This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Heparinase III from Flavobacterium heparinum
catalog :
H8891
citations: 50
Reference
Gavva C, Patel K, Kudre T, Sharan K, Chilkunda D. Glycosaminoglycans from fresh water fish processing discard - Isolation, structural characterization, and osteogenic activity. Int J Biol Macromol. 2020;145:558-567 pubmed publisher
Jeyarajah M, Jaju Bhattad G, Kops B, Renaud S. Syndecan-4 regulates extravillous trophoblast migration by coordinating protein kinase C activation. Sci Rep. 2019;9:10175 pubmed publisher
Cooper S, Teoh H, Campeau M, Verma S, Leask R. Empagliflozin restores the integrity of the endothelial glycocalyx in vitro. Mol Cell Biochem. 2019;: pubmed publisher
Capitano M, Mor Vaknin N, Saha A, Cooper S, Legendre M, Guo H, et al. Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling. J Clin Invest. 2019;129:2555-2570 pubmed publisher
Corti F, Wang Y, Rhodes J, Atri D, Archer Hartmann S, Zhang J, et al. N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization. Nat Commun. 2019;10:1562 pubmed publisher
Chandra N, Liu Y, Liu J, Frängsmyr L, Wu N, Silva L, et al. Sulfated Glycosaminoglycans as Viral Decoy Receptors for Human Adenovirus Type 37. Viruses. 2019;11: pubmed publisher
Butler M, Ramnath R, Kadoya H, Desposito D, Riquier Brison A, Ferguson J, et al. Aldosterone induces albuminuria via matrix metalloproteinase-dependent damage of the endothelial glycocalyx. Kidney Int. 2019;95:94-107 pubmed publisher
Saikia P, Thangavadivel S, Medeiros C, Lassance L, de Oliveira R, Wilson S. IL-1 and TGF-β Modulation of Epithelial Basement Membrane Components Perlecan and Nidogen Production by Corneal Stromal Cells. Invest Ophthalmol Vis Sci. 2018;59:5589-5598 pubmed publisher
Wischhusen J, Wilson K, Delcros J, Molina Pe a R, Gibert B, Jiang S, et al. Ultrasound molecular imaging as a non-invasive companion diagnostic for netrin-1 interference therapy in breast cancer. Theranostics. 2018;8:5126-5142 pubmed publisher
Cooper S, Emmott A, McDonald K, Campeau M, Leask R. Increased MMP activity in curved geometries disrupts the endothelial cell glycocalyx creating a proinflammatory environment. PLoS ONE. 2018;13:e0202526 pubmed publisher
Zhang P, Lu H, Peixoto R, Pines M, Ge Y, Oku S, et al. Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships. Cell. 2018;174:1450-1464.e23 pubmed publisher
Katagiri Y, Morgan A, Yu P, Bangayan N, Junka R, Geller H. Identification of novel binding sites for heparin in receptor protein-tyrosine phosphatase (RPTPσ): Implications for proteoglycan signaling. J Biol Chem. 2018;293:11639-11647 pubmed publisher
Park H, Kim M, Kim H, Lee Y, Seo Y, Pham C, et al. Heparan sulfate proteoglycans (HSPGs) and chondroitin sulfate proteoglycans (CSPGs) function as endocytic receptors for an internalizing anti-nucleic acid antibody. Sci Rep. 2017;7:14373 pubmed publisher
Christianson H, Menard J, Chandran V, Bourseau Guilmain E, Shevela D, Lidfeldt J, et al. Tumor antigen glycosaminoglycan modification regulates antibody-drug conjugate delivery and cytotoxicity. Oncotarget. 2017;8:66960-66974 pubmed publisher
Son S, Moroney G, Butler P. ?1-Integrin-Mediated Adhesion Is Lipid-Bilayer Dependent. Biophys J. 2017;113:1080-1092 pubmed publisher
Prochazkova M, Häkkinen T, Prochazka J, Spoutil F, Jheon A, Ahn Y, et al. FGF signaling refines Wnt gradients to regulate the patterning of taste papillae. Development. 2017;144:2212-2221 pubmed publisher
Rienks M, Papageorgiou A, Wouters K, Verhesen W, Leeuwen R, Carai P, et al. A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis. Cell Mol Life Sci. 2017;74:1511-1525 pubmed publisher
Day P, Thompson C, Lowy D, Schiller J. The HPV16 and MusPV1 papillomaviruses initially interact with distinct host components on the basement membrane. Virology. 2015;481:79-94 pubmed publisher
Douet V, Kerever A, Arikawa Hirasawa E, Mercier F. Fractone-heparan sulphates mediate FGF-2 stimulation of cell proliferation in the adult subventricular zone. Cell Prolif. 2013;46:137-45 pubmed publisher
Douet V, Arikawa Hirasawa E, Mercier F. Fractone-heparan sulfates mediate BMP-7 inhibition of cell proliferation in the adult subventricular zone. Neurosci Lett. 2012;528:120-5 pubmed publisher
Hull R, Peters M, Perigo S, Chan C, Wight T, Kinsella M. Overall sulfation of heparan sulfate from pancreatic islet ?-TC3 cells increases maximal fibril formation but does not determine binding to the amyloidogenic peptide islet amyloid polypeptide. J Biol Chem. 2012;287:37154-64 pubmed publisher
Ding Z, Wang X, Khaidakov M, Liu S, Dai Y, Mehta J. Degradation of heparan sulfate proteoglycans enhances oxidized-LDL-mediated autophagy and apoptosis in human endothelial cells. Biochem Biophys Res Commun. 2012;426:106-11 pubmed publisher
Zeng Y, Ebong E, Fu B, Tarbell J. The structural stability of the endothelial glycocalyx after enzymatic removal of glycosaminoglycans. PLoS ONE. 2012;7:e43168 pubmed publisher
Wilusz R, DeFrate L, Guilak F. A biomechanical role for perlecan in the pericellular matrix of articular cartilage. Matrix Biol. 2012;31:320-7 pubmed publisher
Job K, Dull R, Hlady V. Use of reflectance interference contrast microscopy to characterize the endothelial glycocalyx stiffness. Am J Physiol Lung Cell Mol Physiol. 2012;302:L1242-9 pubmed publisher
Shimoi A, Hatakeyama H, Koizumi H, Satoh H, Watanabe M. Unchanged distribution density of anionic sites on the glomerular wall in rats with streptozotocin-induced diabetic nephropathy. Toxicol Pathol. 2012;40:789-96 pubmed publisher
Nasimuzzaman M, Persons D. Cell Membrane-associated heparan sulfate is a receptor for prototype foamy virus in human, monkey, and rodent cells. Mol Ther. 2012;20:1158-66 pubmed publisher
Podyma Inoue K, Hara Yokoyama M, Shinomura T, Kimura T, Yanagishita M. Syndecans reside in sphingomyelin-enriched low-density fractions of the plasma membrane isolated from a parathyroid cell line. PLoS ONE. 2012;7:e32351 pubmed publisher
Garolla A, Lenzi A, Palu G, Pizzol D, Bertoldo A, De Toni L, et al. Human papillomavirus sperm infection and assisted reproduction: a dangerous hazard with a possible safe solution. Hum Reprod. 2012;27:967-73 pubmed publisher
Lee S, Eskin S, Shah A, Schildmeyer L, McIntire L. Effect of zinc and nitric oxide on monocyte adhesion to endothelial cells under shear stress. Ann Biomed Eng. 2012;40:697-706 pubmed publisher
Searle J, Mockel M, Gwosc S, Datwyler S, Qadri F, Albert G, et al. Heparin strongly induces soluble fms-like tyrosine kinase 1 release in vivo and in vitro--brief report. Arterioscler Thromb Vasc Biol. 2011;31:2972-4 pubmed publisher
Nikmanesh M, Shi Z, Tarbell J. Heparan sulfate proteoglycan mediates shear stress-induced endothelial gene expression in mouse embryonic stem cell-derived endothelial cells. Biotechnol Bioeng. 2012;109:583-94 pubmed publisher
Cehajic Kapetanovic J, Le Goff M, Allen A, Lucas R, Bishop P. Glycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2. Mol Vis. 2011;17:1771-83 pubmed
O Callaghan R, Job K, Dull R, Hlady V. Stiffness and heterogeneity of the pulmonary endothelial glycocalyx measured by atomic force microscopy. Am J Physiol Lung Cell Mol Physiol. 2011;301:L353-60 pubmed publisher
Welch J, Svensson K, Kucharzewska P, Belting M. Heparan sulfate proteoglycan-mediated polyamine uptake. Methods Mol Biol. 2011;720:327-38 pubmed publisher
Constantinescu A, Spaan J, Arkenbout E, Vink H, VanTeeffelen J. Degradation of the endothelial glycocalyx is associated with chylomicron leakage in mouse cremaster muscle microcirculation. Thromb Haemost. 2011;105:790-801 pubmed publisher
Brustkern A, Buhse L, Nasr M, Al Hakim A, Keire D. Characterization of currently marketed heparin products: reversed-phase ion-pairing liquid chromatography mass spectrometry of heparin digests. Anal Chem. 2010;82:9865-70 pubmed publisher
Kuo W, Digman M, Lander A. Heparan sulfate acts as a bone morphogenetic protein coreceptor by facilitating ligand-induced receptor hetero-oligomerization. Mol Biol Cell. 2010;21:4028-41 pubmed publisher
Shi Z, Abraham G, Tarbell J. Shear stress modulation of smooth muscle cell marker genes in 2-D and 3-D depends on mechanotransduction by heparan sulfate proteoglycans and ERK1/2. PLoS ONE. 2010;5:e12196 pubmed publisher
Miller R, Grodzinsky A, Cummings K, Plaas A, Cole A, Lee R, et al. Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate. Arthritis Rheum. 2010;62:3686-94 pubmed publisher
Raman K, Kuberan B. Differential effects of Heparitinase I and Heparitinase III on endothelial tube formation in vitro. Biochem Biophys Res Commun. 2010;398:191-3 pubmed publisher
Prince R, Schreiter E, Zou P, Wiley H, Ting A, Lee R, et al. The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release. J Cell Sci. 2010;123:2308-18 pubmed publisher
Brower J, Targovnik J, Caplan M, Massia S. High glucose-mediated loss of cell surface heparan sulfate proteoglycan impairs the endothelial shear stress response. Cytoskeleton (Hoboken). 2010;67:135-41 pubmed publisher
Smith E, Mitsi M, Nugent M, Symes K. PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation. Proc Natl Acad Sci U S A. 2009;106:21683-8 pubmed publisher
Broutian T, Brendle S, Christensen N. Differential binding patterns to host cells associated with particles of several human alphapapillomavirus types. J Gen Virol. 2010;91:531-40 pubmed publisher
Kumagai R, Lu X, Kassab G. Role of glycocalyx in flow-induced production of nitric oxide and reactive oxygen species. Free Radic Biol Med. 2009;47:600-7 pubmed publisher
Tristan A, Benito Y, Montserret R, Boisset S, Dusserre E, Penin F, et al. The signal peptide of Staphylococcus aureus panton valentine leukocidin LukS component mediates increased adhesion to heparan sulfates. PLoS ONE. 2009;4:e5042 pubmed publisher
Johnson K, Kines R, Roberts J, Lowy D, Schiller J, Day P. Role of heparan sulfate in attachment to and infection of the murine female genital tract by human papillomavirus. J Virol. 2009;83:2067-74 pubmed publisher
Hovingh P, Linker A. The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria. J Biol Chem. 1970;245:6170-5 pubmed
Lohse D, Linhardt R. Purification and characterization of heparin lyases from Flavobacterium heparinum. J Biol Chem. 1992;267:24347-55 pubmed
product information
Catalog Number :
H8891
Product Name :
Heparinase III from Flavobacterium heparinum
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
Lyophilized powder stabilized with approx. 25% (w/w) bovine serum albumin, ?30 units/mg protein (enzyme + BSA)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA