This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Ketorolac tris salt
catalog :
K1136
citations: 67
Reference
Azócar M, Alarcon R, Castillo A, Blamey J, Walter M, Paez M. Capping of silver nanoparticles by anti-inflammatory ligands: Antibacterial activity and superoxide anion generation. J Photochem Photobiol B. 2019;193:100-108 pubmed publisher
El Nabarawi M, Abd El Rehem R, Teaima M, Abary M, El Mofty H, Khafagy M, et al. Natamycin niosomes as a promising ocular nanosized delivery system with ketorolac tromethamine for dual effects for treatment of candida rabbit keratitis; in vitro/in vivo and histopathological studies. Drug Dev Ind Pharm. 2019;45:922-936 pubmed publisher
Sarwahi V, Amaral T, Wendolowski S, Gecelter R, Gambassi M, Plakas C, et al. Minimally Invasive Scoliosis Surgery: A Novel Technique in Patients with Neuromuscular Scoliosis. Biomed Res Int. 2015;2015:481945 pubmed publisher
Oprea T, Sklar L, Agola J, Guo Y, Silberberg M, Roxby J, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS ONE. 2015;10:e0142182 pubmed publisher
Muller M, Drew R, Ross A, Blaha C, Cauffman A, Kaufman M, et al. Inhibition of cyclooxygenase attenuates the blood pressure response to plantar flexion exercise in peripheral arterial disease. Am J Physiol Heart Circ Physiol. 2015;309:H523-8 pubmed publisher
Lima T, Ribeiro A, Conceição L, Bandarra M, Manrique W, Laus J. Ketorolac eye drops reduce inflammation and delay re-epithelization in response to corneal alkali burn in rabbits, without affecting iNOS or MMP-9. Arq Bras Oftalmol. 2015;78:67-72 pubmed publisher
Kim J, Ahmadinia K, Li X, Hamilton J, Andrews S, Haralampus C, et al. Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury-Induced Lumbar Facet Joint Osteoarthritis. J Cell Physiol. 2015;230:2837-47 pubmed publisher
Singer D, Kennedy J, Wittpenn J. Topical NSAIDs effect on corneal sensitivity. Cornea. 2015;34:541-3 pubmed publisher
Venturi M, Boccasanta P, Lombardi B, Brambilla M, Contessini Avesani E, Vergani C. Pudendal Neuralgia: A New Option for Treatment? Preliminary Results on Feasibility and Efficacy. Pain Med. 2015;16:1475-81 pubmed publisher
Kumar A, Garg T, Sarma G, Rath G, Goyal A. Optimization of combinational intranasal drug delivery system for the management of migraine by using statistical design. Eur J Pharm Sci. 2015;70:140-51 pubmed publisher
Linn Pearl R, Powell R, Newman H, Gould D. Validity of aqueocentesis as a component of anterior uveitis investigation in dogs and cats. Vet Ophthalmol. 2015;18:326-34 pubmed publisher
Villa R, Ravasio G, Ferraresi C, Zonca A, Carli S, Borghi L, et al. Pharmacokinetics of intravenous ketorolac in cats undergoing gonadectomy. N Z Vet J. 2015;63:162-6 pubmed publisher
Jinapriya D, D Souza M, Hollands H, El Defrawy S, Irrcher I, Smallman D, et al. Anti-inflammatory therapy after selective laser trabeculoplasty: a randomized, double-masked, placebo-controlled clinical trial. Ophthalmology. 2014;121:2356-61 pubmed publisher
Heinzelmann S, Maier P, Böhringer D, Hüther S, Eberwein P, Reinhard T. Cystoid macular oedema following Descemet membrane endothelial keratoplasty. Br J Ophthalmol. 2015;99:98-102 pubmed publisher
Ragam A, Kolomeyer A, Kim J, Nayak N, Fang C, Kim E, et al. Topical cyclosporine a 1% for the treatment of chronic ocular surface inflammation. Eye Contact Lens. 2014;40:283-8 pubmed publisher
Riggin C, Tucker J, Soslowsky L, Kuntz A. Intra-articular tibiofemoral injection of a nonsteroidal anti-inflammatory drug has no detrimental effects on joint mechanics in a rat model. J Orthop Res. 2014;32:1512-9 pubmed publisher
Xie J, Qu C, Patwardhan A, Ossipov M, Navratilova E, Becerra L, et al. Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: a potential biomarker of efficacy. Pain. 2014;155:1659-66 pubmed publisher
Ticly F, Lira R, Zanetti F, Machado M, Rodrigues G, Arieta C. Prophylactic use of ketorolac tromethamine in cataract surgery: a randomized trial. J Ocul Pharmacol Ther. 2014;30:495-501 pubmed publisher
Morotti M, Calanni L, Gianola G, Anserini P, Venturini P, Ferrero S. Changes in sexual function after medical or surgical termination of pregnancy. J Sex Med. 2014;11:1495-504 pubmed publisher
He L, Liu A, Manche E. Wavefront-guided versus wavefront-optimized laser in situ keratomileusis for patients with myopia: a prospective randomized contralateral eye study. Am J Ophthalmol. 2014;157:1170-1178.e1 pubmed publisher
Schoenberger S, Kim S, Shah R, Sheng J, Cherney E. Reduction of interleukin 8 and platelet-derived growth factor levels by topical ketorolac, 0.45%, in patients with diabetic retinopathy. JAMA Ophthalmol. 2014;132:32-7 pubmed publisher
Ruhlen R, Snider E, Sargentini N, Worthington B, Singh V, Pazdernik V, et al. Influence of manual therapy on functional mobility after joint injury in a rat model. J Am Osteopath Assoc. 2013;113:738-52, e48-9 pubmed publisher
Mettu S, Veerareddy P. Formulation and pharmacokinetics of ketorolac tromethamine fast dissolving tablets. Drug Res (Stuttg). 2013;63:586-90 pubmed publisher
Mirski D. You're the flight surgeon: nephrolithiasis. Aviat Space Environ Med. 2013;84:648-50 pubmed
Chui J, Herkes G, Chang A. Management of fingolimod-associated macular edema. JAMA Ophthalmol. 2013;131:694-6 pubmed publisher
Allegaert K, Van Calsteren K, Hendrickx S, Kelchtermans J, Smits A, Kulo A, et al. Paracetamol and ketorolac pharmacokinetics and metabolism at delivery and during postpartum. Acta Anaesthesiol Belg. 2012;63:121-5 pubmed
Magni G, La Rosa I, Melillo G, Abeni D, Hernandez H, Rosa G. Intracranial hemorrhage requiring surgery in neurosurgical patients given ketorolac: a case-control study within a cohort (2001-2010). Anesth Analg. 2013;116:443-7 pubmed publisher
Park H, Stokes J, Pirie E, Skahen J, Shtaerman Y, Yaksh T. Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanerc. Anesth Analg. 2013;116:224-31 pubmed publisher
Vemula S, Veerareddy P. Development, evaluation and pharmacokinetics of time-dependent ketorolac tromethamine tablets. Expert Opin Drug Deliv. 2013;10:33-45 pubmed publisher
Kulo A, Hendrickx S, de Hoon J, Mulabegović N, Van Calsteren K, Verbesselt R, et al. The impact of pregnancy on urinary ketorolac metabolites after single intravenous bolus. Eur J Drug Metab Pharmacokinet. 2013;38:1-4 pubmed publisher
Bullingham R, Juan A. Comparison of intranasal ketorolac tromethamine pharmacokinetics in younger and older adults. Drugs Aging. 2012;29:899-904 pubmed publisher
Wang M, Liu W, Lu Q, Zeng H, Liu S, Yue Y, et al. Pharmacokinetic comparison of ketorolac after intracameral, intravitreal, and suprachoroidal administration in rabbits. Retina. 2012;32:2158-64 pubmed publisher
He A, Hersh E. A review of intranasal ketorolac tromethamine for the short-term management of moderate to moderately severe pain that requires analgesia at the opioid level. Curr Med Res Opin. 2012;28:1873-80 pubmed publisher
del Valle Laisequilla C, Flores Murrieta F, Granados Soto V, Rocha González H, Reyes Garcia G. Ketorolac tromethamine improves the analgesic effect of hyoscine butylbromide in patients with intense cramping pain from gastrointestinal or genitourinary origin. Arzneimittelforschung. 2012;62:603-8 pubmed publisher
Grimsby G, Conley S, Trentman T, Castle E, Andrews P, Mihalik L, et al. A double-blind randomized controlled trial of continuous intravenous Ketorolac vs placebo for adjuvant pain control after renal surgery. Mayo Clin Proc. 2012;87:1089-97 pubmed publisher
Mylonas G, Sacu S, Deak G, Dunavoelgyi R, Buehl W, Georgopoulos M, et al. Macular edema following cataract surgery in eyes with previous 23-gauge vitrectomy and peeling of the internal limiting membrane. Am J Ophthalmol. 2013;155:253-259.e2 pubmed publisher
Weber M, Kodjikian L, Kruse F, Zagorski Z, Allaire C. Efficacy and safety of indomethacin 0.1% eye drops compared with ketorolac 0.5% eye drops in the management of ocular inflammation after cataract surgery. Acta Ophthalmol. 2013;91:e15-21 pubmed publisher
Kulo A, van de Velde M, Van Calsteren K, Smits A, de Hoon J, Verbesselt R, et al. Pharmacokinetics of intravenous ketorolac following caesarean delivery. Int J Obstet Anesth. 2012;21:334-8 pubmed publisher
Zanetti F, Fulco E, Chaves F, da Costa Pinto A, Arieta C, Lira R. Effect of preoperative use of topical prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery: a randomized trial. Indian J Ophthalmol. 2012;60:277-81 pubmed publisher
Eichner E. Intramuscular ketorolac injections: the pregame Toradol parade. Curr Sports Med Rep. 2012;11:169-70 pubmed publisher
Pfaffenrath V, Fenzl E, Bregman D, Farkkila M. Intranasal ketorolac tromethamine (SPRIX(R)) containing 6% of lidocaine (ROX-828) for acute treatment of migraine: safety and efficacy data from a phase II clinical trial. Cephalalgia. 2012;32:766-77 pubmed publisher
Bacon R, Newman S, Rankin L, Pitcairn G, Whiting R. Pulmonary and nasal deposition of ketorolac tromethamine solution (SPRIX) following intranasal administration. Int J Pharm. 2012;431:39-44 pubmed publisher
Kim S, Doherty T, Cherney E. Intravitreal ketorolac for chronic uveitis and macular edema: a pilot study. Arch Ophthalmol. 2012;130:456-60 pubmed publisher
Drover D, Hammer G, Anderson B. The pharmacokinetics of ketorolac after single postoperative intranasal administration in adolescent patients. Anesth Analg. 2012;114:1270-6 pubmed publisher
Snyder M, Bregmen D. SPRIX (ketorolac tromethamine) nasal spray: a novel nonopioid alternative for managing moderate to moderately severe dental pain. Compend Contin Educ Dent. 2012;33 Spec No 1:2-11 pubmed
Bain M, Bhowmick B, Maity D, Mondal D, Mollick M, Paul B, et al. Effect of PVA on the gel temperature of MC and release kinetics of KT from MC based ophthalmic formulations. Int J Biol Macromol. 2012;50:565-72 pubmed publisher
. Intranasal ketorolac (Sprix). Med Lett Drugs Ther. 2012;54:7-8 pubmed
Turan Vural E, Torun Acar B, Acar S. Effect of ketorolac add-on treatment on intra-ocular pressure in glaucoma patients receiving prostaglandin analogues. Ophthalmologica. 2012;227:205-9 pubmed publisher
Kim B, Shim D, Lee J, Han S, Ko Y, Park E. Comparison of multi-drug injection versus placebo after hallux valgus surgery. Foot Ankle Int. 2011;32:856-60 pubmed
Zhang Y, Buchko G, Qin L, Robinson H, Varnum S. Crystal structure of the receptor binding domain of the botulinum C-D mosaic neurotoxin reveals potential roles of lysines 1118 and 1136 in membrane interactions. Biochem Biophys Res Commun. 2011;404:407-12 pubmed publisher
Sinha V, Kumar R, Singh G. Ketorolac tromethamine formulations: an overview. Expert Opin Drug Deliv. 2009;6:961-75 pubmed publisher
Scarlett J, Zhu X, Enriori P, Bowe D, Batra A, Levasseur P, et al. Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation. Endocrinology. 2008;149:4837-45 pubmed publisher
Schechter B. Ketorolac tromethamine 0.4% as a treatment for allergic conjuctivitis. Expert Opin Drug Metab Toxicol. 2008;4:507-11 pubmed
Scarlett J, Jobst E, Enriori P, Bowe D, Batra A, Grant W, et al. Regulation of central melanocortin signaling by interleukin-1 beta. Endocrinology. 2007;148:4217-25 pubmed
Perry H, Donnenfeld E. An update on the use of ophthalmic ketorolac tromethamine 0.4%. Expert Opin Pharmacother. 2006;7:99-107 pubmed
Dionne R, Khan A, Gordon S. Analgesia and COX-2 inhibition. Clin Exp Rheumatol. 2001;19:S63-70 pubmed
Michel R, Holt J, Domer F. Ketorolac causes the release of methionine-enkephalin in rats. Res Commun Mol Pathol Pharmacol. 1996;91:249-52 pubmed
Cirino G, Wheeler Jones C, Wallace J, Del Soldato P, Baydoun A. Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory derivatives with gastrointestinal-sparing properties. Br J Pharmacol. 1996;117:1421-6 pubmed
Mason H. Morphine sulfate, transdermal fentanyl citrate and ketorolac tromethamine: effects on postoperative pulmonary function. Am J Crit Care. 1993;2:61-4 pubmed
Andersen S, Jensen M. [Ketorolac tromethamine--with special reference to postoperative pain therapy]. Ugeskr Laeger. 1994;156:1160-3 pubmed
Laneuville O, Breuer D, DeWitt D, Hla T, Funk C, Smith W. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 1994;271:927-34 pubmed
Tripathi A, Welch S. Blockade of the antinociceptive activity of centrally administered ketorolac by nor-binaltorphimine. Eur J Pharmacol. 1995;278:27-32 pubmed
Buckley M, Brogden R. Ketorolac. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential. Drugs. 1990;39:86-109 pubmed
Mroszczak E, Jung D, Yee J, Bynum L, Sevelius H, Massey I. Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular, and oral administration in humans and animals. Pharmacotherapy. 1990;10:33S-39S pubmed
Jay G. Ketorolac tromethamine. Conn Med. 1991;55:288-90 pubmed
Brocks D, Jamali F. Clinical pharmacokinetics of ketorolac tromethamine. Clin Pharmacokinet. 1992;23:415-27 pubmed
Redden R. Ketorolac tromethamine: an oral/injectable nonsteroidal anti-inflammatory for postoperative pain control. J Oral Maxillofac Surg. 1992;50:1310-3 pubmed
product information
Catalog Number :
K1136
Product Name :
Ketorolac tris salt
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥99%, crystalline
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA