Dobner J, Simons I, Rufinatscha K, Hänsch S, Schwarten M, Weiergräber O, et al. Deficiency of GABARAP but not its Paralogs Causes Enhanced EGF-induced EGFR Degradation. Cells. 2020;9: pubmed publisher

Delgado Bellido D, Bueno Galera C, López Jiménez L, García Díaz A, Oliver F. Endothelial Phosphatase VE-PTP Participates in Vasculogenic Mimicry by Preventing Autophagic Degradation of VE-Cadherin. Front Oncol. 2020;10:18 pubmed publisher

Chang H, Siarot L, Matsuura R, Lo C, Sato H, Otsuki H, et al. Distinct MCM10 Proteasomal Degradation Profiles by Primate Lentiviruses Vpr Proteins. Viruses. 2020;12: pubmed publisher

Srinivasan V, Bruelle C, Scifo E, Pham D, Soliymani R, Lalowski M, et al. Dynamic Interaction of USP14 with the Chaperone HSC70 Mediates Crosstalk between the Proteasome, ER Signaling, and Autophagy. iScience. 2020;23:100790 pubmed publisher

Mansier O, Prouzet Mauleon V, Jegou G, Barroso K, Raymundo D, Chauveau A, et al. The Expression of Myeloproliferative Neoplasm-Associated Calreticulin Variants Depends on the Functionality of ER-Associated Degradation. Cancers (Basel). 2019;11: pubmed publisher

Luo J, Jin F, Yin M, Jin Z. Regulation of SRF protein stability by an autophagy-dependent pathway. Biochem Biophys Res Commun. 2019;: pubmed publisher

Leskelä S, Huber N, Rostalski H, Natunen T, Remes A, Takalo M, et al. C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner. Cells. 2019;8: pubmed publisher

Lee J, Kang M, Byun W, Kim S, Seo I, Han J, et al. Metformin overcomes resistance to cisplatin in triple-negative breast cancer (TNBC) cells by targeting RAD51. Breast Cancer Res. 2019;21:115 pubmed publisher

Tian S, Wu Q, Zhou B, Choi M, Ding B, Yang W, et al. Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex. Cell Rep. 2019;28:2517-2526.e5 pubmed publisher

Zhang M, Gao H, Liu D, Zhong X, Shi X, Yu P, et al. CaMKII-δ9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair. Nat Cell Biol. 2019;21:1152-1163 pubmed publisher

Belli V, Matrone N, Sagliocchi S, Incarnato R, Conte A, Pizzo E, et al. A dynamic link between H/ACA snoRNP components and cytoplasmic stress granules. Biochim Biophys Acta Mol Cell Res. 2019;1866:118529 pubmed publisher

Olson M, Widner R, Jorgenson L, Lawrence A, Lagundzin D, Woods N, et al. Proximity Labeling To Map Host-Pathogen Interactions at the Membrane of a Bacterium-Containing Vacuole in Chlamydia trachomatis-Infected Human Cells. Infect Immun. 2019;87: pubmed publisher

Eftekharzadeh B, Banduseela V, Chiesa G, Martínez Cristóbal P, Rauch J, Nath S, et al. Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. Nat Commun. 2019;10:3562 pubmed publisher

Ribeiro V, Andrade P, Valentão P, Pereira D. Benzoquinones from Cyperus spp. trigger IRE1α-independent and PERK-dependent ER stress in human stomach cancer cells and are novel proteasome inhibitors. Phytomedicine. 2019;63:153017 pubmed publisher

Qiu Y, Yao J, Jia L, Thompson D, Zacks D. Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis. Cell Death Dis. 2019;10:547 pubmed publisher

Arashiki N, Niitsuma K, Seki M, Takakuwa Y, Nakamura F. ATP11C T418N, a gene mutation causing congenital hemolytic anemia, reduces flippase activity due to improper membrane trafficking. Biochem Biophys Res Commun. 2019;516:705-712 pubmed publisher

Sun L, Bian K. The Nuclear Export and Ubiquitin-Proteasome-Dependent Degradation of PPARγ Induced By Angiotensin II. Int J Biol Sci. 2019;15:1215-1224 pubmed publisher

Chen J, Ko J, Yen T, Chen T, Lin Y, Ma P, et al. Capsaicin enhances erlotinib-induced cytotoxicity via AKT inactivation and excision repair cross-complementary 1 (ERCC1) down-regulation in human lung cancer cells. Toxicol Res (Camb). 2019;8:459-470 pubmed publisher

Tamura N, Kageyama S, Komatsu M, Waguri S. Hyperosmotic stress induces unconventional autophagy independent of the Ulk1 complex. Mol Cell Biol. 2019;: pubmed publisher

Kageyama M, Ota T, Sasaoka M, Katsuta O, Shinomiya K. Chemical proteasome inhibition as a novel animal model of inner retinal degeneration in rats. PLoS ONE. 2019;14:e0217945 pubmed publisher

Weigert A, von Knethen A, Thomas D, Faria I, Namgaladze D, Zezina E, et al. Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:1235-1246 pubmed publisher

Li L, Fan P, Chou H, Li J, Wang K, Li H. Herbacetin suppressed MMP9 mediated angiogenesis of malignant melanoma through blocking EGFR-ERK/AKT signaling pathway. Biochimie. 2019;162:198-207 pubmed publisher

Pellei M, Gandin V, Marchio L, Marzano C, Bagnarelli L, Santini C. Syntheses and Biological Studies of Cu(II) Complexes Bearing Bis(pyrazol-1-yl)- and Bis(triazol-1-yl)-acetato Heteroscorpionate Ligands. Molecules. 2019;24: pubmed publisher

Berryman K, Buhimschi C, Zhao G, Axe M, Locke M, Buhimschi I. Proteasome Levels and Activity in Pregnancies Complicated by Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Thrombocytopenia (HELLP) Syndrome. Hypertension. 2019;73:1308-1318 pubmed publisher

Han K, Zhao D, Liu Y, Liu Q, Huang X, Yang J, et al. The ubiquitin-proteasome system is necessary for the replication of duck Tembusu virus. Microb Pathog. 2019;132:362-368 pubmed publisher

Llamas González Y, Campos D, Pascale J, Arbiza J, González Santamaría J. A Functional Ubiquitin-Proteasome System is Required for Efficient Replication of New World Mayaro and Una Alphaviruses. Viruses. 2019;11: pubmed publisher

Ferrara N, Jarome T, Cullen P, Orsi S, Kwapis J, Trask S, et al. GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating. Sci Rep. 2019;9:5180 pubmed publisher

Zhang J, He J, Johnson J, Napolitano G, Ramadass M, Rahman F, et al. Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency. Autophagy. 2019;:1-19 pubmed publisher

Amarelle L, Katzen J, Shigemura M, Welch L, Cajigas H, Peteranderl C, et al. Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery. Am J Physiol Lung Cell Mol Physiol. 2019;316:L1094-L1106 pubmed publisher

Won G, Park S, Park J, Lee Y, Lee Y. Mammalian Hippo kinase pathway is downregulated by BCL-2 via protein degradation. Biochem Biophys Res Commun. 2019;: pubmed publisher

Kim S, Woo S, Min K, Seo S, Lee T, Kubatka P, et al. WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP. Cancers (Basel). 2019;11: pubmed publisher

Malhotra P, Soni V, Yamanashi Y, Takada T, Suzuki H, Gill R, et al. Mechanisms of Niemann-Pick type C1 Like 1 protein degradation in intestinal epithelial cells. Am J Physiol Cell Physiol. 2019;316:C559-C566 pubmed publisher

Mahajan N, Hoover B, Rajendram M, Shi H, Kawasaki K, Weibel D, et al. Maspin binds to cardiolipin in mitochondria and triggers apoptosis. FASEB J. 2019;33:6354-6364 pubmed publisher

Lee S, Lee J, Lee E, Park S, Kang D, Min C, et al. Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes. Cell Rep. 2019;26:2194-2211.e6 pubmed publisher

Lacefield C, Pnevmatikakis E, Paninski L, Bruno R. Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex. Cell Rep. 2019;26:2000-2008.e2 pubmed publisher

Zhang J, He J, Johnson J, Rahman F, Gavathiotis E, Cuervo A, et al. Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells. Front Endocrinol (Lausanne). 2019;10:21 pubmed publisher

Sachse S, Lievens S, Ribeiro L, Dascenco D, Masschaele D, Horré K, et al. Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation. EMBO J. 2019;38: pubmed publisher

Puscalau Girtu I, Scheller J, Claus S, Fändrich M. Cell assay for the identification of amyloid inhibitors in systemic AA amyloidosis. Amyloid. 2019;26:24-33 pubmed publisher

Chen X, Hu L, Yang H, Ma H, Ye K, Zhao C, et al. DHHC protein family targets different subsets of glioma stem cells in specific niches. J Exp Clin Cancer Res. 2019;38:25 pubmed publisher

Abdullah M, Greenfield L, Bronte Tinkew D, Capurro M, Rizzuti D, Jones N. VacA promotes CagA accumulation in gastric epithelial cells during Helicobacter pylori infection. Sci Rep. 2019;9:38 pubmed publisher

Zaoui K, Duhamel S, Parachoniak C, Park M. CLIP-170 spatially modulates receptor tyrosine kinase recycling to coordinate cell migration. Traffic. 2019;20:187-201 pubmed publisher

Barrera Vázquez O, Cancio Lonches C, Hernández González O, Chavez Munguia B, Villegas Sepúlveda N, Gutiérrez Escolano A. The feline calicivirus leader of the capsid protein causes survivin and XIAP downregulation and apoptosis. Virology. 2019;527:146-158 pubmed publisher

Chen J, Wu C, Peng Y, Zheng H, Lin Y, Ma P, et al. Astaxanthin enhances erlotinib-induced cytotoxicity by p38 MAPK mediated xeroderma pigmentosum complementation group C (XPC) down-regulation in human lung cancer cells. Toxicol Res (Camb). 2018;7:1247-1256 pubmed publisher

Fang C, Cai X, Hayashi S, Hao S, Sakiyama H, Wang X, et al. Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1864:271-280 pubmed publisher

Lillethorup T, Glud A, Alstrup A, Noer O, Nielsen E, Schacht A, et al. Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs. Sci Rep. 2018;8:15715 pubmed publisher

Fornasiero E, Mandad S, Wildhagen H, Alevra M, Rammner B, Keihani S, et al. Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions. Nat Commun. 2018;9:4230 pubmed publisher

Conte C, Griffis E, Hickson I, Pérez Oliva A. USP45 and Spindly are part of the same complex implicated in cell migration. Sci Rep. 2018;8:14375 pubmed publisher

Lopez Coral A, Striz A, Tuma P. A Serine/Threonine Kinase 16-Based Phospho-Proteomics Screen Identifies WD Repeat Protein-1 As A Regulator Of Constitutive Secretion. Sci Rep. 2018;8:13049 pubmed publisher

Balaji V, Kaniyappan S, Mandelkow E, Wang Y, Mandelkow E. Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems. Autophagy. 2018;14:2139-2154 pubmed publisher

Vigneron N, Ferrari V, van den Eynde B, Cresswell P, Leonhardt R. Cytosolic Processing Governs TAP-Independent Presentation of a Critical Melanoma Antigen. J Immunol. 2018;201:1875-1888 pubmed publisher

Qiu F, Becker K, Knight F, Baljon J, Sevimli S, Shae D, et al. Poly(propylacrylic acid)-peptide nanoplexes as a platform for enhancing the immunogenicity of neoantigen cancer vaccines. Biomaterials. 2018;182:82-91 pubmed publisher

Mi ichi F, Miyake Y, Tam V, Yoshida H. A Flow Cytometry Method for Dissecting the Cell Differentiation Process of Entamoeba Encystation. Front Cell Infect Microbiol. 2018;8:250 pubmed publisher

Avet C, Denoyelle C, L hôte D, Petit F, Guigon C, Cohen Tannoudji J, et al. GnRH regulates the expression of its receptor accessory protein SET in pituitary gonadotropes. PLoS ONE. 2018;13:e0201494 pubmed publisher

Liu M, Jiang K, Lin G, Liu P, Yan Y, Ye T, et al. Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation. J Exp Clin Cancer Res. 2018;37:165 pubmed publisher

Kim S, Seo S, Min K, Woo S, Nam J, Kubatka P, et al. Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression. Molecules. 2018;23: pubmed publisher

Chang T, Liou P, Cheng P, Chang H, Tsai P. Borneol and Luteolin from Chrysanthemum morifolium Regulate Ubiquitin Signal Degradation. J Agric Food Chem. 2018;66:8280-8290 pubmed publisher

Tang Huau T, Guéguen P, Goudot C, Durand M, Bohec M, Baulande S, et al. Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway. Nat Commun. 2018;9:2570 pubmed publisher

Yao J, Qiu Y, Frontera E, Jia L, Khan N, Klionsky D, et al. Inhibiting autophagy reduces retinal degeneration caused by protein misfolding. Autophagy. 2018;14:1226-1238 pubmed publisher

Tomiyama N, Ikeda R, Nishizawa Y, Masuda S, Tajitsu Y, Takeda Y. S100A16 up-regulates Oct4 and Nanog expression in cancer stem-like cells of Yumoto human cervical carcinoma cells. Oncol Lett. 2018;15:9929-9933 pubmed publisher

Wang Q, He Q, Chen Y, Shao W, Yuan C, Wang Y. JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss. J Neuroinflammation. 2018;15:184 pubmed publisher

Mehta V, Fields L, Evans I, Yamaji M, Pellet Many C, Jones T, et al. VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy-Terminal NRP1 Fragments That Regulate Angiogenic Signaling. Arterioscler Thromb Vasc Biol. 2018;: pubmed publisher

Hall A, Anderson C, Smith J, Mirshahi T, Elayi C, January C, et al. Visualizing Mutation-Specific Differences in the Trafficking-Deficient Phenotype of Kv11.1 Proteins Linked to Long QT Syndrome Type 2. Front Physiol. 2018;9:584 pubmed publisher

Chen J, Lobb I, Morin P, Novo S, Simpson J, Kennerknecht K, et al. Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway. Nucleic Acids Res. 2018;46:6188-6205 pubmed publisher

Wang D, Hiebl V, Ladurner A, Latkolik S, Bucar F, Heiß E, et al. 6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages. Mol Nutr Food Res. 2018;:e1800011 pubmed publisher

Kerns K, Zigo M, Drobnis E, Sutovsky M, Sutovsky P. Zinc ion flux during mammalian sperm capacitation. Nat Commun. 2018;9:2061 pubmed publisher

Alturki N, McComb S, Ariana A, Rijal D, Korneluk R, Sun S, et al. Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis. Cell Death Dis. 2018;9:592 pubmed publisher

Ugras S, Daniels M, Fazelinia H, Gould N, Yocum A, Luk K, et al. Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders. EBioMedicine. 2018;31:307-319 pubmed publisher

Malet J, Impens F, Carvalho F, Hamon M, Cossart P, Ribet D. Rapid Remodeling of the Host Epithelial Cell Proteome by the Listeriolysin O (LLO) Pore-forming Toxin. Mol Cell Proteomics. 2018;17:1627-1636 pubmed publisher

Milenkovic A, Milenkovic V, Wetzel C, Weber B. BEST1 protein stability and degradation pathways differ between autosomal dominant Best disease and autosomal recessive bestrophinopathy accounting for the distinct retinal phenotypes. Hum Mol Genet. 2018;27:1630-1641 pubmed publisher

Alatrash G, Perakis A, Kerros C, Peters H, Sukhumalchandra P, Zhang M, et al. Targeting the Leukemia Antigen PR1 with Immunotherapy for the Treatment of Multiple Myeloma. Clin Cancer Res. 2018;24:3386-3396 pubmed publisher

Francis A, Melikyan G. Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport. Cell Host Microbe. 2018;23:536-548.e6 pubmed publisher

Singh S, Bhowmick D, Pany S, Joe M, Zaghlula N, Jeremic A. Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells. Biochim Biophys Acta Biomembr. 2018;: pubmed publisher

Smelter D, de Lange W, Cai W, Ge Y, Ralphe J. The HCM-linked W792R mutation in cardiac myosin-binding protein C reduces C6 FnIII domain stability. Am J Physiol Heart Circ Physiol. 2018;314:H1179-H1191 pubmed publisher

Warren N, Voloudakis G, Yoon Y, Robakis N, Georgakopoulos A. The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis. Cell Mol Life Sci. 2018;75:2813-2826 pubmed publisher

de Diego García L, Sebastián Serrano A, Hernández I, Pintor J, Lucas J, Diaz Hernandez M. The regulation of proteostasis in glial cells by nucleotide receptors is key in acute neuroinflammation. FASEB J. 2018;32:3020-3032 pubmed publisher

Wentzel C, Delvendahl I, Sydlik S, Georgiev O, Müller M. Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles. Nat Commun. 2018;9:267 pubmed publisher

Elson J, Kochaj R, Reynolds R, Pienaar I. Temporal-Spatial Profiling of Pedunculopontine Galanin-Cholinergic Neurons in the Lactacystin Rat Model of Parkinson's Disease. Neurotox Res. 2018;34:16-31 pubmed publisher

Amanullah A, Mishra R, Upadhyay A, Reddy P, Das R, Mishra A. Indomethacin elicits proteasomal dysfunctions develops apoptosis through mitochondrial abnormalities. J Cell Physiol. 2018;233:1685-1699 pubmed publisher

Fisher M, Grun D, Adhikary G, Xu W, Eckert R. Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells. Oncotarget. 2017;8:110257-110272 pubmed publisher

Amantini C, Farfariello V, Cardinali C, Morelli M, Marinelli O, Nabissi M, et al. The TRPV1 ion channel regulates thymocyte differentiation by modulating autophagy and proteasome activity. Oncotarget. 2017;8:90766-90780 pubmed publisher

Dong S, Hu W, Ge Y, Ojcius D, Lin X, Yan J. A leptospiral AAA+ chaperone-Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis. Emerg Microbes Infect. 2017;6:e105 pubmed publisher

Signorino G, Covaceuszach S, Bozzi M, Hubner W, Mönkemöller V, Konarev P, et al. A dystroglycan mutation (p.Cys667Phe) associated to Muscle-Eye-Brain disease with multicystic leucodystrophy results in ER-retention of the mutant protein. Hum Mutat. 2017;: pubmed publisher

Pomatto L, Wong S, Tower J, Davies K. Sexual dimorphism in oxidant-induced adaptive homeostasis in multiple wild-type D. melanogaster strains. Arch Biochem Biophys. 2017;636:57-70 pubmed publisher

Fisher M, Ciavattone N, Grun D, Adhikary G, Eckert R. Sulforaphane reduces YAP/?Np63? signaling to reduce cancer stem cell survival and tumor formation. Oncotarget. 2017;8:73407-73418 pubmed publisher

Lorente E, Barriga A, García Arriaza J, Lemonnier F, Esteban M, Lopez D. Complex antigen presentation pathway for an HLA-A*0201-restricted epitope from Chikungunya 6K protein. PLoS Negl Trop Dis. 2017;11:e0006036 pubmed publisher

Jin X, Kim L, Wu Q, Wallace L, Prager B, Sanvoranart T, et al. Targeting glioma stem cells through combined BMI1 and EZH2 inhibition. Nat Med. 2017;23:1352-1361 pubmed publisher

Xu C, Kang W, Chen Y, Jiang T, Zhang J, Zhang L, et al. DJ-1 Inhibits ?-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy. Front Aging Neurosci. 2017;9:308 pubmed publisher

Han C, Zhao R, Kroger J, He J, Wani G, Wang Q, et al. UV radiation-induced SUMOylation of DDB2 regulates nucleotide excision repair. Carcinogenesis. 2017;38:976-985 pubmed publisher

Meshram S, Paul D, Manne R, Choppara S, Sankaran G, Agrawal Y, et al. FBXO32 activates NF-κB through IκBα degradation in inflammatory and genotoxic stress. Int J Biochem Cell Biol. 2017;92:134-140 pubmed publisher

Pal D, Basu A. Protein kinase C-eta regulates Mcl-1 level via ERK1. Cell Signal. 2017;40:166-171 pubmed publisher

Du A, Huang S, Zhao X, Feng K, Zhang S, Huang J, et al. Suppression of CHRN endocytosis by carbonic anhydrase CAR3 in the pathogenesis of myasthenia gravis. Autophagy. 2017;:1-14 pubmed publisher

Heldin J, O Callaghan P, Hernández Vera R, Fuchs P, Gerwins P, Kreuger J. FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation. Cell Signal. 2017;40:125-132 pubmed publisher

Wang L, Palme V, Schilcher N, Ladurner A, Heiss E, Stangl H, et al. The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability. Front Pharmacol. 2017;8:596 pubmed publisher

Díaz Muñoz M, Kiselev V, Le Novère N, Curk T, Ule J, Turner M. Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells. Nat Commun. 2017;8:530 pubmed publisher

Saha K, Fisher M, Adhikary G, Grun D, Eckert R. Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation. Carcinogenesis. 2017;38:827-836 pubmed publisher

Fujimoto T, Yaoi T, Fushiki S, Itoh K. Dp71 is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells. Biochem Biophys Res Commun. 2017;492:349-355 pubmed publisher

Gonyo P, Bergom C, Brandt A, Tsaih S, Sun Y, Bigley T, et al. SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. Oncogene. 2017;36:6873-6883 pubmed publisher

Lirussi D, Ebensen T, Schulze K, Trittel S, Durán V, Liebich I, et al. Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway. EBioMedicine. 2017;22:100-111 pubmed publisher

Götze S, Saborowski R, Martinez Cruz O, Muhlia Almazan A, Sánchez Paz A. Proteasome properties of hemocytes differ between the whiteleg shrimp Penaeus vannamei and the brown shrimp Crangon crangon (Crustacea, Decapoda). Cell Stress Chaperones. 2017;22:879-891 pubmed publisher

Zhang Q, Hsia S, Martin Caraballo M. Regulation of T-type Ca2+ channel expression by herpes simplex virus-1 infection in sensory-like ND7 cells. J Neurovirol. 2017;23:657-670 pubmed publisher

Glück S, Buttafuoco A, Meier A, Arnoldi F, Vogt B, Schraner E, et al. Rotavirus replication is correlated with S/G2 interphase arrest of the host cell cycle. PLoS ONE. 2017;12:e0179607 pubmed publisher

González López L, Carballar Lejarazu R, Arrevillaga Boni G, Cortes Martinez L, Cázares Raga F, Trujillo Ocampo A, et al. Lys48 ubiquitination during the intraerythrocytic cycle of the rodent malaria parasite, Plasmodium chabaudi. PLoS ONE. 2017;12:e0176533 pubmed publisher

Neuhaus W, Kramer T, Neuhoff A, Gölz C, Thal S, Förster C. Multifaceted Mechanisms of WY-14643 to Stabilize the Blood-Brain Barrier in a Model of Traumatic Brain Injury. Front Mol Neurosci. 2017;10:149 pubmed publisher

Lin M, Cheng X, Tammineni P, Xie Y, Zhou B, Cai Q, et al. Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions. Neuron. 2017;94:595-610.e6 pubmed publisher

Ehrhardt N, Doche M, Chen S, Mao H, Walsh M, Bedoya C, et al. Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis. Hum Mol Genet. 2017;26:2719-2731 pubmed publisher

Xiao B, Deng X, Lim G, Zhou W, Saw W, Zhou Z, et al. p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization. Biochim Biophys Acta Mol Cell Res. 2017;1864:1308-1317 pubmed publisher

Okumura F, Joo Okumura A, Nakatsukasa K, Kamura T. Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2. PLoS ONE. 2017;12:e0175593 pubmed publisher

Sangenito L, de Guedes A, Gonçalves D, Seabra S, D Ávila Levy C, Santos A, et al. Deciphering the effects of nelfinavir and lopinavir on epimastigote forms of Trypanosoma cruzi. Parasitol Int. 2017;66:529-536 pubmed publisher

Pomatto L, Wong S, Carney C, Shen B, Tower J, Davies K. The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster. Aging (Albany NY). 2017;9:1153-1185 pubmed publisher

Wright C, Iyer A, Yakisich J, Azad N. Anti-Tumorigenic Effects of Resveratrol in Lung Cancer Cells Through Modulation of c-FLIP. Curr Cancer Drug Targets. 2017;17:669-680 pubmed publisher

da Silva D, Andrade P, Valentão P, Pereira D. Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2? branch of the endoplasmic reticulum. J Steroid Biochem Mol Biol. 2017;171:178-186 pubmed publisher

Liu F, Qin Y, Yu S, Soares D, Yang L, Weng J, et al. Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish. J Biol Chem. 2017;292:6225-6239 pubmed publisher

Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed publisher

Wang C, Gupta P, Fressigne L, Bossé G, Wang X, Simard M, et al. TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells. Nucleic Acids Res. 2017;45:1488-1500 pubmed publisher

Huang H, Weng H, Dong B, Zhao P, Zhou H, Qu L. Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia. Sci Rep. 2017;7:41525 pubmed publisher

Davoli T, Mengwasser K, Duan J, Chen T, Christensen C, Wooten E, et al. Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. Genes Dev. 2016;30:2684-2695 pubmed publisher

Won K, Im J, Kim B, Ban H, Jung Y, Jung K, et al. Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells. Cell Death Dis. 2017;8:e2554 pubmed publisher

Montagne R, Baranzelli A, Muharram G, Catherine L, Lesaffre M, Vinchent A, et al. MET receptor variant R970C favors calpain-dependent generation of a fragment promoting epithelial cell scattering. Oncotarget. 2017;8:11268-11283 pubmed publisher

Ostendorp A, Pahlow S, Krüßel L, Hanhart P, Garbe M, Deke J, et al. Functional analysis of Brassica napus phloem protein and ribonucleoprotein complexes. New Phytol. 2017;214:1188-1197 pubmed publisher

Gannon P, Akay Espinoza C, Yee A, Briand L, Erickson M, Gelman B, et al. HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. Am J Pathol. 2017;187:91-109 pubmed publisher

Pathangey L, McCurry D, Gendler S, Dominguez A, Gorman J, Pathangey G, et al. Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens. Oncotarget. 2017;8:10785-10808 pubmed publisher

Hwang J, Gertner M, Pontarelli F, Court Vazquez B, Bennett M, Ofengeim D, et al. Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die. Cell Death Differ. 2017;24:317-329 pubmed publisher

Nazio F, Carinci M, Valacca C, Bielli P, Strappazzon F, Antonioli M, et al. Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation. J Cell Biol. 2016;215:841-856 pubmed

Reiss Pistilli M, Schuppan D, Barroso M, Assunção Miranda I, Farias S, Lery L, et al. An extracellular proteasome releases endostatin from human collagen XVIII. Angiogenesis. 2017;20:125-137 pubmed publisher

Ding X, Barodia S, Ma L, Goldberg M. Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity. Neurobiol Dis. 2017;98:122-136 pubmed publisher

Eason R, Bell K, Marshall F, Rodgers D, Pineda M, Steiger C, et al. The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ. Sci Rep. 2016;6:37276 pubmed publisher

Castagnola P, Bellese G, Birocchi F, Gagliani M, Tacchetti C, Cortese K. Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells. Oncotarget. 2016;7:85411-85429 pubmed publisher

Tsukamoto Y, Maeda Y, Tamura T, Mukai T, Mitarai S, Yamamoto S, et al. Enhanced protective efficacy against tuberculosis provided by a recombinant urease deficient BCG expressing heat shock protein 70-major membrane protein-II having PEST sequence. Vaccine. 2016;34:6301-6308 pubmed publisher

Myöhänen T, Norrbacka S, Savolainen M. Prolyl oligopeptidase inhibition attenuates the toxicity of a proteasomal inhibitor, lactacystin, in the alpha-synuclein overexpressing cell culture. Neurosci Lett. 2017;636:83-89 pubmed publisher

Liu Q, Tang Y, Chen L, Liu N, Lang F, Liu H, et al. E3 Ligase SCF?TrCP-induced DYRK1A Protein Degradation Is Essential for Cell Cycle Progression in HEK293 Cells. J Biol Chem. 2016;291:26399-26409 pubmed

Lam S, Leung L, Li Y, Zheng C, Ho J. Combination effects of arsenic trioxide and fibroblast growth factor receptor inhibitor in squamous cell lung carcinoma. Lung Cancer. 2016;101:111-119 pubmed publisher

Ott C, König J, Höhn A, Jung T, Grune T. Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts. Free Radic Biol Med. 2016;101:325-333 pubmed publisher

Guo X, Yin H, Chen Y, Li L, Li J, Liu Q. TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints. Cell Death Dis. 2016;7:e2381 pubmed publisher

Lee S, Son Y, Lee K, Lee J, Kim H, Jeong E, et al. 4-n-butylresorcinol enhances proteolytic degradation of tyrosinase in B16F10 melanoma cells. Int J Cosmet Sci. 2017;39:248-255 pubmed publisher

Hrgovic I, Doll M, Pinter A, Kaufmann R, Kippenberger S, Meissner M. Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR-2 protein half-life in part via a VE-cadherin-dependent mechanism. Exp Dermatol. 2017;26:194-201 pubmed publisher

Amanullah A, Upadhyay A, Chhangani D, Joshi V, Mishra R, Yamanaka K, et al. Proteasomal Dysfunction Induced By Diclofenac Engenders Apoptosis Through Mitochondrial Pathway. J Cell Biochem. 2017;118:1014-1027 pubmed publisher

Kumar Y, Shukla N, Thacker G, Kapoor I, Lochab S, Bhatt M, et al. Ubiquitin Ligase, Fbw7, Targets CDX2 for Degradation via Two Phosphodegron Motifs in a GSK3β-Dependent Manner. Mol Cancer Res. 2016;14:1097-1109 pubmed

Kim B, Yoon J, Yoon S, Park B. Onbaekwon Suppresses Colon Cancer Cell Invasion by Inhibiting Expression of the CXC Chemokine Receptor 4. Integr Cancer Ther. 2017;16:244-251 pubmed publisher

Dingjan I, Verboogen D, Paardekooper L, Revelo N, Sittig S, Visser L, et al. Lipid peroxidation causes endosomal antigen release for cross-presentation. Sci Rep. 2016;6:22064 pubmed publisher

Papaevgeniou N, Sakellari M, Jha S, Tavernarakis N, Holmberg C, Gonos E, et al. 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures. Antioxid Redox Signal. 2016;25:855-869 pubmed

Takahashi Y, Shinoda A, Kamada H, Shimizu M, Inoue J, Sato R. Perilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradation. Sci Rep. 2016;6:20975 pubmed publisher

Kwon D, Eom G, Ko J, Shin S, Joung H, Choe N, et al. MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification. Nat Commun. 2016;7:10492 pubmed publisher

Hatanaka M, Kaimori J, Yamamoto S, Matsui I, Hamano T, Takabatake Y, et al. Azilsartan Improves Salt Sensitivity by Modulating the Proximal Tubular Na+-H+ Exchanger-3 in Mice. PLoS ONE. 2016;11:e0147786 pubmed publisher

Spencer B, Kim C, Gonzalez T, Bisquertt A, Patrick C, Rockenstein E, et al. α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease. Hum Mol Genet. 2016;25:1100-15 pubmed publisher

Markosyan R, Miao C, Zheng Y, Melikyan G, Liu S, Cohen F. Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger. PLoS Pathog. 2016;12:e1005373 pubmed publisher

Han M, Lee D, Woo S, Seo B, Min K, Kim S, et al. Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells. Sci Rep. 2016;6:18642 pubmed publisher

Du A, Huang S, Zhao X, Zhang Y, Zhu L, Ding J, et al. Endoplasmic reticulum stress contributes to acetylcholine receptor degradation by promoting endocytosis in skeletal muscle cells. J Neuroimmunol. 2016;290:109-14 pubmed publisher

Dachineni R, Ai G, Kumar D, Sadhu S, Tummala H, Bhat G. Cyclin A2 and CDK2 as Novel Targets of Aspirin and Salicylic Acid: A Potential Role in Cancer Prevention. Mol Cancer Res. 2016;14:241-52 pubmed publisher

Upadhyay A, Amanullah A, Chhangani D, Joshi V, Mishra R, Mishra A. Ibuprofen Induces Mitochondrial-Mediated Apoptosis Through Proteasomal Dysfunction. Mol Neurobiol. 2016;53:6968-6981 pubmed

Staines K, Prideaux M, Allen S, Buttle D, Pitsillides A, Farquharson C. E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models. J Cell Physiol. 2016;231:1392-404 pubmed publisher

Suvorova I, Grigorash B, Chuykin I, Pospelova T, Pospelov V. G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling. Cell Cycle. 2016;15:52-63 pubmed publisher

Cha S, Choi Y, Heo C, Kang S, Joe E, Jou I, et al. Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's disease. Mol Neurodegener. 2015;10:63 pubmed publisher

Rastogi N, Duggal S, Singh S, Porwal K, Srivastava V, Maurya R, et al. Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells. Oncotarget. 2015;6:43310-25 pubmed publisher

Wojcik S, Spodnik J, Sidor Kaczmarek J, Morys J. Reduced level of synapsin I protein in the rat striatum after intraventricular administration of proteasome inhibitors: preliminary studies. Folia Morphol (Warsz). 2015;74:428-33 pubmed publisher

Hyun D, Lee G. Cytochrome b5 reductase, a plasma membrane redox enzyme, protects neuronal cells against metabolic and oxidative stress through maintaining redox state and bioenergetics. Age (Dordr). 2015;37:122 pubmed publisher

Fonteneau J, Brilot F, Münz C, Gannagé M. The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer. J Immunol. 2016;196:64-71 pubmed publisher

Long D, Wang P, Sun Y, Chen R, Wu Y. Neuropathy Target Esterase Is Degraded by the Ubiquitin-Proteasome Pathway with ARA54 as the Ubiquitin Ligase. Biochemistry. 2015;54:7385-92 pubmed publisher

Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res. 2016;44:1161-78 pubmed publisher

Chiang M, Tullett K, Lee Y, Idris A, Ding Y, McDonald K, et al. Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsets. Eur J Immunol. 2016;46:329-39 pubmed publisher

Huseby N, Ravuri C, Moens U. The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells. Free Radic Res. 2016;50:1-13 pubmed publisher

Shi J, Fung G, Deng H, Zhang J, Fiesel F, Springer W, et al. NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1. Cell Death Dis. 2015;6:e1943 pubmed publisher

Kapoor I, Kanaujiya J, Kumar Y, Thota J, Bhatt M, Chattopadhyay N, et al. Proteomic discovery of MNT as a novel interacting partner of E3 ubiquitin ligase E6AP and a key mediator of myeloid differentiation. Oncotarget. 2016;7:7640-56 pubmed publisher

Li S, Liang Y, Mariano J, Metzger M, Stringer D, Hristova V, et al. Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J Biol Chem. 2015;290:30225-39 pubmed publisher

Chang D, Colecraft H. Rad and Rem are non-canonical G-proteins with respect to the regulatory role of guanine nucleotide binding in Ca(V)1.2 channel regulation. J Physiol. 2015;593:5075-90 pubmed publisher

Botbol Y, Patel B, Macian F. Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation. Autophagy. 2015;11:1864-77 pubmed publisher

Hayashi Takagi A, Yagishita S, Nakamura M, Shirai F, Wu Y, Loshbaugh A, et al. Labelling and optical erasure of synaptic memory traces in the motor cortex. Nature. 2015;525:333-8 pubmed publisher

Ridder D, Wenzel J, Müller K, Töllner K, Tong X, Assmann J, et al. Brain endothelial TAK1 and NEMO safeguard the neurovascular unit. J Exp Med. 2015;212:1529-49 pubmed publisher

Crinelli R, Bianchi M, Radici L, Carloni E, Giacomini E, Magnani M. Molecular Dissection of the Human Ubiquitin C Promoter Reveals Heat Shock Element Architectures with Activating and Repressive Functions. PLoS ONE. 2015;10:e0136882 pubmed publisher

Silva G, Marins M, Fachin A, Lee S, Baek S. Anti-cancer activity of trans-chalcone in osteosarcoma: Involvement of Sp1 and p53. Mol Carcinog. 2016;55:1438-48 pubmed publisher

Greaney A, Maier N, Leppla S, Moayeri M. Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism. J Leukoc Biol. 2016;99:189-99 pubmed publisher

Xiao Q, Yang S, Le W. G2019S LRRK2 and aging confer susceptibility to proteasome inhibitor-induced neurotoxicity in nigrostriatal dopaminergic system. J Neural Transm (Vienna). 2015;122:1645-57 pubmed publisher

Locatelli D, Terao M, Kurosaki M, Zanellati M, Pletto D, Finardi A, et al. Different Stability and Proteasome-Mediated Degradation Rate of SMN Protein Isoforms. PLoS ONE. 2015;10:e0134163 pubmed publisher

Husmann K, Ducommun P, Sabile A, Pedersen E, Born W, Fuchs B. Signal transduction and downregulation of C-MET in HGF stimulated low and highly metastatic human osteosarcoma cells. Biochem Biophys Res Commun. 2015;464:1222-1227 pubmed publisher

Kim M, Ryu J, Suh H, Park S, Oh Y, Lee S, et al. cAMP Promotes Cell Migration Through Cell Junctional Complex Dynamics and Actin Cytoskeleton Remodeling: Implications in Skin Wound Healing. Stem Cells Dev. 2015;24:2513-24 pubmed publisher

Hashimoto Y, Inagaki H, Hoshino S. Calpain mediates processing of the translation termination factor eRF3 into the IAP-binding isoform p-eRF3. FEBS Lett. 2015;589:2241-7 pubmed publisher

Harrison I, Crum W, Vernon A, Dexter D. Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors. Br J Pharmacol. 2015;172:4200-15 pubmed publisher

Raule M, Cerruti F, Cascio P. Comparative study of the biochemical properties of proteasomes in domestic animals. Vet Immunol Immunopathol. 2015;166:43-9 pubmed publisher

Montagne R, Berbon M, Doublet L, Debreuck N, Baranzelli A, Drobecq H, et al. Necrosis- and apoptosis-related Met cleavages have divergent functional consequences. Cell Death Dis. 2015;6:e1769 pubmed publisher

Bhattacharya B, Celma C, Roy P. Influence of cellular trafficking pathway on bluetongue virus infection in ovine cells. Viruses. 2015;7:2378-403 pubmed publisher

Mata Cantero L, Cid C, Gomez Lorenzo M, Xolalpa W, Aillet F, Martín J, et al. Development of two novel high-throughput assays to quantify ubiquitylated proteins in cell lysates: application to screening of new anti-malarials. Malar J. 2015;14:200 pubmed publisher

Jeong J, Lee J, Lee S. TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer. Int J Mol Sci. 2015;16:10411-25 pubmed publisher

Kaushik S, Cuervo A. Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis. Nat Cell Biol. 2015;17:759-70 pubmed publisher

Zhang Y, Ye M, Chen L, Li M, Tang Z, Wang C. Role of the ubiquitin-proteasome system and autophagy in regulation of insulin sensitivity in serum-starved 3T3-L1 adipocytes. Endocr J. 2015;62:673-86 pubmed publisher

Koumbadinga G, Mahmood N, Lei L, Kan Y, Cao W, Lobo V, et al. Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor. Biochim Biophys Acta. 2015;1849:1095-103 pubmed publisher

Houston F, Hain B, Adams T, Houston K, O Keeffe R, Dodd S. Heat shock protein 70 overexpression does not attenuate atrophy in botulinum neurotoxin type A-treated skeletal muscle. J Appl Physiol (1985). 2015;119:83-92 pubmed publisher

Isogai T, van der Kammen R, Innocenti M. SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton. Sci Rep. 2015;5:9802 pubmed publisher

Deglincerti A, Liu Y, Colak D, Hengst U, Xu G, Jaffrey S. Coupled local translation and degradation regulate growth cone collapse. Nat Commun. 2015;6:6888 pubmed publisher

Su C, Huang J, Chiang C, Lawrence E, Levine K, Dabovic B, et al. Latent transforming growth factor binding protein 4 regulates transforming growth factor beta receptor stability. Hum Mol Genet. 2015;24:4024-36 pubmed publisher

Sugiura H, Yasuda S, Katsurabayashi S, Kawano H, Endo K, Takasaki K, et al. Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex. Nat Commun. 2015;6:6842 pubmed publisher

Park C, Suh Y, Cuervo A. Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage. Nat Commun. 2015;6:6823 pubmed publisher

Tebbi A, Guittet O, Tuphile K, Cabrié A, Lepoivre M. Caspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis. J Biol Chem. 2015;290:14077-90 pubmed publisher

Woo S, Seo B, Min K, Kwon T. FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells. Oncotarget. 2015;6:11614-26 pubmed

Huang T, Ma G, Osterrieder N. Equine Herpesvirus 1 Multiply Inserted Transmembrane Protein pUL43 Cooperates with pUL56 in Downregulation of Cell Surface Major Histocompatibility Complex Class I. J Virol. 2015;89:6251-63 pubmed publisher

Gavilán E, Pintado C, Gavilan M, Daza P, Sánchez Aguayo I, Castaño A, et al. Age-related dysfunctions of the autophagy lysosomal pathway in hippocampal pyramidal neurons under proteasome stress. Neurobiol Aging. 2015;36:1953-63 pubmed publisher

Kim J, Choi H, Lee H, Shin J, Shin D, Choi J, et al. Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline induces Gâ‚‚/M cell cycle arrest through the activation of ATM/ATR in human cervical carcinoma HeLa cells. Oncol Rep. 2015;33:2639-47 pubmed publisher

Sargiannidou I, Kim G, Kyriakoudi S, Eun B, Kleopa K. A start codon CMT1X mutation associated with transient encephalomyelitis causes complete loss of Cx32. Neurogenetics. 2015;16:193-200 pubmed publisher

Jung E, Hong H, Kim C, Mook Jung I. Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation. Sci Rep. 2015;5:8805 pubmed publisher

Jeong H, Jung E, Sim Y, Kim S, Jang J, Hong K, et al. Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development. Biochim Biophys Acta. 2015;1849:709-21 pubmed publisher

Santos A, Mele M, Vaz S, Kellermayer B, Grimaldi M, Colino Oliveira M, et al. Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP. J Neurosci. 2015;35:3319-29 pubmed publisher

Bianchi F, Sasso M, Turdo F, Beretta G, Casalini P, Ghirelli C, et al. Fhit Nuclear Import Following EGF Stimulation Sustains Proliferation of Breast Cancer Cells. J Cell Physiol. 2015;230:2661-70 pubmed publisher

Arnhold F, Gührs K, von Mikecz A. Amyloid domains in the cell nucleus controlled by nucleoskeletal protein lamin B1 reveal a new pathway of mercury neurotoxicity. Peerj. 2015;3:e754 pubmed publisher

Chittoor Vinod V, Lee S, Judge S, Notterpek L. Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22. ASN Neuro. 2015;7: pubmed publisher

Maier N, Leppla S, Moayeri M. The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes. J Immunol. 2015;194:2776-85 pubmed publisher

Konieczny J, Czarnecka A, Kamińska K, Lenda T, Nowak P. Decreased behavioral response to intranigrally administered GABAA agonist muscimol in the lactacystin model of Parkinson's disease may result from partial lesion of nigral non-dopamine neurons: comparison to the classical neurotoxin 6-OHDA. Behav Brain Res. 2015;283:203-14 pubmed publisher

Conde Aguilera J, Lefaucheur L, Tesseraud S, Mercier Y, Le Floc h N, van Milgen J. Skeletal muscles respond differently when piglets are offered a diet 30% deficient in total sulfur amino acid for 10 days. Eur J Nutr. 2016;55:117-26 pubmed publisher

Wang S, Jiang M, Lin S, Chen M, Wang H, Duh C. Calpains mediate the proteolytic modification of human cytomegalovirus UL112-113 proteins. J Gen Virol. 2015;96:1115-26 pubmed publisher

Yoshioka S, Nagatomo M, Inoue M. Application of two direct C(sp3)-H functionalizations for total synthesis of (+)-lactacystin. Org Lett. 2015;17:90-3 pubmed publisher

Gao L, Zheng Y, Gu S, Tan J, Paul C, Wang Y, et al. Degradation of cardiac myosin light chain kinase by matrix metalloproteinase-2 contributes to myocardial contractile dysfunction during ischemia/reperfusion. J Mol Cell Cardiol. 2014;77:102-12 pubmed publisher

Bae N, Chung S, Kim H, Cha J, Oh H, Gu M, et al. Neuroprotective effect of modified Chungsimyeolda-tang, a traditional Korean herbal formula, via autophagy induction in models of Parkinson's disease. J Ethnopharmacol. 2015;159:93-101 pubmed publisher

Zhao J, Miyamoto S, You Y, Sharma K. AMP-activated protein kinase (AMPK) activation inhibits nuclear translocation of Smad4 in mesangial cells and diabetic kidneys. Am J Physiol Renal Physiol. 2015;308:F1167-77 pubmed publisher

Lukas J, Pockrandt A, Seemann S, Sharif M, Runge F, Pohlers S, et al. Enzyme enhancers for the treatment of Fabry and Pompe disease. Mol Ther. 2015;23:456-64 pubmed publisher

Kim B, Park B. Baohuoside I suppresses invasion of cervical and breast cancer cells through the downregulation of CXCR4 chemokine receptor expression. Biochemistry. 2014;53:7562-9 pubmed publisher

González E, Rother M, Kerr M, Al Zeer M, Abu Lubad M, Kessler M, et al. Chlamydia infection depends on a functional MDM2-p53 axis. Nat Commun. 2014;5:5201 pubmed publisher

Yu X, Long Y. Autophagy modulates amino acid signaling network in myotubes: differential effects on mTORC1 pathway and the integrated stress response. FASEB J. 2015;29:394-407 pubmed publisher

Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour M, et al. Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014;16:1080-91 pubmed publisher

Shin J, Jeong J, Han J, Bhang S, Jeong G, Haque M, et al. Transplantation of heterospheroids of islet cells and mesenchymal stem cells for effective angiogenesis and antiapoptosis. Tissue Eng Part A. 2015;21:1024-35 pubmed publisher

Bir A, Sen O, Anand S, Khemka V, Banerjee P, Cappai R, et al. α-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease. J Neurochem. 2014;131:868-77 pubmed publisher

Volceanov L, Herbst K, Biniossek M, Schilling O, Haller D, Nölke T, et al. Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion. MBio. 2014;5:e01802-14 pubmed publisher

Lv Y, Zhang K, Gao H. Paip1, an effective stimulator of translation initiation, is targeted by WWP2 for ubiquitination and degradation. Mol Cell Biol. 2014;34:4513-22 pubmed publisher

Lei Z, Brizzee C, Johnson G. BAG3 facilitates the clearance of endogenous tau in primary neurons. Neurobiol Aging. 2015;36:241-8 pubmed publisher

Morozov A, Spasskaya D, Karpov D, Karpov V. The central domain of yeast transcription factor Rpn4 facilitates degradation of reporter protein in human cells. FEBS Lett. 2014;588:3713-9 pubmed publisher

Han K, Kang H, Lee J, Yoo L, Im E, Hong A, et al. Histone deacetylase 3 promotes RCAN1 stability and nuclear translocation. PLoS ONE. 2014;9:e105416 pubmed publisher

Chen X, Chinchilla P, Fombonne J, Ho L, Guix C, Keen J, et al. Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog. Mol Cell Biol. 2014;34:3855-66 pubmed publisher

Singh D, Vaughan R, Kao C. LL-37 peptide enhancement of signal transduction by Toll-like receptor 3 is regulated by pH: identification of a peptide antagonist of LL-37. J Biol Chem. 2014;289:27614-24 pubmed publisher

In J, Striz A, Bernad A, Tuma P. Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells. Biochem J. 2014;463:201-13 pubmed publisher

Shi D, Smith M, Campbell R, Zimmerman P, Franks Z, Kraemer B, et al. Proteasome function is required for platelet production. J Clin Invest. 2014;124:3757-66 pubmed publisher

Tarassishin L, Casper D, Lee S. Aberrant expression of interleukin-1? and inflammasome activation in human malignant gliomas. PLoS ONE. 2014;9:e103432 pubmed publisher

Bin B, Hojyo S, Hosaka T, Bhin J, Kano H, Miyai T, et al. Molecular pathogenesis of spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins. EMBO Mol Med. 2014;6:1028-42 pubmed publisher

Yim N, Ryu S, Han E, Yoon J, Choi K, Choi C. Mutant ubiquitin UBB+1 induces mitochondrial fusion by destabilizing mitochondrial fission-specific proteins and confers resistance to oxidative stress-induced cell death in astrocytic cells. PLoS ONE. 2014;9:e99937 pubmed publisher

Nakamura T, Ono K, Suzuki Y, Moriguchi R, Kogure K, Harashima H. Octaarginine-modified liposomes enhance cross-presentation by promoting the C-terminal trimming of antigen peptide. Mol Pharm. 2014;11:2787-95 pubmed publisher

Jang J, Wang Y, Kim H, Lalli M, Kosik K. Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells. Stem Cells. 2014;32:2616-25 pubmed publisher

Pandya C, Kutiyanawalla A, Turecki G, Pillai A. Glucocorticoid regulates TrkB protein levels via c-Cbl dependent ubiquitination: a decrease in c-Cbl mRNA in the prefrontal cortex of suicide subjects. Psychoneuroendocrinology. 2014;45:108-18 pubmed publisher

Konieczny J, Jantas D, Lenda T, Domin H, Czarnecka A, Kuter K, et al. Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson's disease. Neurotox Res. 2014;26:255-73 pubmed publisher

Peverelli E, Giardino E, Treppiedi D, Vitali E, Cambiaghi V, Locatelli M, et al. Filamin A (FLNA) plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells. Endocrinology. 2014;155:2932-41 pubmed publisher

Jiang H, Clise Dwyer K, Ruisaard K, Fan X, Tian W, Gumin J, et al. Delta-24-RGD oncolytic adenovirus elicits anti-glioma immunity in an immunocompetent mouse model. PLoS ONE. 2014;9:e97407 pubmed publisher

Reed A, Kolodecik T, Husain S, Gorelick F. Low pH enhances connexin32 degradation in the pancreatic acinar cell. Am J Physiol Gastrointest Liver Physiol. 2014;307:G24-32 pubmed publisher

Liu H, Wang Z, Yu S, Xu J. Proteasomal degradation of O-GlcNAc transferase elevates hypoxia-induced vascular endothelial inflammatory response†. Cardiovasc Res. 2014;103:131-9 pubmed publisher

Hsu H, Jansen L, Lawand M, Kim J, Pérez Arroyo A, Culina S, et al. Endoplasmic reticulum targeting alters regulation of expression and antigen presentation of proinsulin. J Immunol. 2014;192:4957-66 pubmed publisher

Pérez Girón J, Palacios R, Martin A, Hernanz R, Aguado A, Martinez Revelles S, et al. Pioglitazone reduces angiotensin II-induced COX-2 expression through inhibition of ROS production and ET-1 transcription in vascular cells from spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2014;306:H1582-93 pubmed publisher

Nagarajan A, Dogra S, Liu A, Green M, Wajapeyee N. PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation. Mol Cell Biol. 2014;34:2264-82 pubmed publisher

Chorzalska A, Salloum I, Shafqat H, Khan S, Marjon P, Treaba D, et al. Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia. Leukemia. 2014;28:2165-77 pubmed publisher

Farg M, Sundaramoorthy V, Sultana J, Yang S, Atkinson R, Levina V, et al. C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. Hum Mol Genet. 2014;23:3579-95 pubmed publisher

Rhee Y, Chung P, Kim S, Ahn J. CXCR4 and PTEN are involved in the anti-metastatic regulation of anethole in DU145 prostate cancer cells. Biochem Biophys Res Commun. 2014;447:557-62 pubmed publisher

Jego G, Lanneau D, de Thonel A, Berthenet K, Hazoume A, Droin N, et al. Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes. Leukemia. 2014;28:1676-86 pubmed publisher

Hofmeister Brix A, Lenzen S, Baltrusch S. The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells. Biochem J. 2013;456:173-84 pubmed publisher

Abe A, Takahashi Niki K, Takekoshi Y, Shimizu T, Kitaura H, Maita H, et al. Prefoldin plays a role as a clearance factor in preventing proteasome inhibitor-induced protein aggregation. J Biol Chem. 2013;288:27764-76 pubmed publisher

Mackey S, Jing Y, Flores J, Dinelle K, Doudet D. Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: behavior, positron emission tomography, immunohistochemistry. Exp Neurol. 2013;247:19-24 pubmed publisher

Czupryna J, Tsourkas A. Firefly luciferase and RLuc8 exhibit differential sensitivity to oxidative stress in apoptotic cells. PLoS ONE. 2011;6:e20073 pubmed publisher

Vernon A, Modo M. Non-invasive MR imaging of neurodegeneration in a rodent model of Parkinson's disease. Methods Mol Biol. 2011;711:487-510 pubmed publisher

Lu J, Chiang J, Iyer R, Thompson E, Kaneski C, Xu D, et al. Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl. Proc Natl Acad Sci U S A. 2010;107:21665-70 pubmed publisher

Chew J, Chen M, Lee A, Peng Z, Chong K, He L, et al. Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator. J Cell Biochem. 2010;111:1359-66 pubmed publisher

Musch T, Oz Y, Lyko F, Breiling A. Nucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factors. PLoS ONE. 2010;5:e10726 pubmed publisher

Vernon A, Johansson S, Modo M. Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease. BMC Neurosci. 2010;11:1 pubmed publisher

Broggini Tenzer A, Hollenstein A, Pianowski Z, Wampfler A, Furmanova P, Winssinger N, et al. Substrate screening identifies a novel target sequence for the proteasomal activity regulated by ionizing radiation. Proteomics. 2010;10:304-14 pubmed publisher

Francois M, Romieu Mourez R, Stock Martineau S, Boivin M, Bramson J, Galipeau J. Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties. Blood. 2009;114:2632-8 pubmed publisher

Ster J, de Bock F, Bertaso F, Abitbol K, Daniel H, Bockaert J, et al. Epac mediates PACAP-dependent long-term depression in the hippocampus. J Physiol. 2009;587:101-13 pubmed publisher

Medina M, De Palma G, Ribes Koninckx C, Calabuig M, Sanz Y. Bifidobacterium strains suppress in vitro the pro-inflammatory milieu triggered by the large intestinal microbiota of coeliac patients. J Inflamm (Lond). 2008;5:19 pubmed publisher

Lin H, Chen M, Ku C. Cyclin-dependent kinase 5 regulates steroidogenic acute regulatory protein and androgen production in mouse Leydig cells. Endocrinology. 2009;150:396-403 pubmed publisher

Chastagner P, Israel A, Brou C. AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PLoS ONE. 2008;3:e2735 pubmed publisher

Shibasaki M, Kanai M, Fukuda N. Total synthesis of lactacystin and salinosporamide A. Chem Asian J. 2007;2:20-38 pubmed

Tomoda H, Omura S. Lactacystin, a proteasome inhibitor: discovery and its application in cell biology. Yakugaku Zasshi. 2000;120:935-49 pubmed

Fenteany G, Schreiber S. Lactacystin, proteasome function, and cell fate. J Biol Chem. 1998;273:8545-8 pubmed

Omura S, Takeshima H. [Lactacystin: a tool for elucidation of proteasome functions]. Tanpakushitsu Kakusan Koso. 1996;41:327-36 pubmed

Dick L, Cruikshank A, Grenier L, Melandri F, Nunes S, Stein R. Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone. J Biol Chem. 1996;271:7273-6 pubmed

Fenteany G, Standaert R, Reichard G, Corey E, Schreiber S. A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci U S A. 1994;91:3358-62 pubmed

Fenteany G, Standaert R, Lane W, Choi S, Corey E, Schreiber S. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science. 1995;268:726-31 pubmed