This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Ganciclovir
catalog :
G2536
citations: 92
Reference
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Hong C, Wang J. Comparison of pharmaceutical quality of eight generic ganciclovir injections in China and Cymevene. J Chemother. 2018;30:310-315 pubmed publisher
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Yang F, Chang W, Lin W, Hwang J, Chien Y, Wang H, et al. Focused ultrasound enhanced molecular imaging and gene therapy for multifusion reporter gene in glioma-bearing rat model. Oncotarget. 2015;6:36260-8 pubmed publisher
Goulidaki N, Alarifi S, Alkahtani S, Al Qahtani A, Spandidos D, Stournaras C, et al. RhoB is a component of the human cytomegalovirus assembly complex and is required for efficient viral production. Cell Cycle. 2015;14:2748-63 pubmed publisher
Kim S, Lee C, Lee S. Targeting the MicroRNA Passenger Strand for Regulating Therapeutic Transgenes. Nucleic Acid Ther. 2015;25:209-18 pubmed publisher
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Lenzi J, De Santis R, de Turris V, Morlando M, Laneve P, Calvo A, et al. ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons. Dis Model Mech. 2015;8:755-66 pubmed publisher
Bilavsky E, Schwarz M, Pardo J, Attias J, Levy I, Haimi Cohen Y, et al. Lenticulostriated vasculopathy is a high-risk marker for hearing loss in congenital cytomegalovirus infections. Acta Paediatr. 2015;104:e388-94 pubmed publisher
Giunco S, Celeghin A, Gianesin K, Dolcetti R, Indraccolo S, De Rossi A. Cross talk between EBV and telomerase: the role of TERT and NOTCH2 in the switch of latent/lytic cycle of the virus. Cell Death Dis. 2015;6:e1774 pubmed publisher
Alekseenko I, Snezhkov E, Chernov I, Pleshkan V, Potapov V, Sass A, et al. Therapeutic properties of a vector carrying the HSV thymidine kinase and GM-CSF genes and delivered as a complex with a cationic copolymer. J Transl Med. 2015;13:78 pubmed publisher
Komazin Meredith G, Cardinale S, Comeau K, Magalhaes K, Hartline C, Williams J, et al. TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate. Antiviral Res. 2015;119:23-7 pubmed publisher
Ebina H, Kanemura Y, Misawa N, Sakuma T, Kobayashi T, Yamamoto T, et al. A high excision potential of TALENs for integrated DNA of HIV-based lentiviral vector. PLoS ONE. 2015;10:e0120047 pubmed publisher
Bowers M, Zhang B, Ho Y, Agarwal P, Chen C, Bhatia R. Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development. Blood. 2015;125:2678-88 pubmed publisher
Kimberlin D, Jester P, Sanchez P, Ahmed A, Arav Boger R, Michaels M, et al. Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med. 2015;372:933-43 pubmed publisher
Billat P, Sauvage F, Picard N, Tafzi N, Alain S, Essig M, et al. Liquid chromatography tandem mass spectrometry quantitation of intracellular concentrations of ganciclovir and its phosphorylated forms. Anal Bioanal Chem. 2015;407:3449-56 pubmed publisher
Sanches P, Peters S, Rossin R, Kaijzel E, Que I, Löwik C, et al. Bone metastasis imaging with SPECT/CT/MRI: a preclinical toolbox for therapy studies. Bone. 2015;75:62-71 pubmed publisher
Piret J, Goyette N, Eckenroth B, Drouot E, Götte M, Boivin G. Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility. J Virol. 2015;89:4636-44 pubmed publisher
Hutterer C, Eickhoff J, Milbradt J, Korn K, Zeitträger I, Bahsi H, et al. A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations. Antimicrob Agents Chemother. 2015;59:2062-71 pubmed publisher
Tse E, Kwong Y. Epstein Barr virus-associated lymphoproliferative diseases: the virus as a therapeutic target. Exp Mol Med. 2015;47:e136 pubmed publisher
Gulley M. Genomic assays for Epstein-Barr virus-positive gastric adenocarcinoma. Exp Mol Med. 2015;47:e134 pubmed publisher
Stedt H, Samaranayake H, Kurkipuro J, Wirth G, Christiansen L, Vuorio T, et al. Tomato thymidine kinase-based suicide gene therapy for malignant glioma--an alternative for Herpes Simplex virus-1 thymidine kinase. Cancer Gene Ther. 2015;22:130-7 pubmed publisher
Boeckh M, Nichols W, Chemaly R, Papanicolaou G, Wingard J, Xie H, et al. Valganciclovir for the prevention of complications of late cytomegalovirus infection after allogeneic hematopoietic cell transplantation: a randomized trial. Ann Intern Med. 2015;162:1-10 pubmed publisher
Bhavsar A, Sandler D. Eliminating antibiotic prophylaxis for intravitreal injections: a consecutive series of 18,839 injections by a single surgeon. Retina. 2015;35:783-8 pubmed publisher
Alam Z, Al Mahdi Z, Zhu Y, McKee Z, Parris D, Parikh H, et al. Anti-cytomegalovirus activity of the anthraquinone atanyl blue PRL. Antiviral Res. 2015;114:86-95 pubmed publisher
Bilavsky E, Schwarz M, Bar Sever Z, Pardo J, Amir J. Hepatic involvement in congenital cytomegalovirus infection - infrequent yet significant. J Viral Hepat. 2015;22:763-8 pubmed publisher
Chakraborty S, Ji H, Chen J, Gersbach C, Leong K. Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis. Sci Rep. 2014;4:7403 pubmed publisher
Pescina S, Govoni P, Potenza A, Padula C, Santi P, Nicoli S. Development of a convenient ex vivo model for the study of the transcorneal permeation of drugs: histological and permeability evaluation. J Pharm Sci. 2015;104:63-71 pubmed publisher
Zhang Z, Pannunzio N, Hsieh C, Yu K, Lieber M. The role of G-density in switch region repeats for immunoglobulin class switch recombination. Nucleic Acids Res. 2014;42:13186-93 pubmed publisher
Dixon K, Theus M, Nelersa C, Mier J, Travieso L, Yu T, et al. Endogenous neural stem/progenitor cells stabilize the cortical microenvironment after traumatic brain injury. J Neurotrauma. 2015;32:753-64 pubmed publisher
Vora G, Marr B, Cummings T, Mruthyunjaya P. Conjunctival pseudotumor caused by herpes simplex virus infection. JAMA Ophthalmol. 2015;133:105-7 pubmed publisher
Ballikaya S, Lee J, Warnken U, Schnölzer M, Gebert J, Kopitz J. De Novo proteome analysis of genetically modified tumor cells by a metabolic labeling/azide-alkyne cycloaddition approach. Mol Cell Proteomics. 2014;13:3446-56 pubmed publisher
Bottino R, Wijkstrom M, van der Windt D, Hara H, Ezzelarab M, Murase N, et al. Pig-to-monkey islet xenotransplantation using multi-transgenic pigs. Am J Transplant. 2014;14:2275-87 pubmed publisher
Park J, Han J, Lee M. Thymidine kinase gene delivery using curcumin loaded peptide micelles as a combination therapy for glioblastoma. Pharm Res. 2015;32:528-37 pubmed publisher
Su C, Hu F, Wang T, Huang J, Yeh P, Lin C, et al. Clinical outcomes in cytomegalovirus-positive Posner-Schlossman syndrome patients treated with topical ganciclovir therapy. Am J Ophthalmol. 2014;158:1024-1031.e2 pubmed publisher
Koizumi N, Inatomi T, Suzuki T, Shiraishi A, Ohashi Y, Kandori M, et al. Clinical features and management of cytomegalovirus corneal endotheliitis: analysis of 106 cases from the Japan corneal endotheliitis study. Br J Ophthalmol. 2015;99:54-8 pubmed publisher
Zhu R, Chen D, Lin D, Lu F, Yin J, Li N. Adenovirus vector-mediated herpes simplex virus-thymidine kinase gene/ganciclovir system exhibits anti-tumor effects in an orthotopic hepatocellular carcinoma model. Pharmazie. 2014;69:547-52 pubmed
Samaranayake H, Pikkarainen J, Wirth T, Stedt H, Lesch H, Dragneva G, et al. Soluble vascular endothelial growth factor receptor-1 improves therapeutic efficacy of suicide gene therapy in an angiogenesis-independent manner. Hum Gene Ther. 2014;25:942-54 pubmed publisher
Liu G, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, et al. Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. Nat Commun. 2014;5:4330 pubmed publisher
Rollag H, Hartmann A, Jardine A, Humar A, Bignamini A, Asberg A, et al. Increased osteoprotegerin predicts poor virological outcome during anticytomegalovirus therapy in solid organ transplant recipients. Transplantation. 2015;99:100-5 pubmed publisher
Ponroy N, Taveira A, Mueller N, Millard A. Statins demonstrate a broad anti-cytomegalovirus activity in vitro in ganciclovir-susceptible and resistant strains. J Med Virol. 2015;87:141-53 pubmed publisher
Chien Y, Chen J, Lin W, Ding H, Wang H, Kao C, et al. Using [¹⁸F]FBAU for imaging brain tumor progression in an F98/tk-luc glioma-bearing rat model. Oncol Rep. 2014;32:691-9 pubmed publisher
Kimura S, Yoshioka K. Parathyroid hormone and parathyroid hormone type-1 receptor accelerate myocyte differentiation. Sci Rep. 2014;4:5066 pubmed publisher
Liu Z, Reba S, Chen W, Porwal S, Boom W, Petersen R, et al. Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection. J Exp Med. 2014;211:1197-213 pubmed publisher
Kinhult S, Werlenius K, Hallbeck A, Nyström P, Männikkö V, Johansson M. [Questionable effect of antiviral therapy in malignant brain tumors]. Lakartidningen. 2014;111:809 pubmed
Morales Indiano C, Arenillas Rocha L, Mas Bosch V, Florensa Brichs L. Howell-Jolly body-like inclusions in immunocompromised patients with antiviral treatment. Ann Hematol. 2014;93:2091-2 pubmed publisher
Gujadhur A, Thomson N, Aung A, McLean C, Menahem S. CMV sinusitis in a HIV-negative renal transplant recipient. Transplantation. 2014;97:e55-7 pubmed publisher
Levin R, Felsen C, Yang J, Lin J, Whitney M, Nguyen Q, et al. An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation. PLoS ONE. 2014;9:e97415 pubmed publisher
Lv Y, Lei N, Wang D, An Z, Li G, Han F, et al. Protective effect of curcumin against cytomegalovirus infection in Balb/c mice. Environ Toxicol Pharmacol. 2014;37:1140-7 pubmed publisher
Lynes J, Wibowo M, Koschmann C, Baker G, Saxena V, Muhammad A, et al. Lentiviral-induced high-grade gliomas in rats: the effects of PDGFB, HRAS-G12V, AKT, and IDH1-R132H. Neurotherapeutics. 2014;11:623-35 pubmed publisher
Dell Oste V, Gatti D, Gugliesi F, de Andrea M, Bawadekar M, Lo Cigno I, et al. Innate nuclear sensor IFI16 translocates into the cytoplasm during the early stage of in vitro human cytomegalovirus infection and is entrapped in the egressing virions during the late stage. J Virol. 2014;88:6970-82 pubmed publisher
Bergin S, Ferguson W, Corcoran S, Varughese A, Byrne D, Lawless M, et al. Symptomatic primary Cytomegalovirus infection in a HIV-positive pregnant woman. Int J STD AIDS. 2014;25:1041-3 pubmed publisher
Cheung C, Wong I, Yan K, Kwong Y. Cytomegalovirus oral lesions: harbinger of retinitis in the absence of viraemia. Ann Hematol. 2014;93:1613-5 pubmed publisher
Liu C, Hu Y. Immortal time bias in retrospective analysis: is there a survival benefit in patients with glioblastoma who received prolonged treatment of adjuvant valganciclovir?. Int J Cancer. 2014;135:250-1 pubmed publisher
Soderberg Naucler C, Peredo I, Rahbar A, Hansson F, Nordlund A, Stragliotto G. Use of Cox regression with treatment status as a time-dependent covariate to re-analyze survival benefit excludes immortal time bias effect in patients with glioblastoma who received prolonged adjuvant treatment with valganciclovir. Int J Cancer. 2014;135:248-9 pubmed publisher
Chou S, Boivin G, Ives J, Elston R. Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. J Infect Dis. 2014;209:1219-26 pubmed publisher
Wick W, Wick A, Platten M. Good maths is needed to understand CMV data in glioblastoma. Int J Cancer. 2014;134:2991-2 pubmed publisher
Komatsu T, Pikis A, Naeger L, Harrington P. Resistance of human cytomegalovirus to ganciclovir/valganciclovir: a comprehensive review of putative resistance pathways. Antiviral Res. 2014;101:12-25 pubmed publisher
Kaufman H, Haw W. Ganciclovir ophthalmic gel 0.15%: safety and efficacy of a new treatment for herpes simplex keratitis. Curr Eye Res. 2012;37:654-60 pubmed publisher
Chawla J, Ghobadi A, Mosley J, Verkruyse L, Trinkaus K, Abboud C, et al. Oral valganciclovir versus ganciclovir as delayed pre-emptive therapy for patients after allogeneic hematopoietic stem cell transplant: a pilot trial (04-0274) and review of the literature. Transpl Infect Dis. 2012;14:259-67 pubmed publisher
Croxtall J. Ganciclovir ophthalmic gel 0.15%: in acute herpetic keratitis (dendritic ulcers). Drugs. 2011;71:603-10 pubmed publisher
Mailly L, Leboeuf C, Tiberghien P, Baumert T, Robinet E. Genetically engineered T-cells expressing a ganciclovir-sensitive HSV-tk suicide gene for the prevention of GvHD. Curr Opin Investig Drugs. 2010;11:559-70 pubmed
Määttä A, Samaranayake H, Pikkarainen J, Wirth T, Yla Herttuala S. Adenovirus mediated herpes simplex virus-thymidine kinase/ganciclovir gene therapy for resectable malignant glioma. Curr Gene Ther. 2009;9:356-67 pubmed
Markovic D, Vinnakota K, Chirasani S, Synowitz M, Raguet H, Stock K, et al. Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion. Proc Natl Acad Sci U S A. 2009;106:12530-5 pubmed publisher
Avery R. Update in management of ganciclovir-resistant cytomegalovirus infection. Curr Opin Infect Dis. 2008;21:433-7 pubmed publisher
Chou S. Cytomegalovirus UL97 mutations in the era of ganciclovir and maribavir. Rev Med Virol. 2008;18:233-46 pubmed publisher
Smets K, De Coen K, Dhooge I, Standaert L, Laroche S, Mahieu L, et al. Selecting neonates with congenital cytomegalovirus infection for ganciclovir therapy. Eur J Pediatr. 2006;165:885-90 pubmed
Nawa A, Ishida D, ChenHong L. [New paradigm of herpes simplex virus type 1 thymidine kinase (HSV-TK)/ganciclovir (GCV)]. Nihon Rinsho. 2006;64 Suppl 3:345-9 pubmed
Chang M, Dunn J. Ganciclovir implant in the treatment of cytomegalovirus retinitis. Expert Rev Med Devices. 2005;2:421-7 pubmed
Couzigou C, Mazeron M, Escaut L, Merad M, Vittecoq D. [Valganciclovir maintenance therapy in AIDS: treatment failure due to the development of cytomegalovirus resistance to ganciclovir]. Med Mal Infect. 2005;35:98-100 pubmed
Scott J, Partovi N, Ensom M. Ganciclovir in solid organ transplant recipients: is there a role for clinical pharmacokinetic monitoring?. Ther Drug Monit. 2004;26:68-77 pubmed
Patel S, Cohen P, Pickering M, Gazzard B, Andreyev J. Successful treatment of acute haemorrhagic cytomegalovirus colitis with ganciclovir in an individual without overt immunocompromise. Eur J Gastroenterol Hepatol. 2003;15:1055-60 pubmed
Nicholas T, Read S, Burrows F, Kruse C. Suicide gene therapy with Herpes simplex virus thymidine kinase and ganciclovir is enhanced with connexins to improve gap junctions and bystander effects. Histol Histopathol. 2003;18:495-507 pubmed publisher
Fillat C, Carrio M, Cascante A, Sangro B. Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application. Curr Gene Ther. 2003;3:13-26 pubmed
Yoshida H, Matsunaga K, Ueda T, Yasumi M, Ishikawa J, Tomiyama Y, et al. Human herpesvirus 6 meningoencephalitis successfully treated with ganciclovir in a patient who underwent allogeneic bone marrow transplantation from an HLA-identical sibling. Int J Hematol. 2002;75:421-5 pubmed
Zamora M. Use of cytomegalovirus immune globulin and ganciclovir for the prevention of cytomegalovirus disease in lung transplantation. Transpl Infect Dis. 2001;3 Suppl 2:49-56 pubmed
McGavin J, Goa K. Ganciclovir: an update of its use in the prevention of cytomegalovirus infection and disease in transplant recipients. Drugs. 2001;61:1153-83 pubmed
Singh N. Preemptive therapy versus universal prophylaxis with ganciclovir for cytomegalovirus in solid organ transplant recipients. Clin Infect Dis. 2001;32:742-51 pubmed
Sprung C, Reynolds G, Jasin M, Murnane J. Chromosome healing in mouse embryonic stem cells. Proc Natl Acad Sci U S A. 1999;96:6781-6 pubmed
Oon C, Chen W, Lim N, Koh S, Lim G, Leong A, et al. Hepatitis B virus variants with lamivudine-related mutations in the DNA polymerase and the 'a' epitope of the surface antigen are sensitive to ganciclovir. Antiviral Res. 1999;41:113-8 pubmed
Cannon J, Hamzeh F, Moore S, Nicholas J, Ambinder R. Human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovir. J Virol. 1999;73:4786-93 pubmed
Yamasaki H, Krutovskikh V, Mesnil M, Tanaka T, Zaidan Dagli M, Omori Y. Role of connexin (gap junction) genes in cell growth control and carcinogenesis. C R Acad Sci III. 1999;322:151-9 pubmed
Rubsam L, Boucher P, Murphy P, KuKuruga M, Shewach D. Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells. Cancer Res. 1999;59:669-75 pubmed
Halloran P, Fenton R. Irreversible G2-M arrest and cytoskeletal reorganization induced by cytotoxic nucleoside analogues. Cancer Res. 1998;58:3855-65 pubmed
product information
Catalog Number :
G2536
Product Name :
Ganciclovir
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥99% (HPLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA