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Shu Z, Miao X, Tang T, Zhan P, Zeng L, Jiang Y. The GSK‑3β/β‑catenin signaling pathway is involved in HMGB1‑induced chondrocyte apoptosis and cartilage matrix degradation. Int J Mol Med. 2020;45:769-778 pubmed publisher

Shang J, Liu W, Yin C, Chu H, Zhang M. Cucurbitacin E ameliorates lipopolysaccharide-evoked injury, inflammation and MUC5AC expression in bronchial epithelial cells by restraining the HMGB1-TLR4-NF-κB signaling. Mol Immunol. 2019;114:571-577 pubmed publisher

Zhang L, Yang X, Jiang G, Yu Y, Wu J, Su Y, et al. HMGB1 enhances mechanical stress-induced cardiomyocyte hypertrophy in vitro via the RAGE/ERK1/2 signaling pathway. Int J Mol Med. 2019;44:885-892 pubmed publisher

Ma C, Chen H, Zhang S, Yan Y, Wu R, Wang Y, et al. Exosomal and extracellular HMGB1 have opposite effects on SASH1 expression in rat astrocytes and glioma C6 cells. Biochem Biophys Res Commun. 2019;518:325-330 pubmed publisher

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Tao X, Sun M, Chen M, Ying R, Su W, Zhang J, et al. HMGB1-modified mesenchymal stem cells attenuate radiation-induced vascular injury possibly via their high motility and facilitation of endothelial differentiation. Stem Cell Res Ther. 2019;10:92 pubmed publisher

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Hua S, Ma M, Fei X, Zhang Y, Gong F, Fang M. Glycyrrhizin attenuates hepatic ischemia-reperfusion injury by suppressing HMGB1-dependent GSDMD-mediated kupffer cells pyroptosis. Int Immunopharmacol. 2019;68:145-155 pubmed publisher

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Qu J, Zhang Z, Zhang P, Zheng C, Zhou W, Cui W, et al. Downregulation of HMGB1 is required for the protective role of Nrf2 in EMT-mediated PF. J Cell Physiol. 2019;234:8862-8872 pubmed publisher

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Chen X, Ma J, Kwan T, Stribos E, Messchendorp A, Loh Y, et al. Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice. Sci Rep. 2018;8:8319 pubmed publisher

Zhao J, Yu J, Xu Y, Chen L, Zhou F, Zhai Q, et al. Epidermal HMGB1 Activates Dermal Fibroblasts and Causes Hypertrophic Scar Formation in Reduced Hydration. J Invest Dermatol. 2018;138:2322-2332 pubmed publisher

Wang H, Chen Y, Guo J, Shan T, Deng K, Chen J, et al. Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1. Sci Rep. 2018;8:7080 pubmed publisher

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Hu J, Vacas S, Feng X, Lutrin D, Uchida Y, Lai I, et al. Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice. Anesthesiology. 2018;128:921-931 pubmed publisher

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Wang F, Yang X, Ma Y, Wei Y, Yang M, Chen X, et al. TRIF contributes to epileptogenesis in temporal lobe epilepsy during TLR4 activation. Brain Behav Immun. 2018;67:65-76 pubmed publisher

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Sun L, Li M, Ma X, Feng H, Song J, Lv C, et al. Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-?B signaling in an IL-6-dependent manner. J Neuroinflammation. 2017;14:231 pubmed publisher

Park E, Kim Y, Chang K. Hemin Reduces HMGB1 Release by UVB in an AMPK/HO-1-dependent Pathway in Human Keratinocytes HaCaT Cells. Arch Med Res. 2017;48:423-431 pubmed publisher

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Shimizu K, Kamada Y, Sakamoto A, Matsuda M, Nakatsuka M, Hiramatsu Y. High Expression of High-Mobility Group Box 1 in Menstrual Blood: Implications for Endometriosis. Reprod Sci. 2017;24:1532-1537 pubmed publisher

Wong S, To J, Santos J, Allam V, Dalton J, Djordjevic S, et al. Proteomic Analysis of Extracellular HMGB1 Identifies Binding Partners and Exposes Its Potential Role in Airway Epithelial Cell Homeostasis. J Proteome Res. 2017;: pubmed publisher

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Zhu J, Wang F, Wang H, Dong N, Zhu X, Wu Y, et al. TNF-α mRNA is negatively regulated by microRNA-181a-5p in maturation of dendritic cells induced by high mobility group box-1 protein. Sci Rep. 2017;7:12239 pubmed publisher

Azizan N, Suter M, Liu Y, Logsdon C. RAGE maintains high levels of NF?B and oncogenic Kras activity in pancreatic cancer. Biochem Biophys Res Commun. 2017;493:592-597 pubmed publisher

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Lee I, Kim D, Bae J. Sulforaphane Reduces HMGB1-Mediated Septic Responses and Improves Survival Rate in Septic Mice. Am J Chin Med. 2017;45:1253-1271 pubmed publisher

Zhou Y, Han Q, Wang L, Liu T, Meng X, Wu L, et al. High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen-activated protein kinase signaling pathway. Exp Ther Med. 2017;14:1582-1588 pubmed publisher

Deng H, Wang C, Chang D, Hu N, Chen M, Zhao M. High mobility group box-1 contributes to anti-myeloperoxidase antibody-induced glomerular endothelial cell injury through a moesin-dependent route. Arthritis Res Ther. 2017;19:125 pubmed publisher

Choi J, Cui Y, Chowdhury S, Kim B. High-mobility group box-1 as an autocrine trophic factor in white matter stroke. Proc Natl Acad Sci U S A. 2017;114:E4987-E4995 pubmed publisher

Tang L, Chai W, Ye F, Yu Y, Cao L, Yang M, et al. HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells. Oncotarget. 2017;8:27314-27327 pubmed publisher

Di Candia L, Gomez E, Venereau E, Chachi L, Kaur D, Bianchi M, et al. HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4. J Allergy Clin Immunol. 2017;140:584-587.e8 pubmed publisher

Schaper F, de Leeuw K, Horst G, Maas F, Bootsma H, Heeringa P, et al. Autoantibodies to box A of high mobility group box 1 in systemic lupus erythematosus. Clin Exp Immunol. 2017;188:412-419 pubmed publisher

Trinh Q, Pham N, Fuwa K, Takada K, Komine Aizawa S, Honda M, et al. High Mobility Group Box 1 Protein Enhances HIV Replication in Newly Infected Primary T Cells. Clin Lab. 2016;62:2305-2311 pubmed publisher

Manfredi A, Rovere Querini P, D Angelo A, Maugeri N. Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps. Pharmacol Res. 2017;123:146-156 pubmed publisher

Chen X, Fang D, Li L, Chen L, Li Q, Gong F, et al. Glycyrrhizin ameliorates experimental colitis through attenuating interleukin-17-producing T cell responses via regulating antigen-presenting cells. Immunol Res. 2017;65:666-680 pubmed publisher

Zhu X, Chen X, Wang W, Li X, Huo J, Wang Y, et al. Electroacupuncture pretreatment attenuates spinal cord ischemia-reperfusion injury via inhibition of high-mobility group box 1 production in a LXA4 receptor-dependent manner. Brain Res. 2017;1659:113-120 pubmed publisher

Su Z, Ni P, She P, Liu Y, Richard S, Xu W, et al. Bio-HMGB1 from breast cancer contributes to M-MDSC differentiation from bone marrow progenitor cells and facilitates conversion of monocytes into MDSC-like cells. Cancer Immunol Immunother. 2017;66:391-401 pubmed publisher

Min G, Ku S, Park M, Park T, Lee H, Bae J. Anti-septic effects of pelargonidin on HMGB1-induced responses in vitro and in vivo. Arch Pharm Res. 2016;39:1726-1738 pubmed publisher

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Zheng S, Kummarapurugu A, Afosah D, Sankaranarayanan N, Boothello R, Desai U, et al. 2-O, 3-O Desulfated Heparin Blocks High Mobility Group Box 1 Release by Inhibition of p300 Acetyltransferase Activity. Am J Respir Cell Mol Biol. 2017;56:90-98 pubmed publisher

Wang K, Li W, Yu Q, Guo B, Yang B, Zhang C, et al. High Mobility Group Box 1 Mediates Interferon-γ-Induced Phenotypic Modulation of Vascular Smooth Muscle Cells. J Cell Biochem. 2017;118:518-529 pubmed publisher

Shang D, Peng T, Gou S, Li Y, Wu H, Wang C, et al. High Mobility Group Box Protein 1 Boosts Endothelial Albumin Transcytosis through the RAGE/Src/Caveolin-1 Pathway. Sci Rep. 2016;6:32180 pubmed publisher

Li J, Huang L, Wang S, Yao Y, Zhang Z. Astragaloside IV attenuates inflammatory reaction via activating immune function of regulatory T-cells inhibited by HMGB1 in mice. Pharm Biol. 2016;54:3217-3225 pubmed

Mohammad G, Jomar D, Siddiquei M, Alam K, Abu El Asrar A. High-Mobility Group Box-1 Protein Mediates the Regulation of Signal Transducer and Activator of Transcription-3 in the Diabetic Retina and in Human Retinal Müller Cells. Ophthalmic Res. 2017;57:150-160 pubmed publisher

Xu J, Wang H, Won S, Basu J, Kapfhamer D, Swanson R. Microglial activation induced by the alarmin S100B is regulated by poly(ADP-ribose) polymerase-1. Glia. 2016;64:1869-78 pubmed publisher

Li Z, Scott M, Fan E, Li Y, Liu J, Xiao G, et al. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death Differ. 2016;23:1428-47 pubmed publisher

Lai C, Wang K, Lee F, Tsai H, Ma C, Cheng T, et al. Toll-Like Receptor 4 Is Essential in the Development of Abdominal Aortic Aneurysm. PLoS ONE. 2016;11:e0146565 pubmed publisher

Chen Y, Statt S, Wu R, Chang H, Liao J, Wang C, et al. High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells. Sci Rep. 2016;6:18815 pubmed publisher

Ma Y, Ma T, Wang C, Wang H, Chang D, Chen M, et al. High-mobility group box 1 potentiates antineutrophil cytoplasmic antibody-inducing neutrophil extracellular traps formation. Arthritis Res Ther. 2016;18:2 pubmed publisher

Man L, Liu F, Wang Y, Song H, Xu H, Zhu Z, et al. The HMGB1 signaling pathway activates the inflammatory response in Schwann cells. Neural Regen Res. 2015;10:1706-12 pubmed publisher

Yao H, Zhou M, Zhou Y, Wang L, Zhang D, Han Q, et al. Intravenous high mobility group box 1 upregulates the expression of HIF-1α in the myocardium via a protein kinase B-dependent pathway in rats following acute myocardial ischemia. Mol Med Rep. 2016;13:1211-9 pubmed publisher

Appavoo E, Hajam I, Muneeswaran N, Kondabattula G, Bhanuprakash V, Kishore S. Synergistic effect of high-mobility group box-1 and lipopolysaccharide on cytokine induction in bovine peripheral blood mononuclear cells. Microbiol Immunol. 2016;60:196-202 pubmed publisher

Shao M, Tang S, Liu B, Zhu H. Rac1 mediates HMGB1‑induced hyperpermeability in pulmonary microvascular endothelial cells via MAPK signal transduction. Mol Med Rep. 2016;13:529-35 pubmed publisher

Wang B, Li F, Zhang C, Wei G, Liao P, Dong N. High-mobility group box-1 protein induces osteogenic phenotype changes in aortic valve interstitial cells. J Thorac Cardiovasc Surg. 2016;151:255-62 pubmed publisher

Liu Z, Wang Z, Han G, Huang L, Jiang J, Li S. Ketamine attenuates high mobility group box-1-induced inflammatory responses in endothelial cells. J Surg Res. 2016;200:593-603 pubmed publisher

Ojo O, Ryu M, Jha A, Unruh H, Halayko A. High-mobility group box 1 promotes extracellular matrix synthesis and wound repair in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2015;309:L1354-66 pubmed publisher

Zhu X, Sun L, Wang Y. High mobility group box 1 (HMGB1) is upregulated by the Epstein-Barr virus infection and promotes the proliferation of human nasopharyngeal carcinoma cells. Acta Otolaryngol. 2016;136:87-94 pubmed publisher

Zheng S, Pan Y, Wang C, Liu Y, Shi M, Ding G. HMGB1 Turns Renal Tubular Epithelial Cells into Inflammatory Promoters by Interacting with TLR4 During Sepsis. J Interferon Cytokine Res. 2016;36:9-19 pubmed publisher

Chen Y, Pitzer A, Li X, Li P, Wang L, Zhang Y. Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1. J Cell Mol Med. 2015;19:2715-27 pubmed publisher

Chen Y, Qiao F, Zhao Y, Wang Y, Liu G. HMGB1 is activated in type 2 diabetes mellitus patients and in mesangial cells in response to high glucose. Int J Clin Exp Pathol. 2015;8:6683-91 pubmed

Lee W, Yoon E, Kim K, Park D, Bae J. Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo. Can J Physiol Pharmacol. 2015;93:709-20 pubmed publisher

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Lee W, Kim K, Bae J. Ameliorative Effect of Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) on HMGB1-Induced Septic Responses In Vitro and In Vivo. Am J Chin Med. 2015;43:991-1012 pubmed publisher

Yang E, Ku S, Lee W, Song K, Bae J. Inhibitory effects of polyozellin from Polyozellus multiplex on HMGB1-mediated septic responses. Inflamm Res. 2015;64:733-46 pubmed publisher

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Liu Z, Du R, Long J, Guo K, Ge C, Bi S, et al. microRNA-218 promotes gemcitabine sensitivity in human pancreatic cancer cells by regulating HMGB1 expression. Chin J Cancer Res. 2015;27:267-78 pubmed publisher

Zhu L, Ren L, Chen Y, Fang J, Ge Z, Li X. Redox status of high-mobility group box 1 performs a dual role in angiogenesis of colorectal carcinoma. J Cell Mol Med. 2015;19:2128-35 pubmed publisher

Mohammad G, Alam K, Nawaz M, Siddiquei M, Mousa A, Abu El Asrar A. Mutual enhancement between high-mobility group box-1 and NADPH oxidase-derived reactive oxygen species mediates diabetes-induced upregulation of retinal apoptotic markers. J Physiol Biochem. 2015;71:359-72 pubmed publisher

Zhang W, Lavine K, Epelman S, Evans S, Weinheimer C, Barger P, et al. Necrotic myocardial cells release damage-associated molecular patterns that provoke fibroblast activation in vitro and trigger myocardial inflammation and fibrosis in vivo. J Am Heart Assoc. 2015;4:e001993 pubmed publisher

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Wang C, Wang H, Hao J, Chang D, Zhao M, Chen M. Involvement of high mobility group box 1 in the activation of C5a-primed neutrophils induced by ANCA. Clin Immunol. 2015;159:47-57 pubmed publisher

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Gargus M, Niu C, Vallone J, Binkley J, Rubin D, Shaker A. Human esophageal myofibroblasts secrete proinflammatory cytokines in response to acid and Toll-like receptor 4 ligands. Am J Physiol Gastrointest Liver Physiol. 2015;308:G904-23 pubmed

Matena J, Petersen S, Gieseke M, Kampmann A, Teske M, Beyerbach M, et al. SLM produced porous titanium implant improvements for enhanced vascularization and osteoblast seeding. Int J Mol Sci. 2015;16:7478-92 pubmed publisher

Chung H, Jang S, Kim H, Lim J. Combined targeting of high-mobility group box-1 and interleukin-8 to control micrometastasis potential in gastric cancer. Int J Cancer. 2015;137:1598-609 pubmed publisher

Wu T, Liu L, Zhang W, Zhang Y, Liu Y, Shen X, et al. High-mobility group box-1 was released actively and involved in LPS induced depressive-like behavior. J Psychiatr Res. 2015;64:99-106 pubmed publisher

Liu W, Zhang Z, Zhang Y, Chen X, Guo S, Lei Y, et al. HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway. Cancer Biol Ther. 2015;16:511-7 pubmed publisher

Lee W, Park E, Kwak S, Kim Y, Na D, Bae J. PEGylated lysozymes with anti-septic effects in human endothelial cells and in mice. Biochem Biophys Res Commun. 2015;459:662-7 pubmed publisher

Kim I, Luo L, Lee H, Lee H, Lee J. HMGB1-binding heptamer suppresses the synergistic effect of HMGB1 and LPS by interacting directly with HMGB1. Neurosci Lett. 2015;593:40-4 pubmed publisher

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Liu X, Yu D, Chen M, Sun T, Li G, Huang W, et al. Hesperidin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting HMGB1 release. Int Immunopharmacol. 2015;25:370-6 pubmed publisher

Zhang Q, Wu L, Zhang T, Han Y, Lin X. Autophagy-mediated HMGB1 release promotes gastric cancer cell survival via RAGE activation of extracellular signal-regulated kinases 1/2. Oncol Rep. 2015;33:1630-8 pubmed publisher

Yu S, Wong C, Szeto C, Li E, Cai Z, Tam L. Members of the receptor for advanced glycation end products axis as potential therapeutic targets in patients with lupus nephritis. Lupus. 2015;24:675-86 pubmed publisher

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Tripisciano C, Eichhorn T, Harm S, Weber V. Adsorption of the inflammatory mediator high-mobility group box 1 by polymers with different charge and porosity. Biomed Res Int. 2014;2014:238160 pubmed publisher

Hou C, Kong J, Liang Y, Huang H, Wen H, Zheng X, et al. HMGB1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts. Cell Mol Immunol. 2015;12:409-23 pubmed publisher

Duan E, Wang D, Luo R, Luo J, Gao L, Chen H, et al. Porcine reproductive and respiratory syndrome virus infection triggers HMGB1 release to promote inflammatory cytokine production. Virology. 2014;468-470:1-9 pubmed publisher

Kim H, Park S, Lee S, Lee H, Lee W, Rhim B, et al. Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis. PLoS ONE. 2014;9:e104743 pubmed publisher

Li Q, Li J, Wen T, Zeng W, Peng C, Yan S, et al. Overexpression of HMGB1 in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent pathway. Oncotarget. 2014;5:6387-403 pubmed

Jessop F, Holian A. Extracellular HMGB1 regulates multi-walled carbon nanotube-induced inflammation in vivo. Nanotoxicology. 2015;9:365-72 pubmed publisher

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Hayakawa K, Pham L, Arai K, Lo E. Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling. Stem Cell Res. 2014;12:531-8 pubmed publisher

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