This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Dihydrocapsaicin
catalog :
M1022
citations: 35
Reference
M S, Chhapekar S, Ahmad I, Abraham S, Ramchiary N. Analysis of bioactive components in Ghost chili (Capsicum chinense) for antioxidant, genotoxic, and apoptotic effects in mice. Drug Chem Toxicol. 2020;43:182-191 pubmed publisher
Shim Y, Kim J, Jeong S. Simultaneous Determination of Piperine, Capsaicin, and Dihydrocapsaicin in Korean Instant-Noodle (Ramyun) Soup Base Using High-Performance Liquid Chromatography with Ultraviolet Detection. J AOAC Int. 2016;99:187-92 pubmed publisher
Lim J, Kim G, Mo C, Kim M. Design and Fabrication of a Real-Time Measurement System for the Capsaicinoid Content of Korean Red Pepper (Capsicum annuum L.) Powder by Visible and Near-Infrared Spectroscopy. Sensors (Basel). 2015;15:27420-35 pubmed publisher
Almaghrabi S, Geraghty D, Ahuja K, Adams M. Vanilloid-like agents inhibit aggregation of human platelets. Thromb Res. 2014;134:412-7 pubmed publisher
Feketa V, Zhang Y, Cao Z, Balasubramanian A, Flores C, Player M, et al. Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. Crit Care Med. 2014;42:e355-63 pubmed publisher
Cao Z, Balasubramanian A, Marrelli S. Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. Am J Physiol Regul Integr Comp Physiol. 2014;306:R149-56 pubmed publisher
Feketa V, Balasubramanian A, Flores C, Player M, Marrelli S. Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition. Am J Physiol Regul Integr Comp Physiol. 2013;305:R1040-50 pubmed publisher
Goll J, Frey A, Minceva M. Study of the separation limits of continuous solid support free liquid-liquid chromatography: separation of capsaicin and dihydrocapsaicin by centrifugal partition chromatography. J Chromatogr A. 2013;1284:59-68 pubmed publisher
Tomohiro D, Mizuta K, Fujita T, Nishikubo Y, Kumamoto E. Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves. Life Sci. 2013;92:368-78 pubmed publisher
You Y, Uboh C, Soma L, Guan F, Taylor D, Li X, et al. Validated UHPLC-MS-MS method for rapid analysis of capsaicin and dihydrocapsaicin in equine plasma for doping control. J Anal Toxicol. 2013;37:122-32 pubmed publisher
Zhang Q, Hu J, Wang B, Li Y. Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14:382-95 pubmed publisher
Pauwels J, D Autry W, Van den Bossche L, Dewever C, Forier M, Vandenwaeyenberg S, et al. Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol. J Pharm Biomed Anal. 2012;60:51-8 pubmed publisher
Al Othman Z, Ahmed Y, Habila M, Ghafar A. Determination of capsaicin and dihydrocapsaicin in Capsicum fruit samples using high performance liquid chromatography. Molecules. 2011;16:8919-29 pubmed publisher
Grienke U, Mihaly Bison J, Schuster D, Afonyushkin T, Binder M, Guan S, et al. Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum. Bioorg Med Chem. 2011;19:6779-91 pubmed publisher
Santos M, Vieira da Motta O, Vieira I, Braz Filho R, Gonçalves P, Maria E, et al. Antibacterial activity of Capsicum annuum extract and synthetic capsaicinoid derivatives against Streptococcus mutans. J Nat Med. 2012;66:354-6 pubmed publisher
Wahyuni Y, Ballester A, Sudarmonowati E, Bino R, Bovy A. Metabolite biodiversity in pepper (Capsicum) fruits of thirty-two diverse accessions: variation in health-related compounds and implications for breeding. Phytochemistry. 2011;72:1358-70 pubmed publisher
Jia X, Liu Q, Wei Y, Chen B, Chu Y, Zhang J. [Simultaneously determination of atropine sulphate, diphenhydramine hydrochloride, capsaicin and dihydrocapsaicin in pain-relieving plaster for arthritis by RP-HPLC]. Zhongguo Zhong Yao Za Zhi. 2010;35:2838-41 pubmed
Ha J, Seo H, Shim Y, Nam H, Seog H, Ito M, et al. Rapid method for the determination of capsaicin and dihydrocapsaicin in Gochujang using ultra-high-performance liquid chromatography. J AOAC Int. 2010;93:1905-11 pubmed
Imaizumi K, Sato S, Kumazawa M, Arai N, Aritoshi S, Akimoto S, et al. Capsaicinoids-induced changes of plasma glucose, free fatty acid and glycerol concentrations in rats. J Toxicol Sci. 2011;36:109-16 pubmed
Fosgerau K, Weber U, Gotfredsen J, Jayatissa M, Buus C, Kristensen N, et al. Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. BMC Cardiovasc Disord. 2010;10:51 pubmed publisher
Fosgerau K, Ristagno G, Jayatissa M, Axelsen M, Gotfredsen J, Weber U, et al. Increased susceptibility to cardiovascular effects of dihydrocapcaicin in resuscitated rats. Cardiovascular effects of dihydrocapsaicin. BMC Cardiovasc Disord. 2010;10:39 pubmed publisher
Zhang Q, Hu J, Sheng L, Li Y. Simultaneous quantification of capsaicin and dihydrocapsaicin in rat plasma using HPLC coupled with tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878:2292-7 pubmed publisher
Bloomer R, Canale R, Shastri S, Suvarnapathki S. Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo controlled, double-blind, cross-over study. Lipids Health Dis. 2010;9:72 pubmed publisher
Choi C, Jung Y, Oh S. Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines. Free Radic Biol Med. 2010;49:245-57 pubmed publisher
Gao F, Wang D. Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism. Hypertension. 2010;55:1018-25 pubmed publisher
Liu Y, Nair M. Capsaicinoids in the hottest pepper Bhut Jolokia and its antioxidant and antiinflammatory activities. Nat Prod Commun. 2010;5:91-4 pubmed
Peng A, Ye H, Li X, Chen L. Preparative separation of capsaicin and dihydrocapsaicin from Capsicum frutescens by high-speed counter-current chromatography. J Sep Sci. 2009;32:2967-73 pubmed publisher
Akimoto S, Tanihata J, Kawano F, Sato S, Takei Y, Shirato K, et al. Acute effects of dihydrocapsaicin and capsaicin on the distribution of white blood cells in rats. J Nutr Sci Vitaminol (Tokyo). 2009;55:282-7 pubmed
Adams M, Ahuja K, Geraghty D. Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation. Thromb Res. 2009;124:721-3 pubmed publisher
Oh S, Lim S. Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lu. J Pharmacol Exp Ther. 2009;329:112-22 pubmed publisher
Antonious G, Berke T, Jarret R. Pungency in Capsicum chinense: variation among countries of origin. J Environ Sci Health B. 2009;44:179-84 pubmed publisher
Peña Alvarez A, Ramírez Maya E, Alvarado Suárez L. Analysis of capsaicin and dihydrocapsaicin in peppers and pepper sauces by solid phase microextraction-gas chromatography-mass spectrometry. J Chromatogr A. 2009;1216:2843-7 pubmed publisher
Oh S, Kim Y, Lim S, Hou Y, Chang I, You H. Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner. Autophagy. 2008;4:1009-19 pubmed
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
Surh Y, Ahn S, Kim K, Park J, Sohn Y, Lee S. Metabolism of capsaicinoids: evidence for aliphatic hydroxylation and its pharmacological implications. Life Sci. 1995;56:PL305-11 pubmed
product information
Catalog Number :
M1022
Product Name :
Dihydrocapsaicin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
from Capsicum sp., ≥85%
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA