This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Ganaxolone
catalog :
G7795
citations: 34
Reference
Reddy D, Carver C, Clossen B, Wu X. Extrasynaptic γ-aminobutyric acid type A receptor-mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures. Epilepsia. 2019;60:730-743 pubmed publisher
Reddy D, Yoshimura R, Ramanathan G, Carver C, Johnstone T, Hogenkamp D, et al. Role of β2/3-specific GABA-A receptor isoforms in the development of hippocampus kindling epileptogenesis. Epilepsy Behav. 2018;82:57-63 pubmed publisher
D Hulst C, Heulens I, Van der Aa N, Goffin K, Koole M, Porke K, et al. Positron Emission Tomography (PET) Quantification of GABAA Receptors in the Brain of Fragile X Patients. PLoS ONE. 2015;10:e0131486 pubmed publisher
Qin M, Zeidler Z, Moulton K, Krych L, Xia Z, Smith C. Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome. Behav Brain Res. 2015;291:164-171 pubmed publisher
Gachet M, Rhyn P, Bosch O, Quednow B, Gertsch J. A quantitiative LC-MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;976-977:6-18 pubmed publisher
Yum M, Lee M, Ko T, Velíšek L. A potential effect of ganaxolone in an animal model of infantile spasms. Epilepsy Res. 2014;108:1492-500 pubmed publisher
Ramaker M, Strong M, Ford M, Finn D. Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration. Neuropharmacology. 2012;63:555-64 pubmed publisher
Asiedu M, Mejia G, Ossipov M, Malan T, Kaila K, Price T. Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain. 2012;13:546-54 pubmed publisher
Ramaker M, Ford M, Fretwell A, Finn D. Alteration of ethanol drinking in mice via modulation of the GABA(A) receptor with ganaxolone, finasteride, and gaboxadol. Alcohol Clin Exp Res. 2011;35:1994-2007 pubmed publisher
Reddy D. Neurosteroids: endogenous role in the human brain and therapeutic potentials. Prog Brain Res. 2010;186:113-37 pubmed publisher
Besheer J, Lindsay T, O Buckley T, Hodge C, Morrow A. Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring p rats. Alcohol Clin Exp Res. 2010;34:2044-52 pubmed publisher
Reddy D, Rogawski M. Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model. Epilepsy Res. 2010;89:254-60 pubmed publisher
Mares P, Stehlíková M. Anticonvulsant doses of ganaxolone do not compromise motor performance in immature rats. Neurosci Lett. 2010;469:396-9 pubmed publisher
Mares P, Kubova H, Kasal A. Anticonvulsant action of a new analogue of allopregnanolone in immature rats. Physiol Res. 2010;59:305-8 pubmed
Pieribone V, Tsai J, Soufflet C, Rey E, Shaw K, Giller E, et al. Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy. Epilepsia. 2007;48:1870-4 pubmed
Mellon S, Gong W, Schonemann M. Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease. Brain Res Rev. 2008;57:410-20 pubmed
Miura Y. [A new aspect in the research on antiepileptic drugs]. Nihon Yakurigaku Zasshi. 2007;129:111-5 pubmed
Nohria V, Giller E. Ganaxolone. Neurotherapeutics. 2007;4:102-5 pubmed
Citraro R, Russo E, di Paola E, Ibbadu G, Gratteri S, Marra R, et al. Effects of some neurosteroids injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy. Neuropharmacology. 2006;50:1059-71 pubmed
Robichaud M, Debonnel G. Allopregnanolone and ganaxolone increase the firing activity of dorsal raphe nucleus serotonergic neurons in female rats. Int J Neuropsychopharmacol. 2006;9:191-200 pubmed
Ward K, Nagilla R, Jolivette L. Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. Xenobiotica. 2005;35:191-210 pubmed
Reddy D. Role of neurosteroids in catamenial epilepsy. Epilepsy Res. 2004;62:99-118 pubmed
Reddy D. Pharmacology of catamenial epilepsy. Methods Find Exp Clin Pharmacol. 2004;26:547-61 pubmed
Kaminski R, Livingood M, Rogawski M. Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. Epilepsia. 2004;45:864-7 pubmed
Belelli D, Herd M. The contraceptive agent Provera enhances GABA(A) receptor-mediated inhibitory neurotransmission in the rat hippocampus: evidence for endogenous neurosteroids?. J Neurosci. 2003;23:10013-20 pubmed
Foldvary Schaefer N, Falcone T. Catamenial epilepsy: pathophysiology, diagnosis, and management. Neurology. 2003;61:S2-15 pubmed
Kaminski R, Gasior M, Carter R, Witkin J. Protective efficacy of neuroactive steroids against cocaine kindled-seizures in mice. Eur J Pharmacol. 2003;474:217-22 pubmed
Mascia M, Biggio F, Mancuso L, Cabras S, Cocco P, Gorini G, et al. Changes in GABA(A) receptor gene expression induced by withdrawal of, but not by long-term exposure to, ganaxolone in cultured rat cerebellar granule cells. J Pharmacol Exp Ther. 2002;303:1014-20 pubmed
Hsiao S, Acevedo J, DuBois D, Smith K, West J, Frye G. Early postnatal ethanol intubation blunts GABA(A) receptor up-regulation and modifies 3alpha-hydroxy-5alpha-pregnan-20-one sensitivity in rat MS/DB neurons. Brain Res Dev Brain Res. 2001;130:25-40 pubmed
Ram K, Lam G, Chien B. A high-performance liquid chromatography-tandem mass spectrometric method for the determination of pharmacokinetics of ganaxolone in rat, monkey, dog and human plasma. J Chromatogr B Biomed Sci Appl. 2001;751:49-59 pubmed
Monaghan -, McAuley -, Data -. Ganaxolone: a novel positive allosteric modulator of the GABA(A) receptor complex for the treatment of epilepsy. Expert Opin Investig Drugs. 1999;8:1663-1671 pubmed
Reddy D, Rogawski M. Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself. J Pharmacol Exp Ther. 2000;295:1241-8 pubmed
Kerrigan J, Shields W, Nelson T, Bluestone D, Dodson W, Bourgeois B, et al. Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial. Epilepsy Res. 2000;42:133-9 pubmed
Carter R, Wood P, Wieland S, Hawkinson J, Belelli D, Lambert J, et al. Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor. J Pharmacol Exp Ther. 1997;280:1284-95 pubmed
product information
Catalog Number :
G7795
Product Name :
Ganaxolone
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
solid
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA