Goldsmith J, Marsh T, Asthana S, Leidal A, Suresh D, Olshen A, et al. Ribosome profiling reveals a functional role for autophagy in mRNA translational control. Commun Biol. 2020;3:388 pubmed publisher

Hong C, Tang A, Detter M, Choi J, Wang R, Yang X, et al. Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. J Exp Med. 2020;217: pubmed publisher

Zhang Y, Chan H, Garcia Martinez L, Karl D, Weich N, Slingerland J, et al. Estrogen induces dynamic ERα and RING1B recruitment to control gene and enhancer activities in luminal breast cancer. Sci Adv. 2020;6:eaaz7249 pubmed publisher

Gunne Braden A, Sullivan A, Gharibi B, Sheriff R, Maity A, Wang Y, et al. GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells. Cell Stem Cell. 2020;26:693-706.e9 pubmed publisher

Guerrero A, Guiho R, Herranz N, Uren A, Withers D, Martinez Barbera J, et al. Galactose-modified duocarmycin prodrugs as senolytics. Aging Cell. 2020;19:e13133 pubmed publisher

Webb L, Sengupta S, Edell C, Piedra Quintero Z, Amici S, Miranda J, et al. Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity. J Clin Invest. 2020;130:1683-1698 pubmed publisher

Shi W, Koo D, Kitano M, Chiang H, Trinh L, Turcatel G, et al. Pre-processing visualization of hyperspectral fluorescent data with Spectrally Encoded Enhanced Representations. Nat Commun. 2020;11:726 pubmed publisher

Sabbagh M, Nathans J. A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture. elife. 2020;9: pubmed publisher

Storer M, Mahmud N, Karamboulas K, Borrett M, Yuzwa S, Gont A, et al. Acquisition of a Unique Mesenchymal Precursor-like Blastema State Underlies Successful Adult Mammalian Digit Tip Regeneration. Dev Cell. 2020;52:509-524.e9 pubmed publisher

Steadman P, Xia F, Ahmed M, Mocle A, Penning A, Geraghty A, et al. Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice. Neuron. 2020;105:150-164.e6 pubmed publisher

Nicolai S, Mahen R, Raschellà G, Marini A, Pieraccioli M, Malewicz M, et al. ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining. Oncogene. 2020;39:754-766 pubmed publisher

Post A, Bussink J, Sweep F, Span P. Changes in DNA Damage Repair Gene Expression and Cell Cycle Gene Expression Do Not Explain Radioresistance in Tamoxifen-Resistant Breast Cancer. Oncol Res. 2020;28:33-40 pubmed publisher

Jain P, Guerreiro P, Canato S, Janody F. The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis. Sci Rep. 2019;9:19843 pubmed publisher

Viswanadhapalli S, Ma S, Sareddy G, Lee T, Li M, Gilbreath C, et al. Estrogen receptor coregulator binding modulator (ERX-11) enhances the activity of CDK4/6 inhibitors against estrogen receptor-positive breast cancers. Breast Cancer Res. 2019;21:150 pubmed publisher

Luxan G, Stewen J, Díaz N, Kato K, Maney S, Aravamudhan A, et al. Endothelial EphB4 maintains vascular integrity and transport function in adult heart. elife. 2019;8: pubmed publisher

Seishima R, Leung C, Yada S, Murad K, Tan L, Hajamohideen A, et al. Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development. Nat Commun. 2019;10:5378 pubmed publisher

Chen Q, Liu Y, Jeong H, Stehling M, Dinh V, Zhou B, et al. Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury. Cell Stem Cell. 2019;25:768-783.e6 pubmed publisher

Hasegawa Y, Struhl K. Promoter-specific dynamics of TATA-binding protein association with the human genome. Genome Res. 2019;29:1939-1950 pubmed publisher

Wang Y, Chiang I, Ohara T, Fujii S, Cheng J, Muegge B, et al. Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells. Cell. 2019;179:1144-1159.e15 pubmed publisher

Salvati A, Gigantino V, Nassa G, Giurato G, Alexandrova E, Rizzo F, et al. The Histone Methyltransferase DOT1L Is a Functional Component of Estrogen Receptor Alpha Signaling in Ovarian Cancer Cells. Cancers (Basel). 2019;11: pubmed publisher

Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, et al. 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. Mol Cell. 2019;: pubmed publisher

Donovan M, Selmin O, DOETSCHMAN T, Romagnolo D. Epigenetic Activation of BRCA1 by Genistein In Vivo and Triple Negative Breast Cancer Cells Linked to Antagonism toward Aryl Hydrocarbon Receptor. Nutrients. 2019;11: pubmed publisher

Cocce K, Jasper J, Desautels T, Everett L, Wardell S, Westerling T, et al. The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer. Cell Rep. 2019;29:889-903.e10 pubmed publisher

Sande Melón M, Marques I, Galardi Castilla M, Langa X, Pérez López M, Botos M, et al. Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish. Cell Rep. 2019;29:1041-1054.e5 pubmed publisher

Tavernier S, Athanasopoulos V, Verloo P, Behrens G, Staal J, Bogaert D, et al. A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation. Nat Commun. 2019;10:4779 pubmed publisher

Allen M, Zhou W, Thangaraj J, Kyriakakis P, Wu Y, Huang Z, et al. An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics. ACS Synth Biol. 2019;8:2359-2371 pubmed publisher

Sharma A, Kazim S, Larson C, Ramakrishnan A, Gray J, McEwen B, et al. Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures. Proc Natl Acad Sci U S A. 2019;116:21800-21811 pubmed publisher

Su K, Dai S, Tang Z, Xu M, Dai C. Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase. Mol Cell. 2019;76:546-561.e8 pubmed publisher

Jiang H, Xue X, Panda S, Kawale A, Hooy R, Liang F, et al. Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. EMBO J. 2019;38:e102718 pubmed publisher

Chang E, Tsai S, Aristizabal M, Wells J, Coulombe Y, Busatto F, et al. MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts. Nat Commun. 2019;10:4265 pubmed publisher

Addicks G, Brun C, Sincennes M, Saber J, Porter C, Francis Stewart A, et al. MLL1 is required for PAX7 expression and satellite cell self-renewal in mice. Nat Commun. 2019;10:4256 pubmed publisher

Belver L, Yang A, Albero R, Herranz D, Brundu F, Quinn S, et al. GATA3-Controlled Nucleosome Eviction Drives MYC Enhancer Activity in T-cell Development and Leukemia. Cancer Discov. 2019;9:1774-1791 pubmed publisher

Wang L, Wang Z, Ersing I, Nobre L, Guo R, Jiang S, et al. Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival. PLoS Pathog. 2019;15:e1008030 pubmed publisher

Padmanaban V, Krol I, Suhail Y, Szczerba B, Aceto N, Bader J, et al. E-cadherin is required for metastasis in multiple models of breast cancer. Nature. 2019;573:439-444 pubmed publisher

Sharir A, Marangoni P, Zilionis R, Wan M, Wald T, Hu J, et al. A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage. Nat Cell Biol. 2019;21:1102-1112 pubmed publisher

Costa T, Zhuang T, Lorent J, Turco E, Olofsson H, Masià Balagué M, et al. PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer. Nat Commun. 2019;10:3589 pubmed publisher

Hou P, Miyoshi G, Hanashima C. Sensory cortex wiring requires preselection of short- and long-range projection neurons through an Egr-Foxg1-COUP-TFI network. Nat Commun. 2019;10:3581 pubmed publisher

Marnef A, Finoux A, Arnould C, Guillou E, Daburon V, Rocher V, et al. A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair. Genes Dev. 2019;33:1175-1190 pubmed publisher

Subramanian J, Michel K, Benoit M, Nedivi E. CPG15/Neuritin Mimics Experience in Selecting Excitatory Synapses for Stabilization by Facilitating PSD95 Recruitment. Cell Rep. 2019;28:1584-1595.e5 pubmed publisher

Wu J, Kung J, Dong J, Chang L, Xie C, Habib A, et al. Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning. Cell Rep. 2019;28:1167-1181.e7 pubmed publisher

Post A, Bussink J, Smid M, Sweep F, Span P. Downregulation of matrix Gla protein is a biomarker for tamoxifen-resistant and radioresistant breast cancer. Biomark Med. 2019;13:841-850 pubmed publisher

Batlle R, Andres E, Gonzalez L, Llonch E, Igea A, Gutierrez Prat N, et al. Regulation of tumor angiogenesis and mesenchymal-endothelial transition by p38α through TGF-β and JNK signaling. Nat Commun. 2019;10:3071 pubmed publisher

Masuya T, Iwamoto M, Liu X, Matsushima A. Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors. Sci Rep. 2019;9:9954 pubmed publisher

Bacci M, Lorito N, Ippolito L, Ramazzotti M, Luti S, Romagnoli S, et al. Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer. Cell Rep. 2019;28:104-118.e8 pubmed publisher

Tameire F, Verginadis I, Leli N, Polte C, Conn C, Ojha R, et al. ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nat Cell Biol. 2019;21:889-899 pubmed publisher

Wang L, Shen H, Nobre L, Ersing I, Paulo J, Trudeau S, et al. Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation. Cell Metab. 2019;30:539-555.e11 pubmed publisher

Carvalho J, Fortunato I, Fonseca C, Pezzarossa A, Barbacena P, Domínguez Cejudo M, et al. Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration. elife. 2019;8: pubmed publisher

Saul S, Castelbou C, Fickentscher C, Demaurex N. Signaling and functional competency of neutrophils derived from bone-marrow cells expressing the ER-HOXB8 oncoprotein. J Leukoc Biol. 2019;106:1101-1115 pubmed publisher

Lindhurst M, Brinster L, Kondolf H, Shwetar J, Yourick M, Shiferaw H, et al. A mouse model of Proteus syndrome. Hum Mol Genet. 2019;28:2920-2936 pubmed publisher

Repele A, Krueger S, Bhattacharyya T, Tuineau M, Manu -. The regulatory control of Cebpa enhancers and silencers in the myeloid and red-blood cell lineages. PLoS ONE. 2019;14:e0217580 pubmed publisher

Aquila I, Cianflone E, Scalise M, Marino F, Mancuso T, Filardo A, et al. c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration. Cell Death Dis. 2019;10:436 pubmed publisher

Itkonen H, Urbanucci A, Martin S, Khan A, Mathelier A, Thiede B, et al. High OGT activity is essential for MYC-driven proliferation of prostate cancer cells. Theranostics. 2019;9:2183-2197 pubmed publisher

Zhang Y, Jang Y, Lee J, Ahn J, Xu L, Holden M, et al. Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF. Nat Commun. 2019;10:2314 pubmed publisher

Di Rienzo M, Antonioli M, Fusco C, Liu Y, Mari M, Orhon I, et al. Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains. Sci Adv. 2019;5:eaau8857 pubmed publisher

Yang Y, Zenke Y, Hirai T, Kaplan D. Keratinocyte-derived TGFβ is not required to maintain skin immune homeostasis. J Dermatol Sci. 2019;94:290-297 pubmed publisher

Cho C, Wang Y, Smallwood P, Williams J, Nathans J. Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers. elife. 2019;8: pubmed publisher

Modic M, Grosch M, Rot G, Schirge S, Lepko T, Yamazaki T, et al. Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition. Mol Cell. 2019;74:951-965.e13 pubmed publisher

Cook B, Rafiq R, Lee H, Banks K, El Debs M, Chiaravalli J, et al. Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-β. Cell Chem Biol. 2019;: pubmed publisher

Fursova N, Blackledge N, Nakayama M, Ito S, Koseki Y, Farcas A, et al. Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression. Mol Cell. 2019;74:1020-1036.e8 pubmed publisher

Henninger C, Pohlmann S, Ziegler V, Ohlig J, Schmitt J, Fritz G. Distinct contribution of Rac1 expression in cardiomyocytes to anthracycline-induced cardiac injury. Biochem Pharmacol. 2019;164:82-93 pubmed publisher

O Koren E, Yu C, Klingeborn M, Wong A, Prigge C, Mathew R, et al. Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration. Immunity. 2019;50:723-737.e7 pubmed publisher

Heurtier V, Owens N, González I, Mueller F, Proux C, Mornico D, et al. The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells. Nat Commun. 2019;10:1109 pubmed publisher

Long J, Wongchenko M, Nickles D, Chung W, Wang B, Riegler J, et al. Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptation. Cell Death Differ. 2019;: pubmed publisher

Milevskiy M, Gujral U, Del Lama Marques C, Stone A, Northwood K, Burke L, et al. MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ breast cancer. Br J Cancer. 2019;: pubmed publisher

Yang H, Zhu Q, Cheng J, Wu Y, Fan M, Zhang J, et al. Opposite regulation of Wnt/β-catenin and Shh signaling pathways by Rack1 controls mammalian cerebellar development. Proc Natl Acad Sci U S A. 2019;: pubmed publisher

Bunda S, Heir P, Metcalf J, Li A, Agnihotri S, Pusch S, et al. CIC protein instability contributes to tumorigenesis in glioblastoma. Nat Commun. 2019;10:661 pubmed publisher

Dohn T, Ravisankar P, Tirera F, Martin K, Gafranek J, Duong T, et al. Nr2f-dependent allocation of ventricular cardiomyocyte and pharyngeal muscle progenitors. PLoS Genet. 2019;15:e1007962 pubmed publisher

Nassour J, Radford R, Correia A, Fusté J, Schoell B, Jauch A, et al. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 2019;565:659-663 pubmed publisher

Yuan Z, Vanderwielen B, Giaimo B, Pan L, Collins C, Turkiewicz A, et al. Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site. Cell Rep. 2019;26:845-854.e6 pubmed publisher

Liu B, Salgado O, Singh S, Hippen K, Maynard J, Burlingame A, et al. The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation. Nat Commun. 2019;10:354 pubmed publisher

Lee C, Rudneva V, Erkek S, Zapatka M, Chau L, Tacheva Grigorova S, et al. Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma. Nat Commun. 2019;10:332 pubmed publisher

Santoro A, Vlachou T, Luzi L, Melloni G, Mazzarella L, D Elia E, et al. p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value. Cell Rep. 2019;26:624-638.e8 pubmed publisher

Zhao L, Ben Yair R, BURNS C, Burns C. Endocardial Notch Signaling Promotes Cardiomyocyte Proliferation in the Regenerating Zebrafish Heart through Wnt Pathway Antagonism. Cell Rep. 2019;26:546-554.e5 pubmed publisher

Zarich N, Anta B, Fernández Medarde A, Ballester A, de Lucas M, Cámara A, et al. The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein. Oncogenesis. 2019;8:2 pubmed publisher

Angelova A, Platel J, B clin C, Cremer H, Cor N. Characterization of perinatally born glutamatergic neurons of the mouse olfactory bulb based on NeuroD6 expression reveals their resistance to sensory deprivation. J Comp Neurol. 2019;527:1245-1260 pubmed publisher

Karras P, Riveiro Falkenbach E, Cañón E, Tejedo C, Calvo T, Martínez Herranz R, et al. p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors. Cancer Cell. 2019;35:46-63.e10 pubmed publisher

Cortés E, Lachowski D, Rice A, Thorpe S, Robinson B, Yeldag G, et al. Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor. Oncogene. 2019;38:2910-2922 pubmed publisher

Meisenberg C, Pinder S, Hopkins S, Wooller S, Benstead Hume G, Pearl F, et al. Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. Mol Cell. 2019;73:212-223.e7 pubmed publisher

Cortés E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe S, et al. GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Rep. 2019;20: pubmed publisher

Cortés E, Lachowski D, Robinson B, Sarper M, Teppo J, Thorpe S, et al. Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival. EMBO Rep. 2019;20: pubmed publisher

Nayar U, Cohen O, Kapstad C, Cuoco M, Waks A, Wander S, et al. Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor-directed therapies. Nat Genet. 2019;51:207-216 pubmed publisher

Carr M, Toma J, Johnston A, Steadman P, Yuzwa S, Mahmud N, et al. Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration. Cell Stem Cell. 2019;24:240-256.e9 pubmed publisher

Jang Y, Broun A, Wang C, Park Y, Zhuang L, Lee J, et al. H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development. Nucleic Acids Res. 2019;47:607-620 pubmed publisher

Aden K, Bartsch K, Dahl J, Reijns M, Esser D, Sheibani Tezerji R, et al. Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice. Gastroenterology. 2019;156:145-159.e19 pubmed publisher

Xue Y, Lai L, Lian W, Tu X, Zhou J, Dong P, et al. SOX9/FXYD3/Src Axis Is Critical for ER+ Breast Cancer Stem Cell Function. Mol Cancer Res. 2019;17:238-249 pubmed publisher

Szmyd R, Niska Blakie J, Diril M, Renck Nunes P, Tzelepis K, Lacroix A, et al. Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality. Oncogene. 2019;38:998-1018 pubmed publisher

Zeineddine H, Girard R, Saadat L, Shen L, Lightle R, Moore T, et al. Phenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest. 2019;99:319-330 pubmed publisher

Murillo M, Rana S, Spencer Dene B, Nye E, Stamp G, Downward J. Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer. Cell Rep. 2018;25:3545-3553.e2 pubmed publisher

Chagraoui H, Kristiansen M, Ruiz J, Serra Barros A, Richter J, Hall Ponsele E, et al. SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells. Nat Commun. 2018;9:5375 pubmed publisher

Rosenberg L, Cattin A, Fontana X, Harford Wright E, Burden J, White I, et al. HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State. Cell Rep. 2018;25:2755-2765.e5 pubmed publisher

Wang Y, Cho C, Williams J, Smallwood P, Zhang C, Junge H, et al. Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proc Natl Acad Sci U S A. 2018;115:E11827-E11836 pubmed publisher

Choi J, Wang R, Yang X, Wang X, Wang L, Ting K, et al. Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations. Sci Adv. 2018;4:eaau0731 pubmed publisher

Stierli S, Napoli I, White I, Cattin A, Monteza Cabrejos A, Garcia Calavia N, et al. The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population. Development. 2018;145: pubmed publisher

Anton K, Kajita M, Narumi R, Fujita Y, Tada M. Src-transformed cells hijack mitosis to extrude from the epithelium. Nat Commun. 2018;9:4695 pubmed publisher

Wang J, Batourina E, Schneider K, Souza S, Swayne T, Liu C, et al. Polyploid Superficial Cells that Maintain the Urothelial Barrier Are Produced via Incomplete Cytokinesis and Endoreplication. Cell Rep. 2018;25:464-477.e4 pubmed publisher

Zöller T, Schneider A, Kleimeyer C, Masuda T, Potru P, Pfeifer D, et al. Silencing of TGFβ signalling in microglia results in impaired homeostasis. Nat Commun. 2018;9:4011 pubmed publisher

Clouaire T, Rocher V, Lashgari A, Arnould C, Aguirrebengoa M, Biernacka A, et al. Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures. Mol Cell. 2018;72:250-262.e6 pubmed publisher

Essig K, Kronbeck N, Guimaraes J, Lohs C, Schlundt A, Hoffmann A, et al. Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation. Nat Commun. 2018;9:3810 pubmed publisher

Vincent Mistiaen Z, Elbediwy A, Vanyai H, Cotton J, Stamp G, Nye E, et al. YAP drives cutaneous squamous cell carcinoma formation and progression. elife. 2018;7: pubmed publisher

Wu S, Xue R, Hassan S, Nguyen T, Wang T, Pan H, et al. Il34-Csf1r Pathway Regulates the Migration and Colonization of Microglial Precursors. Dev Cell. 2018;46:552-563.e4 pubmed publisher

Schultz M, Krus K, Kaushik S, Dang D, Chopra R, Qi L, et al. Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD. Nat Commun. 2018;9:3671 pubmed publisher

Kumar R, Ray S, Home P, Saha B, Bhattacharya B, Wilkins H, et al. Regulation of energy metabolism during early mammalian development: TEAD4 controls mitochondrial transcription. Development. 2018;145: pubmed publisher

Lian G, Gnanaprakasam J, Wang T, Wu R, Chen X, Liu L, et al. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. elife. 2018;7: pubmed publisher

Fernandez D, Fogerson P, Lazzerini Ospri L, Thomsen M, Layne R, Severin D, et al. Light Affects Mood and Learning through Distinct Retina-Brain Pathways. Cell. 2018;175:71-84.e18 pubmed publisher

Knouse K, Lopez K, Bachofner M, Amon A. Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture. Cell. 2018;175:200-211.e13 pubmed publisher

Farzi A, Lau J, Ip C, Qi Y, Shi Y, Zhang L, et al. Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure. elife. 2018;7: pubmed publisher

An L, Dong C, Li J, Chen J, Yuan J, Huang J, et al. RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair. Proc Natl Acad Sci U S A. 2018;115:E8286-E8295 pubmed publisher

Neidert N, von Ehr A, Zöller T, Spittau B. Microglia-Specific Expression of Olfml3 Is Directly Regulated by Transforming Growth Factor β1-Induced Smad2 Signaling. Front Immunol. 2018;9:1728 pubmed publisher

Sirka O, Shamir E, Ewald A. Myoepithelial cells are a dynamic barrier to epithelial dissemination. J Cell Biol. 2018;217:3368-3381 pubmed publisher

Feng X, Hsu S, Bhattacharjee A, Wang Y, Diao J, Price C. CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells. Nat Commun. 2018;9:2827 pubmed publisher

Zingg D, Debbache J, Peña Hernández R, Antunes A, Schaefer S, Cheng P, et al. EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation. Cancer Cell. 2018;34:69-84.e14 pubmed publisher

Bornelöv S, Reynolds N, Xenophontos M, Gharbi S, Johnstone E, Floyd R, et al. The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression. Mol Cell. 2018;71:56-72.e4 pubmed publisher

Moore E, Zhu Y, Ryu H, Jacobs C. Periosteal progenitors contribute to load-induced bone formation in adult mice and require primary cilia to sense mechanical stimulation. Stem Cell Res Ther. 2018;9:190 pubmed publisher

Giaimo B, Ferrante F, Vallejo D, Hein K, Gutiérrez Pérez I, Nist A, et al. Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response. Nucleic Acids Res. 2018;46:8197-8215 pubmed publisher

Nakano Y, Kelly M, Rehman A, Boger E, Morell R, Kelley M, et al. Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness. Cell. 2018;174:536-548.e21 pubmed publisher

St Amand M, Bond M, Riedy J, Comly M, Shiloach J, Hanover J. A genetic model to study O-GlcNAc cycling in immortalized mouse embryonic fibroblasts. J Biol Chem. 2018;293:13673-13681 pubmed publisher

Sandlesh P, Juang T, Safina A, Higgins M, Gurova K. Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene. PLoS ONE. 2018;13:e0199785 pubmed publisher

Barutcu S, Girnius N, Vernia S, Davis R. Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy. 2018;14:1586-1595 pubmed publisher

Kato K, Diéguez Hurtado R, Park D, Hong S, Kato Azuma S, Adams S, et al. Pulmonary pericytes regulate lung morphogenesis. Nat Commun. 2018;9:2448 pubmed publisher

Schrank B, Aparicio T, Li Y, Chang W, Chait B, Gundersen G, et al. Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature. 2018;559:61-66 pubmed publisher

Sritana N, Suriyo T, Kanitwithayanun J, Songvasin B, Thiantanawat A, Satayavivad J. Glyphosate induces growth of estrogen receptor alpha positive cholangiocarcinoma cells via non-genomic estrogen receptor/ERK1/2 signaling pathway. Food Chem Toxicol. 2018;118:595-607 pubmed publisher

Canovas B, Igea A, Sartori A, Gomis R, Paull T, Isoda M, et al. Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells. Cancer Cell. 2018;33:1094-1110.e8 pubmed publisher

Ji Z, He L, Rotem A, Janzer A, Cheng C, Regev A, et al. Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation. Nat Commun. 2018;9:2068 pubmed publisher

Li Y, Schang G, Wang Y, Zhou X, Levasseur A, Boyer A, et al. Conditional Deletion of FOXL2 and SMAD4 in Gonadotropes of Adult Mice Causes Isolated FSH Deficiency. Endocrinology. 2018;159:2641-2655 pubmed publisher

Ryu K, Nandu T, Kim J, Challa S, DeBerardinis R, Kraus W. Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis. Science. 2018;360: pubmed publisher

Tsantoulas C, Denk F, Signore M, Nassar M, Futai K, McMahon S. Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity. Pain. 2018;159:1641-1651 pubmed publisher

Miller H, Larson C, Heinzen R. Actin polymerization in the endosomal pathway, but not on the Coxiella-containing vacuole, is essential for pathogen growth. PLoS Pathog. 2018;14:e1007005 pubmed publisher

Corsini N, Peer A, Moeseneder P, Roiuk M, Burkard T, Theussl H, et al. Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation. Cell Stem Cell. 2018;22:543-558.e12 pubmed publisher

Horibata S, Rice E, Mukai C, Marks B, Sams K, Zheng H, et al. ER-positive breast cancer cells are poised for RET-mediated endocrine resistance. PLoS ONE. 2018;13:e0194023 pubmed publisher

Li P, Feng C, Chen H, Jiang Y, Cao F, Liu J, et al. Elevated CRB3 expression suppresses breast cancer stemness by inhibiting ?-catenin signalling to restore tamoxifen sensitivity. J Cell Mol Med. 2018;22:3423-3433 pubmed publisher

Larson V, Mironova Y, Vanderpool K, Waisman A, Rash J, Agarwal A, et al. Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility. elife. 2018;7: pubmed publisher

Gonzalez Malagon S, Lopez Muñoz A, Doro D, Bolger T, Poon E, Tucker E, et al. Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus. Nat Commun. 2018;9:1126 pubmed publisher

Zhao N, Cao J, Xu L, Tang Q, Dobrolecki L, Lv X, et al. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018;128:1283-1299 pubmed publisher

González Fernández E, Jeong H, Fukaya M, Kim H, Khawaja R, Srivastava I, et al. PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling. elife. 2018;7: pubmed publisher

He Y, Hooker E, Yu E, Wu H, Cunha G, Sun Z. An Indispensable Role of Androgen Receptor in Wnt Responsive Cells During Prostate Development, Maturation, and Regeneration. Stem Cells. 2018;36:891-902 pubmed publisher

Jeselsohn R, Bergholz J, Pun M, Cornwell M, Liu W, Nardone A, et al. Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations. Cancer Cell. 2018;33:173-186.e5 pubmed publisher

Qin Y, Sukumaran S, Jyotaki M, Redding K, Jiang P, Margolskee R. Gli3 is a negative regulator of Tas1r3-expressing taste cells. PLoS Genet. 2018;14:e1007058 pubmed publisher

Zuo H, Wood W, Sherafat A, Hill R, Lu Q, Nishiyama A. Age-Dependent Decline in Fate Switch from NG2 Cells to Astrocytes After Olig2 Deletion. J Neurosci. 2018;38:2359-2371 pubmed publisher

Xie H, Tang C, Song J, Mancuso A, Del Valle J, Cao J, et al. IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers. J Clin Invest. 2018;128:1300-1316 pubmed publisher

Halon Golabek M, Borkowska A, Kaczor J, Ziolkowski W, Flis D, Knap N, et al. hmSOD1 gene mutation-induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway. J Cachexia Sarcopenia Muscle. 2018;9:557-569 pubmed publisher

Hatzistergos K, Jiang Z, Valasaki K, Takeuchi L, Balkan W, Atluri P, et al. Simulated microgravity impairs cardiac autonomic neurogenesis from neural crest cells. Stem Cells Dev. 2018;: pubmed publisher

Ishida K, Xu H, Sasakawa N, Lung M, Kudryashev J, Gee P, et al. Site-specific randomization of the endogenous genome by a regulatable CRISPR-Cas9 piggyBac system in human cells. Sci Rep. 2018;8:310 pubmed publisher

Weng H, Huang H, Wu H, Qin X, Zhao B, Dong L, et al. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. Cell Stem Cell. 2018;22:191-205.e9 pubmed publisher

Bu Y, Yoshida A, Chitnis N, Altman B, Tameire F, Oran A, et al. A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nat Cell Biol. 2018;20:104-115 pubmed publisher

Berenjeno I, Piñeiro R, Castillo S, Pearce W, McGranahan N, Dewhurst S, et al. Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling. Nat Commun. 2017;8:1773 pubmed publisher

Tian H, Tackmann N, Jin A, Zheng J, Zhang Y. Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice. J Biol Chem. 2017;292:21614-21622 pubmed publisher

Fei J, Schuez M, Knapp D, Taniguchi Y, Drechsel D, Tanaka E. Efficient gene knockin in axolotl and its use to test the role of satellite cells in limb regeneration. Proc Natl Acad Sci U S A. 2017;114:12501-12506 pubmed publisher

Furuya S, Endo K, Takahashi A, Miyazawa K, Saitoh M. Snail suppresses cellular senescence and promotes fibroblast-led cancer cell invasion. FEBS Open Bio. 2017;7:1586-1597 pubmed publisher

Lopez Ramirez M, Fonseca G, Zeineddine H, Girard R, Moore T, Pham A, et al. Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017;214:3331-3346 pubmed publisher

Cliff T, Wu T, Boward B, Yin A, Yin H, Glushka J, et al. MYC Controls Human Pluripotent Stem Cell Fate Decisions through Regulation of Metabolic Flux. Cell Stem Cell. 2017;21:502-516.e9 pubmed publisher

Lee J, Tammela T, Hofree M, Choi J, Marjanovic N, Han S, et al. Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6. Cell. 2017;170:1149-1163.e12 pubmed publisher

Cho C, Smallwood P, Nathans J. Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron. 2017;95:1056-1073.e5 pubmed publisher

Turrell F, Kerr E, Gao M, Thorpe H, Doherty G, Cridge J, et al. Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity. Genes Dev. 2017;31:1339-1353 pubmed publisher

Sun Q, Sotayo A, Cazzulino A, Snyder A, Denny C, Siegelbaum S. Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall. Neuron. 2017;95:656-672.e3 pubmed publisher

De Biase L, Schuebel K, Fusfeld Z, Jair K, Hawes I, Cimbro R, et al. Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia. Neuron. 2017;95:341-356.e6 pubmed publisher

Hsu J, Hubbell Engler B, Adelmant G, Huang J, Joyce C, Vazquez F, et al. PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer. Cancer Res. 2017;77:4613-4625 pubmed publisher

Gong F, Clouaire T, Aguirrebengoa M, Legube G, Miller K. Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair. J Cell Biol. 2017;216:1959-1974 pubmed publisher

Sakamaki J, Wilkinson S, Hahn M, Tasdemir N, O Prey J, Clark W, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol Cell. 2017;66:517-532.e9 pubmed publisher

Eritja N, Felip I, Dosil M, Vigezzi L, Mirantes C, Yeramian A, et al. A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-? in mouse endometrium. Cell Death Differ. 2017;24:1443-1458 pubmed publisher

Jeselsohn R, Cornwell M, Pun M, Buchwalter G, Nguyen M, Bango C, et al. Embryonic transcription factor SOX9 drives breast cancer endocrine resistance. Proc Natl Acad Sci U S A. 2017;114:E4482-E4491 pubmed publisher

Tang A, Choi J, Kotzin J, Yang Y, Hong C, Hobson N, et al. Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature. 2017;545:305-310 pubmed publisher

Maclary E, Hinten M, Harris C, Sethuraman S, Gayen S, Kalantry S. PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice. Genome Biol. 2017;18:82 pubmed publisher

Decker R, Um H, Dyment N, Cottingham N, Usami Y, Enomoto Iwamoto M, et al. Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. Dev Biol. 2017;426:56-68 pubmed publisher

Ferraiuolo R, Tubman J, Sinha I, Hamm C, Porter L. The cyclin-like protein, SPY1, regulates the ER? and ERK1/2 pathways promoting tamoxifen resistance. Oncotarget. 2017;8:23337-23352 pubmed publisher

Kononenko N, Claßen G, Kuijpers M, Puchkov D, Maritzen T, Tempes A, et al. Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration. Nat Commun. 2017;8:14819 pubmed publisher

de Castro R, Previato L, Goitea V, Felberg A, Guiraldelli M, Filiberti A, et al. The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes. J Biol Chem. 2017;292:8459-8471 pubmed publisher

Feng X, Hsu S, Kasbek C, Chaiken M, Price C. CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance. Nucleic Acids Res. 2017;45:4281-4293 pubmed publisher

Boutin A, Liao W, Wang M, Hwang S, Karpinets T, Cheung H, et al. Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. Genes Dev. 2017;31:370-382 pubmed publisher

Dai F, Lee H, Zhang Y, Zhuang L, Yao H, Xi Y, et al. BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response. Proc Natl Acad Sci U S A. 2017;114:3192-3197 pubmed publisher

Saitoh S, Maruyama T, Yako Y, Kajita M, Fujioka Y, Ohba Y, et al. Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells. Proc Natl Acad Sci U S A. 2017;114:E2327-E2336 pubmed publisher

Welsch M, Kaplan A, Chambers J, Stokes M, Bos P, Zask A, et al. Multivalent Small-Molecule Pan-RAS Inhibitors. Cell. 2017;168:878-889.e29 pubmed publisher

Langen U, Pitulescu M, Kim J, Enriquez Gasca R, Sivaraj K, Kusumbe A, et al. Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol. 2017;19:189-201 pubmed publisher

Agarwal A, Wu P, Hughes E, Fukaya M, Tischfield M, Langseth A, et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017;93:587-605.e7 pubmed publisher

Demitrack E, Gifford G, Keeley T, Horita N, Todisco A, Turgeon D, et al. NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus. Am J Physiol Gastrointest Liver Physiol. 2017;312:G133-G144 pubmed publisher

Rahman S, Zorca C, Traboulsi T, Noutahi E, Krause M, Mader S, et al. Single-cell profiling reveals that eRNA accumulation at enhancer-promoter loops is not required to sustain transcription. Nucleic Acids Res. 2017;45:3017-3030 pubmed publisher

Niknafs Y, Han S, Ma T, Speers C, Zhang C, Wilder Romans K, et al. The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. Nat Commun. 2016;7:12791 pubmed publisher

Shi C, Zhang H, Louie K, Mishina Y, Sun H. BMP Signaling Mediated by BMPR1A in Osteoclasts Negatively Regulates Osteoblast Mineralization Through Suppression of Cx43. J Cell Biochem. 2017;118:605-614 pubmed publisher

Casco Robles M, Islam M, Inami W, Tanaka H, Kunahong A, Yasumuro H, et al. Turning the fate of reprogramming cells from retinal disorder to regeneration by Pax6 in newts. Sci Rep. 2016;6:33761 pubmed publisher

Wrobel K, Zhao Y, Kulkoyluoglu E, Chen K, Hieronymi K, Holloway J, et al. ER?-XPO1 Cross Talk Controls Tamoxifen Sensitivity in Tumors by Altering ERK5 Cellular Localization. Mol Endocrinol. 2016;30:1029-1045 pubmed

Cantú A, Altshuler Keylin S, Laird D. Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling. J Cell Biol. 2016;214:215-29 pubmed publisher

Pan H, Zhong X, Lee S. Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. BMC Biochem. 2016;17:14 pubmed publisher

Shang Y, Wang H, Jia P, Zhao H, Liu C, Liu W, et al. Autophagy regulates spermatid differentiation via degradation of PDLIM1. Autophagy. 2016;12:1575-92 pubmed publisher

Pais A, Degani H. Estrogen Receptor-Targeted Contrast Agents for Molecular Magnetic Resonance Imaging of Breast Cancer Hormonal Status. Front Oncol. 2016;6:100 pubmed publisher

Poburski D, Boerner J, Koenig M, Ristow M, Thierbach R. Time-resolved functional analysis of acute impairment of frataxin expression in an inducible cell model of Friedreich ataxia. Biol Open. 2016;5:654-61 pubmed publisher

Shi C, Iura A, Terajima M, Liu F, Lyons K, Pan H, et al. Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors. Sci Rep. 2016;6:24256 pubmed publisher

Tanaka H, Ng N, Yang Yu Z, Casco Robles M, Maruo F, Tsonis P, et al. A developmentally regulated switch from stem cells to dedifferentiation for limb muscle regeneration in newts. Nat Commun. 2016;7:11069 pubmed publisher

Pindyurin A, Pagie L, Kozhevnikova E, van Arensbergen J, van Steensel B. Inducible DamID systems for genomic mapping of chromatin proteins in Drosophila. Nucleic Acids Res. 2016;44:5646-57 pubmed publisher

Kuales G, Weiss M, Sedelmeier O, Pfeifer D, Arnold S. A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence. Stem Cells Int. 2015;2015:218518 pubmed publisher

Benedykcinska A, Ferreira A, Lau J, Broni J, Richard Loendt A, Henriquez N, et al. Generation of brain tumours in mice by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite endoxifen. Dis Model Mech. 2016;9:211-20 pubmed publisher

Nguyen V, Barozzi I, Faronato M, Lombardo Y, Steel J, Patel N, et al. Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nat Commun. 2015;6:10044 pubmed publisher

Caron P, Choudjaye J, Clouaire T, Bugler B, Daburon V, Aguirrebengoa M, et al. Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks. Cell Rep. 2015;13:1598-609 pubmed publisher

Taty Taty G, Chailleux C, Quaranta M, So A, Guirouilh Barbat J, Lopez B, et al. Control of alternative end joining by the chromatin remodeler p400 ATPase. Nucleic Acids Res. 2016;44:1657-68 pubmed publisher

Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, et al. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015;17:1546-55 pubmed publisher

Simões B, O Brien C, Eyre R, Silva A, Yu L, Sarmiento Castro A, et al. Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity. Cell Rep. 2015;12:1968-77 pubmed publisher

Kraus A, Schley G, Kunzelmann K, Schreiber R, Peters D, Stadler R, et al. Glucose promotes secretion-dependent renal cyst growth. J Mol Med (Berl). 2016;94:107-17 pubmed publisher

Hatsell S, Idone V, Wolken D, Huang L, Kim H, Wang L, et al. ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A. Sci Transl Med. 2015;7:303ra137 pubmed publisher

Ghaye A, Bergemann D, Tarifeño Saldivia E, Flasse L, Von Berg V, Peers B, et al. Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration. BMC Biol. 2015;13:70 pubmed publisher

Mosimann C, Panáková D, Werdich A, Musso G, Burger A, Lawson K, et al. Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015;6:8146 pubmed publisher

Mistri T, Devasia A, Chu L, Ng W, Halbritter F, Colby D, et al. Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells. EMBO Rep. 2015;16:1177-91 pubmed publisher

Lizama C, Hawkins J, Schmitt C, Bos F, Zape J, Cautivo K, et al. Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Nat Commun. 2015;6:7739 pubmed publisher

Maza I, Caspi I, Zviran A, Chomsky E, Rais Y, Viukov S, et al. Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors. Nat Biotechnol. 2015;33:769-74 pubmed publisher

Faronato M, Nguyen V, Patten D, Lombardo Y, Steel J, Patel N, et al. DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation. Oncotarget. 2015;6:22467-79 pubmed

Jungke P, Hammer J, Hans S, Brand M. Isolation of Novel CreERT2-Driver Lines in Zebrafish Using an Unbiased Gene Trap Approach. PLoS ONE. 2015;10:e0129072 pubmed publisher

Alexandrova E, Yallowitz A, Li D, Xu S, Schulz R, Proia D, et al. Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. Nature. 2015;523:352-6 pubmed publisher

Pinto Teixeira F, Viader Llargués O, Torres Mejía E, Turan M, González Gualda E, Pola Morell L, et al. Inexhaustible hair-cell regeneration in young and aged zebrafish. Biol Open. 2015;4:903-9 pubmed publisher

Zhang M, Qiu Q, Li Z, Sachdeva M, Min H, Cardona D, et al. HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism. Radiat Res. 2015;183:594-609 pubmed

Davis K, Pattanayak V, Thompson D, Zuris J, Liu D. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol. 2015;11:316-8 pubmed publisher

Squirewell E, Duffel M. The effects of endoxifen and other major metabolites of tamoxifen on the sulfation of estradiol catalyzed by human cytosolic sulfotransferases hSULT1E1 and hSULT1A1*1. Drug Metab Dispos. 2015;43:843-50 pubmed publisher

Voets E, Wolthuis R. MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C. Biol Open. 2015;4:484-95 pubmed publisher

Ito T, Taniguchi H, Fukagai K, Okamuro S, Kobayashi A. Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis. PLoS ONE. 2015;10:e0118336 pubmed publisher

Finch M, Passman A, Strauss R, Yeoh G, Callus B. Sub-cellular localisation studies may spuriously detect the Yes-associated protein, YAP, in nucleoli leading to potentially invalid conclusions of its function. PLoS ONE. 2015;10:e0114813 pubmed publisher

Galvagni F, Lentucci C, Neri F, Dettori D, De Clemente C, Orlandini M, et al. Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes. Stem Cells. 2015;33:742-50 pubmed publisher

Xu C, Hasan S, Schmidt I, Rocha S, Pitulescu M, Bussmann J, et al. Arteries are formed by vein-derived endothelial tip cells. Nat Commun. 2014;5:5758 pubmed publisher

Dominov J, Uyan O, Sapp P, McKenna Yasek D, Nallamilli B, Hegde M, et al. A novel dysferlin mutant pseudoexon bypassed with antisense oligonucleotides. Ann Clin Transl Neurol. 2014;1:703-20 pubmed publisher

Zhao B, Wu Z, Grillet N, Yan L, Xiong W, Harkins Perry S, et al. TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells. Neuron. 2014;84:954-67 pubmed publisher

WANG Y, McAllister F, Bailey J, Scott S, Hendley A, Leach S, et al. Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. PLoS ONE. 2014;9:e113127 pubmed publisher

Reid J, Goetz M, Buhrow S, Walden C, Safgren S, Kuffel M, et al. Pharmacokinetics of endoxifen and tamoxifen in female mice: implications for comparative in vivo activity studies. Cancer Chemother Pharmacol. 2014;74:1271-8 pubmed publisher

Lapique N, Benenson Y. Digital switching in a biosensor circuit via programmable timing of gene availability. Nat Chem Biol. 2014;10:1020-7 pubmed publisher

Fan P, Cunliffe H, Griffith O, Agboke F, Ramos P, Gray J, et al. Identification of gene regulation patterns underlying both oestrogen- and tamoxifen-stimulated cell growth through global gene expression profiling in breast cancer cells. Eur J Cancer. 2014;50:2877-86 pubmed publisher

Li Y, Choi P, Casey S, Felsher D. Activation of Cre recombinase alone can induce complete tumor regression. PLoS ONE. 2014;9:e107589 pubmed publisher

Squirewell E, Qin X, Duffel M. Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014;42:1843-50 pubmed publisher

Sabour D, Xu X, Chung A, Le Menuet D, Ko K, Tapia N, et al. Germ cell nuclear factor regulates gametogenesis in developing gonads. PLoS ONE. 2014;9:e103985 pubmed publisher

Kobayashi I, Kobayashi Sun J, Kim A, Pouget C, Fujita N, Suda T, et al. Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling. Nature. 2014;512:319-23 pubmed publisher

Duan L, Danzer B, Levenson V, Maki C. Critical roles for nitric oxide and ERK in the completion of prosurvival autophagy in 4OHTAM-treated estrogen receptor-positive breast cancer cells. Cancer Lett. 2014;353:290-300 pubmed publisher

Whissell G, Montagni E, Martinelli P, Hernando Momblona X, Sevillano M, Jung P, et al. The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression. Nat Cell Biol. 2014;16:695-707 pubmed publisher

Pfister S, Ahrabi S, Zalmas L, Sarkar S, Aymard F, Bachrati C, et al. SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability. Cell Rep. 2014;7:2006-18 pubmed publisher

Lombardo Y, Faronato M, Filipovic A, Vircillo V, Magnani L, Coombes R. Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells. Breast Cancer Res. 2014;16:R62 pubmed publisher

Gopinathan L, Tan S, Padmakumar V, Coppola V, Tessarollo L, Kaldis P. Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis. Cancer Res. 2014;74:3870-9 pubmed publisher

Yang W, Lee Y, Jones A, Woolnough J, Zhou D, Dai Q, et al. The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment. Nat Commun. 2014;5:3818 pubmed publisher

Catanzaro J, Sheshadri N, Pan J, Sun Y, Shi C, Li J, et al. Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. Nat Commun. 2014;5:3729 pubmed publisher

Chen J, Chen J, Zhu Y, Liang C, Zhao H. Deafness induced by Connexin 26 (GJB2) deficiency is not determined by endocochlear potential (EP) reduction but is associated with cochlear developmental disorders. Biochem Biophys Res Commun. 2014;448:28-32 pubmed publisher

Karpurapu M, Ranjan R, Deng J, Chung S, Lee Y, Xiao L, et al. Krüppel like factor 4 promoter undergoes active demethylation during monocyte/macrophage differentiation. PLoS ONE. 2014;9:e93362 pubmed publisher

Wilson C, Gamper I, Perfetto A, Auw J, Littlewood T, Evan G. The kinetics of ER fusion protein activation in vivo. Oncogene. 2014;33:4877-80 pubmed publisher

Aymard F, Bugler B, Schmidt C, Guillou E, Caron P, Briois S, et al. Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks. Nat Struct Mol Biol. 2014;21:366-74 pubmed publisher

Cebrian C, Asai N, D AGATI V, Costantini F. The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment. Cell Rep. 2014;7:127-37 pubmed publisher

Gitenay D, Wiel C, Lallet Daher H, Vindrieux D, Aubert S, Payen L, et al. Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence. Cell Death Dis. 2014;5:e1089 pubmed publisher

Lehn S, Tobin N, Sims A, Stal O, Jirstrom K, Axelson H, et al. Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response. BMC Cancer. 2014;14:119 pubmed publisher

Raggioli A, Junghans D, Rudloff S, Kemler R. Beta-catenin is vital for the integrity of mouse embryonic stem cells. PLoS ONE. 2014;9:e86691 pubmed publisher

Fischer B, Metzger M, Richardson R, Knyphausen P, Ramezani T, Franzen R, et al. p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish. PLoS Genet. 2014;10:e1004048 pubmed publisher

Park J, Leach S. TAILOR: transgene activation and inactivation using lox and rox in zebrafish. PLoS ONE. 2013;8:e85218 pubmed publisher

Zhou Y, Caron P, Legube G, Paull T. Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res. 2014;42:e19 pubmed publisher

Azrak S, Ginel Picardo A, Drosten M, Barbacid M, Santos E. Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications. BMC Genomics. 2013;14:731 pubmed publisher

Lafkas D, Rodilla V, Huyghe M, Mourao L, Kiaris H, Fre S. Notch3 marks clonogenic mammary luminal progenitor cells in vivo. J Cell Biol. 2013;203:47-56 pubmed publisher

Zhang F, Fuss I, Yang Z, Strober W. Transcription of RORγt in developing Th17 cells is regulated by E-proteins. Mucosal Immunol. 2014;7:521-32 pubmed publisher

Khattak S, Schuez M, Richter T, Knapp D, Haigo S, Sandoval Guzmán T, et al. Germline transgenic methods for tracking cells and testing gene function during regeneration in the axolotl. Stem Cell Reports. 2013;1:90-103 pubmed publisher

Huntwork Rodriguez S, Wang B, Watkins T, Ghosh A, Pozniak C, Bustos D, et al. JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. J Cell Biol. 2013;202:747-63 pubmed publisher

Floc h N, Kolodziejski J, Akkari L, Simonin Y, Ansieau S, Puisieux A, et al. Modulation of oxidative stress by twist oncoproteins. PLoS ONE. 2013;8:e72490 pubmed publisher

Wang X, Li Z, Ren Y, Jiang T, Wang Y, Chen M, et al. The Wilms tumor gene, Wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans. PLoS Genet. 2013;9:e1003645 pubmed publisher

Gagliardi A, Mullin N, Ying Tan Z, Colby D, Kousa A, Halbritter F, et al. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. EMBO J. 2013;32:2231-47 pubmed publisher

Kerl K, Ries D, Unland R, Borchert C, Moreno N, Hasselblatt M, et al. The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells. BMC Cancer. 2013;13:286 pubmed publisher

Neguembor M, Xynos A, Onorati M, Caccia R, Bortolanza S, Godio C, et al. FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis. J Mol Cell Biol. 2013;5:294-307 pubmed publisher

Kang S, Li Y, Fukaya M, Lorenzini I, Cleveland D, Ostrow L, et al. Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat Neurosci. 2013;16:571-9 pubmed publisher

Ding G, Tanaka Y, Hayashi M, Nishikawa S, Kataoka H. PDGF receptor alpha+ mesoderm contributes to endothelial and hematopoietic cells in mice. Dev Dyn. 2013;242:254-68 pubmed publisher

Ji S, Hao J, Li L, Zhang J, Zheng Q, Li X, et al. Expression of inhibin-alpha is regulated synergistically by Wilms' tumor gene 1 (Wt1) and steroidogenic factor-1 (Sf1) in sertoli cells. PLoS ONE. 2013;8:e53140 pubmed publisher

Schwab K, Smith G, Dressler G. Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes. Dev Biol. 2013;373:64-71 pubmed publisher

Cornacchia D, Dileep V, Quivy J, Foti R, Tili F, Santarella Mellwig R, et al. Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells. EMBO J. 2012;31:3678-90 pubmed publisher

Sfeir A, de Lange T. Removal of shelterin reveals the telomere end-protection problem. Science. 2012;336:593-7 pubmed publisher

Menescal L, Schmidt C, Liedtke D, Schartl M. Liver hyperplasia after tamoxifen induction of Myc in a transgenic medaka model. Dis Model Mech. 2012;5:492-502 pubmed publisher

Fisher J, Kim M, Blinka S, Ge Z, WAN T, Duris C, et al. Stress-induced cell-cycle activation in Tip60 haploinsufficient adult cardiomyocytes. PLoS ONE. 2012;7:e31569 pubmed publisher

Lau J, Minett M, Zhao J, Dennehy U, Wang F, Wood J, et al. Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse. Mol Pain. 2011;7:100 pubmed publisher

Costello I, Pimeisl I, Dräger S, Bikoff E, Robertson E, Arnold S. The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Nat Cell Biol. 2011;13:1084-91 pubmed publisher

Bourassa P, Dubeau S, Maharvi G, Fauq A, Thomas T, Tajmir Riahi H. Locating the binding sites of anticancer tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen on bovine serum albumin. Eur J Med Chem. 2011;46:4344-53 pubmed publisher

Gantier M, McCoy C, Rusinova I, Saulep D, Wang D, Xu D, et al. Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res. 2011;39:5692-703 pubmed publisher

Mosimann C, Kaufman C, Li P, Pugach E, Tamplin O, Zon L. Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish. Development. 2011;138:169-77 pubmed publisher

Cimica V, Smith M, Zhang Z, Mathur D, Mani S, Kalpana G. Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen. BMC Cancer. 2010;10:634 pubmed publisher

Conrad M, Sandin A, Forster H, Seiler A, Frijhoff J, Dagnell M, et al. 12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases. Proc Natl Acad Sci U S A. 2010;107:15774-9 pubmed publisher

Monahan K, Rozenberg G, Krishnamurthy J, Johnson S, Liu W, Bradford M, et al. Somatic p16(INK4a) loss accelerates melanomagenesis. Oncogene. 2010;29:5809-17 pubmed publisher

Jiang Q, Payton Stewart F, Elliott S, Driver J, Rhodes L, Zhang Q, et al. Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells. J Med Chem. 2010;53:6153-63 pubmed publisher

Dettmann S, Szymanowitz K, Wellner A, Schiedel A, Muller C, Gust R. 2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation. Bioorg Med Chem. 2010;18:4905-16 pubmed publisher

Törnqvist G, Sandberg A, Hägglund A, Carlsson L. Cyclic expression of lhx2 regulates hair formation. PLoS Genet. 2010;6:e1000904 pubmed publisher

Schneider M, Wortmann M, Mandal P, Arpornchayanon W, Jannasch K, Alves F, et al. Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity. Neoplasia. 2010;12:254-63 pubmed

Louie C, Caridi G, Lopes V, Brancati F, Kispert A, Lancaster M, et al. AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet. 2010;42:175-80 pubmed publisher

Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher

Bellavance E, Luu The V, Poirier D. Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. J Med Chem. 2009;52:7488-502 pubmed publisher

Minamishima Y, Moslehi J, Padera R, Bronson R, Liao R, Kaelin W. A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Mol Cell Biol. 2009;29:5729-41 pubmed publisher

Kandilci A, Grosveld G. Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation. Blood. 2009;114:1596-606 pubmed publisher

Hans S, Kaslin J, Freudenreich D, Brand M. Temporally-controlled site-specific recombination in zebrafish. PLoS ONE. 2009;4:e4640 pubmed publisher

Scott S, Selvy P, Buck J, Cho H, Criswell T, Thomas A, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009;5:108-17 pubmed publisher

Cowley D, Rivera Perez J, Schliekelman M, He Y, Oliver T, Lu L, et al. Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol. 2009;29:1059-71 pubmed publisher

Aesoy R, Sanchez B, Norum J, Lewensohn R, Viktorsson K, Linderholm B. An autocrine VEGF/VEGFR2 and p38 signaling loop confers resistance to 4-hydroxytamoxifen in MCF-7 breast cancer cells. Mol Cancer Res. 2008;6:1630-8 pubmed publisher

Barrett I, Meegan M, Hughes R, Carr M, Knox A, Artemenko N, et al. Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators. Bioorg Med Chem. 2008;16:9554-73 pubmed publisher

Gao M, Wang M, Miller K, Sledge G, Zheng Q. Synthesis and preliminary biological evaluation of new carbon-11 labeled tetrahydroisoquinoline derivatives as SERM radioligands for PET imaging of ER expression in breast cancer. Eur J Med Chem. 2008;43:2211-9 pubmed publisher

Zhou J, Yu D, Cheng J, Shapiro D. Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death. Steroids. 2007;72:765-77 pubmed

Bologa C, Revankar C, Young S, Edwards B, Arterburn J, Kiselyov A, et al. Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol. 2006;2:207-12 pubmed

Ito C, Itoigawa M, Kumagaya M, Okamoto Y, Ueda K, Nishihara T, et al. Isoflavonoids with antiestrogenic activity from Millettia pachycarpa. J Nat Prod. 2006;69:138-41 pubmed

Chao E, Collins J, Gaillard S, Miller A, Wang L, Orband Miller L, et al. Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg Med Chem Lett. 2006;16:821-4 pubmed

Clegg N, Paruthiyil S, Leitman D, Scanlan T. Differential response of estrogen receptor subtypes to 1,3-diarylindene and 2,3-diarylindene ligands. J Med Chem. 2005;48:5989-6003 pubmed

Lill M, Winiger F, Vedani A, Ernst B. Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. J Med Chem. 2005;48:5666-74 pubmed

Zuercher W, Gaillard S, Orband Miller L, Chao E, Shearer B, Jones D, et al. Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J Med Chem. 2005;48:3107-9 pubmed

Pigeon P, Top S, Vessieres A, Huché M, Hillard E, Salomon E, et al. Selective estrogen receptor modulators in the ruthenocene series. Synthesis and biological behavior. J Med Chem. 2005;48:2814-21 pubmed

Hoekstra W, Patel H, Liang X, Blanc J, Heyer D, Willson T, et al. Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling. J Med Chem. 2005;48:2243-7 pubmed

Obrero M, Yu D, Shapiro D. Estrogen receptor-dependent and estrogen receptor-independent pathways for tamoxifen and 4-hydroxytamoxifen-induced programmed cell death. J Biol Chem. 2002;277:45695-703 pubmed

Rabenoelina F, Semlali A, Duchesne M, Freiss G, Pons M, Badia E. Effect of prolonged hydroxytamoxifen treatment of MCF-7 cells on mitogen activated kinase cascade. Int J Cancer. 2002;98:698-706 pubmed

Arakawa H, Lodygin D, Buerstedde J. Mutant loxP vectors for selectable marker recycle and conditional knock-outs. BMC Biotechnol. 2001;1:7 pubmed

Zhang C, Shapiro D. Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis. J Biol Chem. 2000;275:479-86 pubmed

Murphy C, Langan Fahey S, McCague R, Jordan V. Structure-function relationships of hydroxylated metabolites of tamoxifen that control the proliferation of estrogen-responsive T47D breast cancer cells in vitro. Mol Pharmacol. 1990;38:737-43 pubmed