This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Hepatocyte Growth Factor human
catalog :
H5791
citations: 40
Reference
Pedersen N, Wenzel E, Wang L, Antoine S, Chavrier P, Stenmark H, et al. Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion. J Cell Biol. 2020;219: pubmed publisher
Essex A, Pineda J, Acharya G, Xin H, Evans J, Iorns E, et al. Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. elife. 2019;8: pubmed publisher
Kumar D, New J, Vishwakarma V, Joshi R, Enders J, Lin F, et al. Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression. Cancer Res. 2018;78:3769-3782 pubmed publisher
Reebye V, Huang K, Lin V, Jarvis S, Cutilas P, Dorman S, et al. Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer. Oncogene. 2018;37:3216-3228 pubmed publisher
Nakamura M, Ono Y, Kanemura M, Tanaka T, Hayashi M, Terai Y, et al. Hepatocyte growth factor secreted by ovarian cancer cells stimulates peritoneal implantation via the mesothelial-mesenchymal transition of the peritoneum. Gynecol Oncol. 2015;139:345-54 pubmed publisher
Gao W, Kim H, Ho M. Human Monoclonal Antibody Targeting the Heparan Sulfate Chains of Glypican-3 Inhibits HGF-Mediated Migration and Motility of Hepatocellular Carcinoma Cells. PLoS ONE. 2015;10:e0137664 pubmed publisher
Evans J, Essex A, Xin H, Amitai N, Brinton L, Griner E. Registered report: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. elife. 2015;4: pubmed publisher
Peron M, Lovisa F, Poli E, Basso G, Bonvini P. Understanding the Interplay between Expression, Mutation and Activity of ALK Receptor in Rhabdomyosarcoma Cells for Clinical Application of Small-Molecule Inhibitors. PLoS ONE. 2015;10:e0132330 pubmed publisher
Xie C, Sun H, Wang F, Li Z, Yin Y, Fang Q, et al. Integrated analysis of gene expression and DNA methylation changes induced by hepatocyte growth factor in human hepatocytes. Mol Med Rep. 2015;12:4250-4258 pubmed publisher
Ren X, Meng Z, Yang H, Li H, Xu K, Zheng W, et al. Synergistic Effects of Combining Anti-Midkine and Hepatocyte Growth Factor Therapies Against Diabetic Nephropathy in Rats. Am J Med Sci. 2015;350:47-54 pubmed publisher
Wu H, Fan F, Liu Z, Shen C, Wang A, Lu Y. Norcantharidin combined with EGFR-TKIs overcomes HGF-induced resistance to EGFR-TKIs in EGFR mutant lung cancer cells via inhibition of Met/PI3k/Akt pathway. Cancer Chemother Pharmacol. 2015;76:307-15 pubmed publisher
Ozawa Y, Nakamura Y, Fujishima F, Felizola S, Takeda K, Okamoto H, et al. c-Met in esophageal squamous cell carcinoma: an independent prognostic factor and potential therapeutic target. BMC Cancer. 2015;15:451 pubmed publisher
Montagne R, Berbon M, Doublet L, Debreuck N, Baranzelli A, Drobecq H, et al. Necrosis- and apoptosis-related Met cleavages have divergent functional consequences. Cell Death Dis. 2015;6:e1769 pubmed publisher
Wang L, Lin L, Chen X, Sun L, Liao Y, Huang N, et al. Metastasis-associated in colon cancer-1 promotes vasculogenic mimicry in gastric cancer by upregulating TWIST1/2. Oncotarget. 2015;6:11492-506 pubmed
Zoratti G, Tanabe L, Varela F, Murray A, Bergum C, Colombo Ã, et al. Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nat Commun. 2015;6:6776 pubmed publisher
Ohta K, Hoshino H, Wang J, Ono S, Iida Y, Hata K, et al. MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A. Oncotarget. 2015;6:3211-24 pubmed
Chang J, Wang S, Zhang Z, Liu X, Wu Z, Geng R, et al. Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer. Oncotarget. 2015;6:2009-22 pubmed
Cazet A, Charest J, Bennett D, Sambrooks C, Contessa J. Mannose phosphate isomerase regulates fibroblast growth factor receptor family signaling and glioma radiosensitivity. PLoS ONE. 2014;9:e110345 pubmed publisher
Kikkawa Y, Nakagawa T, Ying L, Tabata Y, Tsubouchi H, Ido A, et al. Growth factor-eluting cochlear implant electrode: impact on residual auditory function, insertional trauma, and fibrosis. J Transl Med. 2014;12:280 pubmed publisher
Koh S, Kim M, Lee K, Kim S, Kim J. RhoGDI2 is associated with HGF-mediated tumor invasion through VEGF in stomach cancer. Clin Exp Metastasis. 2014;31:805-15 pubmed publisher
Kanteti R, Dhanasingh I, Kawada I, Lennon F, Arif Q, Bueno R, et al. MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma. PLoS ONE. 2014;9:e105919 pubmed publisher
Pennacchietti S, Cazzanti M, Bertotti A, Rideout W, Han M, Gyuris J, et al. Microenvironment-derived HGF overcomes genetically determined sensitivity to anti-MET drugs. Cancer Res. 2014;74:6598-609 pubmed publisher
Zhang Z, Wang J, Ji D, Wang C, Liu R, Wu Z, et al. Functional genetic approach identifies MET, HER3, IGF1R, INSR pathways as determinants of lapatinib unresponsiveness in HER2-positive gastric cancer. Clin Cancer Res. 2014;20:4559-73 pubmed publisher
Tsai P, Chu C, Tseng C, Chen Y, Chang L, Lin S. Inhibitory action of naphtho[1,2-b]furan-4,5-dione on hepatocyte growth factor-induced migration and invasion of MDA-MB-231 cells: mechanisms of action. Clin Exp Pharmacol Physiol. 2014;41:716-26 pubmed publisher
Patnaik A, Weiss G, Papadopoulos K, Hofmeister C, Tibes R, Tolcher A, et al. Phase I ficlatuzumab monotherapy or with erlotinib for refractory advanced solid tumours and multiple myeloma. Br J Cancer. 2014;111:272-80 pubmed publisher
Arlov Ø, Aachmann F, Sundan A, Espevik T, Skjåk Bræk G. Heparin-like properties of sulfated alginates with defined sequences and sulfation degrees. Biomacromolecules. 2014;15:2744-50 pubmed publisher
Oppelt A, Haugsten E, Zech T, Danielsen H, Sveen A, Lobert V, et al. PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1. Biochem J. 2014;461:383-90 pubmed publisher
Ménard L, Parker P, Kermorgant S. Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways. Nat Commun. 2014;5:3907 pubmed publisher
Diem M, Hyun L, Yi F, Hippensteel R, Kuhar E, Lowenstein C, et al. Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions. Protein Eng Des Sel. 2014;27:419-29 pubmed publisher
Ito Y, Correll K, Schiel J, Finigan J, Prekeris R, Mason R. Lung fibroblasts accelerate wound closure in human alveolar epithelial cells through hepatocyte growth factor/c-Met signaling. Am J Physiol Lung Cell Mol Physiol. 2014;307:L94-105 pubmed publisher
Nakagawa T, Matsushima T, Kawano S, Nakazawa Y, Kato Y, Adachi Y, et al. Lenvatinib in combination with golvatinib overcomes hepatocyte growth factor pathway-induced resistance to vascular endothelial growth factor receptor inhibitor. Cancer Sci. 2014;105:723-30 pubmed publisher
Tabernero J, Elez M, Herranz M, Rico I, Prudkin L, Andreu J, et al. A pharmacodynamic/pharmacokinetic study of ficlatuzumab in patients with advanced solid tumors and liver metastases. Clin Cancer Res. 2014;20:2793-804 pubmed publisher
Kusunoki H, Taniyama Y, Otsu R, Rakugi H, Morishita R. Anti-inflammatory effects of hepatocyte growth factor on the vicious cycle of macrophages and adipocytes. Hypertens Res. 2014;37:500-6 pubmed publisher
Meng L, Shu M, Chen Y, Yang D, He Q, Zhao H, et al. A novel lead compound CM-118: antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers. Cancer Biol Ther. 2014;15:721-34 pubmed publisher
Valletta D, Czech B, Spruss T, Ikenberg K, Wild P, Hartmann A, et al. Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma. Carcinogenesis. 2014;35:1407-15 pubmed publisher
Isono K, Jono H, Ohya Y, Shiraki N, Yamazoe T, Sugasaki A, et al. Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells. Stem Cell Res. 2014;12:574-83 pubmed publisher
Kim J, Kim W, Sung Y, Kwack M, Song S, Choi J, et al. The molecular mechanism underlying the proliferating and preconditioning effect of vitamin C on adipose-derived stem cells. Stem Cells Dev. 2014;23:1364-76 pubmed publisher
Okada M, Ishkitiev N, Yaegaki K, Imai T, Tanaka T, Fukuda M, et al. Hydrogen sulphide increases hepatic differentiation of human tooth pulp stem cells compared with human bone marrow stem cells. Int Endod J. 2014;47:1142-50 pubmed publisher
Mahtouk K, Tjin E, Spaargaren M, Pals S. The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas. Biochim Biophys Acta. 2010;1806:208-19 pubmed publisher
Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A, et al. Molecular cloning and expression of human hepatocyte growth factor. Nature. 1989;342:440-3 pubmed
product information
Catalog Number :
H5791
Product Name :
Hepatocyte Growth Factor human
Product Type :
GROWTH FACTORS
Product Group :
Cell Biology
Product Description :
HGF, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA