product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Anti-DAXX antibody produced in rabbit
catalog :
HPA008736
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
immunohistochemistry
more info or order :
citations: 25
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:500; fig 2
Mäkinen N, Aavikko M, Heikkinen T, Taipale M, Taipale J, Koivisto Korander R, et al. Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12. PLoS Genet. 2016;12:e1005850 pubmed publisher
Graham M, Kim J, Da J, Brosnan Cashman J, Rizzo A, Baena Del Valle J, et al. Functional Loss of ATRX and TERC Activates Alternative Lengthening of Telomeres (ALT) in LAPC4 Prostate Cancer Cells. Mol Cancer Res. 2019;17:2480-2491 pubmed publisher
Jin C, Hacking S, Komforti M, Nasim M. A Comparison of Death Domain-Associated Protein 6 in Different Endometrial Carcinomas Histotypes. Biomark Insights. 2019;14:1177271919864892 pubmed publisher
Bell W, Meeker A, Rizzo A, Rajpara S, Rosenthal I, Flores Bellver M, et al. A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease. Brain Pathol. 2019;29:45-52 pubmed publisher
Liverani C, Bongiovanni A, Mercatali L, Foca F, Pieri F, De Vita A, et al. Grading of Neuroendocrine Carcinomas: Correlation of 68Ga-PET/CT Scan with Tissue Biomarkers. Dis Markers. 2018;2018:6878409 pubmed publisher
Hossain M, Ohsaki E, Honda T, Ueda K. Importance of Promyelocytic Leukema Protein (PML) for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. Front Microbiol. 2018;9:2324 pubmed publisher
Chou A, Itchins M, de Reuver P, Arena J, Clarkson A, Sheen A, et al. ATRX loss is an independent predictor of poor survival in pancreatic neuroendocrine tumors. Hum Pathol. 2018;82:249-257 pubmed publisher
Ueda H, Akiyama Y, Shimada S, Mogushi K, Serizawa M, Matsumura S, et al. Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs. Endocr Relat Cancer. 2018;25:619-631 pubmed publisher
Panse G, Chrisinger J, Leung C, Ingram D, Khan S, Wani K, et al. Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas. Histopathology. 2018;72:239-247 pubmed publisher
Dagg R, Pickett H, Neumann A, Napier C, Henson J, Teber E, et al. Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres. Cell Rep. 2017;19:2544-2556 pubmed publisher
Park J, Paik W, Lee K, Ryu J, Lee S, Kim Y. DAXX/ATRX and MEN1 genes are strong prognostic markers in pancreatic neuroendocrine tumors. Oncotarget. 2017;8:49796-49806 pubmed publisher
Fürtjes G, Heß K, Wagner A, Senner V, Brokinkel C, Stummer W, et al. Letter: Retention of ATRX and DAXX Expression in Meningiomas. Neurosurgery. 2017;81:E22-E23 pubmed publisher
Mohamed A, Romano D, Saveanu A, Roche C, Albertelli M, Barbieri F, et al. Anti-proliferative and anti-secretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs?. Oncotarget. 2017;8:41044-41063 pubmed publisher
Vandenbussche C, Allison D, Graham M, Charu V, Lennon A, Wolfgang C, et al. Alternative lengthening of telomeres and ATRX/DAXX loss can be reliably detected in FNAs of pancreatic neuroendocrine tumors. Cancer Cytopathol. 2017;125:544-551 pubmed publisher
Lin C, Wang L, Wang S, Chang Y, Wu Y, Chen H, et al. Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1?/HDAC1/Slug axis. Nat Commun. 2016;7:13867 pubmed publisher
Kim J, Brosnan Cashman J, An S, Kim S, Song K, Kim M, et al. Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival. Clin Cancer Res. 2017;23:1598-1606 pubmed publisher
Cives M, Ghayouri M, Morse B, Brelsford M, Black M, Rizzo A, et al. Analysis of potential response predictors to capecitabine/temozolomide in metastatic pancreatic neuroendocrine tumors. Endocr Relat Cancer. 2016;23:759-67 pubmed publisher
Slatter T, Hsia H, Samaranayaka A, Sykes P, Clow W, Devenish C, et al. Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma. J Pathol Clin Res. 2015;1:95-105 pubmed publisher
Vinagre J, Nabais J, Pinheiro J, Batista R, Oliveira R, Gonçalves A, et al. TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes. Sci Rep. 2016;6:29714 pubmed publisher
Singhi A, Liu T, Roncaioli J, Cao D, Zeh H, Zureikat A, et al. Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors. Clin Cancer Res. 2017;23:600-609 pubmed publisher
Yoshida M, Ogawa R, Yoshida H, Maeshima A, Kanai Y, Kinoshita T, et al. TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast. Br J Cancer. 2015;113:1244-8 pubmed publisher
Napier C, Huschtscha L, Harvey A, Bower K, Noble J, Hendrickson E, et al. ATRX represses alternative lengthening of telomeres. Oncotarget. 2015;6:16543-58 pubmed
Pipinikas C, Dibra H, Karpathakis A, Feber A, Novelli M, Oukrif D, et al. Epigenetic dysregulation and poorer prognosis in DAXX-deficient pancreatic neuroendocrine tumours. Endocr Relat Cancer. 2015;22:L13-8 pubmed publisher
Fishbein L, Khare S, Wubbenhorst B, Desloover D, D Andrea K, Merrill S, et al. Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas. Nat Commun. 2015;6:6140 pubmed publisher
Geis C, Fendrich V, Rexin P, Di Fazio P, Bartsch D, Ocker M, et al. Ileal neuroendocrine tumors show elevated activation of mammalian target of rapamycin complex. J Surg Res. 2015;194:388-93 pubmed publisher
product information
Product No. :
HPA008736
Product Name :
Anti-DAXX antibody produced in rabbit
Host :
rabbit
Conjugate :
unconjugated
Antibody Type :
polyclonal
Applications/Description :
Suitable for immunoblotting: 0.04-0.4 μg/mL; immunohistochemistry: 1:200-1:500
Species Reactivity :
human
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA