This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Idebenone
catalog :
I5659
citations: 41
Reference
Tiefenbach J, Magomedova L, Liu J, Reunov A, Tsai R, Eappen N, et al. Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases. Dis Model Mech. 2018;11: pubmed publisher
Wang H, Xu Z, Wu A, Dong Y, Zhang Y, Yue Y, et al. 2-deoxy-D-glucose enhances anesthetic effects in mice. Anesth Analg. 2015;120:312-9 pubmed publisher
Fiebiger S, Bros H, Grobosch T, Janssen A, Chanvillard C, Paul F, et al. The antioxidant idebenone fails to prevent or attenuate chronic experimental autoimmune encephalomyelitis in the mouse. J Neuroimmunol. 2013;262:66-71 pubmed publisher
Parkinson M, Schulz J, Giunti P. Co-enzyme Q10 and idebenone use in Friedreich's ataxia. J Neurochem. 2013;126 Suppl 1:125-41 pubmed publisher
Sadun A, La Morgia C, Carelli V. Mitochondrial optic neuropathies: our travels from bench to bedside and back again. Clin Exp Ophthalmol. 2013;41:702-12 pubmed publisher
Klopstock T, Metz G, Yu Wai Man P, Buchner B, Gallenmüller C, Bailie M, et al. Persistence of the treatment effect of idebenone in Leber's hereditary optic neuropathy. Brain. 2013;136:e230 pubmed publisher
Barboni P, Valentino M, La Morgia C, Carbonelli M, Savini G, De Negri A, et al. Idebenone treatment in patients with OPA1-mutant dominant optic atrophy. Brain. 2013;136:e231 pubmed publisher
Goldschmidt R, Arce P, Khdour O, Collin V, Dey S, Jaruvangsanti J, et al. Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases. Bioorg Med Chem. 2013;21:969-78 pubmed publisher
Rudolph G, Dimitriadis K, Büchner B, Heck S, Al Tamami J, Seidensticker F, et al. Effects of idebenone on color vision in patients with leber hereditary optic neuropathy. J Neuroophthalmol. 2013;33:30-6 pubmed publisher
Bababeygy S, Wang M, Khaderi K, Sadun A. Visual improvement with the use of idebenone in the treatment of Wolfram syndrome. J Neuroophthalmol. 2012;32:386-9 pubmed publisher
Carbone C, Pignatello R, Musumeci T, Puglisi G. Chemical and technological delivery systems for idebenone: a review of literature production. Expert Opin Drug Deliv. 2012;9:1377-92 pubmed publisher
Heitz F, Erb M, Anklin C, Robay D, Pernet V, Gueven N. Idebenone protects against retinal damage and loss of vision in a mouse model of Leber's hereditary optic neuropathy. PLoS ONE. 2012;7:e45182 pubmed publisher
Gamondi O, Chapela S, Nievas I, Burgos I, Alonso M, Stella C. Idebenone treatment mediates the effect of menadione oxidative stress damage in Saccharomyces cerevisiae. Drug Metab Lett. 2012;6:120-3 pubmed
Ojano Dirain C, Antonelli P. Prevention of gentamicin-induced apoptosis with the mitochondria-targeted antioxidant mitoquinone. Laryngoscope. 2012;122:2543-8 pubmed publisher
Kiblboeck D, Braeuer Mocker M, Siostrzonek P, Reisinger J. A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest. BMJ Case Rep. 2012;2012: pubmed publisher
Montenegro L, Ottimo S, Puglisi G, Castelli F, Sarpietro M. Idebenone loaded solid lipid nanoparticles interact with biomembrane models: calorimetric evidence. Mol Pharm. 2012;9:2534-41 pubmed publisher
Nohara Y, Suzuki J, Yamazaki Y, Kubo H. Determination of idebenone in plasma by HPLC with post-column fluorescence derivatization using 2-cyanoacetamide. Chem Pharm Bull (Tokyo). 2012;60:598-602 pubmed
Montenegro L, Sinico C, Castangia I, Carbone C, Puglisi G. Idebenone-loaded solid lipid nanoparticles for drug delivery to the skin: in vitro evaluation. Int J Pharm. 2012;434:169-74 pubmed publisher
Erb M, Hoffmann Enger B, Deppe H, Soeberdt M, Haefeli R, Rummey C, et al. Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I. PLoS ONE. 2012;7:e36153 pubmed publisher
Montenegro L, Trapani A, Latrofa A, Puglisi G. In vitro evaluation on a model of blood brain barrier of idebenone-loaded solid lipid nanoparticles. J Nanosci Nanotechnol. 2012;12:330-7 pubmed
Kearney M, Orrell R, Fahey M, Pandolfo M. Antioxidants and other pharmacological treatments for Friedreich ataxia. Cochrane Database Syst Rev. 2012;:CD007791 pubmed publisher
Rauchova H, Vokurkova M, Drahota Z. Idebenone-induced recovery of glycerol-3-phosphate and succinate oxidation inhibited by digitonin. Physiol Res. 2012;61:259-65 pubmed
Koopman W, Willems P, Smeitink J. Monogenic mitochondrial disorders. N Engl J Med. 2012;366:1132-41 pubmed publisher
Mariotti C, Fancellu R, Caldarazzo S, Nanetti L, Di Bella D, Plumari M, et al. Erythropoietin in Friedreich ataxia: no effect on frataxin in a randomized controlled trial. Mov Disord. 2012;27:446-9 pubmed publisher
Anheim M, Mariani L, Calvas P, Cheuret E, Zagnoli F, Odent S, et al. Exonic deletions of FXN and early-onset Friedreich ataxia. Arch Neurol. 2012;69:912-6 pubmed
Sabet Peyman E, Khaderi K, Sadun A. Is Leber hereditary optic neuropathy treatable? Encouraging results with idebenone in both prospective and retrospective trials and an illustrative case. J Neuroophthalmol. 2012;32:54-7 pubmed publisher
Li B, Ge Z. Nanostructured lipid carriers improve skin permeation and chemical stability of idebenone. AAPS PharmSciTech. 2012;13:276-83 pubmed publisher
Gerhardt E, Graber S, Szego E, Moisoi N, Martins L, Outeiro T, et al. Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice. PLoS ONE. 2011;6:e28855 pubmed publisher
Giorgio V, Petronilli V, Ghelli A, Carelli V, Rugolo M, Lenaz G, et al. The effects of idebenone on mitochondrial bioenergetics. Biochim Biophys Acta. 2012;1817:363-9 pubmed publisher
Newman N. Treatment of Leber hereditary optic neuropathy. Brain. 2011;134:2447-50 pubmed publisher
Becker C, Bray French K, Drewe J. Pharmacokinetic evaluation of idebenone. Expert Opin Drug Metab Toxicol. 2010;6:1437-44 pubmed publisher
Schulz J, Di Prospero N, Fischbeck K. Clinical experience with high-dose idebenone in Friedreich ataxia. J Neurol. 2009;256 Suppl 1:42-5 pubmed publisher
Meier T, Buyse G. Idebenone: an emerging therapy for Friedreich ataxia. J Neurol. 2009;256 Suppl 1:25-30 pubmed publisher
Tonon C, Lodi R. Idebenone in Friedreich's ataxia. Expert Opin Pharmacother. 2008;9:2327-37 pubmed
Farris P. Idebenone, green tea, and Coffeeberry extract: new and innovative antioxidants. Dermatol Ther. 2007;20:322-9 pubmed
Damulin I. [The use of idebenone (noben) in neurological practice]. Zh Nevrol Psikhiatr Im S S Korsakova. 2006;106:66-71 pubmed
Geromel V, Darin N, Chretien D, Benit P, DeLonlay P, Rotig A, et al. Coenzyme Q(10) and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits. Mol Genet Metab. 2002;77:21-30 pubmed
. Idebenone - monograph. Altern Med Rev. 2001;6:83-6 pubmed
Gillis J, Benefield P, McTavish D. Idebenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in age-related cognitive disorders. Drugs Aging. 1994;5:133-52 pubmed
Suno M, Nagaoka A. Inhibition of brain mitochondrial swelling by idebenone. Arch Gerontol Geriatr. 1989;8:299-305 pubmed
Morimoto H. [Synthesis and biochemical actions of idebenone and related compounds. Ubiquinone and related compounds, XL]. Naturwissenschaften. 1989;76:200-5 pubmed
product information
Catalog Number :
I5659
Product Name :
Idebenone
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA