This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Ganaxolone
catalog :
G7795
citations: 34
Reference |
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Mares P, Kubova H, Kasal A. Anticonvulsant action of a new analogue of allopregnanolone in immature rats. Physiol Res. 2010;59:305-8 pubmed
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Pieribone V, Tsai J, Soufflet C, Rey E, Shaw K, Giller E, et al. Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy. Epilepsia. 2007;48:1870-4 pubmed
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Mellon S, Gong W, Schonemann M. Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease. Brain Res Rev. 2008;57:410-20 pubmed
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Miura Y. [A new aspect in the research on antiepileptic drugs]. Nihon Yakurigaku Zasshi. 2007;129:111-5 pubmed
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Nohria V, Giller E. Ganaxolone. Neurotherapeutics. 2007;4:102-5 pubmed
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Citraro R, Russo E, di Paola E, Ibbadu G, Gratteri S, Marra R, et al. Effects of some neurosteroids injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy. Neuropharmacology. 2006;50:1059-71 pubmed
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Robichaud M, Debonnel G. Allopregnanolone and ganaxolone increase the firing activity of dorsal raphe nucleus serotonergic neurons in female rats. Int J Neuropsychopharmacol. 2006;9:191-200 pubmed
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Ward K, Nagilla R, Jolivette L. Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. Xenobiotica. 2005;35:191-210 pubmed
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Reddy D. Role of neurosteroids in catamenial epilepsy. Epilepsy Res. 2004;62:99-118 pubmed
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Reddy D. Pharmacology of catamenial epilepsy. Methods Find Exp Clin Pharmacol. 2004;26:547-61 pubmed
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Kaminski R, Livingood M, Rogawski M. Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. Epilepsia. 2004;45:864-7 pubmed
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Belelli D, Herd M. The contraceptive agent Provera enhances GABA(A) receptor-mediated inhibitory neurotransmission in the rat hippocampus: evidence for endogenous neurosteroids?. J Neurosci. 2003;23:10013-20 pubmed
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Foldvary Schaefer N, Falcone T. Catamenial epilepsy: pathophysiology, diagnosis, and management. Neurology. 2003;61:S2-15 pubmed
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Kaminski R, Gasior M, Carter R, Witkin J. Protective efficacy of neuroactive steroids against cocaine kindled-seizures in mice. Eur J Pharmacol. 2003;474:217-22 pubmed
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Mascia M, Biggio F, Mancuso L, Cabras S, Cocco P, Gorini G, et al. Changes in GABA(A) receptor gene expression induced by withdrawal of, but not by long-term exposure to, ganaxolone in cultured rat cerebellar granule cells. J Pharmacol Exp Ther. 2002;303:1014-20 pubmed
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Hsiao S, Acevedo J, DuBois D, Smith K, West J, Frye G. Early postnatal ethanol intubation blunts GABA(A) receptor up-regulation and modifies 3alpha-hydroxy-5alpha-pregnan-20-one sensitivity in rat MS/DB neurons. Brain Res Dev Brain Res. 2001;130:25-40 pubmed
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Ram K, Lam G, Chien B. A high-performance liquid chromatography-tandem mass spectrometric method for the determination of pharmacokinetics of ganaxolone in rat, monkey, dog and human plasma. J Chromatogr B Biomed Sci Appl. 2001;751:49-59 pubmed
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Monaghan -, McAuley -, Data -. Ganaxolone: a novel positive allosteric modulator of the GABA(A) receptor complex for the treatment of epilepsy. Expert Opin Investig Drugs. 1999;8:1663-1671 pubmed
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Reddy D, Rogawski M. Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself. J Pharmacol Exp Ther. 2000;295:1241-8 pubmed
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Kerrigan J, Shields W, Nelson T, Bluestone D, Dodson W, Bourgeois B, et al. Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial. Epilepsy Res. 2000;42:133-9 pubmed
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Carter R, Wood P, Wieland S, Hawkinson J, Belelli D, Lambert J, et al. Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor. J Pharmacol Exp Ther. 1997;280:1284-95 pubmed
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product information
Catalog Number :
G7795
Product Name :
Ganaxolone
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
solid
company information

MilliporeSigma
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