Published Application/Species/Sample/Dilution | Reference |
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- immunocytochemistry knockout validation; mouse; loading ...; fig 2a
- immunohistochemistry knockout validation; mouse; loading ...; fig 3a
- western blot knockout validation; mouse; 1:5000; loading ...; fig 2c
- immunohistochemistry - paraffin section; mouse; loading ...; fig 3a
| Brabletz S, Lasierra Losada M, Schmalhofer O, Mitschke J, Krebs A, Brabletz T, et al. Generation and characterization of mice for conditional inactivation of Zeb1. Genesis. 2017;55: pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 4a, 4b, 4c
| Asnaghi L, White D, Key N, Choi J, Mahale A, Alkatan H, et al. ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma. Oncogene. 2019;38:2056-2075 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:500
| Rickelt S, Hynes R. Antibodies and methods for immunohistochemistry of extracellular matrix proteins. Matrix Biol. 2018;71-72:10-27 pubmed publisher
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- western blot; human; loading ...; fig 4a
| Yu R, Longo J, van Leeuwen J, Mullen P, Ba Alawi W, Haibe Kains B, et al. Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins. Cancer Res. 2018;78:1347-1357 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 6c
- western blot; human; loading ...; fig 1g
| Siddiqui A, Vazakidou M, Schwab A, Napoli F, Fernandez Molina C, Rapa I, et al. Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial-to-mesenchymal transition of cancer cells. J Pathol. 2017;242:221-233 pubmed publisher
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- western blot; human; loading ...; fig 1b
| Koch K, Hartmann R, Schröter F, Suwala A, Maciaczyk D, Krüger A, et al. Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells. Oncotarget. 2016;7:73414-73431 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:400; fig 2
| Fessler E, Drost J, van Hooff S, Linnekamp J, Wang X, Jansen M, et al. TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO Mol Med. 2016;8:745-60 pubmed publisher
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- immunocytochemistry; human; 1:1000; loading ...; fig 5
| Tomei P, Masola V, Granata S, Bellin G, Carratu P, Ficial M, et al. Everolimus-induced epithelial to mesenchymal transition (EMT) in bronchial/pulmonary cells: when the dosage does matter in transplantation. J Nephrol. 2016;29:881-891 pubmed
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- western blot; human; 1:5000; fig 2
| Lehmann W, Mossmann D, Kleemann J, Mock K, Meisinger C, Brummer T, et al. ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types. Nat Commun. 2016;7:10498 pubmed publisher
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- immunohistochemistry; human; 1:800; loading ...; fig 1a
| Kulemann B, Liss A, Warshaw A, Seifert S, Bronsert P, Glatz T, et al. KRAS mutations in pancreatic circulating tumor cells: a pilot study. Tumour Biol. 2016;37:7547-54 pubmed publisher
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- immunohistochemistry; human; fig 4
- western blot; human; fig 1c
| Barbáchano A, Fernández Barral A, Pereira F, Segura M, Ordóñez Morán P, Carrillo de Santa Pau E, et al. SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150. Oncogene. 2016;35:2991-3003 pubmed publisher
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| Tian C, Ohlund D, Rickelt S, Lidström T, Huang Y, Hao L, et al. Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2020;80:1461-1474 pubmed publisher
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| De la Cuesta F, Passalacqua I, Rodor J, Bhushan R, Denby L, Baker A. Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling. Cell Commun Signal. 2019;17:143 pubmed publisher
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| Yoshimoto S, Tanaka F, Morita H, Hiraki A, Hashimoto S. Hypoxia-induced HIF-1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF-β-dependent EMT. Cancer Med. 2019;8:7822-7832 pubmed publisher
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| Filipovic J, Bosic M, Cirovic S, Zivotić M, Dunđerović D, Đorđević D, et al. PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance. Diagn Pathol. 2019;14:120 pubmed publisher
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| Asnaghi L, White D, Yoon L, Price A, Lee G, Sahoo A, et al. Downregulation of Nodal inhibits metastatic progression in retinoblastoma. Acta Neuropathol Commun. 2019;7:137 pubmed publisher
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| Yang H, Liang S, Xu D, Yang Z, Marti T, Gao Y, et al. HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer. Oncogenesis. 2019;8:45 pubmed publisher
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| Matsumura Y, Ito Y, Mezawa Y, Sulidan K, Daigo Y, Hiraga T, et al. Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity. Life Sci Alliance. 2019;2: pubmed publisher
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| Kim Y, Lee S, Shim S, Kim A, Park J, Jang W, et al. Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling. Cancer Sci. 2019;110:2226-2236 pubmed publisher
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| Hirano D, Urabe Y, Tanaka S, Nakamura K, Ninomiya Y, Yuge R, et al. Early-stage serrated adenocarcinomas are divided into several molecularly distinct subtypes. PLoS ONE. 2019;14:e0211477 pubmed publisher
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| Franke F, Muller J, Abal M, Medina E, Nitsche U, Weidmann H, et al. The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Cell Mol Gastroenterol Hepatol. 2019;7:33-53 pubmed publisher
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| Zhang Q, Wang C, Cliby W. Cancer-associated stroma significantly contributes to the mesenchymal subtype signature of serous ovarian cancer. Gynecol Oncol. 2019;152:368-374 pubmed publisher
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| Rogers T, Christenson J, Greene L, O Neill K, Williams M, Gordon M, et al. Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression. Mol Cancer Res. 2019;17:30-41 pubmed publisher
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| Jolly M, Preca B, Tripathi S, Jia D, George J, Hanash S, et al. Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer. APL Bioeng. 2018;2:031908 pubmed publisher
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| Qiu B, Wei W, Zhu J, Fu G, Lu D. EMT induced by loss of LKB1 promotes migration and invasion of liver cancer cells through ZEB1-induced YAP signaling. Oncol Lett. 2018;16:6465-6471 pubmed publisher
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| Hoang Minh L, Siebzehnrubl F, Yang C, Suzuki Hatano S, Dajac K, Loche T, et al. Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma. EMBO J. 2018;37: pubmed publisher
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| Dhayat S, Traeger M, Rehkaemper J, Stroese A, Steinestel K, Wardelmann E, et al. Clinical Impact of Epithelial-to-Mesenchymal Transition Regulating MicroRNAs in Pancreatic Ductal Adenocarcinoma. Cancers (Basel). 2018;10: pubmed publisher
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| Tekin C, Shi K, Daalhuisen J, Ten Brink M, Bijlsma M, Spek C. PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer. Oncotarget. 2018;9:32010-32023 pubmed publisher
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| Hong D, Fritz A, Finstad K, Fitzgerald M, Weinheimer A, Viens A, et al. Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor. Mol Cancer Res. 2018;16:1952-1964 pubmed publisher
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| Cui Y, Kim H, Lee M, Yi J, Kim R, Uddin N, et al. FBXL14 abolishes breast cancer progression by targeting CDCP1 for proteasomal degradation. Oncogene. 2018;37:5794-5809 pubmed publisher
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| Roumane A, Berthenet K, El Fassi C, Ichim G. Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cells. BMC Cell Biol. 2018;19:11 pubmed publisher
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| Rosmaninho P, Mükusch S, Piscopo V, Teixeira V, Raposo A, Warta R, et al. Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion. EMBO J. 2018;37: pubmed publisher
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| Mishra P, Tang W, Putluri V, Dorsey T, Jin F, Wang F, et al. ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming. J Clin Invest. 2018;128:323-340 pubmed publisher
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| Jia D, Jolly M, Tripathi S, den Hollander P, Huang B, Lu M, et al. Distinguishing mechanisms underlying EMT tristability. Cancer Converg. 2017;1:2 pubmed publisher
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| Kang H, Son H, Cui Y, Youn B, Son B, Kaushik N, et al. Phytosphingosine exhibits an anti-epithelial-mesenchymal transition function by the inhibition of EGFR signaling in human breast cancer cells. Oncotarget. 2017;8:77794-77808 pubmed publisher
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| Cortés M, Sanchez Moral L, de Barrios O, Fernández Aceñero M, Martínez Campanario M, Esteve Codina A, et al. Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles. EMBO J. 2017;36:3336-3355 pubmed publisher
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| Euskirchen P, Radke J, Schmidt M, Schulze Heuling E, Kadikowski E, Maricos M, et al. Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma. PLoS ONE. 2017;12:e0185376 pubmed publisher
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| Larsson C, Ali M, Pandzic T, Lindroth A, He L, Sjöblom T. Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition. BMC Cancer. 2017;17:487 pubmed publisher
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| Ball C, Oppel F, Ehrenberg K, Dubash T, Dieter S, Hoffmann C, et al. Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts. EMBO Mol Med. 2017;9:918-932 pubmed publisher
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| Johnson M, Stone B, Thibodeau B, Baschnagel A, Galoforo S, Fortier L, et al. The significance of Trk receptors in pancreatic cancer. Tumour Biol. 2017;39:1010428317692256 pubmed publisher
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| Preca B, Bajdak K, Mock K, Lehmann W, Sundararajan V, Bronsert P, et al. A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer. Oncotarget. 2017;8:11530-11543 pubmed publisher
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| Galardi S, Savino M, Scagnoli F, Pellegatta S, Pisati F, Zambelli F, et al. Resetting cancer stem cell regulatory nodes upon MYC inhibition. EMBO Rep. 2016;17:1872-1889 pubmed
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| Montorsi L, Guizzetti F, Alecci C, Caporali A, Martello A, Atene C, et al. Loss of ZFP36 expression in colorectal cancer correlates to wnt/ ß-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of ZEB1, SOX9 and MACC1. Oncotarget. 2016;7:59144-59157 pubmed publisher
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| Kim R, Kaushik N, Suh Y, Yoo K, Cui Y, Kim M, et al. Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer. Oncotarget. 2016;7:53430-53442 pubmed publisher
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| Trinh A, Trumpi K, De Sousa E Melo F, Wang X, de Jong J, Fessler E, et al. Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry. Clin Cancer Res. 2017;23:387-398 pubmed publisher
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| Singh S, Howell D, Trivedi N, Kessler K, Ong T, Rosmaninho P, et al. Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition. elife. 2016;5: pubmed publisher
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| Wang F, Jiang C, Sun Q, Yan F, Wang L, Fu Z, et al. Downregulation of miR‑429 and inhibition of cell migration and invasion in nasopharyngeal carcinoma. Mol Med Rep. 2016;13:3236-42 pubmed publisher
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| Li X, Huang R, Li R, Trope C, Nesland J, Suo Z. Expression of zinc finger E-box-binding homeobox factor 1 in epithelial ovarian cancer: A clinicopathological analysis of 238 patients. Mol Clin Oncol. 2016;4:18-22 pubmed
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| Flanagan L, Meyer M, Fay J, Curry S, Bacon O, Duessmann H, et al. Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach. Cell Death Dis. 2016;7:e2087 pubmed publisher
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| Kikuchi M, Yamashita K, Waraya M, Minatani N, Ushiku H, Kojo K, et al. Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer. Oncotarget. 2016;7:1741-53 pubmed publisher
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| Sundararajan V, Gengenbacher N, Stemmler M, Kleemann J, Brabletz T, Brabletz S. The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5. Oncotarget. 2015;6:27083-96 pubmed publisher
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| Asnaghi L, Gezgin G, Tripathy A, Handa J, Merbs S, van der Velden P, et al. EMT-associated factors promote invasive properties of uveal melanoma cells. Mol Vis. 2015;21:919-29 pubmed
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| Preca B, Bajdak K, Mock K, Sundararajan V, Pfannstiel J, Maurer J, et al. A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells. Int J Cancer. 2015;137:2566-77 pubmed publisher
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| Mock K, Preca B, Brummer T, Brabletz S, Stemmler M, Brabletz T. The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors. Oncotarget. 2015;6:14399-412 pubmed
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| Meidhof S, Brabletz S, Lehmann W, Preca B, Mock K, Ruh M, et al. ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat. EMBO Mol Med. 2015;7:831-47 pubmed publisher
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| Kim R, Cui Y, Yoo K, Kim I, Lee M, Choi Y, et al. Radiation promotes malignant phenotypes through SRC in breast cancer cells. Cancer Sci. 2015;106:78-85 pubmed publisher
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| Davidson B, Holth A, Hellesylt E, Tan T, Huang R, Tropé C, et al. The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions. Hum Pathol. 2015;46:1-8 pubmed publisher
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