Shi L, Huang C, Luo Q, Xia Y, Liu W, Zeng W, et al. Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson's disease through AKT/mTOR pathway. Aging (Albany NY). 2020;12:9515-9533 pubmed publisher

Lang Y, Li Y, Yu H, Lin L, Chen X, Wang S, et al. HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 via miR-221-3p binding. Aging (Albany NY). 2020;12:7660-7678 pubmed publisher

Ugalde Muñiz P, Fetter Pruneda I, Navarro L, Garcia E, Chavarria A. Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson's Disease Model. Oxid Med Cell Longev. 2020;2020:4807179 pubmed publisher

Heo J, Nam M, Yoon H, Kim J, Hwang Y, Won W, et al. Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease. Curr Biol. 2020;30:276-291.e9 pubmed publisher

Neal M, Fleming S, Budge K, Boyle A, Kim C, Alam G, et al. Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration. FASEB J. 2020;34:1679-1694 pubmed publisher

Liu H, Wu H, Zhu N, Xu Z, Wang Y, Qu Y, et al. Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in mice. J Neurochem. 2020;152:397-415 pubmed publisher

Verma A, Ravindranath V. CaV1.3 L-Type Calcium Channels Increase the Vulnerability of Substantia Nigra Dopaminergic Neurons in MPTP Mouse Model of Parkinson's Disease. Front Aging Neurosci. 2019;11:382 pubmed publisher

Wang L, Yu X, Li X, Zhao Y, Wang C, Wang Z, et al. Catalpol Exerts a Neuroprotective Effect in the MPTP Mouse Model of Parkinson's Disease. Front Aging Neurosci. 2019;11:316 pubmed publisher

Sn S, Pandurangi J, Murumalla R, Dj V, Garimella L, Acharya A, et al. Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration. EBioMedicine. 2019;50:260-273 pubmed publisher

Singh S, Mishra A, Tiwari V, Shukla S. Enhanced neuroinflammation and oxidative stress are associated with altered hippocampal neurogenesis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treated mice. Behav Pharmacol. 2019;30:689-699 pubmed publisher

Wang Y, Chen C, Huang W, Huang M, Wang J, Chen X, et al. Beneficial effects of PGC-1α in the substantia nigra of a mouse model of MPTP-induced dopaminergic neurotoxicity. Aging (Albany NY). 2019;11:8937-8950 pubmed publisher

Han J, Kim S, Ryu M, Jang Y, Lee M, Ju X, et al. Chloramphenicol Mitigates Oxidative Stress by Inhibiting Translation of Mitochondrial Complex I in Dopaminergic Neurons of Toxin-Induced Parkinson's Disease Model. Oxid Med Cell Longev. 2019;2019:4174803 pubmed publisher

Yu Y, Lang X, Li X, Gu R, Liu Q, Lan R, et al. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside attenuates MPP+/MPTP-induced neurotoxicity in vitro and in vivo by restoring the BDNF-TrkB and FGF2-Akt signaling axis and inhibition of apoptosis. Food Funct. 2019;10:6009-6019 pubmed publisher

Wang Y, Chen A, Xue Y, Liu M, Liu C, Liu Y, et al. Orexins alleviate motor deficits via increasing firing activity of pallidal neurons in a mouse model of Parkinson's disease. Am J Physiol Cell Physiol. 2019;317:C800-C812 pubmed publisher

Yuan L, Wang X, Wang H, Zhang M, Sun J, Chen W. G protein-coupled estrogen receptor is involved in the neuroprotective effect of IGF-1 against MPTP/MPP+-induced dopaminergic neuronal injury. J Steroid Biochem Mol Biol. 2019;192:105384 pubmed publisher

Kim S, Ryu M, Han J, Jang Y, Lee M, Ju X, et al. Non-cell autonomous modulation of tyrosine hydroxylase by HMGB1 released from astrocytes in an acute MPTP-induced Parkinsonian mouse model. Lab Invest. 2019;: pubmed publisher

Yang J, Lv D, Li L, Wang Y, Qi D, Chen J, et al. Nicotine improved the olfactory impairment in MPTP-induced mouse model of Parkinson's disease. Neurotoxicology. 2019;73:175-182 pubmed publisher

Xue J, Liu Y, Darabi M, Tu G, Huang L, Ying L, et al. An injectable conductive Gelatin-PANI hydrogel system serves as a promising carrier to deliver BMSCs for Parkinson's disease treatment. Mater Sci Eng C Mater Biol Appl. 2019;100:584-597 pubmed publisher

Selvaraj V, Venkatasubramanian H, Ilango K, Santhakumar K. A simple method to study motor and non-motor behaviors in adult zebrafish. J Neurosci Methods. 2019;320:16-25 pubmed publisher

Liang Y, Chen C, Xia B, Wu W, Tang J, Chen Q, et al. Neuroprotective Effect of Echinacoside in Subacute Mouse Model of Parkinson's Disease. Biomed Res Int. 2019;2019:4379639 pubmed publisher

Acar N, Parlak H, Ozkan A, Soylu H, Avcı S, Ustunel I, et al. The effect of docosahexaenoic acid on apelin distribution of nervous system in the experimental mouse model of Parkinson's disease. Tissue Cell. 2019;56:41-51 pubmed publisher

Xu S, Zhang Y, Wang S, Pang Z, Fan Y, Li J, et al. Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice. Redox Biol. 2019;21:101090 pubmed publisher

Qu L, Xu H, Jia W, Jiang H, Xie J. Rosmarinic acid protects against MPTP-induced toxicity and inhibits iron-induced α-synuclein aggregation. Neuropharmacology. 2019;144:291-300 pubmed publisher

García Domínguez I, Veselá K, García Revilla J, Carrillo Jimenez A, Roca Ceballos M, Santiago M, et al. Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson's Disease. Front Cell Neurosci. 2018;12:398 pubmed publisher

Su J, Huang P, Qin M, Lu Q, Sang X, Cai Y, et al. Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models. Cell Death Dis. 2018;9:1020 pubmed publisher

Suresh S, Chavalmane A, Pillai M, Ammanathan V, Vidyadhara D, Yarreiphang H, et al. Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective. Front Mol Neurosci. 2018;11:109 pubmed publisher

Bhattacharya S, Ma Y, Dunn A, Bradner J, Scimemi A, Miller G, et al. NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate. J Neurosci Res. 2018;96:1324-1335 pubmed publisher

Yang W, Chen Y, Liu H, Qu H. Neuroprotective effects of piperine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model. Int J Mol Med. 2015;36:1369-76 pubmed publisher

Zuo F, Bao X, Sun X, Wu J, Bai Q, Chen G, et al. Transplantation of Human Neural Stem Cells in a Parkinsonian Model Exerts Neuroprotection via Regulation of the Host Microenvironment. Int J Mol Sci. 2015;16:26473-92 pubmed publisher

Liu W, Li Y, Jalewa J, Saunders Wood T, Li L, Hölscher C. Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease. Eur J Pharmacol. 2015;765:284-90 pubmed publisher

Kikuta S, Nakamura Y, Yamamura Y, Tamura A, Homma N, Yanagawa Y, et al. Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice. Sci Rep. 2015;5:12800 pubmed publisher

Jiang W, Wang Z, Jiang Y, Lü M, Li X. Ginsenoside Rg1 Ameliorates Motor Function in an Animal Model of Parkinson's Disease. Pharmacology. 2015;96:25-31 pubmed publisher

Sa F, Zhang L, Chong C, Guo B, Li S, Zhang Z, et al. Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo. Neurosci Lett. 2015;593:7-12 pubmed publisher

Cannella M, Motolese M, Bucci D, Molinaro G, Gradini R, Bruno V, et al. Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism. Neuropharmacology. 2015;95:50-8 pubmed publisher

Masoud S, Vecchio L, Bergeron Y, Hossain M, Nguyen L, Bermejo M, et al. Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits. Neurobiol Dis. 2015;74:66-75 pubmed publisher

Badruzzaman M, Imamura S, Takeuchi Y, Ikegami T, Takemura A. Effects of neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment on ovarian development of the sapphire devil, Chrysiptera cyanea. Fish Physiol Biochem. 2015;41:61-71 pubmed publisher

Wang Q, Chu C, Qian L, Chen S, Wilson B, Oyarzabal E, et al. Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase. J Neurosci. 2014;34:12490-503 pubmed publisher

Lohr K, Bernstein A, Stout K, Dunn A, Lazo C, Alter S, et al. Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo. Proc Natl Acad Sci U S A. 2014;111:9977-82 pubmed publisher

Fernández Suárez D, Celorrio M, Riezu Boj J, Ugarte A, Pacheco R, Gonzalez H, et al. Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. Neurobiol Aging. 2014;35:2603-2616 pubmed publisher

Joniec Maciejak I, Ciesielska A, Wawer A, Sznejder Pachołek A, Schwenkgrub J, Cudna A, et al. The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease. Pharmacol Rep. 2014;66:660-9 pubmed publisher

Gyoneva S, Shapiro L, Lazo C, Garnier Amblard E, Smith Y, Miller G, et al. Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease. Neurobiol Dis. 2014;67:191-202 pubmed publisher

Huot P, Johnston T, Lewis K, Koprich J, Reyes M, Fox S, et al. UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances L-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset. Neuropharmacology. 2014;82:76-87 pubmed publisher

Souza B, Romano Silva M, Tropepe V. Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae. J Neurosci. 2011;31:5512-25 pubmed publisher

Pretorius A, Ogunrombi M, Fourie H, Terre Blanche G, Castagnoli N, Bergh J, et al. Interactions of 1-methyl-3-phenylpyrrolidine and 3-methyl-1-phenyl-3-azabicyclo[3.1.0]hexane with monoamine oxidase B. Bioorg Med Chem. 2010;18:4111-8 pubmed publisher

Medvedeva Y, Lin B, Shuttleworth C, Weiss J. Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia. J Neurosci. 2009;29:1105-14 pubmed publisher

Elsworth J, Redmond D, Leranth C, Bjugstad K, Sladek J, Collier T, et al. AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons. Exp Neurol. 2008;211:252-8 pubmed publisher

Wimalasena D, Perera R, Heyen B, Balasooriya I, Wimalasena K. Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study. J Med Chem. 2008;51:760-8 pubmed publisher

Sampson N, Ryan S, Enke D, Cosgrove D, Koteliansky V, Gotwals P. Global gene expression analysis reveals a role for the alpha 1 integrin in renal pathogenesis. J Biol Chem. 2001;276:34182-8 pubmed