Bai P, Liu Y, Xue S, Hamri G, Saxena P, Ye H, et al. A fully human transgene switch to regulate therapeutic protein production by cooling sensation. Nat Med. 2019;25:1266-1273 pubmed publisher

Sahoo S, Singh P, Kalha B, Singh O, Pal R. Gonadotropin-mediated chemoresistance: Delineation of molecular pathways and targets. BMC Cancer. 2015;15:931 pubmed publisher

Knight J, Mak G, Shaw J, Porter P, McDermott C, Roberts L, et al. Long-Acting Beta Agonists Enhance Allergic Airway Disease. PLoS ONE. 2015;10:e0142212 pubmed publisher

Ranganath S, Bhandari A, Avitahl Curtis N, McMahon J, Wachtel D, Zhang J, et al. Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo. PLoS ONE. 2015;10:e0141330 pubmed publisher

Castellana B, Aasen T, Moreno Bueno G, Dunn S, Ramón y Cajal S. Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells. Oncotarget. 2015;6:38239-56 pubmed publisher

de Mattos Arruda L, Bottai G, Nuciforo P, Di Tommaso L, Giovannetti E, Peg V, et al. MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients. Oncotarget. 2015;6:37269-80 pubmed publisher

Wienke J, Janssen W, Scholman R, Spits H, van Gijn M, Boes M, et al. A novel human STAT3 mutation presents with autoimmunity involving Th17 hyperactivation. Oncotarget. 2015;6:20037-42 pubmed

Lin W, Yi Z, Stunz L, Maine C, Sherman L, Bishop G. The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development. Sci Signal. 2015;8:ra88 pubmed publisher

Liu R, Li X, Zhang Z, Zhou M, Sun Y, Su D, et al. Allogeneic mesenchymal stem cells inhibited T follicular helper cell generation in rheumatoid arthritis. Sci Rep. 2015;5:12777 pubmed publisher

Dong B, Shi Z, Wang J, Wu J, Yang Z, Fang K. IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate Cancer. PLoS ONE. 2015;10:e0134366 pubmed publisher

Huang R, Chen G, Wang W, Herller T, Xie Y, Gu B, et al. Synergy between IL-6 and soluble IL-6 receptor enhances bone morphogenetic protein-2/absorbable collagen sponge-induced bone regeneration via regulation of BMPRIA distribution and degradation. Biomaterials. 2015;67:308-22 pubmed publisher

Lissat A, Joerschke M, Shinde D, Braunschweig T, Meier A, Makowska A, et al. IL6 secreted by Ewing sarcoma tumor microenvironment confers anti-apoptotic and cell-disseminating paracrine responses in Ewing sarcoma cells. BMC Cancer. 2015;15:552 pubmed publisher

Patel S, Gooderham N. IL6 Mediates Immune and Colorectal Cancer Cell Cross-talk via miR-21 and miR-29b. Mol Cancer Res. 2015;13:1502-8 pubmed publisher

Fujimoto K, Ida H, Hirota Y, Ishigai M, Amano J, Tanaka Y. Intracellular Dynamics and Fate of a Humanized Anti-Interleukin-6 Receptor Monoclonal Antibody, Tocilizumab. Mol Pharmacol. 2015;88:660-75 pubmed publisher

Ma S, Zhuang Q, Shen W, Peng Y, Qiu Y. Interleukin-6 reduces NMDAR-mediated cytosolic Ca²⁺ overload and neuronal death via JAK/CaN signaling. Cell Calcium. 2015;58:286-95 pubmed publisher

Lu X, Luo F, Liu Y, Zhang A, Li J, Wang B, et al. The IL-6/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes. Toxicol Lett. 2015;237:191-9 pubmed publisher

Xue Q, Lu Y, Eisele M, Sulistijo E, Khan N, Fan R, et al. Analysis of single-cell cytokine secretion reveals a role for paracrine signaling in coordinating macrophage responses to TLR4 stimulation. Sci Signal. 2015;8:ra59 pubmed publisher

Kawano A, Kadomatsu R, Ono M, Kojima S, Tsukimoto M, Sakamoto H. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS ONE. 2015;10:e0127919 pubmed publisher

Minichsdorfer C, Wasinger C, Sieczkowski E, Atil B, Hohenegger M. Tocilizumab unmasks a stage-dependent interleukin-6 component in statin-induced apoptosis of metastatic melanoma cells. Melanoma Res. 2015;25:284-94 pubmed publisher

Relja B, Omid N, Schaible A, Perl M, Meier S, Oppermann E, et al. Pre- or post-treatment with ethanol and ethyl pyruvate results in distinct anti-inflammatory responses of human lung epithelial cells triggered by interleukin-6. Mol Med Rep. 2015;12:2991-8 pubmed publisher

Borowiec A, Kontny E, Smolis Bąk E, Kowalik I, Majos E, Załucka L, et al. Prospective assessment of cytokine IL-15 activity in patients with refractory atrial fibrillation episodes. Cytokine. 2015;74:164-70 pubmed publisher

Schütz A, Röser K, Klitzsch J, Lieder F, Aberger F, Gruber W, et al. Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation. Transl Oncol. 2015;8:97-105 pubmed publisher

Li P, Shan J, Chen X, Zhang D, Su L, Huang X, et al. Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment. Cell Res. 2015;25:588-603 pubmed publisher

Chen Q, Zhao M, Guo F, Yin Y, Xiao J, Stone P, et al. The reduction of circulating levels of IL-6 in pregnant women with preeclampsia by magnesium sulphate and nifedipine: In vitro evidence for potential mechanisms. Placenta. 2015;36:661-6 pubmed publisher

Stubbington M, Mahata B, Svensson V, Deonarine A, Nissen J, Betz A, et al. An atlas of mouse CD4(+) T cell transcriptomes. Biol Direct. 2015;10:14 pubmed publisher

Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, et al. Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. PLoS ONE. 2015;10:e0123232 pubmed publisher

Kajita A, Morizane S, Takiguchi T, Yamamoto T, Yamada M, Iwatsuki K. Interferon-Gamma Enhances TLR3 Expression and Anti-Viral Activity in Keratinocytes. J Invest Dermatol. 2015;135:2005-2011 pubmed publisher

Joo M, Park J, Kim S, Yoo H, Lee B, Chun H, et al. Antitumorigenic effect of plumbagin by induction of SH2-containing protein tyrosine phosphatase 1 in human gastric cancer cells. Int J Oncol. 2015;46:2380-8 pubmed publisher

Siwetz M, Dieber Rotheneder M, Cervar Zivkovic M, Kummer D, Kremshofer J, Weiss G, et al. Placental fractalkine is up-regulated in severe early-onset preeclampsia. Am J Pathol. 2015;185:1334-43 pubmed publisher

Bouezzedine F, Fardel O, Gripon P. Interleukin 6 inhibits HBV entry through NTCP down regulation. Virology. 2015;481:34-42 pubmed publisher

Luo Q, Zhang J, Wang H, Chen F, Luo X, Miao B, et al. Expression and Regulation of Transcription Factor FoxA2 in Chronic Rhinosinusitis With and Without Nasal Polyps. Allergy Asthma Immunol Res. 2015;7:458-66 pubmed publisher

Mao F, Xu M, Zuo X, Yu J, Xu W, Moussalli M, et al. 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. FASEB J. 2015;29:2359-70 pubmed publisher

Nikkheslat N, Zunszain P, Horowitz M, Barbosa I, Parker J, Myint A, et al. Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression. Brain Behav Immun. 2015;48:8-18 pubmed publisher

Gritsina G, Xiao F, O Brien S, Gabbasov R, Maglaty M, Xu R, et al. Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth. Mol Cancer Ther. 2015;14:1035-47 pubmed publisher

Kawabata H, Uchiyama T, Sakamoto S, Kanda J, Oishi S, Fujii N, et al. A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. Exp Hematol. 2015;43:404-413.e5 pubmed publisher

Kondo M, Yamaoka K, Sakata K, Sonomoto K, Lin L, Nakano K, et al. Contribution of the Interleukin-6/STAT-3 Signaling Pathway to Chondrogenic Differentiation of Human Mesenchymal Stem Cells. Arthritis Rheumatol. 2015;67:1250-60 pubmed publisher

Lai C, Moon Y, Kuchenbauer F, Starzcynowski D, Argiropoulos B, Yung E, et al. Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene. PLoS ONE. 2014;9:e112671 pubmed publisher

Kshirsagar S, Riedl M, Billing H, Tönshoff B, Thangavadivel S, Steuber C, et al. Akt-dependent enhanced migratory capacity of Th17 cells from children with lupus nephritis. J Immunol. 2014;193:4895-903 pubmed publisher

Caiello I, Minnone G, Holzinger D, Vogl T, Prencipe G, Manzo A, et al. IL-6 amplifies TLR mediated cytokine and chemokine production: implications for the pathogenesis of rheumatic inflammatory diseases. PLoS ONE. 2014;9:e107886 pubmed publisher

Wang S, Hu J, Guo Q, Zhao Y, Cheng J, Zhang D, et al. AZD1480, a JAK inhibitor, inhibits cell growth and survival of colorectal cancer via modulating the JAK2/STAT3 signaling pathway. Oncol Rep. 2014;32:1991-8 pubmed publisher

Mandai H, Omori K, Yamamoto D, Tsumura T, Murota K, Yamamoto S, et al. Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts. Bioorg Med Chem. 2014;22:5338-44 pubmed publisher

Kåbjörn Gustafsson C, Ståhlberg A, Engtröm K, Danielsson A, Turesson I, Aman P. Cell senescence in myxoid/round cell liposarcoma. Sarcoma. 2014;2014:208786 pubmed publisher

Li C, Xu F, Chow S, Feng L, Yin D, Ng T, et al. Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression. Eur J Cancer. 2014;50:2560-9 pubmed publisher

O TOOLE A, Michielsen A, Nolan B, Tosetto M, Sheahan K, Mulcahy H, et al. Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive. Br J Cancer. 2014;111:927-32 pubmed publisher

Melemedjian O, Tillu D, Moy J, Asiedu M, Mandell E, Ghosh S, et al. Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Mol Pain. 2014;10:45 pubmed publisher

Yan H, Huang X, Ke S, Jiang Y, Zhang Y, Wang Y, et al. Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activation. Cancer Sci. 2014;105:1220-7 pubmed publisher

Zhao Y, Yao J, Wu X, Zhao L, Zhou Y, Zhang Y, et al. Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway. Mol Carcinog. 2015;54 Suppl 1:E81-93 pubmed publisher

Arranz Valsero I, Soriano Romaní L, García Posadas L, López García A, Diebold Y. IL-6 as a corneal wound healing mediator in an in vitro scratch assay. Exp Eye Res. 2014;125:183-92 pubmed publisher

Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, et al. Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition. Cancer Res. 2014;74:4458-69 pubmed publisher

Song L, Smith M, Doshi P, Sasser K, Fulp W, Altiok S, et al. Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer. J Thorac Oncol. 2014;9:974-82 pubmed publisher

Fischer A, Zelinka C, Gallina D, Scott M, Todd L. Reactive microglia and macrophage facilitate the formation of Müller glia-derived retinal progenitors. Glia. 2014;62:1608-28 pubmed publisher

Linher Melville K, Singh G. The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells. BMC Cancer. 2014;14:415 pubmed publisher

Mace T, King S, Ameen Z, Elnaggar O, Young G, Riedl K, et al. Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling. Cancer Immunol Immunother. 2014;63:889-900 pubmed publisher

Vartoukian S, Tilakaratne W, Seoudi N, Bombardieri M, Bergmeier L, Tappuni A, et al. Dysregulation of the suppressor of cytokine signalling 3-signal transducer and activator of transcription-3 pathway in the aetiopathogenesis of Sjögren's syndrome. Clin Exp Immunol. 2014;177:618-29 pubmed publisher

Duek A, Lundberg P, Shimizu T, Grisouard J, Karow A, Kubovcakova L, et al. Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs. Blood. 2014;123:3943-50 pubmed publisher

Catalli A, Karpov V, Erdos L, Tancowny B, Schleimer R, Kulka M. Stimulus-selective regulation of human mast cell gene expression, degranulation and leukotriene production by fluticasone and salmeterol. PLoS ONE. 2014;9:e96891 pubmed publisher

Miao J, Liu L, Huang J. Interleukin-6-induced epithelial-mesenchymal transition through signal transducer and activator of transcription 3 in human cervical carcinoma. Int J Oncol. 2014;45:165-76 pubmed publisher

Jimeno R, Leceta J, Martinez C, Gutierrez Cañas I, Carrión M, Pérez García S, et al. Vasoactive intestinal peptide maintains the nonpathogenic profile of human th17-polarized cells. J Mol Neurosci. 2014;54:512-25 pubmed publisher

Abdi J, Mutis T, Garssen J, Redegeld F. Toll-like receptor (TLR)-1/2 triggering of multiple myeloma cells modulates their adhesion to bone marrow stromal cells and enhances bortezomib-induced apoptosis. PLoS ONE. 2014;9:e96608 pubmed publisher

Zhao Z, Cheng X, Wang Y, Han R, Li L, Xiang T, et al. Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis. PLoS ONE. 2014;9:e95884 pubmed publisher

Cai Y, Yuchi Y, De Groef S, Coppens V, Leuckx G, Baeyens L, et al. IL-6-dependent proliferation of alpha cells in mice with partial pancreatic-duct ligation. Diabetologia. 2014;57:1420-7 pubmed publisher

Borsi E, Perrone G, Terragna C, Martello M, Dico A, Solaini G, et al. Hypoxia inducible factor-1 alpha as a therapeutic target in multiple myeloma. Oncotarget. 2014;5:1779-92 pubmed

Lee H, Lee M, Bhang S, Kim B, Kim Y, Ju J, et al. Hyaluronate-gold nanoparticle/tocilizumab complex for the treatment of rheumatoid arthritis. ACS Nano. 2014;8:4790-8 pubmed publisher

Bu Y, Su F, Wang X, Gao H, Lei L, Chang N, et al. Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish. J Cell Sci. 2014;127:2761-70 pubmed publisher

Dehai C, Bo P, Qiang T, Lihua S, Fang L, Shi J, et al. Enhanced invasion of lung adenocarcinoma cells after co-culture with THP-1-derived macrophages via the induction of EMT by IL-6. Immunol Lett. 2014;160:1-10 pubmed publisher

Li L, Han R, Xiao H, Lin C, Wang Y, Liu H, et al. Metformin sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal. Clin Cancer Res. 2014;20:2714-26 pubmed publisher

Seed T, Inal C, Singh V. Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis. Int J Radiat Biol. 2014;90:594-604 pubmed publisher

Shive C, Mudd J, Funderburg N, Sieg S, Kyi B, Bazdar D, et al. Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease. J Infect Dis. 2014;210:619-29 pubmed publisher

Minashima T, Zhang Y, Lee Y, Kirsch T. Lithium protects against cartilage degradation in osteoarthritis. Arthritis Rheumatol. 2014;66:1228-36 pubmed publisher

Imai F, Kishi H, Nakao K, Nishimura T, Minegishi T. IL-6 up-regulates the expression of rat LH receptors during granulosa cell differentiation. Endocrinology. 2014;155:1436-44 pubmed publisher

Zhang B, Yin Y, Lai R, Tan S, Choo A, Lim S. Mesenchymal stem cells secrete immunologically active exosomes. Stem Cells Dev. 2014;23:1233-44 pubmed publisher

Johnston P, Sen M, Hua Y, Camarco D, Shun T, Lazo J, et al. High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines. Assay Drug Dev Technol. 2014;12:55-79 pubmed publisher