This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Leptin human
catalog :
L4146
citations: 37
Reference
Menezes V, Monte A, Gouveia B, Lins T, Donfack N, Macedo T, et al. Effects of leptin on the follicular development and mitochondrial activity of ovine isolated early antral follicles cultured in vitro. Theriogenology. 2019;138:77-83 pubmed publisher
Taskin A, Kocabay A, Ebrahimi A, Karahuseyinoglu S, Sahin G, Özçimen B, et al. Leptin treatment of in vitro cultured embryos increases outgrowth rate of inner cell mass during embryonic stem cell derivation. In Vitro Cell Dev Biol Anim. 2019;: pubmed publisher
Tencerova M, Frost M, Figeac F, Nielsen T, Ali D, Lauterlein J, et al. Obesity-Associated Hypermetabolism and Accelerated Senescence of Bone Marrow Stromal Stem Cells Suggest a Potential Mechanism for Bone Fragility. Cell Rep. 2019;27:2050-2062.e6 pubmed publisher
Meshkani R, Nasimian A, Taheripak G, Zarghooni M, Rezaei M, Sadeghi A, et al. Association between Leptin G2548A and Leptin Receptor Q223R Polymorphisms with Type 2 Diabetes in an Iranian Population. Clin Lab. 2016;62:89-96 pubmed
Chang S, Hsieh R, Huang K, Chang C, Chiu F, Kuo H, et al. Upregulation of Bone Morphogenetic Protein-2 Synthesis and Consequent Collagen II Expression in Leptin-stimulated Human Chondrocytes. PLoS ONE. 2015;10:e0144252 pubmed publisher
Quiñones M, Folgueira C, Sánchez Rebordelo E, Al Massadi O. Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents. Mediators Inflamm. 2015;2015:620919 pubmed publisher
Jahn J, Spielau M, Brandsch C, Stangl G, Delank K, Bähr I, et al. Decreased NK cell functions in obesity can be reactivated by fat mass reduction. Obesity (Silver Spring). 2015;23:2233-41 pubmed publisher
Kurajoh M, Koyama H, Kadoya M, Naka M, Miyoshi A, Kanzaki A, et al. Plasma leptin level is associated with cardiac autonomic dysfunction in patients with type 2 diabetes: HSCAA study. Cardiovasc Diabetol. 2015;14:117 pubmed publisher
Suzukawa M, Koketsu R, Baba S, Igarashi S, Nagase H, Yamaguchi M, et al. Leptin enhances ICAM-1 expression, induces migration and cytokine synthesis, and prolongs survival of human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2015;309:L801-11 pubmed publisher
Zeng W, Lu Y, Lee J, Friedman J. Reanalysis of parabiosis of obesity mutants in the age of leptin. Proc Natl Acad Sci U S A. 2015;112:E3874-82 pubmed publisher
García Méndez S, Rivera Bahena C, Montiel Hernández J, Xibillé Friedmann D, Álvarez Hernández E, Peláez Ballestas I, et al. A Prospective Follow-Up of Adipocytokines in Cohort Patients With Gout: Association With Metabolic Syndrome But Not With Clinical Inflammatory Findings: Strobe-Compliant Article. Medicine (Baltimore). 2015;94:e935 pubmed publisher
Manjunathan R, Ragunathan M. In ovo administration of human recombinant leptin shows dose dependent angiogenic effect on chicken chorioallantoic membrane. Biol Res. 2015;48:29 pubmed publisher
Kato S, Abarzua Catalan L, Trigo C, Delpiano A, Sanhueza C, García K, et al. Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women. Oncotarget. 2015;6:21100-19 pubmed
Ericson E, Wennberg Huldt C, Strömstedt M, Brodin P. A novel role of the checkpoint kinase ATR in leptin signaling. Mol Cell Endocrinol. 2015;412:257-64 pubmed publisher
Fan Y, Gan Y, Shen Y, Cai X, Song Y, Zhao F, et al. Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production. Oncotarget. 2015;6:16120-34 pubmed
Xibillé Friedmann D, Ortiz Panozo E, Bustos Rivera Bahena C, Sandoval Ríos M, Hernández Góngora S, Dominguez Hernandez L, et al. Leptin and adiponectin as predictors of disease activity in rheumatoid arthritis. Clin Exp Rheumatol. 2015;33:471-7 pubmed
Nishimuta J, Levenston M. Meniscus is more susceptible than cartilage to catabolic and anti-anabolic effects of adipokines. Osteoarthritis Cartilage. 2015;23:1551-62 pubmed publisher
Trevellin E, Scarpa M, Carraro A, Lunardi F, Kotsafti A, Porzionato A, et al. Esophageal adenocarcinoma and obesity: peritumoral adipose tissue plays a role in lymph node invasion. Oncotarget. 2015;6:11203-15 pubmed
Chang C, Wu M, Yang J, CAMARILLO I, Chang C. Leptin-STAT3-G9a Signaling Promotes Obesity-Mediated Breast Cancer Progression. Cancer Res. 2015;75:2375-2386 pubmed publisher
Barrientos G, Toro A, Moschansky P, Cohen M, Garcia M, Rose M, et al. Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways. Placenta. 2015;36:419-26 pubmed publisher
Papanikolaou V, Stefanou N, Dubos S, Papathanasiou I, Palianopoulou M, Valiakou V, et al. Synergy of leptin/STAT3 with HER2 receptor induces tamoxifen resistance in breast cancer cells through regulation of apoptosis-related genes. Cell Oncol (Dordr). 2015;38:155-64 pubmed publisher
Song Y, Luo Z, Pan Y, Zhang L, Chen Q, Zheng J. Three unsaturated fatty acid biosynthesis-related genes in yellow catfish Pelteobagrus fulvidraco: Molecular characterization, tissue expression and transcriptional regulation by leptin. Gene. 2015;563:1-9 pubmed publisher
Pliszka M, Oleszczak B, Szablewski L. Leptin at gender-specific concentrations does not affect glucose transport, expression of glucose transporters and leptin receptors in human lymphocytes. Endocrine. 2015;49:97-105 pubmed publisher
Kasiappan R, Sun Y, Lungchukiet P, Quarni W, Zhang X, Bai W. Vitamin D suppresses leptin stimulation of cancer growth through microRNA. Cancer Res. 2014;74:6194-204 pubmed publisher
Allison M, Myers M. 20 years of leptin: connecting leptin signaling to biological function. J Endocrinol. 2014;223:T25-35 pubmed publisher
Santucci N, Diaz A, Bianchi E, Spinelli S, D Attilio L, Bongiovanni B, et al. Leptin does not enhance cell-mediated immune responses following mycobacterial antigen stimulation. Int J Tuberc Lung Dis. 2014;18:981-7 pubmed publisher
Molek P, Vodnik M, Strukelj B, Bratkovič T. Screening of synthetic phage display scFv libraries yields competitive ligands of human leptin receptor. Biochem Biophys Res Commun. 2014;452:479-83 pubmed publisher
Galvão A, Tramontano A, Rebordão M, Amaral A, Bravo P, Szóstek A, et al. Opposing roles of leptin and ghrelin in the equine corpus luteum regulation: an in vitro study. Mediators Inflamm. 2014;2014:682193 pubmed publisher
Sueblinvong V, Liangpunsakul S. Relationship between serum leptin and chronic obstructive pulmonary disease in US adults: results from the third National Health and Nutrition Examination Survey. J Investig Med. 2014;62:934-7 pubmed publisher
Mancini M, Soldovieri M, Gessner G, Wissuwa B, Barrese V, Boscia F, et al. Critical role of large-conductance calcium- and voltage-activated potassium channels in leptin-induced neuroprotection of N-methyl-d-aspartate-exposed cortical neurons. Pharmacol Res. 2014;87:80-6 pubmed publisher
Yoon K, Park S, Kim J, Lee S, Park C, Cho S, et al. Leptin-induced adhesion and invasion in colorectal cancer cell lines. Oncol Rep. 2014;31:2493-8 pubmed publisher
Yau S, Henry B, Russo V, McConell G, Clarke I, Werther G, et al. Leptin enhances insulin sensitivity by direct and sympathetic nervous system regulation of muscle IGFBP-2 expression: evidence from nonrodent models. Endocrinology. 2014;155:2133-43 pubmed publisher
Piao L, Park J, Li Y, Shin S, Shin S, Kong G, et al. SOCS3 and SOCS6 are required for the risperidone-mediated inhibition of insulin and leptin signaling in neuroblastoma cells. Int J Mol Med. 2014;33:1364-70 pubmed publisher
Lange Consiglio A, Dell Aquila M, Fiandanese N, Ambruosi B, Cho Y, Bosi G, et al. Effects of leptin on in vitro maturation, fertilization and embryonic cleavage after ICSI and early developmental expression of leptin (Ob) and leptin receptor (ObR) proteins in the horse. Reprod Biol Endocrinol. 2009;7:113 pubmed publisher
Hongo S, Watanabe T, Arita S, Kanome T, Kageyama H, Shioda S, et al. Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages. Am J Physiol Endocrinol Metab. 2009;297:E474-82 pubmed publisher
Greco S, Sarkar S, Casadesus G, Zhu X, Smith M, Ashford J, et al. Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells. Neurosci Lett. 2009;455:191-4 pubmed publisher
Perusse L, Chagnon Y, Weisnagel S, Rankinen T, Snyder E, Sands J, et al. The human obesity gene map: the 2000 update. Obes Res. 2001;9:135-69 pubmed
product information
Catalog Number :
L4146
Product Name :
Leptin human
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA