This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
GW5074
catalog :
G6416
citations: 39
Reference
Kizilboga T, Baskale E, Yıldız J, Akcay I, Zemheri E, Can N, et al. Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer. BMC Cancer. 2019;19:1254 pubmed publisher
Wang D, Gao S, Chen J, Zhao Y, Jiang Y, Chu X, et al. Dectin-1 stimulates IL-33 expression in dendritic cells via upregulation of IRF4. Lab Invest. 2018;98:708-714 pubmed publisher
Tasseff R, Jensen H, Congleton J, Dai D, Rogers K, Sagar A, et al. An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program. Sci Rep. 2017;7:14327 pubmed publisher
Zhang Y, Ke X, Zheng C, Liu Y, Xie L, Zheng Z, et al. Development of a luciferase-based biosensor to assess enterovirus 71 3C protease activity in living cells. Sci Rep. 2017;7:10385 pubmed publisher
Xue H, Liu L, Zhao Z, Zhang Z, Guan Y, Cheng H, et al. The N-terminal tail coordinates with carbohydrate recognition domain to mediate galectin-3 induced apoptosis in T cells. Oncotarget. 2017;8:49824-49838 pubmed publisher
Ferraiuolo R, Tubman J, Sinha I, Hamm C, Porter L. The cyclin-like protein, SPY1, regulates the ER? and ERK1/2 pathways promoting tamoxifen resistance. Oncotarget. 2017;8:23337-23352 pubmed publisher
He W, Wu Y, Tang X, Xia Y, He G, Min Z, et al. HDAC inhibitors suppress c-Jun/Fra-1-mediated proliferation through transcriptionally downregulating MKK7 and Raf1 in neuroblastoma cells. Oncotarget. 2016;7:6727-47 pubmed publisher
Hsiao Y, Yeh M, Chen Y, Liu J, Tang C, Huang W. Lapatinib increases motility of triple-negative breast cancer cells by decreasing miRNA-7 and inducing Raf-1/MAPK-dependent interleukin-6. Oncotarget. 2015;6:37965-78 pubmed publisher
Wiersma V, de Bruyn M, Wei Y, van Ginkel R, Hirashima M, Niki T, et al. The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy. 2015;11:1373-88 pubmed publisher
Chernyavsky A, Galitovskiy V, Grando S. Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression. Int Immunopharmacol. 2015;29:15-20 pubmed publisher
Grefte S, Wagenaars J, Jansen R, Willems P, Koopman W. Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2. Biochim Biophys Acta. 2015;1853:1606-14 pubmed publisher
Bakema J, Tuk C, van Vliet S, Bruijns S, Vos J, Letsiou S, et al. Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs. J Immunol. 2015;194:1856-66 pubmed publisher
Shan J, Donelan W, Hayner J, Zhang F, Dudenhausen E, Kilberg M. MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells. Biochim Biophys Acta. 2015;1853:539-48 pubmed publisher
Miyamoto L, Yagi Y, Hatano A, Kawazoe K, Ishizawa K, Minakuchi K, et al. Spontaneously hyperactive MEK-Erk pathway mediates paradoxical facilitation of cell proliferation in mild hypoxia. Biochim Biophys Acta. 2015;1850:640-6 pubmed publisher
Won J, Ahn K, Back M, Ha H, Jang J, Kim H, et al. DA-9801 promotes neurite outgrowth via ERK1/2-CREB pathway in PC12 cells. Biol Pharm Bull. 2015;38:169-78 pubmed publisher
Yan X, Liang F, Li D, Zheng J. Ouabain elicits human glioblastoma cells apoptosis by generating reactive oxygen species in ERK-p66SHC-dependent pathway. Mol Cell Biochem. 2015;398:95-104 pubmed publisher
Li Z, Jiang J, Kong W. Berberine up-regulates hepatic low-density lipoprotein receptor through Ras-independent but AMP-activated protein kinase-dependent Raf-1 activation. Biol Pharm Bull. 2014;37:1766-75 pubmed
Li T, Yang D, Zhong S, Thomas J, Xue F, Liu J, et al. Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models. Hum Mol Genet. 2014;23:6212-22 pubmed publisher
Nakayama M, Niki Y, Kawasaki T, Takeda Y, Ikegami H, Toyama Y, et al. IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis. Sci Rep. 2013;3:2960 pubmed publisher
Schmitt S, Safferling K, Westphal K, Hrabowski M, Muller U, Angel P, et al. Stathmin regulates keratinocyte proliferation and migration during cutaneous regeneration. PLoS ONE. 2013;8:e75075 pubmed publisher
Mobraten K, Haug T, Kleiveland C, Lea T. Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells. Lipids Health Dis. 2013;12:101 pubmed publisher
Cipriano R, Miskimen K, Bryson B, Foy C, Bartel C, Jackson M. FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Oncotarget. 2013;4:729-38 pubmed
Rayappa S, Kowluru R. Role of raf-1 kinase in diabetes-induced accelerated apoptosis of retinal capillary cells. Int J Biomed Sci. 2008;4:20-8 pubmed
D Amici S, Ceccarelli S, Vescarelli E, Romano F, Frati L, Marchese C, et al. TNF? modulates Fibroblast Growth Factor Receptor 2 gene expression through the pRB/E2F1 pathway: identification of a non-canonical E2F binding motif. PLoS ONE. 2013;8:e61491 pubmed publisher
Lin S, Hoffmann K, Xiao Z, Jin N, Galli U, Mohr E, et al. MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma. Cancer Cell Int. 2013;13:3 pubmed publisher
Hermanson S, Carlson C, Riddle S, Zhao J, Vogel K, Nichols R, et al. Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation. PLoS ONE. 2012;7:e43580 pubmed publisher
Yotova I, Quan P, Gaba A, Leditznig N, Pateisky P, Kurz C, et al. Raf-1 levels determine the migration rate of primary endometrial stromal cells of patients with endometriosis. J Cell Mol Med. 2012;16:2127-39 pubmed publisher
Ye D, Jin S, Zhuo Y, Field J. p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112. PLoS ONE. 2011;6:e27637 pubmed publisher
Hashimoto K, Ishima T. Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol. PLoS ONE. 2011;6:e17431 pubmed publisher
Magarinos M, Aburto M, Sanchez Calderon H, Muñoz Agudo C, Rapp U, Varela Nieto I. RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development. PLoS ONE. 2010;5:e14435 pubmed publisher
Hashimoto K, Ishima T. A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI. PLoS ONE. 2010;5:e15430 pubmed publisher
Kupcho K, Bruinsma R, Hallis T, Lasky D, Somberg R, Turek Etienne T, et al. Fluorescent cascade and direct assays for characterization of RAF signaling pathway inhibitors. Curr Chem Genomics. 2008;1:43-53 pubmed publisher
Tumati S, Yamamura H, Vanderah T, Roeske W, Varga E. Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner. J Pharmacol Exp Ther. 2009;330:810-7 pubmed publisher
Nishimura T, Ishima T, Iyo M, Hashimoto K. Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways. PLoS ONE. 2008;3:e2558 pubmed publisher
Liu C, Xie L, Li M, Durairajan S, Goto S, Huang J. Salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt signaling. PLoS ONE. 2007;2:e1321 pubmed
Morrison B, Majdzadeh N, Zhang X, Lyles A, Bassel Duby R, Olson E, et al. Neuroprotection by histone deacetylase-related protein. Mol Cell Biol. 2006;26:3550-64 pubmed
Zhang Q, Adiseshaiah P, Kalvakolanu D, Reddy S. A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression. J Biol Chem. 2006;281:10174-81 pubmed
Suzuki M, Mimuro H, Suzuki T, Park M, Yamamoto T, Sasakawa C. Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. J Exp Med. 2005;202:1235-47 pubmed
Lackey K, Cory M, Davis R, Frye S, Harris P, Hunter R, et al. The discovery of potent cRaf1 kinase inhibitors. Bioorg Med Chem Lett. 2000;10:223-6 pubmed
product information
Catalog Number :
G6416
Product Name :
GW5074
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA