Degen M, Wiederkehr A, La Scala G, Carmann C, Schnyder I, Katsaros C. Keratinocytes Isolated From Individual Cleft Lip/Palate Patients Display Variations in Their Differentiation Potential in vitro. Front Physiol. 2018;9:1703 pubmed publisher

Wang R, Cao X, Kulej K, Liu W, Ma T, MacDonald M, et al. Uncovering BRD4 hyperphosphorylation associated with cellular transformation in NUT midline carcinoma. Proc Natl Acad Sci U S A. 2017;114:E5352-E5361 pubmed publisher

Na T, Kim G, Oh H, Lee M, Han Y, Kim K, et al. The trisaccharide raffinose modulates epidermal differentiation through activation of liver X receptor. Sci Rep. 2017;7:43823 pubmed publisher

Ajiro M, Tang S, Doorbar J, Zheng Z. Serine/Arginine-Rich Splicing Factor 3 and Heterogeneous Nuclear Ribonucleoprotein A1 Regulate Alternative RNA Splicing and Gene Expression of Human Papillomavirus 18 through Two Functionally Distinguishable cis Elements. J Virol. 2016;90:9138-52 pubmed publisher

Klymenko T, Hernández López H, MacDonald A, Bodily J, Graham S. Human Papillomavirus E2 Regulates SRSF3 (SRp20) To Promote Capsid Protein Expression in Infected Differentiated Keratinocytes. J Virol. 2016;90:5047-58 pubmed publisher

Nawandar D, Wang A, Makielski K, Lee D, Ma S, Barlow E, et al. Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. PLoS Pathog. 2015;11:e1005195 pubmed publisher

Manils J, Gómez D, Salla Martret M, Fischer H, Fye J, Marzo E, et al. Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis. Oncotarget. 2015;6:22375-96 pubmed

Sauder C, Koziel J, Choi M, Fox M, Grimes B, Badve S, et al. Phenotypic plasticity in normal breast derived epithelial cells. BMC Cell Biol. 2014;15:20 pubmed publisher

Aberdam E, Roux L, Secrétan P, Boralevi F, Schlatter J, Morice Picard F, et al. Improvement of epidermal covering on AEC patients with severe skin erosions by PRIMA-1MET/APR-246. Cell Death Dis. 2020;11:30 pubmed publisher

Bezié S, Charreau B, Vimond N, Lasselin J, Gerard N, Nerrière Daguin V, et al. Human CD8+ Tregs expressing a MHC-specific CAR display enhanced suppression of human skin rejection and GVHD in NSG mice. Blood Adv. 2019;3:3522-3538 pubmed publisher

Mollinedo P, Kapitansky O, González Lamuño D, Zaslavsky A, Real P, Gozes I, et al. Cellular and animal models of skin alterations in the autism-related ADNP syndrome. Sci Rep. 2019;9:736 pubmed publisher

Alameda J, Ramirez A, Garcia Fernandez R, Navarro M, Page A, Segovia J, et al. Premature aging and cancer development in transgenic mice lacking functional CYLD. Aging (Albany NY). 2019;11:127-159 pubmed publisher

Duchatelet S, Boyden L, Ishida Yamamoto A, Zhou J, Guibbal L, Hu R, et al. Mutations in PERP Cause Dominant and Recessive Keratoderma. J Invest Dermatol. 2019;139:380-390 pubmed publisher

Caves E, Cook S, Lee N, Stoltz D, Watkins S, Shair K. Air-Liquid Interface Method To Study Epstein-Barr Virus Pathogenesis in Nasopharyngeal Epithelial Cells. mSphere. 2018;3: pubmed publisher

Kasagi Y, Chandramouleeswaran P, Whelan K, Tanaka K, Giroux V, Sharma M, et al. The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes. Cell Mol Gastroenterol Hepatol. 2018;5:333-352 pubmed publisher

Eldakhakhny S, Zhou Q, Crosbie E, Sayan B. Human papillomavirus E7 induces p63 expression to modulate DNA damage response. Cell Death Dis. 2018;9:127 pubmed publisher

Li H, Zhou L, Dai J. Retinoic acid receptor-related orphan receptor RORα regulates differentiation and survival of keratinocytes during hypoxia. J Cell Physiol. 2018;233:641-650 pubmed publisher

Natsuizaka M, Whelan K, Kagawa S, Tanaka K, Giroux V, Chandramouleeswaran P, et al. Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma. Nat Commun. 2017;8:1758 pubmed publisher

Muther C, Jobeili L, Garion M, Heraud S, Thépot A, Damour O, et al. An expression screen for aged-dependent microRNAs identifies miR-30a as a key regulator of aging features in human epidermis. Aging (Albany NY). 2017;9:2376-2396 pubmed publisher

Noguchi K, Wakai K, Kiyono T, Kawabe M, Yoshikawa K, Hashimoto Tamaoki T, et al. Molecular analysis of keratocystic odontogenic tumor cell lines derived from sporadic and basal cell nevus syndrome patients. Int J Oncol. 2017;51:1731-1738 pubmed publisher

Klymenko T, Gu Q, Herbert I, Stevenson A, Iliev V, Watkins G, et al. RNA-Seq Analysis of Differentiated Keratinocytes Reveals a Massive Response to Late Events during Human Papillomavirus 16 Infection, Including Loss of Epithelial Barrier Function. J Virol. 2017;91: pubmed publisher

Yoshioka M, Ohashi S, Ida T, Nakai Y, Kikuchi O, Amanuma Y, et al. Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells. J Exp Clin Cancer Res. 2017;36:101 pubmed publisher

Kraus R, Yu X, Cordes B, Sathiamoorthi S, Iempridee T, Nawandar D, et al. Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter. PLoS Pathog. 2017;13:e1006404 pubmed publisher

Nawandar D, Ohashi M, Djavadian R, Barlow E, Makielski K, Ali A, et al. Differentiation-Dependent LMP1 Expression Is Required for Efficient Lytic Epstein-Barr Virus Reactivation in Epithelial Cells. J Virol. 2017;91: pubmed publisher

Meuris F, Carthagena L, Jaracz Ros A, Gaudin F, Cutolo P, Deback C, et al. The CXCL12/CXCR4 Signaling Pathway: A New Susceptibility Factor in Human Papillomavirus Pathogenesis. PLoS Pathog. 2016;12:e1006039 pubmed publisher

Jugé R, Breugnot J, Da Silva C, Bordes S, Closs B, Aouacheria A. Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes. Sci Rep. 2016;6:35065 pubmed publisher

Mochizuki M, Tamai K, Imai T, Sugawara S, Ogama N, Nakamura M, et al. CD271 regulates the proliferation and motility of hypopharyngeal cancer cells. Sci Rep. 2016;6:30707 pubmed publisher

Carretero M, Guerrero Aspizua S, Illera N, Gálvez V, Navarro M, García García F, et al. Differential Features between Chronic Skin Inflammatory Diseases Revealed in Skin-Humanized Psoriasis and Atopic Dermatitis Mouse Models. J Invest Dermatol. 2016;136:136-45 pubmed publisher

Alekseyenko A, Walsh E, Wang X, Grayson A, Hsi P, Kharchenko P, et al. The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains. Genes Dev. 2015;29:1507-23 pubmed publisher

Reusch J, Nawandar D, Wright K, Kenney S, Mertz J. Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters. J Virol. 2015;89:1731-43 pubmed publisher

Kagawa S, Natsuizaka M, Whelan K, Facompre N, Naganuma S, Ohashi S, et al. Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities. Oncogene. 2015;34:2347-59 pubmed publisher

Okumura T, Shimada Y, Moriyama M, Takei Y, Omura T, Sekine S, et al. MicroRNA-203 inhibits the progression of esophageal squamous cell carcinoma with restored epithelial tissue architecture in vivo. Int J Oncol. 2014;44:1923-32 pubmed publisher

Schumacher M, Schuster C, Rogon Z, Bauer T, Caushaj N, Baars S, et al. Efficient keratinocyte differentiation strictly depends on JNK-induced soluble factors in fibroblasts. J Invest Dermatol. 2014;134:1332-1341 pubmed publisher

Dai J, Brooks Y, Lefort K, Getsios S, Dotto G. The retinoid-related orphan receptor ROR? promotes keratinocyte differentiation via FOXN1. PLoS ONE. 2013;8:e70392 pubmed publisher

Radner F, Marrakchi S, Kirchmeier P, Kim G, Ribierre F, Kamoun B, et al. Mutations in CERS3 cause autosomal recessive congenital ichthyosis in humans. PLoS Genet. 2013;9:e1003536 pubmed publisher

Roggenkamp D, Köpnick S, Stäb F, Wenck H, Schmelz M, Neufang G. Epidermal nerve fibers modulate keratinocyte growth via neuropeptide signaling in an innervated skin model. J Invest Dermatol. 2013;133:1620-8 pubmed publisher

Rosa Garrido M, Ceballos L, Alonso Lecue P, Abraira C, Delgado M, Gandarillas A. A cell cycle role for the epigenetic factor CTCF-L/BORIS. PLoS ONE. 2012;7:e39371 pubmed publisher

Pickard A, Cichon A, Menges C, Patel D, McCance D. Regulation of epithelial differentiation and proliferation by the stroma: a role for the retinoblastoma protein. J Invest Dermatol. 2012;132:2691-9 pubmed publisher

Kalabis J, Wong G, Vega M, Natsuizaka M, Robertson E, Herlyn M, et al. Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture. Nat Protoc. 2012;7:235-46 pubmed publisher

Lugassy J, Zaffryar Eilot S, Soueid S, Mordoviz A, Smith V, Kessler O, et al. The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation. J Biol Chem. 2012;287:3541-9 pubmed publisher

Di W, Larcher F, Semenova E, Talbot G, Harper J, Del Rio M, et al. Ex-vivo gene therapy restores LEKTI activity and corrects the architecture of Netherton syndrome-derived skin grafts. Mol Ther. 2011;19:408-16 pubmed publisher

Bodo E, Kany B, Gáspár E, Knüver J, Kromminga A, Ramot Y, et al. Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones. Endocrinology. 2010;151:1633-42 pubmed publisher

Sen G, Reuter J, Webster D, Zhu L, Khavari P. DNMT1 maintains progenitor function in self-renewing somatic tissue. Nature. 2010;463:563-7 pubmed publisher

Han S, Lee M, Park G, Bang S, Kang Y, Kim T, et al. Investigation of papulopustular eruptions caused by cetuximab treatment shows altered differentiation markers and increases in inflammatory cytokines. Br J Dermatol. 2010;162:371-9 pubmed publisher

Kim S, Cho H, Kim D, Choi H, Kwon S, Na J, et al. Differential expression of p63 isoforms in normal skin and hyperproliferative conditions. J Cutan Pathol. 2009;36:825-30 pubmed publisher

Nobre R, Herráez Hernández E, Fei J, Langbein L, Kaden S, Grone H, et al. E7 oncoprotein of novel human papillomavirus type 108 lacking the E6 gene induces dysplasia in organotypic keratinocyte cultures. J Virol. 2009;83:2907-16 pubmed publisher

Mole S, Milligan S, Graham S. Human papillomavirus type 16 E2 protein transcriptionally activates the promoter of a key cellular splicing factor, SF2/ASF. J Virol. 2009;83:357-67 pubmed publisher

Bhattacharya A, Toth K, Durrani F, Cao S, Slocum H, Chintala S, et al. Hypoxia-specific drug tirapazamine does not abrogate hypoxic tumor cells in combination therapy with irinotecan and methylselenocysteine in well-differentiated human head and neck squamous cell carcinoma a253 xenografts. Neoplasia. 2008;10:857-65 pubmed

Escamez M, Carretero M, Garcia M, Martinez Santamaria L, Mirones I, Duarte B, et al. Assessment of optimal virus-mediated growth factor gene delivery for human cutaneous wound healing enhancement. J Invest Dermatol. 2008;128:1565-75 pubmed publisher

Cheunim T, Zhang J, Milligan S, McPhillips M, Graham S. The alternative splicing factor hnRNP A1 is up-regulated during virus-infected epithelial cell differentiation and binds the human papillomavirus type 16 late regulatory element. Virus Res. 2008;131:189-98 pubmed

Medina A, Kilani R, Carr N, Brown E, Ghahary A. Transdifferentiation of peripheral blood mononuclear cells into epithelial-like cells. Am J Pathol. 2007;171:1140-52 pubmed

Yugawa T, Handa K, Narisawa Saito M, Ohno S, Fujita M, Kiyono T. Regulation of Notch1 gene expression by p53 in epithelial cells. Mol Cell Biol. 2007;27:3732-42 pubmed

Kim D, Cho H, Lee H, Lee W, Park E, Youn S, et al. Terrein, a fungal metabolite, inhibits the epidermal proliferation of skin equivalents. J Dermatol Sci. 2007;46:65-8 pubmed

Herz C, Aumailley M, Schulte C, Schlötzer Schrehardt U, Bruckner Tuderman L, Has C. Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes. J Biol Chem. 2006;281:36082-90 pubmed

Florin L, Maas Szabowski N, Werner S, Szabowski A, Angel P. Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts. J Cell Sci. 2005;118:1981-9 pubmed

Alibardi L, Dockal M, Reinisch C, Tschachler E, Eckhart L. Ultrastructural localization of caspase-14 in human epidermis. J Histochem Cytochem. 2004;52:1561-74 pubmed

Ohkawa T, Naomoto Y, Takaoka M, Nobuhisa T, Noma K, Motoki T, et al. Localization of heparanase in esophageal cancer cells: respective roles in prognosis and differentiation. Lab Invest. 2004;84:1289-304 pubmed

Chou S, Azuma Y, Varia M, Raleigh J. Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas. Br J Cancer. 2004;90:728-35 pubmed

Okumura T, Shimada Y, Imamura M, Yasumoto S. Neurotrophin receptor p75(NTR) characterizes human esophageal keratinocyte stem cells in vitro. Oncogene. 2003;22:4017-26 pubmed

Maas Szabowski N, Szabowski A, Stark H, Andrecht S, Kolbus A, Schorpp Kistner M, et al. Organotypic cocultures with genetically modified mouse fibroblasts as a tool to dissect molecular mechanisms regulating keratinocyte growth and differentiation. J Invest Dermatol. 2001;116:816-20 pubmed

Germain L, Fradette J, Robitaille H, Guignard R, Grondin G, Nadeau A, et al. The mixed lineage kinase leucine-zipper protein kinase exhibits a differentiation-associated localization in normal human skin and induces keratinocyte differentiation upon overexpression. J Invest Dermatol. 2000;115:860-7 pubmed

Flores E, Allen Hoffmann B, Lee D, Lambert P. The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle. J Virol. 2000;74:6622-31 pubmed

Fabre Jonca N, Viard I, French L, Masson D. Upregulation and redistribution of E-MAP-115 (epithelial microtubule-associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts. J Invest Dermatol. 1999;112:216-25 pubmed

Ruesch M, Stubenrauch F, Laimins L. Activation of papillomavirus late gene transcription and genome amplification upon differentiation in semisolid medium is coincident with expression of involucrin and transglutaminase but not keratin-10. J Virol. 1998;72:5016-24 pubmed

Gniadecki R. Effects of 1,25-dihydroxyvitamin D3 and its 20-epi analogues (MC 1288, MC 1301, KH 1060), on clonal keratinocyte growth: evidence for differentiation of keratinocyte stem cells and analysis of the modulatory effects of cytokines. Br J Pharmacol. 1997;120:1119-27 pubmed

Suo Z, Holm R, Nesland J. Squamous cell carcinomas. An immunohistochemical study of cytokeratins and involucrin in primary and metastatic tumours. Histopathology. 1993;23:45-54 pubmed

Watt F. Involucrin and other markers of keratinocyte terminal differentiation. J Invest Dermatol. 1983;81:100s-3s pubmed

Eckert R, Green H. Structure and evolution of the human involucrin gene. Cell. 1986;46:583-9 pubmed

Hudson D, Weiland K, Dooley T, Simon M, Watt F. Characterisation of eight monoclonal antibodies to involucrin. Hybridoma. 1992;11:367-79 pubmed