Zhou N, Gutierrez Uzquiza A, Zheng X, Chang R, Vogl D, Garfall A, et al. RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation. Leukemia. 2019;: pubmed publisher

Zhu Y, Shi C, Bruins L, Wang X, Riggs D, Porter B, et al. Identification of lenalidomide resistance pathways in myeloma and targeted resensitization using cereblon replacement, inhibition of STAT3 or targeting of IRF4. Blood Cancer J. 2019;9:19 pubmed publisher

Nguyen T, Li J, Lu C, Mamrosh J, Lu G, Cathers B, et al. p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates. Proc Natl Acad Sci U S A. 2017;114:3565-3571 pubmed publisher

Millrine D, Tei M, Gemechu Y, Kishimoto T. Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production. Proc Natl Acad Sci U S A. 2016;113:10625-30 pubmed publisher

Kim K, Lee D, Park S, Jo S, Ku B, Park S, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019;9:19654 pubmed publisher

Bai L, Zhou H, Xu R, Zhao Y, Chinnaswamy K, McEachern D, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019;36:498-511.e17 pubmed publisher

Abruzzese M, Bilotta M, Fionda C, Zingoni A, Soriani A, Petrucci M, et al. The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors. Cell Death Dis. 2019;10:324 pubmed publisher

Lim S, Damnernsawad A, Shyamsunder P, Chng W, Han B, Xu L, et al. Proteolysis targeting chimeric molecules as therapy for multiple myeloma: efficacy, biomarker and drug combinations. Haematologica. 2019;104:1209-1220 pubmed publisher

Dimopoulos K, Søgaard Helbo A, Fibiger Munch Petersen H, Sjö L, Christensen J, Sommer Kristensen L, et al. Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon-independent manner. Mol Oncol. 2018;12:180-195 pubmed publisher

Del Prete D, Rice R, Rajadhyaksha A, D ADAMIO L. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. J Biol Chem. 2016;291:17209-27 pubmed publisher