A, et al. Overexpression of Yin Yang 1 in bone marrow-derived human multiple myeloma and its clinical significance. Int J Oncol. 2014;45:1184-92 pubmed publisher
Peng M, Xie J, Ucher A, Stavnezer J, Cantor S. Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses. EMBO J. 2014;33:1698-712 pubmed publisher
McCarthy P. Second transplant as a standard for multiple myeloma. Lancet Oncol. 2014;15:786-8 pubmed publisher
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product information
Catalog Number :
M2011
Product Name :
Melphalan
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA