This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Disialoganglioside GD 1a from bovine brain
catalog :
G2392
citations: 31
Reference
Xu X, Denic A, Jordan L, Wittenberg N, Warrington A, Wootla B, et al. A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis. Dis Model Mech. 2015;8:831-42 pubmed publisher
Uncini A, Notturno F, Capasso M. Natura non facit saltus in anti-ganglioside antibody-mediated neuropathies. Muscle Nerve. 2013;48:484-7 pubmed publisher
Wakerley B, Soon D, Chan Y, Yuki N. Atypical Bickerstaff brainstem encephalitis: ataxic hypersomnolence without ophthalmoplegia. J Neurol Neurosurg Psychiatry. 2013;84:1206-7 pubmed publisher
Kim S, Kim J, Suh C. Polycranial neuropathy and sensory ataxia with IgG anti-GD1a antibody as a variant of Guillain-Barré syndrome. J Clin Neurosci. 2013;20:473-5 pubmed publisher
Ogawa G, Kaida K, Kuwahara M, Kimura F, Kamakura K, Kusunoki S. An antibody to the GM1/GalNAc-GD1a complex correlates with development of pure motor Guillain-Barré syndrome with reversible conduction failure. J Neuroimmunol. 2013;254:141-5 pubmed publisher
Lee H, Wondimu A, Liu Y, Ma J, Radoja S, Ladisch S. Ganglioside inhibition of CD8+ T cell cytotoxicity: interference with lytic granule trafficking and exocytosis. J Immunol. 2012;189:3521-7 pubmed
Venkateshwari S, Veluraja K. Molecular Modelling and Molecular Dynamics studies of GD1A, GD1B and their complexes with BoNT/B--perspectives in interaction and specificity. J Struct Biol. 2012;180:497-508 pubmed publisher
Uncini A. A common mechanism and a new categorization for anti-ganglioside antibody-mediated neuropathies. Exp Neurol. 2012;235:513-6 pubmed publisher
Yalinay Dikmen P, Emre Oge A. Recurrent GBS with GD1a anti-ganglioside antibodies. J Peripher Nerv Syst. 2012;17:135-7 pubmed publisher
Viljetić B, Labak I, Majić S, Stambuk A, Heffer M. Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes. Biochim Biophys Acta. 2012;1820:1437-43 pubmed publisher
Lai L, Bumstead J, Liu Y, Garnett J, Campanero Rhodes M, Blake D, et al. The role of sialyl glycan recognition in host tissue tropism of the avian parasite Eimeria tenella. PLoS Pathog. 2011;7:e1002296 pubmed publisher
Sekiguchi Y, Uncini A, Yuki N, Misawa S, Notturno F, Nasu S, et al. Antiganglioside antibodies are associated with axonal Guillain-Barré syndrome: a Japanese-Italian collaborative study. J Neurol Neurosurg Psychiatry. 2012;83:23-8 pubmed publisher
Santos A, Maia J, Crespo P, Pettenuzzo L, Daniotti J, Barbé Tuana F, et al. GD1a modulates GM-CSF-induced cell proliferation. Cytokine. 2011;56:600-7 pubmed publisher
Mauri L, Casellato R, Ciampa M, Uekusa Y, Kato K, Kaida K, et al. Anti-GM1/GD1a complex antibodies in GBS sera specifically recognize the hybrid dimer GM1-GD1a. Glycobiology. 2012;22:352-60 pubmed publisher
Benson M, Fu Z, KIM J, Baldwin M. Unique ganglioside recognition strategies for clostridial neurotoxins. J Biol Chem. 2011;286:34015-22 pubmed publisher
Viljetić B, Degmecić I, Krajina V, Bogdanović T, Mojsović Cuić A, Dikic D, et al. Distribution of major brain gangliosides in olfactory tract of frogs. Coll Antropol. 2011;35 Suppl 1:121-6 pubmed
Zhang L, Wang Y, Wang L, Cao T, Hyuga S, Sato T, et al. Ganglioside GD1a negatively regulates hepatocyte growth factor expression through caveolin-1 at the transcriptional level in murine osteosarcoma cells. Biochim Biophys Acta. 2011;1810:759-68 pubmed publisher
Bax M, Kuijf M, Heikema A, van Rijs W, Bruijns S, García Vallejo J, et al. Campylobacter jejuni lipooligosaccharides modulate dendritic cell-mediated T cell polarization in a sialic acid linkage-dependent manner. Infect Immun. 2011;79:2681-9 pubmed publisher
Yang H, Jung K, Kwak D, Lee S, Ryu J, Kim J, et al. Inhibition of ganglioside GD1a synthesis suppresses the differentiation of human mesenchymal stem cells into osteoblasts. Dev Growth Differ. 2011;53:323-32 pubmed publisher
Simon O, Lacour A, Delval A, Beaume A, Vermersch P. Recurrent multiple cranial nerve palsy and anti-GD1a antibodies. Muscle Nerve. 2011;43:447-8 pubmed publisher
Del Favero E, Brocca P, Motta S, Rondelli V, Sonnino S, Cantu L. Nanoscale structural response of ganglioside-containing aggregates to the interaction with sialidase. J Neurochem. 2011;116:833-9 pubmed publisher
Hatano K, Miyamoto Y, Nonomura N, Kaneda Y. Expression of gangliosides, GD1a, and sialyl paragloboside is regulated by NF-?B-dependent transcriptional control of ?2,3-sialyltransferase I, II, and VI in human castration-resistant prostate cancer cells. Int J Cancer. 2011;129:1838-47 pubmed publisher
Qian M, Tsai B. Lipids and proteins act in opposing manners to regulate polyomavirus infection. J Virol. 2010;84:9840-52 pubmed publisher
Cao T, Zhang T, Wang L, Zhang L, Adachi T, Sato T, et al. Ganglioside GD1a suppression of NOS2 expression via ERK1 pathway in mouse osteosarcoma FBJ cells. J Cell Biochem. 2010;110:1165-74 pubmed publisher
McGonigal R, Rowan E, Greenshields K, Halstead S, Humphreys P, Rother R, et al. Anti-GD1a antibodies activate complement and calpain to injure distal motor nodes of Ranvier in mice. Brain. 2010;133:1944-60 pubmed publisher
Neuwirth C, Mojon D, Weber M. GD1a-associated pure motor Guillain-Barré syndrome with hyperreflexia and bilateral papillitis. J Clin Neuromuscul Dis. 2010;11:114-9 pubmed publisher
Cencioni M, Notturno F, Caporale C, Creati B, Prencipe V, Battistini L, et al. T cell response in acute motor axonal neuropathy. Int J Immunopathol Pharmacol. 2009;22:1043-50 pubmed
Yuki N. Human gangliosides and bacterial lipo-oligosaccharides in the development of autoimmune neuropathies. Methods Mol Biol. 2010;600:51-65 pubmed publisher
Rojas Garcia R, Gallardo E, De Luna N, Juarez C, Martinez Hernandez E, Carvajal A, et al. Bulbar involvement in patients with antiganglioside antibodies against NeuNAc(alpha2-3)Gal. J Neurol Neurosurg Psychiatry. 2010;81:623-8 pubmed publisher
Yamaguchi S, Miyazaki Y, Oka S, Yano I. Stimulatory effect of gangliosides on phagocytosis, phagosome-lysosome fusion, and intracellular signal transduction system by human polymorphonuclear leukocytes. Glycoconj J. 1997;14:707-14 pubmed
Meiri K, Beverly M. Effects of gangliosides GM1 and GD1a on GAP-43 phosphorylation and dephosphorylation in isolated growth cones. J Neurochem. 1994;62:291-9 pubmed
product information
Catalog Number :
G2392
Product Name :
Disialoganglioside GD 1a from bovine brain
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥95% (TLC), lyophilized powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA