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product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
DL-threo-β-Hydroxyaspartic acid
catalog :
H2775
citations: 30
Reference
Kanai Y, Clémençon B, Simonin A, Leuenberger M, Lochner M, Weisstanner M, et al. The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med. 2013;34:108-20 pubmed publisher
Laurido C, Hernandez A, Pelissier T, Constandil L. Antinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model. ScientificWorldJournal. 2012;2012:279147 pubmed publisher
Bionda N, Cudic M, Barišić L, Stawikowski M, Stawikowska R, Binetti D, et al. A practical synthesis of N α-Fmoc protected L-threo-β-hydroxyaspartic acid derivatives for coupling via α- or β-carboxylic group. Amino Acids. 2012;42:285-93 pubmed publisher
Liu X, Li C, Bu H, Li Z, Li B, Sun M, et al. Neuroprotective effect of CPDT on THA-induced cortical motor neuron death in an organotypic culture model. Brain Res Bull. 2010;83:345-50 pubmed publisher
Phillips R, Lima S, Khristoforov R, Sudararaju B. Insights into the mechanism of Pseudomonas dacunhae aspartate beta-decarboxylase from rapid-scanning stopped-flow kinetics. Biochemistry. 2010;49:5066-73 pubmed publisher
Naganska E, Taraszewska A, Matyja E, Grieb P, Rafałowska J. Neuroprotective effect of erythropoietin in amyotrophic lateral sclerosis (ALS) model in vitro. Ultrastructural study. Folia Neuropathol. 2010;48:35-44 pubmed
Kosuge Y, Sekikawa Nishida K, Negi H, Ishige K, Ito Y. Characterization of chronic glutamate-mediated motor neuron toxicity in organotypic spinal cord culture prepared from ALS model mice. Neurosci Lett. 2009;454:165-9 pubmed publisher
Kawakami Z, Kanno H, Ueki T, Terawaki K, Tabuchi M, Ikarashi Y, et al. Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells. Neuroscience. 2009;159:1397-407 pubmed publisher
Yu J, Guo Y, Sun M, Li B, Zhang Y, Li C. Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons. Brain Res. 2009;1257:102-7 pubmed publisher
Castellino F, Ploplis V, Zhang L. gamma-Glutamate and beta-hydroxyaspartate in proteins. Methods Mol Biol. 2008;446:85-94 pubmed publisher
Borisova T, Kasatkina L. Glutamate transporters of blood platelets as potential peripheral markers to analyze changes of glutamate transport activity in brain under altered gravity conditions. J Gravit Physiol. 2007;14:P81-2 pubmed
Hemendinger R, Armstrong E, Persinski R, Todd J, Mougeot J, Volvovitz F, et al. Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death. Neurotox Res. 2008;13:49-61 pubmed
Strieker M, Essen L, Walsh C, Marahiel M. Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid. Chembiochem. 2008;9:374-6 pubmed publisher
Bonomo J, Lynch M, Warnecke T, Price J, Gill R. Genome-scale analysis of anti-metabolite directed strain engineering. Metab Eng. 2008;10:109-20 pubmed
Khalaf J, Datta A. A concise, asymmetric synthesis of (2R,3R)-3-hydroxyaspartic acid. Amino Acids. 2008;35:507-10 pubmed
Myint A, Kim Y, Verkerk R, Park S, Scharpe S, Steinbusch H, et al. Tryptophan breakdown pathway in bipolar mania. J Affect Disord. 2007;102:65-72 pubmed
Borisova T, Krysanova N, Himmelreich N. [Modulating effect of glutamate transporter inhibitors on accumulation and release of the neuromediator by the brain nerve terminals in rats]. Ukr Biokhim Zh (1999). 2005;77:61-7 pubmed
Matyja E, Taraszewska A, Naganska E, Rafałowska J. Autophagic degeneration of motor neurons in a model of slow glutamate excitotoxicity in vitro. Ultrastruct Pathol. 2005;29:331-9 pubmed
Borisova T, Himmelreich N. Effects of the inhibitors on glutamate uptake by nerve terminals after exposure of rats to centrifuge-induced hypergravity. J Gravit Physiol. 2004;11:P37-8 pubmed
Meera P, Dodson P, Karakossian M, Otis T. Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons. Neuropharmacology. 2005;49:883-9 pubmed
Darman J, Backovic S, Dike S, Maragakis N, Krishnan C, Rothstein J, et al. Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity. J Neurosci. 2004;24:7566-75 pubmed
Lozovaya N, Melnik S, Tsintsadze T, Grebenyuk S, Kirichok Y, Krishtal O. Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density. Brain Res. 2004;1011:195-205 pubmed
Wang Z, Li W, Mitchell C, Carter Dawson L. Activation of protein kinase C reduces GLAST in the plasma membrane of rat Müller cells in primary culture. Vis Neurosci. 2003;20:611-9 pubmed
Hu J, Yang N, Ma Y, Jiang J, Zhang J, Fei J, et al. Identification of glutamate transporters and receptors in mouse testis. Acta Pharmacol Sin. 2004;25:366-71 pubmed
Zhang H, Sulzer D. Glutamate spillover in the striatum depresses dopaminergic transmission by activating group I metabotropic glutamate receptors. J Neurosci. 2003;23:10585-92 pubmed
Wada M, Nakamori S, Takagi H. Serine racemase homologue of Saccharomyces cerevisiae has L-threo-3-hydroxyaspartate dehydratase activity. FEMS Microbiol Lett. 2003;225:189-93 pubmed
Kidd F, Isaac J. Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortex. Neuropharmacology. 2000;39:725-32 pubmed
Shimamoto K, Lebrun B, Yasuda Kamatani Y, Sakaitani M, Shigeri Y, Yumoto N, et al. DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol Pharmacol. 1998;53:195-201 pubmed
Hirata A, Nakamura R, Kwak S, Nagata N, Kamakura K. AMPA receptor-mediated slow neuronal death in the rat spinal cord induced by long-term blockade of glutamate transporters with THA. Brain Res. 1997;771:37-44 pubmed
Klegeris A, Walker D, McGeer P. Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells. J Neuroimmunol. 1997;78:152-61 pubmed
product information
Catalog Number :
H2775
Product Name :
DL-threo-β-Hydroxyaspartic acid
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA