This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Kifunensine
catalog :
K1140
citations: 42
Reference
Wang J, Li J, Wu J, Dong M, Shen Z, Lin Y, et al. Host Gene SEL1L Involved in Endoplasmic Reticulum-Associated Degradation Pathway Could Inhibit Hepatitis B Virus at RNA, DNA, and Protein Levels. Front Microbiol. 2019;10:2869 pubmed publisher
Trevor C, González Muñoz A, Macleod O, Woodcock P, Rust S, Vaughan T, et al. Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion. Nat Microbiol. 2019;4:2074-2081 pubmed publisher
Mehta N, Maddineni S, Mathews I, Andres Parra Sperberg R, Huang P, Cochran J. Structure and Functional Binding Epitope of V-domain Ig Suppressor of T Cell Activation. Cell Rep. 2019;28:2509-2516.e5 pubmed publisher
SWEENEY J, Liang J, Antonopoulos A, Giovannone N, Kang S, Mondala T, et al. Loss of GCNT2/I-branched glycans enhances melanoma growth and survival. Nat Commun. 2018;9:3368 pubmed publisher
Phoomak C, Silsirivanit A, Park D, Sawanyawisuth K, Vaeteewoottacharn K, Wongkham C, et al. O-GlcNAcylation mediates metastasis of cholangiocarcinoma through FOXO3 and MAN1A1. Oncogene. 2018;37:5648-5665 pubmed publisher
Estornes Y, Dondelinger Y, Weber K, Bruggeman I, Peall A, MacFarlane M, et al. N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis. Cell Death Dis. 2018;9:494 pubmed publisher
Cervin J, Wands A, Casselbrant A, Wu H, Krishnamurthy S, Cvjetkovic A, et al. GM1 ganglioside-independent intoxication by Cholera toxin. PLoS Pathog. 2018;14:e1006862 pubmed publisher
Vernon C, Copits B, Stolz J, Guzman Y, Swanson G. N-glycan content modulates kainate receptor functional properties. J Physiol. 2017;595:5913-5930 pubmed publisher
Horn A, Celic I, Dong C, Martirosyan I, Han J. A conserved role for the ESCRT membrane budding complex in LINE retrotransposition. PLoS Genet. 2017;13:e1006837 pubmed publisher
Wands A, Fujita A, McCombs J, Cervin J, Dedic B, Rodriguez A, et al. Fucosylation and protein glycosylation create functional receptors for cholera toxin. elife. 2015;4:e09545 pubmed publisher
Hüttner S, Veit C, Vavra U, Schoberer J, Dicker M, Maresch D, et al. A context-independent N-glycan signal targets the misfolded extracellular domain of Arabidopsis STRUBBELIG to endoplasmic-reticulum-associated degradation. Biochem J. 2014;464:401-11 pubmed publisher
Horimoto S, Ninagawa S, Okada T, Koba H, Sugimoto T, Kamiya Y, et al. The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein. J Biol Chem. 2013;288:31517-27 pubmed publisher
Moncada Velez M, Martinez Barricarte R, Bogunovic D, Kong X, Blancas Galicia L, Tirpan C, et al. Partial IFN-?R2 deficiency is due to protein misfolding and can be rescued by inhibitors of glycosylation. Blood. 2013;122:2390-401 pubmed publisher
Song H, Chu Y, Zhang H, Wang X, Zhang T, Qiu M, et al. Epitope specificity of cross-clade neutralizing sera from Chinese HIV-1-positive individuals. Scand J Immunol. 2013;78:357-70 pubmed publisher
Kong L, Lee J, Doores K, Murin C, Julien J, McBride R, et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nat Struct Mol Biol. 2013;20:796-803 pubmed publisher
Chen H, Li R, Liu Z, Wei S, Zhang H, Li X. Synthesis of kifunensine thioanalogs and their inhibitory activities against HIV-RT and α-mannosidase. Carbohydr Res. 2013;365:1-8 pubmed publisher
Mikell I, Stamatatos L. Evolution of cross-neutralizing antibody specificities to the CD4-BS and the carbohydrate cloak of the HIV Env in an HIV-1-infected subject. PLoS ONE. 2012;7:e49610 pubmed publisher
Tyler R, Pearce M, Shaler T, Olzmann J, Greenblatt E, Kopito R. Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. Mol Biol Cell. 2012;23:4668-78 pubmed publisher
Mo D, Costa S, Ihrke G, Youker R, Pastor Soler N, Hughey R, et al. Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism. Mol Biol Cell. 2012;23:3636-46 pubmed publisher
Hassler S, Lemke L, Jung B, Möhlmann T, Krüger F, Schumacher K, et al. Lack of the Golgi phosphate transporter PHT4;6 causes strong developmental defects, constitutively activated disease resistance mechanisms and altered intracellular phosphate compartmentation in Arabidopsis. Plant J. 2012;72:732-44 pubmed publisher
Yu M, Brown D, Reed C, CHUNG S, Lutman J, Stefanich E, et al. Production, characterization, and pharmacokinetic properties of antibodies with N-linked mannose-5 glycans. MAbs. 2012;4:475-87 pubmed publisher
Kim Y, Park J, Lee H, Lee S, Kim S. TGF-? sensitivity is determined by N-linked glycosylation of the type II TGF-? receptor. Biochem J. 2012;445:403-11 pubmed publisher
Su H, Carter C, Fröhlich O, Cummings R, Chen G. Glycoforms of UT-A3 urea transporter with poly-N-acetyllactosamine glycosylation have enhanced transport activity. Am J Physiol Renal Physiol. 2012;303:F201-8 pubmed publisher
Soheili T, Gicquel E, Poupiot J, N Guyen L, Le Roy F, Bartoli M, et al. Rescue of sarcoglycan mutations by inhibition of endoplasmic reticulum quality control is associated with minimal structural modifications. Hum Mutat. 2012;33:429-39 pubmed publisher
Wang F, Song W, Brancati G, Segatori L. Inhibition of endoplasmic reticulum-associated degradation rescues native folding in loss of function protein misfolding diseases. J Biol Chem. 2011;286:43454-64 pubmed publisher
Saeed M, Suzuki R, Watanabe N, Masaki T, Tomonaga M, Muhammad A, et al. Role of the endoplasmic reticulum-associated degradation (ERAD) pathway in degradation of hepatitis C virus envelope proteins and production of virus particles. J Biol Chem. 2011;286:37264-73 pubmed publisher
Yu C, Crispin M, Sonnen A, Harvey D, Chang V, Evans E, et al. Use of the ?-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:785-9 pubmed publisher
Gebuhr I, Keeren K, Vogt K, Höflich C, Appelt C, Schlieer U, et al. Differential expression and function of ?-mannosidase I in stimulated naive and memory CD4+ T cells. J Immunother. 2011;34:428-37 pubmed publisher
Ryan S, Bonomo J, Zhao F, Cobb B. MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation. J Exp Med. 2011;208:1041-53 pubmed publisher
Lomako J, Lomako W, Carothers Carraway C, Carraway K. Regulation of the membrane mucin Muc4 in corneal epithelial cells by proteosomal degradation and TGF-beta. J Cell Physiol. 2010;223:209-14 pubmed publisher
Cameron P, Chevet E, Pluquet O, Thomas D, Bergeron J. Calnexin phosphorylation attenuates the release of partially misfolded alpha1-antitrypsin to the secretory pathway. J Biol Chem. 2009;284:34570-9 pubmed publisher
Saijo Y, Tintor N, Lu X, Rauf P, Pajerowska Mukhtar K, Häweker H, et al. Receptor quality control in the endoplasmic reticulum for plant innate immunity. EMBO J. 2009;28:3439-49 pubmed publisher
van Berkel P, Gerritsen J, van Voskuilen E, Perdok G, Vink T, van de Winkel J, et al. Rapid production of recombinant human IgG With improved ADCC effector function in a transient expression system. Biotechnol Bioeng. 2010;105:350-7 pubmed publisher
Butters T, Alonzi D, Kukushkin N, Ren Y, Blériot Y. Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells. Glycoconj J. 2009;26:1109-16 pubmed publisher
Nettleship J, Rahman Huq N, Owens R. The production of glycoproteins by transient expression in Mammalian cells. Methods Mol Biol. 2009;498:245-63 pubmed publisher
Bartoli M, Gicquel E, Barrault L, Soheili T, Malissen M, Malissen B, et al. Mannosidase I inhibition rescues the human alpha-sarcoglycan R77C recurrent mutation. Hum Mol Genet. 2008;17:1214-21 pubmed publisher
Kim P, Lee J, Jongsamak P, Menon S, Li B, Hossain S, et al. Defective protein folding and intracellular retention of thyroglobulin-R19K mutant as a cause of human congenital goiter. Mol Endocrinol. 2008;22:477-84 pubmed
Hosokawa N, You Z, Tremblay L, Nagata K, Herscovics A. Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin by Golgi alpha1,2-mannosidases. Biochem Biophys Res Commun. 2007;362:626-32 pubmed
Zhou Q, Shankara S, Roy A, Qiu H, Estes S, McVie Wylie A, et al. Development of a simple and rapid method for producing non-fucosylated oligomannose containing antibodies with increased effector function. Biotechnol Bioeng. 2008;99:652-65 pubmed
Scanlan C, Ritchie G, Baruah K, Crispin M, Harvey D, Singer B, et al. Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody. J Mol Biol. 2007;372:16-22 pubmed
Izumi S, Okuhara M. [FK506 and kifunensine, new immunomodulators of microbial origin]. Tanpakushitsu Kakusan Koso. 1993;38:1800-12 pubmed
Elbein A, Tropea J, Mitchell M, Kaushal G. Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J Biol Chem. 1990;265:15599-605 pubmed
product information
Catalog Number :
K1140
Product Name :
Kifunensine
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
mannosidase inhibitor
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA