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product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Guanosine 3′,5′-cyclic monophosphate sodium salt
catalog :
G6129
citations: 143
Reference
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Ma S, Mayer E, Lee P, Li X, Gao E. Transcutaneous Electrical Stimulation Increased Nitric Oxide-Cyclic GMP Release Biocaptured Over Skin Surface of Pericardium Meridian and Acupuncture Points in Humans. Acupunct Electrother Res. 2015;40:73-86 pubmed
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Scheib U, Stehfest K, Gee C, Körschen H, Fudim R, Oertner T, et al. The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling. Sci Signal. 2015;8:rs8 pubmed publisher
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Hasegawa K, Akieda Asai S, Fujii Y, Bae C, Yasuda M, Date Y. Guanylin-Guanylyl cyclase-C signaling in macrophages regulates mesenteric fat inflammation induced by high-fat diet. Endocr J. 2015;62:939-47 pubmed publisher
Park D, Shawl A, Ha T, Park K, Kim S, Kim U. Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca2+-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets. PLoS ONE. 2015;10:e0134962 pubmed publisher
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Felipo V, Piedrafita B, Barios J, Agusti A, Ahabrach H, Romero Vives M, et al. Rats with minimal hepatic encephalopathy show reduced cGMP-dependent protein kinase activity in hypothalamus correlating with circadian rhythms alterations. Chronobiol Int. 2015;32:966-79 pubmed publisher
Lankhorst S, Baelde H, Kappers M, Smedts F, Hansen A, Clahsen van Groningen M, et al. Greater Sensitivity of Blood Pressure Than Renal Toxicity to Tyrosine Kinase Receptor Inhibition With Sunitinib. Hypertension. 2015;66:543-9 pubmed publisher
Wang Y, Chen Y, Wu M, Lan T, Wu Y, Li Y, et al. Type II cyclic guanosine monophosphate-dependent protein kinase inhibits Rac1 activation in gastric cancer cells. Oncol Lett. 2015;10:502-508 pubmed
Yao X, Wu Y, Zhu M, Qian H, Chen Y. Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine monophosphate-dependent protein kinase. Oncol Lett. 2015;10:479-484 pubmed
Kovacevic I, Müller M, Kojonazarov B, Ehrke A, Randriamboavonjy V, Kohlstedt K, et al. The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function. Circ Res. 2015;117:460-9 pubmed publisher
Straubinger J, Schöttle V, Bork N, Subramanian H, Dünnes S, Russwurm M, et al. Sildenafil Does Not Prevent Heart Hypertrophy and Fibrosis Induced by Cardiomyocyte Angiotensin II Type 1 Receptor Signaling. J Pharmacol Exp Ther. 2015;354:406-16 pubmed publisher
Ma H, Butler M, Thapa A, Belcher J, Yang F, Baehr W, et al. cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice. J Biol Chem. 2015;290:20880-92 pubmed publisher
Schneider J, Rothmann S, Schroder F, Langen J, Lücke T, Mariotti F, et al. Effects of chronic oral L-arginine administration on the L-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: L-Arginine prevents renal loss of nitrite, the major NO reservoir. Amino Acids. 2015;47:1961-74 pubmed publisher
Silva C, Nunes K, Torres F, Cassoli J, Santos D, Almeida F, et al. PnPP-19, a Synthetic and Nontoxic Peptide Designed from a Phoneutria nigriventer Toxin, Potentiates Erectile Function via NO/cGMP. J Urol. 2015;194:1481-90 pubmed publisher
Chen C, Wang Z, Hsu C, Lin H, Chen J. In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity. Nutrients. 2015;7:4938-54 pubmed publisher
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Hisado Oliva A, Garre Vázquez A, Santaolalla Caballero F, Belinchón A, Barreda Bonis A, Vasques G, et al. Heterozygous NPR2 Mutations Cause Disproportionate Short Stature, Similar to Léri-Weill Dyschondrosteosis. J Clin Endocrinol Metab. 2015;100:E1133-42 pubmed publisher
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Zhang Q, Wang G, Yuan W, Wu J, Wang M, Li C. The effects of phosphodiesterase-5 inhibitor sildenafil against post-resuscitation myocardial and intestinal microcirculatory dysfunction by attenuating apoptosis and regulating microRNAs expression: essential role of nitric oxide syntheses signaling. J Transl Med. 2015;13:177 pubmed publisher
Kaneda T, Saito E, Kanda H, Urakawa N, Shimizu K. Effects of papaverine on carbachol- and high K+ -induced contraction in the bovine abomasum. J Vet Med Sci. 2015;77:1269-74 pubmed publisher
Hoffmann L, Etzrodt J, Willkomm L, Sanyal A, Scheja L, Fischer A, et al. Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nat Commun. 2015;6:7235 pubmed publisher
Bai Y, An R. Resveratrol and sildenafil synergistically improve diabetes-associated erectile dysfunction in streptozotocin-induced diabetic rats. Life Sci. 2015;135:43-8 pubmed publisher
Rahaman M, Reinders F, Koes D, Nguyen A, Mutchler S, Sparacino Watkins C, et al. Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability. J Biol Chem. 2015;290:16861-72 pubmed publisher
van Huet R, Pierrache L, Meester Smoor M, Klaver C, van den Born L, Hoyng C, et al. The efficacy of microarray screening for autosomal recessive retinitis pigmentosa in routine clinical practice. Mol Vis. 2015;21:461-76 pubmed
Sridharan S, Kini R. Tail wags the dog: activity of krait natriuretic peptide is determined by its C-terminal tail in a natriuretic peptide receptor-independent manner. Biochem J. 2015;469:255-66 pubmed publisher
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Sürmeli N, Müskens F, Marletta M. The Influence of Nitric Oxide on Soluble Guanylate Cyclase Regulation by Nucleotides: ROLE OF THE PSEUDOSYMMETRIC SITE. J Biol Chem. 2015;290:15570-80 pubmed publisher
Vollmer S, Richert C. Effect of preorganization on the affinity of synthetic DNA binding motifs for nucleotide ligands. Org Biomol Chem. 2015;13:5734-42 pubmed publisher
Lv H, Che T, Tang X, Liu L, Cheng J. Puerarin enhances proliferation and osteoblastic differentiation of human bone marrow stromal cells via a nitric oxide/cyclic guanosine monophosphate signaling pathway. Mol Med Rep. 2015;12:2283-90 pubmed publisher
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Mellough C, Collin J, Khazim M, White K, Sernagor E, Steel D, et al. IGF-1 Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures From Human Embryonic Stem Cells. Stem Cells. 2015;33:2416-30 pubmed publisher
Vasconcelos A, Kinoshita P, Yshii L, Marques Orellana A, Böhmer A, de Sá Lima L, et al. Effects of intermittent fasting on age-related changes on Na,K-ATPase activity and oxidative status induced by lipopolysaccharide in rat hippocampus. Neurobiol Aging. 2015;36:1914-23 pubmed publisher
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Zhan R, Yang S, He W, Wang F, Tan J, Zhou J, et al. Nitric oxide enhances keratinocyte cell migration by regulating Rho GTPase via cGMP-PKG signalling. PLoS ONE. 2015;10:e0121551 pubmed publisher
Phan Duy A, Pham H, Pansiot J, Gressens P, Charriaut Marlangue C, Baud O. Nitric Oxide Pathway and Proliferation of Neural Progenitors in the Neonatal Rat. Dev Neurosci. 2015;37:417-27 pubmed publisher
Premkumar K, Chaube S. Nitric oxide signals postovulatory aging-induced abortive spontaneous egg activation in rats. Redox Rep. 2015;20:184-92 pubmed publisher
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Wendt D, Dvorak Ewell M, Bullens S, Lorget F, Bell S, Peng J, et al. Neutral endopeptidase-resistant C-type natriuretic peptide variant represents a new therapeutic approach for treatment of fibroblast growth factor receptor 3-related dwarfism. J Pharmacol Exp Ther. 2015;353:132-49 pubmed publisher
Hotchkiss A, Feridooni T, Baguma Nibasheka M, McNeil K, Chinni S, Pasumarthi K. Atrial natriuretic peptide inhibits cell cycle activity of embryonic cardiac progenitor cells via its NPRA receptor signaling axis. Am J Physiol Cell Physiol. 2015;308:C557-69 pubmed publisher
Deng M, Loughran P, Zhang L, Scott M, Billiar T. Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling. Sci Signal. 2015;8:ra11 pubmed publisher
Prasad S, Tiwari M, Tripathi A, Pandey A, Chaube S. Changes in signal molecules and maturation promoting factor levels associate with spontaneous resumption of meiosis in rat oocytes. Cell Biol Int. 2015;39:759-69 pubmed publisher
Kumar S, Ashraf M. Tadalafil, a Phosphodiesterase Inhibitor Protects Stem Cells over Longer Period Against Hypoxia/Reoxygenation Injury Through STAT3/PKG-I Signaling. Stem Cells Dev. 2015;24:1332-41 pubmed publisher
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Ugarte A, Gil Bea F, Garcia Barroso C, Cedazo Minguez A, Ramírez M, Franco R, et al. Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease. Neuropathol Appl Neurobiol. 2015;41:471-82 pubmed publisher
Akand M, Gencer E, Yaman O, Erişgen G, Tekin D, Ozdiler E. Effect of sildenafil on platelet function and platelet cGMP of patients with erectile dysfunction. Andrologia. 2015;47:1098-102 pubmed publisher
Marada V, Flörl S, Kühne A, Müller J, Burckhardt G, Hagos Y. Interaction of human organic anion transporter 2 (OAT2) and sodium taurocholate cotransporting polypeptide (NTCP) with antineoplastic drugs. Pharmacol Res. 2015;91:78-87 pubmed publisher
Moubarak M, Magaud C, Saliba Y, Chatelier A, Bois P, Faivre J, et al. Effects of atrial natriuretic peptide on rat ventricular fibroblasts during differentiation into myofibroblasts. Physiol Res. 2015;64:495-503 pubmed
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Tain Y, Huang L, Lee C, Chan J, Hsu C. Maternal citrulline supplementation prevents prenatal N(G)-nitro-L-arginine-methyl ester (L-NAME)-induced programmed hypertension in rats. Biol Reprod. 2015;92:7 pubmed publisher
Sun Z, Jin X, Albert R, Assmann S. Multi-level modeling of light-induced stomatal opening offers new insights into its regulation by drought. PLoS Comput Biol. 2014;10:e1003930 pubmed publisher
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BinMahfouz H, Borthakur B, Yan D, George T, Giembycz M, Newton R. Superiority of combined phosphodiesterase PDE3/PDE4 inhibition over PDE4 inhibition alone on glucocorticoid- and long-acting β2-adrenoceptor agonist-induced gene expression in human airway epithelial cells. Mol Pharmacol. 2015;87:64-76 pubmed publisher
Weed D, Vella J, Reis I, De La Fuente A, Gomez C, Sargi Z, et al. Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma. Clin Cancer Res. 2015;21:39-48 pubmed publisher
Nagy D, Tingley F, Stoiljkovic M, Hajós M. Application of neurophysiological biomarkers for Huntington's disease: evaluating a phosphodiesterase 9A inhibitor. Exp Neurol. 2015;263:122-31 pubmed publisher
Wang J, Krizowski S, Fischer Schrader K, Niks D, Tejero J, Sparacino Watkins C, et al. Sulfite Oxidase Catalyzes Single-Electron Transfer at Molybdenum Domain to Reduce Nitrite to Nitric Oxide. Antioxid Redox Signal. 2015;23:283-94 pubmed publisher
Lu W, Chang N, Jayakumar T, Liao J, Lin M, Wang S, et al. Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation by activating adenylate cyclase/cyclic AMP. Thromb Res. 2014;134:1301-10 pubmed publisher
Fabbiano S, Menacho Márquez M, Sevilla M, Albarrán Juárez J, Zheng Y, Offermanns S, et al. Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells. Mol Cell Biol. 2014;34:4404-19 pubmed publisher
Read L, Hahn R, Thompson C, Bauer D, Norton E, Clements J. Simultaneous exposure to Escherichia coli heat-labile and heat-stable enterotoxins increases fluid secretion and alters cyclic nucleotide and cytokine production by intestinal epithelial cells. Infect Immun. 2014;82:5308-16 pubmed publisher
Jin X, Zhang Y, Li X, Zhang J, Xu D. C-type natriuretic peptide ameliorates ischemia/reperfusion-induced acute kidney injury by inhibiting apoptosis and oxidative stress in rats. Life Sci. 2014;117:40-5 pubmed publisher
Maruhashi T, Noma K, Iwamoto Y, Iwamoto A, Oda N, Kajikawa M, et al. Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells. PLoS ONE. 2014;9:e109017 pubmed publisher
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Monti M, Solito R, Puccetti L, Pasotti L, Roggeri R, Monzani E, et al. Protective effects of novel metal-nonoates on the cellular components of the vascular system. J Pharmacol Exp Ther. 2014;351:500-9 pubmed publisher
Cosyns S, Huyghe L, Thoonen R, Stasch J, Brouckaert P, Lefebvre R. Influence of cinaciguat on gastrointestinal motility in apo-sGC mice. Neurogastroenterol Motil. 2014;26:1573-85 pubmed publisher
Silva F, Leiria L, Alexandre E, Davel A, Mónica F, De Nucci G, et al. Prolonged therapy with the soluble guanylyl cyclase activator BAY 60-2770 restores the erectile function in obese mice. J Sex Med. 2014;11:2661-70 pubmed publisher
Joshua J, Schwaerzer G, Kalyanaraman H, Cory E, Sah R, Li M, et al. Soluble guanylate cyclase as a novel treatment target for osteoporosis. Endocrinology. 2014;155:4720-30 pubmed publisher
Egbert J, Shuhaibar L, Edmund A, Van Helden D, Robinson J, Uliasz T, et al. Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes. Development. 2014;141:3594-604 pubmed publisher
Guo S, Duan J, Qian D, Tang Y, Wu D, Su S, et al. Content variations of triterpenic acid, nucleoside, nucleobase, and sugar in jujube (Ziziphus jujuba) fruit during ripening. Food Chem. 2015;167:468-74 pubmed publisher
Gu Q, Yang X, Lin L, Li S, Li Q, Zhong S, et al. Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. Hepatology. 2014;60:1929-41 pubmed publisher
Qiao L, Wang S, Li H, Shan Y, Dou A, Shi X, et al. A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography. J Chromatogr A. 2014;1360:240-7 pubmed publisher
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Pandey A, Chaube S. Reduction of nitric oxide level leads to spontaneous resumption of meiosis in diplotene-arrested rat oocytes cultured in vitro. Exp Biol Med (Maywood). 2015;240:15-25 pubmed publisher
Laourdakis C, Merino E, Neilson A, Cassera M. Comprehensive quantitative analysis of purines and pyrimidines in the human malaria parasite using ion-pairing ultra-performance liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;967:127-33 pubmed publisher
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Ding S, Huang W, Ye Y, Yang J, Hu J, Wang X, et al. Elevated intracranial dopamine impairs the glutamate‑nitric oxide‑cyclic guanosine monophosphate pathway in cortical astrocytes in rats with minimal hepatic encephalopathy. Mol Med Rep. 2014;10:1215-24 pubmed publisher
Abdel Aziz M, Rezq A, Atta H, Fouad H, Zaahkouk A, Ahmed H, et al. Molecular signalling of a novel curcumin derivative versus Tadalafil in erectile dysfunction. Andrologia. 2015;47:616-25 pubmed publisher
Hubert F, Belacel Ouari M, Manoury B, Zhai K, Domergue Dupont V, Mateo P, et al. Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4. Br J Pharmacol. 2014;171:5361-75 pubmed publisher
Hosgood S, Randle L, Patel M, Watson C, Bradley J, Nicholson M. Sildenafil citrate in a donation after circulatory death experimental model of renal ischemia-reperfusion injury. Transplantation. 2014;98:612-7 pubmed publisher
. Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle. J Pharmacol Exp Ther. 2014;350:681-90 pubmed publisher
Lo H, Yang R, Lee C. Guanylyl cyclase-G modulates jejunal apoptosis and inflammation in mice with intestinal ischemia and reperfusion. PLoS ONE. 2014;9:e101314 pubmed publisher
Liu J, Liu H, Li Y, Xu X, Chen Z, Liu L, et al. Cross regulation between cGMP-dependent protein kinase and Akt in vasodilatation of porcine pulmonary artery. J Cardiovasc Pharmacol. 2014;64:452-9 pubmed publisher
Nomura N, Nunes P, Bouley R, Nair A, SHAW S, Ueda E, et al. High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration. Am J Physiol Cell Physiol. 2014;307:C597-605 pubmed publisher
Liu S, Zhang M, Chen L, Liu Y, Liu G. cGMP and cGMP-dependent protein kinase I pathway in dorsal root ganglia contributes to bone cancer pain in rats. Spine (Phila Pa 1976). 2014;39:1533-41 pubmed publisher
Gilotti A, Nimlamool W, Pugh R, Slee J, Barthol T, Miller E, et al. Heparin responses in vascular smooth muscle cells involve cGMP-dependent protein kinase (PKG). J Cell Physiol. 2014;229:2142-52 pubmed publisher
Chen Z, Zhang X, Ying L, Dou D, Li Y, Bai Y, et al. cIMP synthesized by sGC as a mediator of hypoxic contraction of coronary arteries. Am J Physiol Heart Circ Physiol. 2014;307:H328-36 pubmed publisher
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product information
Catalog Number :
G6129
Product Name :
Guanosine 3′,5′-cyclic monophosphate sodium salt
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥99% (HPLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA