product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Anti-APOL1 antibody produced in rabbit
catalog :
HPA018885
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
citations: 18
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:100; loading ...; fig 1a
  • western blot; human; 1:1000; loading ...; fig 5b
Chun J, Zhang J, Wilkins M, Subramanian B, Riella C, Magraner J, et al. Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity. Proc Natl Acad Sci U S A. 2019;116:3712-3721 pubmed publisher
Wakashin H, Heymann J, Roshanravan H, Daneshpajouhnejad P, Rosenberg A, Shin M, et al. APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress. BMC Nephrol. 2020;21:371 pubmed publisher
Davis S, Khatua A, Popik W. Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway. Sci Rep. 2019;9:15485 pubmed publisher
Shah S, Lannon H, Dias L, Zhang J, Alper S, Pollak M, et al. APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore. J Am Soc Nephrol. 2019;30:2355-2368 pubmed publisher
Ryu J, Ge M, Merscher S, Rosenberg A, Desante M, Roshanravan H, et al. APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice. PLoS ONE. 2019;14:e0211559 pubmed publisher
Okamoto K, Rausch J, Wakashin H, Fu Y, Chung J, Dummer P, et al. APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R. Commun Biol. 2018;1:188 pubmed publisher
Cheatham A, Davis S, Khatua A, Popik W. Blocking the 5' splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch. Sci Rep. 2018;8:8739 pubmed publisher
Skorecki K, Lee J, Langefeld C, Rosset S, Tzur S, Wasser W, et al. A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy. Nephrol Dial Transplant. 2018;33:323-330 pubmed publisher
Fontaine F, Lecordier L, Vanwalleghem G, Uzureau P, Van Reet N, Fontaine M, et al. APOLs with low pH dependence can kill all African trypanosomes. Nat Microbiol. 2017;2:1500-1506 pubmed publisher
Madhavan S, O Toole J, Konieczkowski M, Barisoni L, Thomas D, Ganesan S, et al. APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8. JCI Insight. 2017;2: pubmed publisher
Granado D, Muller D, Krausel V, Kruzel Davila E, Schuberth C, Eschborn M, et al. Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion. J Am Soc Nephrol. 2017;28:3227-3238 pubmed publisher
Hayek S, Koh K, Grams M, Wei C, Ko Y, Li J, et al. A tripartite complex of suPAR, APOL1 risk variants and ?v?3 integrin on podocytes mediates chronic kidney disease. Nat Med. 2017;23:945-953 pubmed publisher
Beckerman P, Bi Karchin J, Park A, Qiu C, Dummer P, Soomro I, et al. Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice. Nat Med. 2017;23:429-438 pubmed publisher
Kruzel Davila E, Shemer R, Ofir A, Bavli Kertselli I, Darlyuk Saadon I, Oren Giladi P, et al. APOL1-Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes. J Am Soc Nephrol. 2017;28:1117-1130 pubmed publisher
Heneghan J, Vandorpe D, Shmukler B, Giovinazzo J, Giovinnazo J, Raper J, et al. BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins. Am J Physiol Cell Physiol. 2015;309:C332-47 pubmed publisher
Cheng D, Weckerle A, Yu Y, Ma L, Zhu X, Murea M, et al. Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells. J Lipid Res. 2015;56:1583-93 pubmed publisher
Khatua A, Cheatham A, Kruzel E, Singhal P, Skorecki K, Popik W. Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1. Am J Physiol Cell Physiol. 2015;309:C22-37 pubmed publisher
Ma L, Shelness G, Snipes J, Murea M, Antinozzi P, Cheng D, et al. Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines. J Am Soc Nephrol. 2015;26:339-48 pubmed publisher
product information
Product No. :
HPA018885
Product Name :
Anti-APOL1 antibody produced in rabbit
Host :
rabbit
Conjugate :
unconjugated
Antibody Type :
polyclonal
Applications/Description :
Suitable for immunoblotting: 0.04-0.4 μg/mL; immunohistochemistry: 1:2500-1:5000
Species Reactivity :
human
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA