This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Hydroxyurea
catalog :
H8627
citations: 343
Reference
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Psakhye I, Castellucci F, Branzei D. SUMO-Chain-Regulated Proteasomal Degradation Timing Exemplified in DNA Replication Initiation. Mol Cell. 2019;76:632-645.e6 pubmed publisher
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Xu F, Byström A, Johansson M. SSD1 suppresses phenotypes induced by the lack of Elongator-dependent tRNA modifications. PLoS Genet. 2019;15:e1008117 pubmed publisher
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Michelena J, Gatti M, Teloni F, Imhof R, Altmeyer M. Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions. J Cell Biol. 2019;218:2865-2875 pubmed publisher
Gupta R, Walvekar A, Liang S, Rashida Z, Shah P, Laxman S. A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis. elife. 2019;8: pubmed publisher
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Coulombe P, Nassar J, Peiffer I, Stanojcic S, Sterkers Y, Delamarre A, et al. The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing. Nat Commun. 2019;10:2426 pubmed publisher
Ahmed O, Avila Herrera A, Tun K, Serpa P, Peng J, Parthasarathy S, et al. Evolution of Mechanisms that Control Mating in Drosophila Males. Cell Rep. 2019;27:2527-2536.e4 pubmed publisher
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Li S, Lavagnino Z, Lemaçon D, Kong L, Ustione A, Ng X, et al. Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection. Mol Cell. 2019;74:1123-1137.e6 pubmed publisher
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Pillay N, Tighe A, Nelson L, Littler S, Coulson Gilmer C, Bah N, et al. DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. Cancer Cell. 2019;35:519-533.e8 pubmed publisher
Laflamme G, Sim S, Leary A, Pascariu M, Vogel J, D Amours D. Interphase Microtubules Safeguard Mitotic Progression by Suppressing an Aurora B-Dependent Arrest Induced by DNA Replication Stress. Cell Rep. 2019;26:2875-2889.e3 pubmed publisher
Kang H, Zhang C, An Z, Shen W, Zhu Y. AtINO80 and AtARP5 physically interact and play common as well as distinct roles in regulating plant growth and development. New Phytol. 2019;223:336-353 pubmed publisher
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Tay Y, Leda M, Spanos C, Rappsilber J, Goryachev A, Sawin K. Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex. Cell Rep. 2019;26:1654-1667.e7 pubmed publisher
Keil M, Meyer M, Dannheisig D, Maerz L, Philipp M, Pfister A. Loss of Peter Pan protein is associated with cell cycle defects and apoptotic events. Biochim Biophys Acta Mol Cell Res. 2019;1866:882-895 pubmed publisher
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Marzio A, Puccini J, Kwon Y, Maverakis N, Arbini A, Sung P, et al. The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers. Mol Cell. 2019;73:224-237.e6 pubmed publisher
Planques A, Malem J, Parapar J, Vervoort M, Gazave E. Morphological, cellular and molecular characterization of posterior regeneration in the marine annelid Platynereis dumerilii. Dev Biol. 2019;445:189-210 pubmed publisher
Oh J, Lee S, Rothstein R, Symington L. Xrs2 and Tel1 Independently Contribute to MR-Mediated DNA Tethering and Replisome Stability. Cell Rep. 2018;25:1681-1692.e4 pubmed publisher
Tonzi P, Yin Y, Lee C, Rothenberg E, Huang T. Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery. elife. 2018;7: pubmed publisher
Chakraborty P, Huang J, Hiom K. DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing. Nat Commun. 2018;9:4346 pubmed publisher
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Choppara S, Ganga S, Manne R, Dutta P, Singh S, Santra M. The SCFFBXO46 ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. J Biol Chem. 2018;293:16291-16306 pubmed publisher
Majumder K, Wang J, Boftsi M, Fuller M, Rede J, Joshi T, et al. Parvovirus minute virus of mice interacts with sites of cellular DNA damage to establish and amplify its lytic infection. elife. 2018;7: pubmed publisher
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Wu X, An X, Zhang C, Huang M. Clb6-Cdc28 Promotes Ribonucleotide Reductase Subcellular Redistribution during S Phase. Mol Cell Biol. 2018;38: pubmed publisher
Humphrey L, Felzer Kim I, Joglekar A. Stu2 acts as a microtubule destabilizer in metaphase budding yeast spindles. Mol Biol Cell. 2018;29:247-255 pubmed publisher
Hata K, Maeno Hikichi Y, Yumoto N, Burden S, Landmesser L. Distinct Roles of Different Presynaptic and Postsynaptic NCAM Isoforms in Early Motoneuron-Myotube Interactions Required for Functional Synapse Formation. J Neurosci. 2018;38:498-510 pubmed publisher
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Wang Q, Tang Y, Xu Y, Xu S, Jiang Y, Dong Q, et al. The X-linked deubiquitinase USP9X is an integral component of centrosome. J Biol Chem. 2017;292:12874-12884 pubmed publisher
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Weems J, Slaughter B, Unruh J, Boeing S, Hall S, McLaird M, et al. Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage. J Biol Chem. 2017;292:6431-6437 pubmed publisher
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Morita H, Grigolon S, Bock M, Krens S, Salbreux G, Heisenberg C. The Physical Basis of Coordinated Tissue Spreading in Zebrafish Gastrulation. Dev Cell. 2017;40:354-366.e4 pubmed publisher
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Cinquin A, Chiang M, Paz A, Hallman S, Yuan O, Vysniauskaite I, et al. Intermittent Stem Cell Cycling Balances Self-Renewal and Senescence of the C. elegans Germ Line. PLoS Genet. 2016;12:e1005985 pubmed publisher
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Amiel A, Johnston H, Nedoncelle K, Warner J, Ferreira S, Röttinger E. Characterization of Morphological and Cellular Events Underlying Oral Regeneration in the Sea Anemone, Nematostella vectensis. Int J Mol Sci. 2015;16:28449-71 pubmed publisher
Zyuz kov G, Zhdanov V, Udut E, Miroshnichenko L, Chaikovskii A, Simanina E, et al. Role of JNK and Involvement of p53 in Stimulation of Growth Potential Realization of Mesenchymal Precursor Cells by Alkaloid Songorine. Bull Exp Biol Med. 2015;160:64-7 pubmed publisher
Fraser D, Liu K, Reid B, Hawkins E, Sevier A, Pyle M, et al. Widespread Natural Occurrence of Hydroxyurea in Animals. PLoS ONE. 2015;10:e0142890 pubmed publisher
Rybaczek D, Musiałek M, Balcerczyk A. Caffeine-Induced Premature Chromosome Condensation Results in the Apoptosis-Like Programmed Cell Death in Root Meristems of Vicia faba. PLoS ONE. 2015;10:e0142307 pubmed publisher
Aristizabal M, Negri G, Kobor M. The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition. PLoS Genet. 2015;11:e1005608 pubmed publisher
Rubio Peña K, Fontrodona L, Aristizábal Corrales D, Torres S, Cornes E, García Rodríguez F, et al. Modeling of autosomal-dominant retinitis pigmentosa in Caenorhabditis elegans uncovers a nexus between global impaired functioning of certain splicing factors and cell type-specific apoptosis. RNA. 2015;21:2119-31 pubmed publisher
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Sidhu K, Kumar V. c-ETS transcription factors play an essential role in the licensing of human MCM4 origin of replication. Biochim Biophys Acta. 2015;1849:1319-28 pubmed publisher
Cao L, Ding J, Dong L, Zhao J, Su J, Wang L, et al. Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability. PLoS ONE. 2015;10:e0137411 pubmed publisher
Pace B, Liu L, Li B, Makala L. Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease. Exp Biol Med (Maywood). 2015;240:1050-64 pubmed publisher
Ahmed S, Carruthers R, Gilmour L, Yildirim S, Watts C, Chalmers A. Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells. Cancer Res. 2015;75:4416-28 pubmed publisher
Cervera L, Fuenmayor J, González Domínguez I, Gutiérrez Granados S, Segura M, Gòdia F. Selection and optimization of transfection enhancer additives for increased virus-like particle production in HEK293 suspension cell cultures. Appl Microbiol Biotechnol. 2015;99:9935-49 pubmed publisher
Mitra P, Banu K, Deshmukh A, Subbarao N, Dhar S. Functional dissection of proliferating-cell nuclear antigens (1 and 2) in human malarial parasite Plasmodium falciparum: possible involvement in DNA replication and DNA damage response. Biochem J. 2015;470:115-29 pubmed publisher
García Rodríguez L, De Piccoli G, Marchesi V, Jones R, Edmondson R, Labib K. A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1. Nucleic Acids Res. 2015;43:8830-8 pubmed publisher
Zebrowski D, Vergarajauregui S, Wu C, Piatkowski T, Becker R, Leone M, et al. Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes. elife. 2015;4: pubmed publisher
Li Y, Peng L, Seto E. Histone Deacetylase 10 Regulates the Cell Cycle G2/M Phase Transition via a Novel Let-7-HMGA2-Cyclin A2 Pathway. Mol Cell Biol. 2015;35:3547-65 pubmed publisher
Wang S, Lin P, Chiu Y, Huang J, Kuo Y, Wu J, et al. Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity. PLoS ONE. 2015;10:e0134110 pubmed publisher
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Tsakraklides V, Brevnova E, Stephanopoulos G, Shaw A. Improved Gene Targeting through Cell Cycle Synchronization. PLoS ONE. 2015;10:e0133434 pubmed publisher
Rein K, Yanez D, Terré B, Palenzuela L, Aivio S, Wei K, et al. EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele. Nucleic Acids Res. 2015;43:7371-87 pubmed publisher
Matito A, Morgado J, Sánchez López P, Alvarez Twose I, Sánchez Muñoz L, Orfao A, et al. Management of Anesthesia in Adult and Pediatric Mastocytosis: A Study of the Spanish Network on Mastocytosis (REMA) Based on 726 Anesthetic Procedures. Int Arch Allergy Immunol. 2015;167:47-56 pubmed publisher
Chung W, Park J, Kang H, Song M. Downregulation of Poly(ADP-Ribose) Polymerase 1 by a Viral Processivity Factor Facilitates Lytic Replication of Gammaherpesvirus. J Virol. 2015;89:9676-82 pubmed publisher
Abernethy G. Generation of semicarbazide from natural azine development in foods, followed by reaction with urea compounds. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32:1416-30 pubmed publisher
Zyuz kov G, Zhdanov V, Udut E, Miroshnichenko L, Danilets M, Simanina E, et al. Role of JNK and Contribution of p53 into Growth Potential of Mesenchymal Progenitor Cells In Vitro. Bull Exp Biol Med. 2015;159:245-7 pubmed publisher
Burla R, Carcuro M, Raffa G, Galati A, Raimondo D, Rizzo A, et al. AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance. PLoS Genet. 2015;11:e1005167 pubmed publisher
Arregi I, Falces J, Olazabal Herrero A, Alonso Mariño M, Taneva S, Rodríguez J, et al. Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport. PLoS ONE. 2015;10:e0130610 pubmed publisher
Specks J, Lecona E, Lopez Contreras A, Fernandez Capetillo O. A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development. Mol Cell Biol. 2015;35:2910-7 pubmed publisher
Hoijman E, Rubbini D, Colombelli J, Alsina B. Mitotic cell rounding and epithelial thinning regulate lumen growth and shape. Nat Commun. 2015;6:7355 pubmed publisher
Zyuz kov G, Zhdanov V, Miroshnichenko L, Udut E, Chaikovskii A, Simanina E, et al. Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine. Bull Exp Biol Med. 2015;159:58-61 pubmed publisher
Xie C, Chen W, Zhang M, Cai Q, Xu W, Li X, et al. MDM4 regulation by the let-7 miRNA family in the DNA damage response of glioma cells. FEBS Lett. 2015;589:1958-65 pubmed publisher
Tong K, Skibbens R. Pds5 regulators segregate cohesion and condensation pathways in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2015;112:7021-6 pubmed publisher
Garg U, Scott D, Frazee C, Kearns G, Neville K. Isotope-dilution gas chromatography-mass spectrometry method for the analysis of hydroxyurea. Ther Drug Monit. 2015;37:325-30 pubmed publisher
Ohira M, Iwasaki Y, Tanaka C, Kuroki M, Matsuo N, Kitamura T, et al. A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo. Biochim Biophys Acta. 2015;1850:1676-84 pubmed publisher
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Chen X, Hansen D, Merry G, DeJarnette C, Nolen G, Sloper D, et al. Developing osteoblasts as an endpoint for the mouse embryonic stem cell test. Reprod Toxicol. 2015;53:131-40 pubmed publisher
Mackay D, Ullman K. ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission. Mol Biol Cell. 2015;26:2217-26 pubmed publisher
Park C, Ryu H, Kim S, Lee D, Song H, Kim K. Presumed pseudokinase VRK3 functions as a BAF kinase. Biochim Biophys Acta. 2015;1853:1738-48 pubmed publisher
Lawrence K, Chau T, Engebrecht J. DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity. PLoS Genet. 2015;11:e1005150 pubmed publisher
Wang G, Liu Y, Cheng X, Zhou G. Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents. Cancer Sci. 2015;106:902-8 pubmed publisher
Weems J, Slaughter B, Unruh J, Hall S, McLaird M, Gilmore J, et al. Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses. J Biol Chem. 2015;290:15030-41 pubmed publisher
Iacovella M, Golfieri C, Massari L, Busnelli S, Pagliuca C, Dal Maschio M, et al. Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation. Nat Commun. 2015;6:6643 pubmed publisher
Hori A, Peddie C, Collinson L, Toda T. Centriolar satellite- and hMsd1/SSX2IP-dependent microtubule anchoring is critical for centriole assembly. Mol Biol Cell. 2015;26:2005-19 pubmed publisher
Mishra P, Guo J, Dittman L, Haase J, Yeh E, Bloom K, et al. Pat1 protects centromere-specific histone H3 variant Cse4 from Psh1-mediated ubiquitination. Mol Biol Cell. 2015;26:2067-79 pubmed publisher
Gagnon D, Lehoux M, Archambault J. Artificial Recruitment of UAF1-USP Complexes by a PHLPP1-E1 Chimeric Helicase Enhances Human Papillomavirus DNA Replication. J Virol. 2015;89:6227-39 pubmed publisher
Lechat M, Brun G, Montiel G, Véronési C, Simier P, Thoiron S, et al. Seed response to strigolactone is controlled by abscisic acid-independent DNA methylation in the obligate root parasitic plant, Phelipanche ramosa L. Pomel. J Exp Bot. 2015;66:3129-40 pubmed publisher
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product information
Catalog Number :
H8627
Product Name :
Hydroxyurea
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
98%, powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA