product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Anti-LC3 antibody produced in rabbit
catalog :
L8918
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation
more info or order :
citations: 154
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 2g
Liu D, Wu H, Wang C, Li Y, Tian H, Siraj S, et al. STING directly activates autophagy to tune the innate immune response. Cell Death Differ. 2018;: pubmed publisher
  • immunocytochemistry; human; 1:50; loading ...; fig 7a
  • western blot; human; loading ...; fig 5a
Guo J, Fang W, Chen X, Lin Y, Hu G, Wei J, et al. Upstream stimulating factor 1 suppresses autophagy and hepatic lipid droplet catabolism by activating mTOR. FEBS Lett. 2018;592:2725-2738 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Bustos V, Pulina M, Kelahmetoglu Y, Sinha S, Gorelick F, Flajolet M, et al. Bidirectional regulation of Aβ levels by Presenilin 1. Proc Natl Acad Sci U S A. 2017;114:7142-7147 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 2d
Xie Y, Ma W, Meng J, Ren X. Knockdown of ZFPL1 results in increased autophagy and autophagy‑related cell death in NCI‑N87 and BGC‑823 human gastric carcinoma cell lines. Mol Med Rep. 2017;15:2633-2642 pubmed publisher
  • western blot; human; loading ...; fig 3a,4a,4i,4j
Li Y, Chang Y, Ye N, Dai D, Chen Y, Zhang N, et al. Advanced Glycation End Products Inhibit the Proliferation of Human Umbilical Vein Endothelial Cells by Inhibiting Cathepsin D. Int J Mol Sci. 2017;18: pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig 2E
  • western blot; mouse; 1:2000; loading ...; fig 2A
Redmann M, Wani W, Volpicelli Daley L, Darley Usmar V, Zhang J. Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils. Redox Biol. 2017;11:429-437 pubmed publisher
  • western blot; human; 1:2500; loading ...; fig s1
Piccolella M, Crippa V, Cristofani R, Rusmini P, Galbiati M, Cicardi M, et al. The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells. Oncotarget. 2017;8:10400-10415 pubmed publisher
  • western blot; human; 1:2000; fig 3d
Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, et al. MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun. 2016;7:12109 pubmed publisher
  • western blot; rat; 1:600; fig 2
Gui L, Liu B, Lv G. Hypoxia induces autophagy in cardiomyocytes via a hypoxia-inducible factor 1-dependent mechanism. Exp Ther Med. 2016;11:2233-2239 pubmed
  • western blot; human; fig 3
Bretin A, Carrière J, Dalmasso G, Bergougnoux A, B chir W, Maurin A, et al. Activation of the EIF2AK4-EIF2A/eIF2?-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection. Autophagy. 2016;12:770-83 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 1b
Crippa V, D Agostino V, Cristofani R, Rusmini P, Cicardi M, Messi E, et al. Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases. Sci Rep. 2016;6:22827 pubmed publisher
  • western blot; human; fig 1
Jennewein L, Ronellenfitsch M, Antonietti P, Ilina E, Jung J, Stadel D, et al. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget. 2016;7:20016-32 pubmed publisher
Kim Y, Kim J, Hanh B, Kim S, Kim H, Kim Y, et al. The Peroxisome Proliferator-Activated Receptor α- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections. Cells. 2020;9: pubmed publisher
Li Y, Xie J, Li X, Fang J. Poly (ADP-ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation-associated chemotherapy-induced autophagy in leukaemia cells. Oncol Lett. 2020;19:368-378 pubmed publisher
Casagrande F, Amadeo A, Cartelli D, Calogero A, Modena D, Costa I, et al. The imbalance between dynamic and stable microtubules underlies neurodegeneration induced by 2,5-hexanedione. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165581 pubmed publisher
Zhou J, Xue Z, He H, Liu X, Yin S, Wu D, et al. Resveratrol delays postovulatory aging of mouse oocytes through activating mitophagy. Aging (Albany NY). 2019;11:11504-11519 pubmed publisher
Zhai R, Dong X, Feng L, Li S, Hu Z. The Effect of Heat Stress on Autophagy and Apoptosis of Rumen, Abomasum, Duodenum, Liver and Kidney Cells in Calves. Animals (Basel). 2019;9: pubmed publisher
Luparello C, Ragona D, Asaro D, Lazzara V, Affranchi F, Celi M, et al. Cytotoxic Potential of the Coelomic Fluid Extracted from the Sea Cucumber Holothuria tubulosa against Triple-Negative MDA-MB231 Breast Cancer Cells. Biology (Basel). 2019;8: pubmed publisher
BasuRay S. RAB18 modulates autophagy in human stellate cells. J Clin Lipidol. 2019;13:832-838 pubmed publisher
Choi J, Lee J, Lee J, Park B, Lee E, Shin S, et al. Omega-3 Polyunsaturated Fatty Acids Prevent Toxoplasma gondii Infection by Inducing Autophagy via AMPK Activation. Nutrients. 2019;11: pubmed publisher
Cicardi M, Cristofani R, Crippa V, Ferrari V, Tedesco B, Casarotto E, et al. Autophagic and Proteasomal Mediated Removal of Mutant Androgen Receptor in Muscle Models of Spinal and Bulbar Muscular Atrophy. Front Endocrinol (Lausanne). 2019;10:569 pubmed publisher
Zhang H, Alsaleh G, Feltham J, Sun Y, Napolitano G, Riffelmacher T, et al. Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. Mol Cell. 2019;76:110-125.e9 pubmed publisher
Koerver L, Papadopoulos C, Liu B, Kravic B, Rota G, Brecht L, et al. The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage. EMBO Rep. 2019;20:e48014 pubmed publisher
Liu C, Peng M, Zheng L, Zhao Y, Wang R, Su Q, et al. Enhanced autophagy alleviates injury during hindlimb ischemia/reperfusion in mice. Exp Ther Med. 2019;18:1669-1676 pubmed publisher
Rasheduzzaman M, Yin H, Park S. Cardiac glycoside sensitized hepatocellular carcinoma cells to TRAIL via ROS generation, p38MAPK, mitochondrial transition, and autophagy mediation. Mol Carcinog. 2019;58:2040-2051 pubmed publisher
Auburger G, Gispert S, Torres Odio S, Jendrach M, Brehm N, Canet Pons J, et al. SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. Int J Mol Sci. 2019;20: pubmed publisher
Dong X, Zhai R, Liu Z, Lin X, Wang Z, Hu Z. The Effect of Intravenous Infusions of Glutamine on Duodenal Cell Autophagy and Apoptosis in Early-Weaned Calves. Animals (Basel). 2019;9: pubmed publisher
Mohseni Ahooyi T, Torkzaban B, Shekarabi M, Tahrir F, Decoppet E, Cotto B, et al. Perturbation of synapsins homeostasis through HIV-1 Tat-mediated suppression of BAG3 in primary neuronal cells. Cell Death Dis. 2019;10:473 pubmed publisher
Zhang G, Wang Z, Chen W, Cao Y, Wu J, Qiang G, et al. Dual effects of gossypol on human hepatocellular carcinoma via endoplasmic reticulum stress and autophagy. Int J Biochem Cell Biol. 2019;113:48-57 pubmed publisher
Ghasemi Tahrir F, Gupta M, Myers V, Gordon J, Cheung J, Feldman A, et al. Role of Bcl2-associated Athanogene 3 in Turnover of Gap Junction Protein, Connexin 43, in Neonatal Cardiomyocytes. Sci Rep. 2019;9:7658 pubmed publisher
Sghaier R, Zarrouk A, Nury T, Badreddine I, O Brien N, Mackrill J, et al. Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes. Free Radic Res. 2019;53:535-561 pubmed publisher
Sassi K, Nury T, Zarrouk A, Sghaier R, Khalafi Nezhad A, Vejux A, et al. Induction of a non-apoptotic mode of cell death associated with autophagic characteristics with steroidal maleic anhydrides and 7β-hydroxycholesterol on glioma cells. J Steroid Biochem Mol Biol. 2019;191:105371 pubmed publisher
Ding X, Jiang X, Tian R, Zhao P, Li L, Wang X, et al. RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. Autophagy. 2019;:1-13 pubmed publisher
Wan J, Yang X, Ren Y, Li X, Zhu Y, Haddock A, et al. Inhibition of miR-155 reduces impaired autophagy and improves prognosis in an experimental pancreatitis mouse model. Cell Death Dis. 2019;10:303 pubmed publisher
Souriant S, Balboa L, Dupont M, Pingris K, Kviatcovsky D, Cougoule C, et al. Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages. Cell Rep. 2019;26:3586-3599.e7 pubmed publisher
Liu P, de la Vega M, Dodson M, Yue F, Shi B, Fang D, et al. Spermidine Confers Liver Protection by Enhancing NRF2 Signaling Through a MAP1S-Mediated Noncanonical Mechanism. Hepatology. 2019;70:372-388 pubmed publisher
Park H, Back Y, Shin K, Bae H, Lee K, Choi H, et al. Mycobacterium tuberculosis Rv3463 induces mycobactericidal activity in macrophages by enhancing phagolysosomal fusion and exhibits therapeutic potential. Sci Rep. 2019;9:4246 pubmed publisher
Kakimoto Y, Okada C, Kawabe N, Sasaki A, Tsukamoto H, Nagao R, et al. Myocardial lipofuscin accumulation in ageing and sudden cardiac death. Sci Rep. 2019;9:3304 pubmed publisher
Luparello C, Asaro D, Cruciata I, Hassell Hart S, Sansook S, Spencer J, et al. Cytotoxic Activity of the Histone Deacetylase 3-Selective Inhibitor Pojamide on MDA-MB-231 Triple-Negative Breast Cancer Cells. Int J Mol Sci. 2019;20: pubmed publisher
Foggetti G, Ottaggio L, Russo D, Mazzitelli C, Monti P, Degan P, et al. Autophagy induced by SAHA affects mutant P53 degradation and cancer cell survival. Biosci Rep. 2019;39: pubmed publisher
Fontana F, Moretti R, Raimondi M, Marzagalli M, Beretta G, Procacci P, et al. δ-Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells. Cell Prolif. 2019;52:e12576 pubmed publisher
Park S, Lee S, Lee W, Choi R, Kim S, Woo H, et al. MicroRNA expression profiling of adult hippocampal neural stem cells upon cell death reveals an autophagic cell death-like pattern. Biochem Biophys Res Commun. 2019;509:674-679 pubmed publisher
Crociara P, Chieppa M, Vallino Costassa E, Berrone E, Gallo M, Lo Faro M, et al. Motor neuron degeneration, severe myopathy and TDP-43 increase in a transgenic pig model of SOD1-linked familiar ALS. Neurobiol Dis. 2019;124:263-275 pubmed publisher
Grottelli S, Mezzasoma L, Scarpelli P, Cacciatore I, Cellini B, Bellezza I. Cyclo(His-Pro) inhibits NLRP3 inflammasome cascade in ALS microglial cells. Mol Cell Neurosci. 2019;94:23-31 pubmed publisher
Luo X, Yao H, Song J, Song Q, Shi B, Xia D, et al. Coxsackievirus B3 Infection Triggers Autophagy through 3 Pathways of Endoplasmic Reticulum Stress. Biomed Environ Sci. 2018;31:867-875 pubmed publisher
Claude Taupin A, Fonderflick L, Gauthier T, Mansi L, Pallandre J, Borg C, et al. ATG9A Is Overexpressed in Triple Negative Breast Cancer and Its In Vitro Extinction Leads to the Inhibition of Pro-Cancer Phenotypes. Cells. 2018;7: pubmed publisher
Moghadam A, da Silva Rosa S, Samiei E, Alizadeh J, Field J, Kawalec P, et al. Autophagy modulates temozolomide-induced cell death in alveolar Rhabdomyosarcoma cells. Cell Death Discov. 2018;4:52 pubmed publisher
Wen D, Cui C, Duan W, Wang W, Wang Y, Liu Y, et al. The role of insulin-like growth factor 1 in ALS cell and mouse models: A mitochondrial protector. Brain Res Bull. 2018;144:1-13 pubmed publisher
Humphry N, Wheatley S. Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3. Biol Open. 2018;7: pubmed publisher
Rizzo M, Beffy P, Del Carratore R, Falleni A, Pretini V, D Aurizio R, et al. Activation of the interferon type I response rather than autophagy contributes to myogenesis inhibition in congenital DM1 myoblasts. Cell Death Dis. 2018;9:1071 pubmed publisher
Kim J, Kim Y, Lee H, Jin H, Neupane C, Kim S, et al. GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections. Nat Commun. 2018;9:4184 pubmed publisher
Joy S, Thirunavukkarasu L, Agrawal P, Singh A, Sagar B, Manjithaya R, et al. Basal and starvation-induced autophagy mediates parasite survival during intraerythrocytic stages of Plasmodium falciparum. Cell Death Discov. 2018;4:43 pubmed publisher
Zorea J, Prasad M, Cohen L, Li N, Schefzik R, Ghosh S, et al. IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer. Cell Death Dis. 2018;9:944 pubmed publisher
Wang Y, Chen P, Wang L, Zhao J, Zhong Z, Wang Y, et al. Inhibition of Histone Deacetylases Prevents Cardiac Remodeling After Myocardial Infarction by Restoring Autophagosome Processing in Cardiac Fibroblasts. Cell Physiol Biochem. 2018;49:1999-2011 pubmed publisher
Yuan Y, Zhang Y, Han L, Sun S, Shu Y. miR-183 inhibits autophagy and apoptosis in gastric cancer cells by targeting ultraviolet radiation resistance-associated gene. Int J Mol Med. 2018;42:3562-3570 pubmed publisher
Xue X, Lv Y, Leng Y, Zhang Y. Protective effects of extracellular polymeric substances from Aphanizomenon flos-aquae on neurotoxicity induced by local anesthetics. Exp Ther Med. 2018;16:3011-3019 pubmed publisher
Cristofani R, Montagnani Marelli M, Cicardi M, Fontana F, Marzagalli M, Limonta P, et al. Dual role of autophagy on docetaxel-sensitivity in prostate cancer cells. Cell Death Dis. 2018;9:889 pubmed publisher
Krause K, Caution K, Badr A, Hamilton K, Saleh A, Patel K, et al. CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection. Autophagy. 2018;14:1928-1942 pubmed publisher
Cicardi M, Cristofani R, Rusmini P, Meroni M, Ferrari V, Vezzoli G, et al. Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells. Sci Rep. 2018;8:12390 pubmed publisher
Meddeb W, Rezig L, Zarrouk A, Nury T, Vejux A, Prost M, et al. Cytoprotective Activities of Milk Thistle Seed Oil Used in Traditional Tunisian Medicine on 7-Ketocholesterol and 24S-Hydroxycholesterol-Induced Toxicity on 158N Murine Oligodendrocytes. Antioxidants (Basel). 2018;7: pubmed publisher
He Q, Song X, Huang Y, Huang W, Ye B, Luo H, et al. Dexamethasone Stimulates Hepatitis B Virus (HBV) Replication Through Autophagy. Med Sci Monit. 2018;24:4617-4624 pubmed publisher
Savikj M, Ruby M, Kostovski E, Iversen P, Zierath J, Krook A, et al. Retained differentiation capacity of human skeletal muscle satellite cells from spinal cord-injured individuals. Physiol Rep. 2018;6:e13739 pubmed publisher
Mitsui S, Otomo A, Nozaki M, Ono S, Sato K, Shirakawa R, et al. Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model. Mol Brain. 2018;11:30 pubmed publisher
Zhou X, Curbo S, Li F, Krishnan S, Karlsson A. Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose. BMC Cancer. 2018;18:559 pubmed publisher
Marlier Q, Jibassia F, Verteneuil S, Linden J, Kaldis P, Meijer L, et al. Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death. Cell Death Discov. 2018;4:43 pubmed publisher
Bresciani A, Spiezia M, Boggio R, Cariulo C, Nordheim A, Altobelli R, et al. Quantifying autophagy using novel LC3B and p62 TR-FRET assays. PLoS ONE. 2018;13:e0194423 pubmed publisher
Zhou J, Li C, Yao W, Alsiddig M, Huo L, Liu H, et al. Hypoxia-inducible factor-1α-dependent autophagy plays a role in glycolysis switch in mouse granulosa cells. Biol Reprod. 2018;99:308-318 pubmed publisher
Xiang Y, Zhao J, Zhao M, Wang K. Allicin activates autophagic cell death to alleviate the malignant development of thyroid cancer. Exp Ther Med. 2018;15:3537-3543 pubmed publisher
Ding D, Xu S, Zhang H, Zhao W, Zhang X, Jiang Y, et al. 3-Methyladenine and dexmedetomidine reverse lipopolysaccharide-induced acute lung injury through the inhibition of inflammation and autophagy. Exp Ther Med. 2018;15:3516-3522 pubmed publisher
Piao Y, Gwon D, Kang D, Hwang T, Shin N, Kwon H, et al. TLR4-mediated autophagic impairment contributes to neuropathic pain in chronic constriction injury mice. Mol Brain. 2018;11:11 pubmed publisher
Li H, Miao D, Zhu Q, Huang J, Lu G, Xu W. MicroRNA-17-5p contributes to osteoarthritis progression by binding p62/SQSTM1. Exp Ther Med. 2018;15:1789-1794 pubmed publisher
Cheng F, Fransson L, Mani K. Common traffic routes for imported spermine and endosomal glypican-1-derived heparan sulfate in fibroblasts. Exp Cell Res. 2018;364:133-142 pubmed publisher
Döring T, Zeyen L, Bartusch C, Prange R. Hepatitis B Virus Subverts the Autophagy Elongation Complex Atg5-12/16L1 and Does Not Require Atg8/LC3 Lipidation for Viral Maturation. J Virol. 2018;92: pubmed publisher
Zhang Z, Chu S, Wang S, Jiang Y, Gao Y, Yang P, et al. RTP801 is a critical factor in the neurodegeneration process of A53T α-synuclein in a mouse model of Parkinson's disease under chronic restraint stress. Br J Pharmacol. 2018;175:590-605 pubmed publisher
Ghavami S, Yeganeh B, Zeki A, Shojaei S, Kenyon N, Ott S, et al. Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2018;314:L493-L504 pubmed publisher
Kim S, Yang C, Lee H, Kim J, Kim Y, Kim Y, et al. ESRRA (estrogen-related receptor α) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Autophagy. 2018;14:152-168 pubmed publisher
Tahrir F, Shanmughapriya S, Ahooyi T, Knezevic T, Gupta M, Kontos C, et al. Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. J Cell Physiol. 2018;233:748-758 pubmed publisher
Chaves R, Kazi A, Silva C, Almeida M, Lima R, Carrettiero D, et al. Presence of insoluble Tau following rotenone exposure ameliorates basic pathways associated with neurodegeneration. IBRO Rep. 2016;1:32-45 pubmed publisher
Cammalleri M, Locri F, Catalani E, Filippi L, Cervia D, Dal Monte M, et al. The Beta Adrenergic Receptor Blocker Propranolol Counteracts Retinal Dysfunction in a Mouse Model of Oxygen Induced Retinopathy: Restoring the Balance between Apoptosis and Autophagy. Front Cell Neurosci. 2017;11:395 pubmed publisher
Yong M, Yu T, Tian S, Liu S, Xu J, Hu J, et al. DR2 blocker thioridazine: A promising drug for ovarian cancer therapy. Oncol Lett. 2017;14:8171-8177 pubmed publisher
Piras A, Schiaffino L, Boido M, Valsecchi V, Guglielmotto M, De Amicis E, et al. Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy. Cell Death Dis. 2017;8:3223 pubmed publisher
Huang K, Kuo I, Tsai M, Wu C, Hsu L, Chen L, et al. Factor VII-Induced MicroRNA-135a Inhibits Autophagy and Is Associated with Poor Prognosis in Hepatocellular Carcinoma. Mol Ther Nucleic Acids. 2017;9:274-283 pubmed publisher
Wang A, Wang J, Zhang S, Zhang H, Xu Z, Li X. Curcumin inhibits the development of non-small cell lung cancer by inhibiting autophagy and apoptosis. Exp Ther Med. 2017;14:5075-5080 pubmed publisher
Alegre F, Moragrega A, Polo M, Marti Rodrigo A, Esplugues J, Blas García A, et al. Role of p62/SQSTM1 beyond autophagy: a lesson learned from drug-induced toxicity in vitro. Br J Pharmacol. 2017;: pubmed publisher
Lee M, Koh D, Na H, Ka N, Kim S, Kim H, et al. MTA1 is a novel regulator of autophagy that induces tamoxifen resistance in breast cancer cells. Autophagy. 2017;: pubmed publisher
Badreddine A, Zarrouk A, Karym E, Debbabi M, Nury T, Meddeb W, et al. Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N. Int J Mol Sci. 2017;18: pubmed publisher
Kawano S, Torisu T, Esaki M, Torisu K, Matsuno Y, Kitazono T. Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion. Biol Open. 2017;6:1644-1653 pubmed publisher
Liu N, Lei R, Tang M, Cheng W, Luo M, Xu Q, et al. Autophagy is activated to protect renal tubular epithelial cells against iodinated contrast media‑induced cytotoxicity. Mol Med Rep. 2017;16:8277-8282 pubmed publisher
Riffelmacher T, Clarke A, Richter F, Stranks A, Pandey S, Danielli S, et al. Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation. Immunity. 2017;47:466-480.e5 pubmed publisher
Poillet Perez L, Jacquet M, Hervouet E, Gauthier T, Fraichard A, Borg C, et al. GABARAPL1 tumor suppressive function is independent of its conjugation to autophagosomes in MCF-7 breast cancer cells. Oncotarget. 2017;8:55998-56020 pubmed publisher
de Oliveira Alves N, Vessoni A, Quinet A, Fortunato R, Kajitani G, Peixoto M, et al. Biomass burning in the Amazon region causes DNA damage and cell death in human lung cells. Sci Rep. 2017;7:10937 pubmed publisher
Zhu C, Bao N, Chen S, Zhao J. Dioscin enhances osteoblastic cell differentiation and proliferation by inhibiting cell autophagy via the ASPP2/NF-κβ pathway. Mol Med Rep. 2017;16:4922-4926 pubmed publisher
Dodson M, Wani W, Redmann M, Benavides G, Johnson M, Ouyang X, et al. Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons. Autophagy. 2017;13:1828-1840 pubmed publisher
Zhou J, Yao W, Li C, Wu W, Li Q, Liu H. Administration of follicle-stimulating hormone induces autophagy via upregulation of HIF-1? in mouse granulosa cells. Cell Death Dis. 2017;8:e3001 pubmed publisher
Wani W, Ouyang X, Benavides G, Redmann M, Cofield S, Shacka J, et al. O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease. Mol Brain. 2017;10:32 pubmed publisher
Zhang R, Xu J, Zhao J, Bai J. Mir-30d suppresses cell proliferation of colon cancer cells by inhibiting cell autophagy and promoting cell apoptosis. Tumour Biol. 2017;39:1010428317703984 pubmed publisher
Xin Y, Huang Q, Zhang P, Guo W, Zhang L, Jiang G. Demethoxycurcumin in combination with ultraviolet radiation B induces apoptosis through the mitochondrial pathway and caspase activation in A431 and HaCaT cells. Tumour Biol. 2017;39:1010428317706216 pubmed publisher
Kim T, Shin Y, Lee H, Kim J, Choe J, Jang J, et al. Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway. Sci Rep. 2017;7:3431 pubmed publisher
Liu H, Ma Y, He H, Zhao W, Shao R. SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells. Autophagy. 2017;13:900-913 pubmed publisher
Lin T, Filek R, Wang J, Wu C, Liu H, Hutnik C. Impression cytology implicates cell autophagy in aqueous deficiency dry eye. Clin Ophthalmol. 2017;11:773-779 pubmed publisher
Zhang T, Wang T, Cai P. Sclareol inhibits cell proliferation and sensitizes cells to the antiproliferative effect of bortezomib via upregulating the tumor suppressor caveolin-1 in cervical cancer cells. Mol Med Rep. 2017;15:3566-3574 pubmed publisher
Cheng S, Wani W, Hottman D, Jeong A, Cao D, LeBlanc K, et al. Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice. J Neurochem. 2017;142:297-304 pubmed publisher
Cristofani R, Crippa V, Rusmini P, Cicardi M, Meroni M, Licata N, et al. Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases. Autophagy. 2017;13:1280-1303 pubmed publisher
Yang Y, Luo P, Xu H, Dai S, Rao W, Peng C, et al. RNF146 Inhibits Excessive Autophagy by Modulating the Wnt-?-Catenin Pathway in Glutamate Excitotoxicity Injury. Front Cell Neurosci. 2017;11:59 pubmed publisher
Cheng X, Ma X, Ding X, Li L, Jiang X, Shen Z, et al. Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17. Mol Cell. 2017;65:1029-1043.e5 pubmed publisher
Dos Santos A, Terra L, Wailemann R, Oliveira T, Gomes V, Mineiro M, et al. Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells. BMC Cancer. 2017;17:194 pubmed publisher
Le Borgne F, Ravaut G, Bernard A, Demarquoy J. L-carnitine protects C2C12 cells against mitochondrial superoxide overproduction and cell death. World J Biol Chem. 2017;8:86-94 pubmed publisher
Kim Y, Lee H, Kim J, Yang C, Kim T, Jung M, et al. PPAR-? Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism. J Immunol. 2017;198:3283-3295 pubmed publisher
Wald Altman S, Pichinuk E, Kakhlon O, Weil M. A differential autophagy-dependent response to DNA double-strand breaks in bone marrow mesenchymal stem cells from sporadic ALS patients. Dis Model Mech. 2017;10:645-654 pubmed publisher
Sun M, Hou L, Tang Y, Liu Y, Wang S, Wang J, et al. Pseudorabies virus infection inhibits autophagy in permissive cells in vitro. Sci Rep. 2017;7:39964 pubmed publisher
Brahmi F, Hadj Ahmed S, Zarrouk A, Bezine M, Nury T, Madani K, et al. Evidence of biological activity of Mentha species extracts on apoptotic and autophagic targets on murine RAW264.7 and human U937 monocytic cells. Pharm Biol. 2017;55:286-293 pubmed
Redmann M, Benavides G, Berryhill T, Wani W, Ouyang X, Johnson M, et al. Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons. Redox Biol. 2017;11:73-81 pubmed publisher
Zheng N, Liu L, Liu W, Li F, Hayashi T, Tashiro S, et al. Crosstalk of ROS/RNS and autophagy in silibinin-induced apoptosis of MCF-7 human breast cancer cells in vitro. Acta Pharmacol Sin. 2017;38:277-289 pubmed publisher
Kim J, Lee H, Park K, Shin D, Kim T, Kim Y, et al. MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2. Autophagy. 2017;13:423-441 pubmed publisher
Antón Z, Landajuela A, Hervás J, Montes L, Hernandez Tiedra S, Velasco G, et al. Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP. Autophagy. 2016;12:2386-2403 pubmed
Baisantry A, Bhayana S, Wrede C, Hegermann J, Haller H, Melk A, et al. The impact of autophagy on the development of senescence in primary tubular epithelial cells. Cell Cycle. 2016;15:2973-2979 pubmed
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product information
Product No. :
L8918
Product Name :
Anti-LC3 antibody produced in rabbit
Host :
rabbit
Conjugate :
unconjugated
Antibody Type :
polyclonal
Applications/Description :
Suitable for immunoprecipitation (IP): 5-10 μg using extracts of human U87 cells; western blot: 1-2 μg/mL using whole extracts of rat and mouse brain
Species Reactivity :
mouse, human, rat
Concentration :
~1 mg/mL
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA