This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Guanosine 3′,5′-cyclic monophosphate
catalog :
G7504
citations: 302
Reference
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Sunitha B, Kumar M, Gowthami N, Unni S, Gayathri N, Keshava Prasad T, et al. Human muscle pathology is associated with altered phosphoprotein profile of mitochondrial proteins in the skeletal muscle. J Proteomics. 2020;211:103556 pubmed publisher
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Sharma S, Zajac M, Krishnan Y. A DNA Aptamer for Cyclic Adenosine Monophosphate that Shows Adaptive Recognition. Chembiochem. 2020;21:157-162 pubmed publisher
Liang S, Deng X, Lei L, Zheng Y, Ai J, Chen L, et al. The Comparative Study of the Therapeutic Effects and Mechanism of Baicalin, Baicalein, and Their Combination on Ulcerative Colitis Rat. Front Pharmacol. 2019;10:1466 pubmed publisher
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Ying W, Zhao D, Ouyang P, Subramanya V, Vaidya D, Ndumele C, et al. Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA. J Am Heart Assoc. 2019;8:e013149 pubmed publisher
Zhang F, Xu Y, Pan Y, Sun S, Chen A, Li P, et al. Effects of Angiotensin-(1-7) and Angiotensin II on Acetylcholine-Induced Vascular Relaxation in Spontaneously Hypertensive Rats. Oxid Med Cell Longev. 2019;2019:6512485 pubmed publisher
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Bae I, Kim S. Expression and Secretion of an Atrial Natriuretic Peptide in Beige-Like 3T3-L1 Adipocytes. Int J Mol Sci. 2019;20: pubmed publisher
Urios A, Ordoño F, García García R, Mangas Losada A, Leone P, José Gallego J, et al. Tadalafil Treatment Improves Inflammation, Cognitive Function, And Mismatch Negativity Of Patients With Low Urinary Tract Symptoms And Erectile Dysfunction. Sci Rep. 2019;9:17119 pubmed publisher
Carvalho M, Vendramini P, Kubo C, Soreiro Pereira P, de Albuquerque R, Antunes E, et al. BAY 41-2272 inhibits human T lymphocyte functions. Int Immunopharmacol. 2019;77:105976 pubmed publisher
Khiatah B, Qi M, Du W, T Chen K, van Megen K, Perez R, et al. Intra-pancreatic tissue-derived mesenchymal stromal cells: a promising therapeutic potential with anti-inflammatory and pro-angiogenic profiles. Stem Cell Res Ther. 2019;10:322 pubmed publisher
Park H, Gonzalez Islas C, Kang Y, Li J, Choi I. Deletion of the Na/HCO3 Transporter NBCn1 Protects Hippocampal Neurons from NMDA-induced Seizures and Neurotoxicity in Mice. Sci Rep. 2019;9:15981 pubmed publisher
Leong Z, Hikasa Y. Effects of masitinib compared with tadalafil for the treatment of monocrotaline-induced pulmonary arterial hypertension in rats. Vascul Pharmacol. 2019;122-123:106599 pubmed publisher
Chen L, He W, Peng B, Yuan M, Wang N, Wang J, et al. Sodium Tanshinone IIA sulfonate improves post-ischemic angiogenesis in hyperglycemia. Biochem Biophys Res Commun. 2019;520:580-585 pubmed publisher
Bhullar S, Shah A, Dhalla N. Store-operated calcium channels: Potential target for the therapy of hypertension. Rev Cardiovasc Med. 2019;20:139-151 pubmed publisher
Rosenbrock H, Giovannini R, Schänzle G, Koros E, Runge F, Fuchs H, et al. The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents. J Pharmacol Exp Ther. 2019;371:633-641 pubmed publisher
Enomoto T, Tatara A, Goda M, Nishizato Y, Nishigori K, Kitamura A, et al. A Novel Phosphodiesterase 1 Inhibitor DSR-141562 Exhibits Efficacies in Animal Models for Positive, Negative, and Cognitive Symptoms Associated with Schizophrenia. J Pharmacol Exp Ther. 2019;371:692-702 pubmed publisher
Shen Q, Zhan X, Yang P, Li J, Chen J, Tang B, et al. Dual Activities of Plant cGMP-Dependent Protein Kinase and Its Roles in Gibberellin Signaling and Salt Stress. Plant Cell. 2019;31:3073-3091 pubmed publisher
Song J, Tang Z, Li H, Jiang H, Sun T, Lan R, et al. Role of JAK2 in the Pathogenesis of Diabetic Erectile Dysfunction and an Intervention With Berberine. J Sex Med. 2019;16:1708-1720 pubmed publisher
Song M, Li L, Lei Y, Sun X. NOS3 Deletion in Cav1 Deficient Mice Decreases Drug Sensitivity to a Nitric Oxide Donor and Two Nitric Oxide Synthase Inhibitors. Invest Ophthalmol Vis Sci. 2019;60:4002-4007 pubmed publisher
Umbrasas D, Jokubka R, Kaupinis A, Valius M, Arandarcikaite O, Borutaite V. Nitric Oxide Donor NOC-18-Induced Changes of Mitochondrial Phosphoproteome in Rat Cardiac Ischemia Model. Medicina (Kaunas). 2019;55: pubmed publisher
Akieda Asai S, Ma H, Date Y. Palmitic acid induces guanylin gene expression through the Toll-like receptor 4/nuclear factor-κB pathway in rat macrophages. Am J Physiol Cell Physiol. 2019;317:C1239-C1246 pubmed publisher
Hu L, Feng Y, Liu W, Jin L, Nie Z. Botulinum toxin type A suppresses arterial vasoconstriction by regulating calcium sensitization and the endothelium-dependent endothelial nitric oxide synthase/soluble guanylyl cyclase/cyclic guanosine monophosphate pathway: An in vitro study. Exp Biol Med (Maywood). 2019;244:1475-1484 pubmed publisher
Wang Q, Wu Z, Yuan X, Dong H, Xu X, Xin H, et al. Bilobetin induces kidney injury by influencing cGMP-mediated AQP-2 trafficking and podocyte cell cycle arrest. Phytomedicine. 2019;64:153073 pubmed publisher
Sciacca M, Belgorosky D, Zambrano M, Gómez Escalante J, Roca F, Langle Y, et al. Inhibition of breast tumor growth by N(G)-nitro-l-arginine methyl ester (l-NAME) is accompanied by activation of fibroblasts. Nitric Oxide. 2019;93:34-43 pubmed publisher
Xu H, Yue C, Chen L. Post-Transcriptional Regulation of Soluble Guanylate Cyclase that Governs Neuropathic Pain in Alzheimer's Disease. J Alzheimers Dis. 2019;71:1331-1338 pubmed publisher
Reginauld S, Cannone V, Iyer S, Scott C, Bailey K, Schaefer J, et al. Differential Regulation of ANP and BNP in Acute Decompensated Heart Failure: Deficiency of ANP. JACC Heart Fail. 2019;7:891-898 pubmed publisher
Chow B, Kocan M, Shen M, Wang Y, Han L, Chew J, et al. AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis. J Am Soc Nephrol. 2019;30:2191-2207 pubmed publisher
Celik S, Sadegh M, Morley M, Roselli C, Ellinor P, Cappola T, et al. Antisense regulation of atrial natriuretic peptide expression. JCI Insight. 2019;4: pubmed publisher
Malek V, Sharma N, Gaikwad A. Simultaneous inhibition of neprilysin and activation of ACE2 prevented diabetic cardiomyopathy. Pharmacol Rep. 2019;71:958-967 pubmed publisher
Zborníková E, Knejzlík Z, Hauryliuk V, Krásný L, Rejman D. Analysis of nucleotide pools in bacteria using HPLC-MS in HILIC mode. Talanta. 2019;205:120161 pubmed publisher
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Lan T, Pang J, Wang Z, Wang Y, Qian H, Chen Y, et al. Type II cGMP-dependent protein kinase phosphorylates EGFR at threonine 669 and thereby inhibits its activation. Biochem Biophys Res Commun. 2019;518:14-18 pubmed publisher
Yu Z, Zhang Y, Tang Z, Song J, Gao X, Sun T, et al. Intracavernosal Adeno-Associated Virus-Mediated S100A1 Gene Transfer Enhances Erectile Function in Diabetic Rats by Promoting Cavernous Angiogenesis via VEGF-A/VEGFR2 Signaling. J Sex Med. 2019;16:1344-1354 pubmed publisher
Rosa P, de Carvalho M, Soeiro Pereira P, Harumi R, de Albuquerque R, Antunes E, et al. BAY 41-2272 inhibits human neutrophil functions. Int Immunopharmacol. 2019;75:105767 pubmed publisher
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Jia T, Wang Y, Zhang J, Hao X, Zhang D, Xu X. Cinaciguat in combination with insulin induces a favorable effect on implant osseointegration in type 2 diabetic rats. Biomed Pharmacother. 2019;118:109216 pubmed publisher
Gu G, Scott T, Yan Y, Warren N, Zhang A, Tabatabaei A, et al. Target Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat. J Pharmacol Exp Ther. 2019;370:399-407 pubmed publisher
Yang L, Yao Y, Yong L, Feng Y, Su H, Yao Q, et al. Dopamine D1 receptor agonists inhibit lung metastasis of breast cancer reducing cancer stemness. Eur J Pharmacol. 2019;859:172499 pubmed publisher
Breinholt V, Rasmussen C, Mygind P, Kjelgaard Hansen M, Faltinger F, Bernhard A, et al. TransCon CNP, a sustained-release C-Type Natriuretic Peptide prodrug, a potentially safe and efficacious new therapeutic modality for the treatment of comorbidities associated with FGFR3-related skeletal dysplasias. J Pharmacol Exp Ther. 2019;: pubmed publisher
de Oliveira M, Rojas Moscoso J, Bertollotto G, Candido T, de Almeida Kiguti L, Pupo A, et al. Mirabegron elicits rat corpus cavernosum relaxation and increases in vivo erectile response. Eur J Pharmacol. 2019;:172447 pubmed publisher
Elbardisy B, Galal S, Abdelmonsif D, Boraie N. Intranasal Tadalafil nanoemulsions: formulation, characterization and pharmacodynamic evaluation. Pharm Dev Technol. 2019;24:1083-1094 pubmed publisher
Cheval L, Bakouh N, Walter C, Tembely D, Morla L, Escher G, et al. ANP-stimulated Na+ secretion in the collecting duct prevents Na+ retention in the renal adaptation to acid load. Am J Physiol Renal Physiol. 2019;317:F435-F443 pubmed publisher
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Cheng C, Liu H, Tan C, Tong D, Zhao Y, Liu X, et al. Mutation in NPPA causes atrial fibrillation by activating inflammation and cardiac fibrosis in a knock-in rat model. FASEB J. 2019;33:8878-8891 pubmed publisher
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Joshi S, Jarajapu Y. Mitochondrial depolarization stimulates vascular repair-relevant functions of CD34+ cells via reactive oxygen species-induced nitric oxide generation. Br J Pharmacol. 2019;176:4373-4387 pubmed publisher
Yu W, Chen H, Yang H, Ding J, Xia P, Mei X, et al. Dissecting Molecular Mechanisms Underlying Pulmonary Vascular Smooth Muscle Cell Dedifferentiation in Pulmonary Hypertension: Role of Mutated Caveolin-1 (Cav1F92A)-Bone Marrow Mesenchymal Stem Cells. Heart Lung Circ. 2018;: pubmed publisher
Meier S, Andressen K, Aronsen J, Sjaastad I, Hougen K, Skomedal T, et al. PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts. Eur J Pharmacol. 2017;812:174-183 pubmed publisher
Wang G, Zhang Q, Yuan W, Wu J, Li C. Sildenafil Protects against Myocardial Ischemia-Reperfusion Injury Following Cardiac Arrest in a Porcine Model: Possible Role of the Renin-Angiotensin System. Int J Mol Sci. 2015;16:27015-31 pubmed publisher
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Mátyás C, Németh B, Oláh A, Hidi L, Birtalan E, Kellermayer D, et al. The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus. Cardiovasc Diabetol. 2015;14:145 pubmed publisher
Thoonen R, Cauwels A, Decaluwé K, Geschka S, Tainsh R, Delanghe J, et al. Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice. Nat Commun. 2015;6:8482 pubmed publisher
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Correa F, Buelna Chontal M, Chagoya V, García Rivas G, Vigueras R, Pedraza Chaverri J, et al. Inhibition of the nitric oxide/cyclic guanosine monophosphate pathway limited the cardioprotective effect of post-conditioning in hearts with apical myocardial infarction. Eur J Pharmacol. 2015;765:472-81 pubmed publisher
Ma S, Mayer E, Lee P, Li X, Gao E. Transcutaneous Electrical Stimulation Increased Nitric Oxide-Cyclic GMP Release Biocaptured Over Skin Surface of Pericardium Meridian and Acupuncture Points in Humans. Acupunct Electrother Res. 2015;40:73-86 pubmed
Ledgerwood J, Coates E, Yamshchikov G, Saunders J, Holman L, Enama M, et al. Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults. Clin Exp Immunol. 2015;182:289-301 pubmed publisher
Lagos Carvajal A, Teixeira Neto F, Becerra Velásquez D, Diniz M, Klein A, Rocha T, et al. Adrenomedullin induces pulmonary vasodilation but does not attenuate pulmonary hypertension in a sheep model of acute pulmonary embolism. Life Sci. 2015;139:139-44 pubmed publisher
Pace B, Liu L, Li B, Makala L. Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease. Exp Biol Med (Maywood). 2015;240:1050-64 pubmed publisher
Kurtzberg J, Buntz S, Gentry T, Noeldner P, Ozamiz A, Rusche B, et al. Reprint of: Preclinical characterization of DUOC-01, a cell therapy product derived from banked umbilical cord blood for use as an adjuvant to umbilical cord blood transplantation for treatment of inherited metabolic diseases. Cytotherapy. 2015;17:1314-26 pubmed publisher
Scheib U, Stehfest K, Gee C, Körschen H, Fudim R, Oertner T, et al. The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling. Sci Signal. 2015;8:rs8 pubmed publisher
Wei S, Huang J, Li Y, Zhao J, Luo Y, Meng X, et al. Novel zinc finger transcription factor ZFP580 promotes differentiation of bone marrow-derived endothelial progenitor cells into endothelial cells via eNOS/NO pathway. J Mol Cell Cardiol. 2015;87:17-26 pubmed publisher
Hasegawa K, Akieda Asai S, Fujii Y, Bae C, Yasuda M, Date Y. Guanylin-Guanylyl cyclase-C signaling in macrophages regulates mesenteric fat inflammation induced by high-fat diet. Endocr J. 2015;62:939-47 pubmed publisher
Park D, Shawl A, Ha T, Park K, Kim S, Kim U. Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca2+-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets. PLoS ONE. 2015;10:e0134962 pubmed publisher
Yester J, Bryan L, Waters M, Mierzenski B, Biswas D, Gupta A, et al. Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop. FASEB J. 2015;29:4853-65 pubmed publisher
Felipo V, Piedrafita B, Barios J, Agusti A, Ahabrach H, Romero Vives M, et al. Rats with minimal hepatic encephalopathy show reduced cGMP-dependent protein kinase activity in hypothalamus correlating with circadian rhythms alterations. Chronobiol Int. 2015;32:966-79 pubmed publisher
Lankhorst S, Baelde H, Kappers M, Smedts F, Hansen A, Clahsen van Groningen M, et al. Greater Sensitivity of Blood Pressure Than Renal Toxicity to Tyrosine Kinase Receptor Inhibition With Sunitinib. Hypertension. 2015;66:543-9 pubmed publisher
Wang Y, Chen Y, Wu M, Lan T, Wu Y, Li Y, et al. Type II cyclic guanosine monophosphate-dependent protein kinase inhibits Rac1 activation in gastric cancer cells. Oncol Lett. 2015;10:502-508 pubmed
Yao X, Wu Y, Zhu M, Qian H, Chen Y. Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine monophosphate-dependent protein kinase. Oncol Lett. 2015;10:479-484 pubmed
Kovacevic I, Müller M, Kojonazarov B, Ehrke A, Randriamboavonjy V, Kohlstedt K, et al. The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function. Circ Res. 2015;117:460-9 pubmed publisher
Straubinger J, Schöttle V, Bork N, Subramanian H, Dünnes S, Russwurm M, et al. Sildenafil Does Not Prevent Heart Hypertrophy and Fibrosis Induced by Cardiomyocyte Angiotensin II Type 1 Receptor Signaling. J Pharmacol Exp Ther. 2015;354:406-16 pubmed publisher
Ma H, Butler M, Thapa A, Belcher J, Yang F, Baehr W, et al. cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice. J Biol Chem. 2015;290:20880-92 pubmed publisher
Schneider J, Rothmann S, Schroder F, Langen J, Lücke T, Mariotti F, et al. Effects of chronic oral L-arginine administration on the L-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: L-Arginine prevents renal loss of nitrite, the major NO reservoir. Amino Acids. 2015;47:1961-74 pubmed publisher
Silva C, Nunes K, Torres F, Cassoli J, Santos D, Almeida F, et al. PnPP-19, a Synthetic and Nontoxic Peptide Designed from a Phoneutria nigriventer Toxin, Potentiates Erectile Function via NO/cGMP. J Urol. 2015;194:1481-90 pubmed publisher
Chen C, Wang Z, Hsu C, Lin H, Chen J. In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity. Nutrients. 2015;7:4938-54 pubmed publisher
Majumder A, Pahlberg J, Muradov H, Boyd K, Sampath A, Artemyev N. Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation. J Neurosci. 2015;35:9225-35 pubmed publisher
Hisado Oliva A, Garre Vázquez A, Santaolalla Caballero F, Belinchón A, Barreda Bonis A, Vasques G, et al. Heterozygous NPR2 Mutations Cause Disproportionate Short Stature, Similar to Léri-Weill Dyschondrosteosis. J Clin Endocrinol Metab. 2015;100:E1133-42 pubmed publisher
Wilson H, Welikson R, Luo J, Kean T, Cao B, Dennis J, et al. Can Cytoprotective Cobalt Protoporphyrin Protect Skeletal Muscle and Muscle-derived Stem Cells From Ischemic Injury?. Clin Orthop Relat Res. 2015;473:2908-19 pubmed publisher
Jeanne A, Sick E, Devy J, Floquet N, Belloy N, Theret L, et al. Identification of TAX2 peptide as a new unpredicted anti-cancer agent. Oncotarget. 2015;6:17981-8000 pubmed
Zhang Q, Wang G, Yuan W, Wu J, Wang M, Li C. The effects of phosphodiesterase-5 inhibitor sildenafil against post-resuscitation myocardial and intestinal microcirculatory dysfunction by attenuating apoptosis and regulating microRNAs expression: essential role of nitric oxide syntheses signaling. J Transl Med. 2015;13:177 pubmed publisher
Kaneda T, Saito E, Kanda H, Urakawa N, Shimizu K. Effects of papaverine on carbachol- and high K+ -induced contraction in the bovine abomasum. J Vet Med Sci. 2015;77:1269-74 pubmed publisher
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Bai Y, An R. Resveratrol and sildenafil synergistically improve diabetes-associated erectile dysfunction in streptozotocin-induced diabetic rats. Life Sci. 2015;135:43-8 pubmed publisher
Rahaman M, Reinders F, Koes D, Nguyen A, Mutchler S, Sparacino Watkins C, et al. Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability. J Biol Chem. 2015;290:16861-72 pubmed publisher
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product information
Catalog Number :
G7504
Product Name :
Guanosine 3′,5′-cyclic monophosphate
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA