This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
LY-364947
catalog :
L6293
citations: 13
Reference
Shen X, Hu X, Mao J, Wu Y, Liu H, Shen J, et al. The long noncoding RNA TUG1 is required for TGF-β/TWIST1/EMT-mediated metastasis in colorectal cancer cells. Cell Death Dis. 2020;11:65 pubmed publisher
Wang X, Huang C. Difference of TGF-β/Smads signaling pathway in epithelial-mesenchymal transition of normal colonic epithelial cells induced by tumor-associated fibroblasts and colon cancer cells. Mol Biol Rep. 2019;46:2749-2759 pubmed publisher
Shan L, Kang X, Liu F, Cai X, Han X, Shang Y. Epigallocatechin gallate improves airway inflammation through TGF‑β1 signaling pathway in asthmatic mice. Mol Med Rep. 2018;18:2088-2096 pubmed publisher
Gregory K, Morin S, Schneider S. Regulation of early growth response 2 expression by secreted frizzled related protein 1. BMC Cancer. 2017;17:473 pubmed publisher
Liang Y, Zhu F, Zhang H, Chen D, Zhang X, Gao Q, et al. Conditional ablation of TGF-? signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model. Sci Rep. 2016;6:29479 pubmed publisher
Zhao Y, Londono P, Cao Y, Sharpe E, Proenza C, O Rourke R, et al. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun. 2015;6:8243 pubmed publisher
Vanhauwaert S, Van Peer G, Rihani A, Janssens E, Rondou P, Lefever S, et al. Expressed repeat elements improve RT-qPCR normalization across a wide range of zebrafish gene expression studies. PLoS ONE. 2014;9:e109091 pubmed publisher
Nassar K, Grisanti S, Tura A, Lüke J, Lüke M, Soliman M, et al. A TGF-β receptor 1 inhibitor for prevention of proliferative vitreoretinopathy. Exp Eye Res. 2014;123:72-86 pubmed publisher
Dhasarathy A, Phadke D, Mav D, Shah R, Wade P. The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer. PLoS ONE. 2011;6:e26514 pubmed publisher
Shiou S, Datta P, Dhawan P, Law B, Yingling J, Dixon D, et al. Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta. J Biol Chem. 2006;281:33971-81 pubmed
Li H, Wang Y, Heap C, King C, Mundla S, Voss M, et al. Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7. J Med Chem. 2006;49:2138-42 pubmed
Singh J, Chuaqui C, Boriack Sjodin P, Lee W, Pontz T, Corbley M, et al. Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI). Bioorg Med Chem Lett. 2003;13:4355-9 pubmed
Sawyer J, Anderson B, Beight D, Campbell R, Jones M, Herron D, et al. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. J Med Chem. 2003;46:3953-6 pubmed
product information
Catalog Number :
L6293
Product Name :
LY-364947
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA