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product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Idazoxan hydrochloride
catalog :
I6138
citations: 52
Reference
Wu Z, Wang T, Li L, Hui Y, Zhang Q, Yuan H. Activation and blockade of α2-adrenoceptors in the prelimbic cortex regulate anxiety-like behaviors in hemiparkinsonian rats. Biochem Biophys Res Commun. 2019;519:697-704 pubmed publisher
Obradović D, Stavrianidi A, Ustinovich K, Parenago O, Shpigun O, Agbaba D. The comparison of retention behaviour of imidazoline and serotonin receptor ligands in non-aqueous hydrophilic interaction chromatography and supercritical fluid chromatography. J Chromatogr A. 2019;: pubmed publisher
Taksande B, Khade S, Aglawe M, Gujar S, Chopde C, Kotagale N. Agmatine Inhibits Behavioral Sensitization to Ethanol Through Imidazoline Receptors. Alcohol Clin Exp Res. 2019;43:747-757 pubmed publisher
Obara K, Michino M, Ito M, Ao L, Sawada A, Yamaki F, et al. Evaluation of Antidepressant Effects on Recovery of Electrical Field Stimulation-Induced Contractions that have been Suppressed by Clonidine in Isolated Rat Vas Deferens. Pharmacology. 2019;103:189-201 pubmed publisher
Obradović D, Oljacic S, Nikolic K, Agbaba D. Investigation and prediction of retention characteristics of imidazoline and serotonin receptor ligands and their related compounds on mixed-mode stationary phase. J Chromatogr A. 2019;1585:92-104 pubmed publisher
Siemian J, Shang L, Seaman R, Zhu Q, Zhang Y, Li J. Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats. Behav Pharmacol. 2019;30:429-434 pubmed publisher
Kato D, Suto T, Obata H, Saito S. Spinal Activation of Tropomyosin Receptor Kinase-B Recovers the Impaired Endogenous Analgesia in Neuropathic Pain Rats. Anesth Analg. 2019;129:578-586 pubmed publisher
Narayanaswami V, Dahl K, Bernard Gauthier V, Josephson L, Cumming P, Vasdev N. Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO. Mol Imaging. 2018;17:1536012118792317 pubmed publisher
Hayashida K, Kimuram M, Eisenach J. Blockade of α2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity. Neurosci Lett. 2018;676:41-45 pubmed publisher
Yssel J, O Neill E, Nolan Y, Connor T, Harkin A. Treatment with the noradrenaline re-uptake inhibitor atomoxetine alone and in combination with the α2-adrenoceptor antagonist idazoxan attenuates loss of dopamine and associated motor deficits in the LPS inflammatory rat model of Parkinson's disease. Brain Behav Immun. 2018;69:456-469 pubmed publisher
Siemian J, Qiu Y, Zhang Y, Li J. Role of intracellular Ca2+ signaling in the antinociceptive and discriminative stimulus effects of the imidazoline I2 receptor agonist 2-BFI in rats. Psychopharmacology (Berl). 2017;234:3299-3307 pubmed publisher
Bortolotto V, Mancini F, Mangano G, Salem R, Xia E, Del Grosso E, et al. Proneurogenic Effects of Trazodone in Murine and Human Neural Progenitor Cells. ACS Chem Neurosci. 2017;8:2027-2038 pubmed publisher
Mizuyama R, Soma S, Suemastu N, Shimegi S. Noradrenaline Improves Behavioral Contrast Sensitivity via the β-Adrenergic Receptor. PLoS ONE. 2016;11:e0168455 pubmed publisher
Uys M, Shahid M, Sallinen J, Harvey B. The α2C-adrenoceptor antagonist, ORM-10921, exerts antidepressant-like effects in the Flinders Sensitive Line rat. Behav Pharmacol. 2017;28:9-18 pubmed publisher
Filipic S, Antic A, Vujovic M, Nikolic K, Agbaba D. A Comparative Study of Chromatographic Behavior and Lipophilicity of Selected Imidazoline Derivatives. J Chromatogr Sci. 2016;54:1137-45 pubmed publisher
Alexandre E, Kiguti L, Calmasini F, Silva F, da Silva K, Ferreira R, et al. Mirabegron relaxes urethral smooth muscle by a dual mechanism involving ?3 -adrenoceptor activation and ?1 -adrenoceptor blockade. Br J Pharmacol. 2016;173:415-28 pubmed publisher
Sarac B, Korkmaz O, Altun A, Bagcivan I, Göksel S, Yildirim S, et al. Investigation of the vasorelaxant effects of moxonidine and its relaxation mechanism on the human radial artery when used as a coronary bypass graft. Interact Cardiovasc Thorac Surg. 2015;21:342-5 pubmed publisher
Qiu Y, He X, Zhang Y, Li J. Discriminative stimulus effects of the novel imidazoline Iâ‚‚ receptor ligand CR4056 in rats. Sci Rep. 2014;4:6605 pubmed publisher
Courtney N, Ford C. The timing of dopamine- and noradrenaline-mediated transmission reflects underlying differences in the extent of spillover and pooling. J Neurosci. 2014;34:7645-56 pubmed publisher
Wang X, Fang H, Chen Y, Liang S, Zhu Z, Zeng Q, et al. Idazoxan reduces blood-brain barrier damage during experimental autoimmune encephalomyelitis in mouse. Eur J Pharmacol. 2014;736:70-6 pubmed publisher
Torres Sanchez S, Alba Delgado C, Llorca Torralba M, Mico J, Berrocoso E. Effect of tapentadol on neurons in the locus coeruleus. Neuropharmacology. 2013;72:250-8 pubmed publisher
Madden C, Tupone D, Cano G, Morrison S. α2 Adrenergic receptor-mediated inhibition of thermogenesis. J Neurosci. 2013;33:2017-28 pubmed publisher
Serres F, Rodriguez M, Rivet J, Galizzi J, Lockhart B, Sharp T, et al. Blockade of α2-adrenoceptors induces Arc gene expression in rat brain in a glutamate receptor-dependent manner: a combined qPCR, in situ hybridisation and immunocytochemistry study. Neuropharmacology. 2012;63:992-1001 pubmed publisher
Bhalla S, Andurkar S, Gulati A. Involvement of ??-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice. Fundam Clin Pharmacol. 2013;27:498-509 pubmed publisher
Delaville C, Zapata J, Cardoit L, Benazzouz A. Activation of subthalamic alpha 2 noradrenergic receptors induces motor deficits as a consequence of neuronal burst firing. Neurobiol Dis. 2012;47:322-30 pubmed publisher
Smith C, Holschbach M, Olsewicz J, Lonstein J. Effects of noradrenergic alpha-2 receptor antagonism or noradrenergic lesions in the ventral bed nucleus of the stria terminalis and medial preoptic area on maternal care in female rats. Psychopharmacology (Berl). 2012;224:263-76 pubmed publisher
Saigusa T, Aono Y, Uchida T, Takada K, Verheij M, Koshikawa N, et al. The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats. Eur J Pharmacol. 2012;688:35-41 pubmed publisher
Gerlach M, Halley P, Riederer P, van den Buuse M. The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of ?(2) adrenergic mechanisms. J Neural Transm (Vienna). 2013;120:31-6 pubmed publisher
Fortaleza E, Scopinho A, de Aguiar Corrêa F. α1 and α2-adrenoceptors in the medial amygdaloid nucleus modulate differently the cardiovascular responses to restraint stress in rats. Pharmacol Res. 2012;66:154-62 pubmed publisher
Hott S, Gomes F, Fabri D, Reis D, Crestani C, Correa F, et al. Both ?1- and ?1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear. Br J Pharmacol. 2012;167:207-21 pubmed publisher
Jahnsen J, Uhlen S. The predicted N-terminal signal sequence of the human ??C-adrenoceptor does not act as a functional cleavable signal peptide. Eur J Pharmacol. 2012;684:51-8 pubmed publisher
Ogawa N, Ito M, Yamaguchi H, Shiuchi T, Okamoto S, Wakitani K, et al. Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. Metabolism. 2012;61:1312-20 pubmed publisher
Nakajima K, Obata H, Iriuchijima N, Saito S. An increase in spinal cord noradrenaline is a major contributor to the antihyperalgesic effect of antidepressants after peripheral nerve injury in the rat. Pain. 2012;153:990-7 pubmed publisher
Andrade C, Margatho L, Andrade Franzé G, De Luca L, Antunes Rodrigues J, Menani J. Moxonidine into the lateral parabrachial nucleus reduces renal and hormonal responses to cell dehydration. Neuroscience. 2012;208:69-78 pubmed publisher
Mammoli V, Bonifazi A, Del Bello F, Diamanti E, Giannella M, Hudson A, et al. Favourable involvement of ?2A-adrenoreceptor antagonism in the I?-imidazoline binding sites-mediated morphine analgesia enhancement. Bioorg Med Chem. 2012;20:2259-65 pubmed publisher
Docherty J. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012;679:90-4 pubmed publisher
Kang S, Roh D, Yoon S, Moon J, Kim H, Lee H, et al. Repetitive treatment with diluted bee venom reduces neuropathic pain via potentiation of locus coeruleus noradrenergic neuronal activity and modulation of spinal NR1 phosphorylation in rats. J Pain. 2012;13:155-66 pubmed publisher
Scopinho A, Alves F, Resstel L, Correa F, Crestani C. Lateral septal area α1- and α2-adrenoceptors differently modulate baroreflex activity in unanaesthetized rats. Exp Physiol. 2012;97:1018-29 pubmed publisher
Zhang F, Ding T, Yu L, Zhong Y, Dai H, Yan M. Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells. J Pharm Pharmacol. 2012;64:120-7 pubmed publisher
Alba Delgado C, Borges G, Sánchez Blázquez P, Ortega J, Horrillo I, Mico J, et al. The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain. Psychopharmacology (Berl). 2012;221:53-65 pubmed publisher
Andurkar S, Gulati A. Assessment of the analgesic effect of centhaquin in mouse tail flick and hot-plate tests. Pharmacology. 2011;88:233-41 pubmed publisher
Barnum C, Bhide N, Lindenbach D, Surrena M, Goldenberg A, Tignor S, et al. Effects of noradrenergic denervation on L-DOPA-induced dyskinesia and its treatment by ?- and ?-adrenergic receptor antagonists in hemiparkinsonian rats. Pharmacol Biochem Behav. 2012;100:607-15 pubmed publisher
Kang S, Kim C, Roh D, Yoon S, Park J, Lee H, et al. Chemical stimulation of the ST36 acupoint reduces both formalin-induced nociceptive behaviors and spinal astrocyte activation via spinal alpha-2 adrenoceptors. Brain Res Bull. 2011;86:412-21 pubmed publisher
Decamp E, Clark K, Schneider J. Effects of the alpha-2 adrenoceptor agonist guanfacine on attention and working memory in aged non-human primates. Eur J Neurosci. 2011;34:1018-22 pubmed publisher
Li J, Zhang Y, Winter J. Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I? receptor ligands. Eur J Pharmacol. 2011;669:59-65 pubmed publisher
Kuo S, Trussell L. Spontaneous spiking and synaptic depression underlie noradrenergic control of feed-forward inhibition. Neuron. 2011;71:306-18 pubmed publisher
Dominguez Lopez S, Mahar I, Bambico F, Labonte B, Ochoa Sanchez R, Leyton M, et al. Short-term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light-dark cycle. J Psychopharmacol. 2012;26:830-44 pubmed publisher
Hayashida K, Eisenach J. Multiplicative interactions to enhance gabapentin to treat neuropathic pain. Eur J Pharmacol. 2008;598:21-6 pubmed publisher
Koo S, Lim K, Chung K, Ju H, Chung J. Electroacupuncture-induced analgesia in a rat model of ankle sprain pain is mediated by spinal alpha-adrenoceptors. Pain. 2008;135:11-9 pubmed
Clarke R, Harris J, Ogilvie J. Imidazoline I(2)-receptors and spinal reflexes in the decerebrated rabbit. Neuropharmacology. 2000;39:1904-12 pubmed
Happe H, Bylund D, Murrin L. Alpha(2)-adrenoceptor-stimulated GTP gamma S binding in rat brain: an autoradiographic study. Eur J Pharmacol. 2000;399:17-27 pubmed
Bousquet P, Bruban V, Schann S, Feldman J. Imidazoline receptors: a challenge. Pharm Acta Helv. 2000;74:205-9 pubmed
product information
Catalog Number :
I6138
Product Name :
Idazoxan hydrochloride
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA