product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Monoclonal Anti-Insulin antibody produced in mouse
catalog :
I2018
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K36aC10
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, radioimmunoassay, immunohistochemistry - paraffin section
more info or order :
citations: 124
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 2k, 6l
Yung T, Poon F, Liang M, Coquenlorge S, McGaugh E, Hui C, et al. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat Commun. 2019;10:4647 pubmed publisher
  • immunohistochemistry; mouse; 1:250; fig 3c
Wang L, Sun Z, Xiang B, Wei C, Wang Y, Sun K, et al. Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance. J Transl Med. 2018;16:297 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s2b
Millership S, Da Silva Xavier G, Choudhury A, Bertazzo S, Chabosseau P, Pedroni S, et al. Neuronatin regulates pancreatic β cell insulin content and secretion. J Clin Invest. 2018;128:3369-3381 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 5a
Smith Anttila C, Bensing S, Alimohammadi M, Dalin F, Oscarson M, Zhang M, et al. Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1. Autoimmunity. 2017;50:223-231 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:5000; loading ...; fig st9
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
  • immunohistochemistry; rat; 1:1000; loading ...; fig s1a
Alba Delgado C, Cebada Aleu A, Mico J, Berrocoso E. Comorbid anxiety-like behavior and locus coeruleus impairment in diabetic peripheral neuropathy: A comparative study with the chronic constriction injury model. Prog Neuropsychopharmacol Biol Psychiatry. 2016;71:45-56 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1e
Han J, Song B, Kim J, Kodali V, Pottekat A, Wang M, et al. Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis. Diabetes. 2015;64:2892-904 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 6e
Pettinato G, Wen X, Zhang N. Formation of well-defined embryoid bodies from dissociated human induced pluripotent stem cells using microfabricated cell-repellent microwell arrays. Sci Rep. 2014;4:7402 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Kapodistria K, Tsilibary E, Politis P, Moustardas P, Charonis A, Kitsiou P. Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling. Mol Cell Endocrinol. 2015;400:112-28 pubmed publisher
  • immunohistochemistry; human; 1:500
  • immunohistochemistry; mouse; 1:500
Aragón F, Karaca M, Novials A, Maldonado R, Maechler P, Rubí B. Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells. Biochim Biophys Acta. 2015;1850:343-51 pubmed publisher
  • immunocytochemistry; human; 1:100
Pettinato G, Vanden Berg Foels W, Zhang N, Wen X. ROCK inhibitor is not required for embryoid body formation from singularized human embryonic stem cells. PLoS ONE. 2014;9:e100742 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:1000
Chen Y, Hong F, Chen H, Fan R, Zhang X, Zhang Y, et al. Distinctive expression and cellular distribution of dopamine receptors in the pancreatic islets of rats. Cell Tissue Res. 2014;357:597-606 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:1000
Oh T, Shin J, Kang G, Park K, Cho Y. Effect of the combination of metformin and fenofibrate on glucose homeostasis in diabetic Goto-Kakizaki rats. Exp Mol Med. 2013;45:e30 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000
Feng M, Xiang Y, Wang S, Lu W. An autocrine ?-aminobutyric acid signaling system exists in pancreatic ?-cell progenitors of fetal and postnatal mice. Int J Physiol Pathophysiol Pharmacol. 2013;5:91-101 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:500
Carrasco M, Delgado I, Soria B, Martin F, Rojas A. GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest. 2012;122:3504-15 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:200
Romero Zerbo S, Rafacho A, Diaz Arteaga A, Suarez J, Quesada I, Imbernon M, et al. A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans. J Endocrinol. 2011;211:177-85 pubmed publisher
Legøy T, Vethe H, Abadpour S, Strand B, Scholz H, Paulo J, et al. Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. Sci Rep. 2020;10:414 pubmed publisher
Wang A, Xiang Y, Yang B, Lu W. Neurexin-1α regulates neurite growth of rat hippocampal neurons. Int J Physiol Pathophysiol Pharmacol. 2019;11:115-125 pubmed
Araki K, Araki A, Honda D, Izumoto T, Hashizume A, Hijikata Y, et al. TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets. J Clin Invest. 2019;130:3578-3593 pubmed publisher
Pasquier A, Vivot K, Erbs E, Spiegelhalter C, Zhang Z, Aubert V, et al. Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes. Nat Commun. 2019;10:3312 pubmed publisher
Szlapinski S, King R, Retta G, Yeo E, Strutt B, Hill D. A mouse model of gestational glucose intolerance through exposure to a low protein diet during fetal and neonatal development. J Physiol. 2019;597:4237-4250 pubmed publisher
Wei R, Gu L, Yang J, Yang K, Liu J, Le Y, et al. Antagonistic Glucagon Receptor Antibody Promotes α-Cell Proliferation and Increases β-Cell Mass in Diabetic Mice. iScience. 2019;16:326-339 pubmed publisher
Yang J, Lv Y, Zhao Z, Li W, Xiang S, Zhou L, et al. A microRNA‑24‑to‑secretagogin regulatory pathway mediates cholesterol‑induced inhibition of insulin secretion. Int J Mol Med. 2019;44:608-616 pubmed publisher
Proshchina A, Krivova Y, Barabanov V, Saveliev S. Pancreatic endocrine cell arrangement during human ontogeny. Acta Histochem. 2019;121:638-645 pubmed publisher
Liu W, Mao Y, Schoenborn J, Wang Z, Tang G, Tang X. Whole blueberry protects pancreatic beta-cells in diet-induced obese mouse. Nutr Metab (Lond). 2019;16:34 pubmed publisher
Vethe H, Ghila L, Berle M, Hoareau L, Haaland Ø, Scholz H, et al. The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation. Front Endocrinol (Lausanne). 2019;10:293 pubmed publisher
Sarkar S, Munshi C, Chatterjee S, Mukherjee S, Bhattacharya S. Vector-free in vivo trans-determination of adult hepatic stem cells to insulin-producing cells. Mol Biol Rep. 2019;: pubmed publisher
Wang C, Chi J, Che K, Ma X, Qiu M, Wang Z, et al. The combined effect of mesenchymal stem cells and resveratrol on type 1 diabetic neuropathy. Exp Ther Med. 2019;17:3555-3563 pubmed publisher
Camacho Ramírez A, Almorza Gomar D, Díaz Gómez A, Mateo Gavira I, Macias Rodriguez M, Pérez Arana G, et al. The histomorphometric parameters of endocrine pancreas after bariatric surgery in healthy animal models. Tissue Cell. 2019;57:78-83 pubmed publisher
Kluth O, Stadion M, Gottmann P, Aga H, Jähnert M, Scherneck S, et al. Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans. Cell Rep. 2019;26:3027-3036.e3 pubmed publisher
Ohara Imaizumi M, Aoyagi K, Yamauchi H, Yoshida M, Mori M, Hida Y, et al. ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells. Cell Rep. 2019;26:1213-1226.e7 pubmed publisher
Giannios I, Serafimidis I, Anastasiou V, Pezzolla D, Lesche M, Andree C, et al. Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression. Stem Cells. 2019;37:640-651 pubmed publisher
Sevim C, Comaklı S, Taghizadehghalehjoughi A, Ozkaraca M, Mesnage R, Kovatsi L, et al. An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas. Toxicol Rep. 2019;6:42-50 pubmed publisher
Wu S, Zhou J, Guo J, Hua Z, Li J, Wang Z. Apatinib inhibits tumor growth and angiogenesis in PNET models. Endocr Connect. 2019;8:8-19 pubmed publisher
Young C, Baker R, Howlett C, Hryciw T, Herman J, Higgs D, et al. The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice. Cell Mol Gastroenterol Hepatol. 2019;7:93-113 pubmed publisher
Moreno Arciniegas A, Falckenheiner Soria J, Bancalero de Los Reyes J, Camacho Ramírez A, de Los Angeles Mayo Ossorio M, Pacheco García J, et al. The main participation of the enterohormone GLP-1 after bariatric surgery. Minerva Chir. 2019;74:7-13 pubmed publisher
Kuljanin M, Elgamal R, Bell G, Xenocostas D, Xenocostas A, Hess D, et al. Quantitative Proteomics Evaluation of Human Multipotent Stromal Cell for β Cell Regeneration. Cell Rep. 2018;25:2524-2536.e4 pubmed publisher
Templin A, Meier D, Willard J, Wolden Hanson T, Conway K, Lin Y, et al. Use of the PET ligand florbetapir for in vivo imaging of pancreatic islet amyloid deposits in hIAPP transgenic mice. Diabetologia. 2018;61:2215-2224 pubmed publisher
Ramond C, Beydag Tasöz B, Azad A, van de Bunt M, Petersen M, Beer N, et al. Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling. Development. 2018;145: pubmed publisher
Tozzi M, Larsen A, Lange S, Giannuzzo A, Andersen M, Novak I. The P2X7 receptor and pannexin-1 are involved in glucose-induced autocrine regulation in ?-cells. Sci Rep. 2018;8:8926 pubmed publisher
Czeczor J, Genders A, Aston Mourney K, Connor T, Hall L, Hasebe K, et al. APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding. J Endocrinol. 2018;237:311-322 pubmed publisher
Inoue R, Kamimura K, Nagoya T, Sakai N, Yokoo T, Goto R, et al. Effect of a neural relay on liver regeneration in mice: activation of serotonin release from the gastrointestinal tract. FEBS Open Bio. 2018;8:449-460 pubmed publisher
Sowers C, Wang R, Bourne R, McGrath B, Hu J, Bevilacqua S, et al. The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones. J Biol Chem. 2018;293:5134-5149 pubmed publisher
Hull R, Gibson R, McNamara S, Deutsch G, Fligner C, Frevert C, et al. Islet Interleukin-1β Immunoreactivity Is an Early Feature of Cystic Fibrosis That May Contribute to β-Cell Failure. Diabetes Care. 2018;41:823-830 pubmed publisher
Puri S, Roy N, Russ H, Leonhardt L, French E, Roy R, et al. Replication confers β cell immaturity. Nat Commun. 2018;9:485 pubmed publisher
Munakata Y, Yamada T, Imai J, Takahashi K, Tsukita S, Shirai Y, et al. Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion. Sci Rep. 2018;8:1499 pubmed publisher
Villamayor L, Rodríguez Seguel E, Araujo R, Carrasco M, Bru Tari E, Mellado Gil J, et al. GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells. Diabetes. 2018;67:448-460 pubmed publisher
Nagy N, de la Zerda A, Kaber G, Johnson P, Hu K, Kratochvil M, et al. Hyaluronan content governs tissue stiffness in pancreatic islet inflammation. J Biol Chem. 2018;293:567-578 pubmed publisher
Wu T, Xu J, Xu S, Wu L, Zhu Y, Li G, et al. 17β-Estradiol Promotes Islet Cell Proliferation in a Partial Pancreatectomy Mouse Model. J Endocr Soc. 2017;1:965-979 pubmed publisher
Yamamoto J, Imai J, Izumi T, Takahashi H, Kawana Y, Takahashi K, et al. Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism. Nat Commun. 2017;8:1930 pubmed publisher
Sakata N, Yamaguchi Y, Chen Y, Shimoda M, Yoshimatsu G, Unno M, et al. Pleckstrin homology-like domain family A, member 3 (PHLDA3) deficiency improves islets engraftment through the suppression of hypoxic damage. PLoS ONE. 2017;12:e0187927 pubmed publisher
Loh K, Shi Y, Walters S, Bensellam M, Lee K, Dezaki K, et al. Inhibition of Y1 receptor signaling improves islet transplant outcome. Nat Commun. 2017;8:490 pubmed publisher
Lim S, Jin L, Luo K, Jin J, Yang C. Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells. Lab Invest. 2017;97:1271-1281 pubmed publisher
Blutke A, Renner S, Flenkenthaler F, Backman M, Haesner S, Kemter E, et al. The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes. Mol Metab. 2017;6:931-940 pubmed publisher
Templin A, Samarasekera T, Meier D, Hogan M, Mellati M, Crow M, et al. Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation. Diabetes. 2017;66:2636-2645 pubmed publisher
Camacho Ramírez A, Blandino Rosano M, Segundo Iglesias M, Lechuga Sancho A, Aguilar Diosdado M, Pérez Arana G, et al. Bariatric surgery influences ?-cell turnover in non obese rats. Histol Histopathol. 2017;32:1341-1350 pubmed publisher
Mitutsova V, Yeo W, Davaze R, Franckhauser C, Hani E, Abdullah S, et al. Adult muscle-derived stem cells engraft and differentiate into insulin-expressing cells in pancreatic islets of diabetic mice. Stem Cell Res Ther. 2017;8:86 pubmed publisher
Melo E, Lopes C, Gollwitzer P, Lortz S, Lenzen S, Mehmeti I, et al. TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2. BMC Biol. 2017;15:24 pubmed publisher
Martins H, Bazotte R, Vicentini G, Lima M, Guarnier F, Hermes Uliana C, et al. l-Glutamine supplementation promotes an improved energetic balance in Walker-256 tumor-bearing rats. Tumour Biol. 2017;39:1010428317695960 pubmed publisher
Niu G, McQuilling J, Zhou Y, Opara E, Orlando G, Soker S. In Vitro Proliferation of Porcine Pancreatic Islet Cells for β-Cell Therapy Applications. J Diabetes Res. 2016;2016:5807876 pubmed publisher
Tsukita S, Yamada T, Takahashi K, Munakata Y, Hosaka S, Takahashi H, et al. MicroRNAs 106b and 222 Improve Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes via Pancreatic ?-Cell Proliferation. EBioMedicine. 2017;15:163-172 pubmed publisher
Jung H, Kang Y, Park H, Ahn B, Lee H, Kim M, et al. Senp2 expression was induced by chronic glucose stimulation in INS1 cells, and it was required for the associated induction of Ccnd1 and Mafa. Islets. 2016;8:207-216 pubmed
Zhang L, Lanzoni G, Battarra M, Inverardi L, Zhang Q. Proteomic profiling of human islets collected from frozen pancreata using laser capture microdissection. J Proteomics. 2017;150:149-159 pubmed publisher
Klee P, Bosco D, Guerardel A, Somm E, Toulotte A, Maechler P, et al. Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets. Endocrinology. 2016;157:3800-3808 pubmed
Lim S, Jin L, Jin J, Yang C. Effect of Exendin-4 on Autophagy Clearance in Beta Cell of Rats with Tacrolimus-induced Diabetes Mellitus. Sci Rep. 2016;6:29921 pubmed publisher
Nakamura K, Iwazawa R, Yoshioka Y. Introduction to a new cell transplantation platform via recombinant peptide petaloid pieces and its application to islet transplantation with mesenchymal stem cells. Transpl Int. 2016;29:1039-50 pubmed publisher
Chen Y, Xia Z, Wang L, Yu Y, Liu P, Song E, et al. An efficient two-step subcellular fractionation method for the enrichment of insulin granules from INS-1 cells. Biophys Rep. 2015;1:34-40 pubmed publisher
Gan W, Zavortink M, Ludick C, Templin R, Webb R, Webb R, et al. Cell polarity defines three distinct domains in pancreatic β-cells. J Cell Sci. 2017;130:143-151 pubmed publisher
Rhett J, Wang H, Bainbridge H, Song L, Yost M. Connexin-Based Therapeutics and Tissue Engineering Approaches to the Amelioration of Chronic Pancreatitis and Type I Diabetes: Construction and Characterization of a Novel Prevascularized Bioartificial Pancreas. J Diabetes Res. 2016;2016:7262680 pubmed publisher
Kumar D, Asgharpour A, Mirshahi F, Park S, Liu S, Imai Y, et al. Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis. J Biol Chem. 2016;291:6626-40 pubmed publisher
Karaca M, Frigerio F, Migrenne S, Martin Levilain J, Skytt D, Pajęcka K, et al. GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution. Cell Rep. 2015;13:365-75 pubmed publisher
Andrés Blasco I, Herrero Cervera A, Vinué Ã, Martínez Hervás S, Piqueras L, Sanz M, et al. Hepatic lipase deficiency produces glucose intolerance, inflammation and hepatic steatosis. J Endocrinol. 2015;227:179-91 pubmed publisher
Meier D, Entrup L, Templin A, Hogan M, Samarasekera T, Zraika S, et al. Determination of Optimal Sample Size for Quantification of β-Cell Area, Amyloid Area and β-Cell Apoptosis in Isolated Islets. J Histochem Cytochem. 2015;63:663-73 pubmed publisher
Jiménez Moreno C, Herrera Gómez I, López Noriega L, Lorenzo P, Cobo Vuilleumier N, Fuente Martín E, et al. A Simple High Efficiency Intra-Islet Transduction Protocol Using Lentiviral Vectors. Curr Gene Ther. 2015;15:436-46 pubmed
Solon Biet S, Mitchell S, Coogan S, Cogger V, Gokarn R, McMahon A, et al. Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice. Cell Rep. 2015;11:1529-34 pubmed publisher
Singh H, Ganneru S, Malakapalli V, Chalasani M, Nappanveettil G, Bhonde R, et al. Islet adaptation to obesity and insulin resistance in WNIN/GR-Ob rats. Islets. 2014;6:e998099 pubmed publisher
Martin B, Samy K, Lowe M, Thompson P, Cano J, Farris A, et al. Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction. Am J Transplant. 2015;15:1241-52 pubmed publisher
Schwenk R, Baumeier C, Finan B, Kluth O, Brauer C, Joost H, et al. GLP-1-oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice. Diabetologia. 2015;58:604-14 pubmed publisher
Riopel M, Li J, Fellows G, Goodyer C, Wang R. Ultrastructural and immunohistochemical analysis of the 8-20 week human fetal pancreas. Islets. 2014;6:e982949 pubmed publisher
Ahlgren K, Fall T, Landegren N, Grimelius L, von Euler H, Sundberg K, et al. Lack of evidence for a role of islet autoimmunity in the aetiology of canine diabetes mellitus. PLoS ONE. 2014;9:e105473 pubmed publisher
Rafacho A, Gonçalves Neto L, Santos Silva J, Alonso Magdalena P, Merino B, Taboga S, et al. Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats. PLoS ONE. 2014;9:e93531 pubmed publisher
Zhou Y, Waanders L, Holmseth S, Guo C, Berger U, Li Y, et al. Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice. J Biol Chem. 2014;289:1329-44 pubmed publisher
Gillespie J, Bush J, Bell G, Aubrey L, Dupuis H, Ferron M, et al. GSK-3? function in bone regulates skeletal development, whole-body metabolism, and male life span. Endocrinology. 2013;154:3702-18 pubmed publisher
Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, et al. The Keap1-Nrf2 system prevents onset of diabetes mellitus. Mol Cell Biol. 2013;33:2996-3010 pubmed publisher
Cao M, Mao Z, Kam C, Xiao N, Cao X, Shen C, et al. PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. PLoS Biol. 2013;11:e1001541 pubmed publisher
Absood A, Gandomani B, Zaki A, Nasta V, Michail A, Habib P, et al. Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding. PLoS ONE. 2013;8:e54351 pubmed publisher
Harding H, Zyryanova A, Ron D. Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK. J Biol Chem. 2012;287:44338-44 pubmed publisher
Zeng X, Wang Y, Cantley J, Iseli T, Molero J, Hegarty B, et al. Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice. PLoS ONE. 2012;7:e42115 pubmed publisher
Hull R, Johnson P, Braun K, Day A, Wight T. Hyaluronan and hyaluronan binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types. J Histochem Cytochem. 2012;60:749-60 pubmed
Eizirik D, Sammeth M, Bouckenooghe T, Bottu G, Sisino G, Igoillo Esteve M, et al. The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet. 2012;8:e1002552 pubmed publisher
Ohmine S, Squillace K, Hartjes K, Deeds M, Armstrong A, Thatava T, et al. Reprogrammed keratinocytes from elderly type 2 diabetes patients suppress senescence genes to acquire induced pluripotency. Aging (Albany NY). 2012;4:60-73 pubmed
Meabon J, Lee A, Meeker K, Bekris L, Fujimura R, Yu C, et al. Differential expression of the glutamate transporter GLT-1 in pancreas. J Histochem Cytochem. 2012;60:139-51 pubmed publisher
Ohmine S, Dietz A, Deeds M, Hartjes K, Miller D, Thatava T, et al. Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells. Stem Cell Res Ther. 2011;2:46 pubmed publisher
Landsman L, Parent A, Hebrok M. Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. Proc Natl Acad Sci U S A. 2011;108:17010-5 pubmed publisher
Akerfeldt M, Laybutt D. Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance. Diabetes. 2011;60:2506-14 pubmed publisher
Gosmain Y, Cheyssac C, Heddad Masson M, Dibner C, Philippe J. Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in ?-cell differentiation, glucagon biosynthesis and secretion. Diabetes Obes Metab. 2011;13 Suppl 1:31-8 pubmed publisher
Jurgens C, Toukatly M, Fligner C, Udayasankar J, Subramanian S, Zraika S, et al. ?-cell loss and ?-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition. Am J Pathol. 2011;178:2632-40 pubmed publisher
Kim J, Oh B, Lee H, Park H, Park S, Park K. Endothelial colony-forming cell coating of pig islets prevents xenogeneic instant blood-mediated inflammatory reaction. Cell Transplant. 2011;20:1805-15 pubmed publisher
Thatava T, Nelson T, Edukulla R, Sakuma T, Ohmine S, Tonne J, et al. Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny. Gene Ther. 2011;18:283-93 pubmed publisher
Masters S, Dunne A, Subramanian S, Hull R, Tannahill G, Sharp F, et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1? in type 2 diabetes. Nat Immunol. 2010;11:897-904 pubmed publisher
Eberhard D, Jockusch H. Clonal and territorial development of the pancreas as revealed by eGFP-labelled mouse chimeras. Cell Tissue Res. 2010;342:31-8 pubmed publisher
Ramin N, Thieme R, Fischer S, Schindler M, Schmidt T, Fischer B, et al. Maternal diabetes impairs gastrulation and insulin and IGF-I receptor expression in rabbit blastocysts. Endocrinology. 2010;151:4158-67 pubmed publisher
Gosmain Y, Marthinet E, Cheyssac C, Guerardel A, Mamin A, Katz L, et al. Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function. J Biol Chem. 2010;285:33381-93 pubmed publisher
Beall C, Piipari K, Al Qassab H, Smith M, Parker N, Carling D, et al. Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. Biochem J. 2010;429:323-33 pubmed publisher
Muniappan L, Ozcan S. Adenoviral gene transfer into isolated pancreatic islets. Methods Mol Biol. 2009;590:131-42 pubmed publisher
Bulur N, Virreira M, Soyfoo M, Louchami K, Delporte C, Perret J, et al. Expression of the electrogenic Na+-HCO3--cotransporter NBCe1 in tumoral insulin-producing BRIN-BD11 cells. Cell Physiol Biochem. 2009;24:187-92 pubmed publisher
Soyfoo M, Bulur N, Virreira M, Louchami K, Lybaert P, Crutzen R, et al. Expression of the electrogenic Na+-HCO3--cotransporters NBCe1-A and NBCe1-B in rat pancreatic islet cells. Endocrine. 2009;35:449-58 pubmed publisher
Martin Pagola A, Sisino G, Allende G, Dominguez Bendala J, Gianani R, Reijonen H, et al. Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity. Diabetologia. 2008;51:1803-13 pubmed publisher
Zhao M, Amiel S, Ajami S, Jiang J, Rela M, Heaton N, et al. Amelioration of streptozotocin-induced diabetes in mice with cells derived from human marrow stromal cells. PLoS ONE. 2008;3:e2666 pubmed publisher
Alonso Magdalena P, Ropero A, Carrera M, Cederroth C, Baquie M, Gauthier B, et al. Pancreatic insulin content regulation by the estrogen receptor ER alpha. PLoS ONE. 2008;3:e2069 pubmed publisher
Lopez J, Kwan E, Xie L, He Y, James D, Gaisano H. The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells. J Biol Chem. 2008;283:17939-45 pubmed publisher
Glauser D, Brun T, Gauthier B, Schlegel W. Transcriptional response of pancreatic beta cells to metabolic stimulation: large scale identification of immediate-early and secondary response genes. BMC Mol Biol. 2007;8:54 pubmed
Ghosh J, Shenoy A, Clark J. Interactions between important regulatory proteins and human alphaB crystallin. Biochemistry. 2007;46:6308-17 pubmed
Lehmann R, Zuellig R, Kugelmeier P, Baenninger P, Moritz W, Perren A, et al. Superiority of small islets in human islet transplantation. Diabetes. 2007;56:594-603 pubmed
Laybutt D, Preston A, Akerfeldt M, Kench J, Busch A, Biankin A, et al. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia. 2007;50:752-63 pubmed
Fodor A, Harel C, Fodor L, Armoni M, Salmon P, Trono D, et al. Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach. Diabetologia. 2007;50:121-30 pubmed
Kim H, Schleiffarth J, Jessurun J, Sumanas S, Petryk A, Lin S, et al. Wnt5 signaling in vertebrate pancreas development. BMC Biol. 2005;3:23 pubmed
Zhao M, Amiel S, Christie M, Rela M, Heaton N, Huang G. Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia. 2005;48:2051-61 pubmed
Csaba G, Kovacs P, Pallinger E. Immunologically demonstrable hormones and hormone-like molecules in rat white blood cells and mast cells. Cell Biol Int. 2004;28:487-90 pubmed
Hughes W, Elgundi Z, Huang P, Frohman M, Biden T. Phospholipase D1 regulates secretagogue-stimulated insulin release in pancreatic beta-cells. J Biol Chem. 2004;279:27534-41 pubmed
Li F, Zhu J, Tessem J, Beilke J, Varella Garcia M, Jensen J, et al. The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss. Proc Natl Acad Sci U S A. 2003;100:12935-40 pubmed
Keilacker H, Dietz H, Witt S, Woltanski K, Berling R, Ziegler M. Kinetic properties of monoclonal insulin antibodies. Biomed Biochim Acta. 1986;45:1093-102 pubmed
Witt S, Dietz H, Ziegler B, Keilacker H, Ziegler M. [Production and use of monoclonal glucagon and insulin antibodies--reduction of pancreatic insulin in rats by treatment with complete Freund's adjuvant]. Acta Histochem Suppl. 1988;35:217-23 pubmed
Madsen O. Proinsulin-specific monoclonal antibodies. Immunocytochemical application as beta-cell markers and as probes for conversion. Diabetes. 1987;36:1203-11 pubmed
product information
Product No. :
I2018
Product Name :
Monoclonal Anti-Insulin antibody produced in mouse
Host :
mouse
Conjugate :
unconjugated
Antibody Type :
monoclonal
Clone Number (if monoclonal) :
K36AC10
Applications/Description :
Suitable for dot blot; radioimmunoassay; immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using human or animal pancreas
Species Reactivity :
rat, horse, canine, rabbit, guinea pig, monkey, human, bovine, feline, sheep, pig
Isotype :
IgG1
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA