Dweck H, Carlson J. Molecular Logic and Evolution of Bitter Taste in Drosophila. Curr Biol. 2020;30:17-30.e3 pubmed publisher

Kim H, Lee B, Jeon J, Kim D, Kang S, Shim J, et al. Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres. Biomolecules. 2019;9: pubmed publisher

Aitken R, Muscio L, Whiting S, Connaughton H, Fraser B, Nixon B, et al. Analysis of the effects of polyphenols on human spermatozoa reveals unexpected impacts on mitochondrial membrane potential, oxidative stress and DNA integrity; implications for assisted reproductive technology. Biochem Pharmacol. 2016;121:78-96 pubmed publisher

Zeng Q, Yang G, Liu G, Wang J, Bai S, Ding X, et al. Effects of dietary gossypol concentration on growth performance, blood profiles, and hepatic histopathology in meat ducks. Poult Sci. 2014;93:2000-9 pubmed publisher

Jang G, Lee M. BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). Life Sci. 2014;102:41-8 pubmed publisher

Paulus A, Masood A, Miller K, Khan A, Akhtar D, Advani P, et al. The investigational agent MLN2238 induces apoptosis and is cytotoxic to CLL cells in vitro, as a single agent and in combination with other drugs. Br J Haematol. 2014;165:78-88 pubmed publisher

Sonpavde G, Pond G, Armstrong A, Galsky M, Leopold L, Wood B, et al. Radiographic progression by Prostate Cancer Working Group (PCWG)-2 criteria as an intermediate endpoint for drug development in metastatic castration-resistant prostate cancer. BJU Int. 2014;114:E25-E31 pubmed publisher

Kogan P, Wald M. Male contraception: history and development. Urol Clin North Am. 2014;41:145-61 pubmed publisher

Guo J, Wu G, Wan F. Effects of high-gossypol cotton on the development and reproduction of Bemisia tabaci (Hemiptera: Aleyrodidae) MEAM1 cryptic species. J Econ Entomol. 2013;106:1379-85 pubmed

Soderquist R, Bates D, Danilov A, Eastman A. Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. Leukemia. 2013;27:2262-4 pubmed publisher

Zelaya C, Stevens E, Dowd M. Di(phenylpropylamino)gossypol: a derivative of the dimeric natural product gossypol. Acta Crystallogr C. 2013;69:439-43 pubmed publisher

Zhong S, LEONG J, Ye W, Xu P, Lin S, Liu J, et al. (-)-Gossypol-enriched cottonseed oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. Anticancer Res. 2013;33:949-55 pubmed

Mao Y, Xue X, Tao X, Yang C, Wang L, Chen X. Cysteine protease enhances plant-mediated bollworm RNA interference. Plant Mol Biol. 2013;83:119-29 pubmed publisher

Varadarajan S, Tanaka K, Smalley J, Bampton E, Pellecchia M, Dinsdale D, et al. Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. PLoS ONE. 2013;8:e56603 pubmed publisher

Cheng P, Ni Z, Dai X, Wang B, Ding W, Rae Smith A, et al. The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. Cell Death Dis. 2013;4:e489 pubmed publisher

Goff D, Court Recart A, Sadarangani A, Chun H, Barrett C, Krajewska M, et al. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013;12:316-28 pubmed publisher

Ansari N, Müller S, Stelzer E, Pampaloni F. Quantitative 3D cell-based assay performed with cellular spheroids and fluorescence microscopy. Methods Cell Biol. 2013;113:295-309 pubmed publisher

Cho H, Lai T, Kwon G. Poly(ethylene glycol)-block-poly(?-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer. J Control Release. 2013;166:1-9 pubmed publisher

Wong F, Liem N, Xie C, Yan F, Wong W, Wang L, et al. Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression. PLoS ONE. 2012;7:e50786 pubmed publisher

Xin J, Zhan Y, Xia L, Zhu H, Nie Y, Liang J, et al. ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells. Biomed Pharmacother. 2013;67:88-95 pubmed publisher

Thakur A, Lum L, Schalk D, Azmi A, Banerjee S, Sarkar F, et al. Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. PLoS ONE. 2012;7:e47520 pubmed publisher

Vshivkov S, Pshenichnov E, Golubenko Z, Akhunov A, Namazov S, Stipanovic R. Capillary electrophoresis to quantitate gossypol enantiomers in cotton flower petals and seed. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;908:94-7 pubmed publisher

Sarwar Gilani G, Wu Xiao C, Cockell K. Impact of antinutritional factors in food proteins on the digestibility of protein and the bioavailability of amino acids and on protein quality. Br J Nutr. 2012;108 Suppl 2:S315-32 pubmed publisher

Hall C, Troutman S, Price D, Figg W, Kang M. Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms. Clin Genitourin Cancer. 2013;11:10-9 pubmed publisher

Pond G, Berry W, Galsky M, Wood B, Leopold L, Sonpavde G. Neutropenia as a potential pharmacodynamic marker for docetaxel-based chemotherapy in men with metastatic castration-resistant prostate cancer. Clin Genitourin Cancer. 2012;10:239-45 pubmed publisher

Varadarajan S, Bampton E, Smalley J, Tanaka K, Caves R, Butterworth M, et al. A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum. Cell Death Differ. 2012;19:1896-907 pubmed publisher

Hedvat M, Emdad L, Das S, Kim K, Dasgupta S, Thomas S, et al. Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules. Anticancer Agents Med Chem. 2012;12:1143-55 pubmed

Schuler M. Insect P450s: mounted for battle in their war against toxins. Mol Ecol. 2012;21:4157-9 pubmed publisher

Wang A, Zhang J, Meng Y, Deng L, Lv Y, Li C, et al. Effects of different sources and levels of dietary gossypol on gossypol residues in plasma and milk of lactating cows. J Dairy Sci. 2012;95:5127-5132 pubmed publisher

Jackson R, Placzek W, Fernandez A, Ziaee S, Chu C, Wei J, et al. Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer. Neoplasia. 2012;14:656-65 pubmed

Hsiao W, Tsai M, Jow G, Tien L, Lee Y. Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. Mol Vis. 2012;18:2033-42 pubmed

Sun P, Liu Y, Ying H, Li S. Action of db-cAMP on the bystander effect and chemosensitivity through connexin 43 and Bcl-2-mediated pathways in medulloblastoma cells. Oncol Rep. 2012;28:969-76 pubmed publisher

Ignatova M, Manolova N, Toshkova R, Rashkov I, Gardeva E, Yossifova L, et al. Quaternized chitosan-coated nanofibrous materials containing gossypol: preparation by electrospinning, characterization and antiproliferative activity towards HeLa cells. Int J Pharm. 2012;436:10-24 pubmed publisher

El Mokadem M, Taha T, Samak M, Yassen A. Alleviation of reproductive toxicity of gossypol using selenium supplementation in rams. J Anim Sci. 2012;90:3274-85 pubmed publisher

Zubair H, Khan H, Ullah M, Ahmad A, Wu D, Hadi S. Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage. Eur J Pharm Sci. 2012;47:280-6 pubmed publisher

Celorio Mancera M, Ahn S, Vogel H, Heckel D. Transcriptional responses underlying the hormetic and detrimental effects of the plant secondary metabolite gossypol on the generalist herbivore Helicoverpa armigera. BMC Genomics. 2011;12:575 pubmed publisher

Kovacic P. Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer. Curr Med Chem. 2003;10:2711-8 pubmed